W G McCluggage

Summary

Affiliation: Northern Ireland
Country: UK

Publications

  1. pmc Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    J Clin Pathol 53:603-5. 2000
  2. ncbi request reprint Primary adenocarcinoma of the vagina arising in endocervicosis
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BL, Northern Ireland
    Int J Gynecol Pathol 20:399-402. 2001
  3. ncbi request reprint An immunohistochemical and morphological analysis of post-chemotherapy ovarian carcinoma
    K Miller
    Department of Pathology, Belfast City Hospital Trust, Belfast, UK
    J Clin Pathol 61:652-7. 2008
  4. ncbi request reprint Superficial myofibroblastoma of the lower female genital tract: report of a series including tumours with a vulval location
    R Ganesan
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Histopathology 46:137-43. 2005
  5. doi request reprint Morules in endometrioid proliferations of the uterus and ovary consistently express the intestinal transcription factor CDX2
    O Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 53:156-65. 2008
  6. doi request reprint Peritoneal stromal endometriosis: a detailed morphological analysis of a large series of cases of a common and under-recognised form of endometriosis
    D P Boyle
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 62:530-3. 2009
  7. ncbi request reprint Uterine serous carcinoma and endometrial intraepithelial carcinoma arising in endometrial polyps: report of 5 cases, including 2 associated with tamoxifen therapy
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Hum Pathol 34:939-43. 2003
  8. doi request reprint Intestinal endometriosis morphologically mimicking colonic adenocarcinoma
    P Kelly
    Department of Pathology, Royal Group of Hospitals, Belfast, UK
    Histopathology 52:510-4. 2008
  9. pmc Thyroglobulin immunoreactivity in lymph node histiocytes: a potential diagnostic pitfall
    L Venkatraman
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 54:314-6. 2001
  10. ncbi request reprint the management of vulval intraepithelial neoplasia in Northern Ireland
    A A Zawislak
    Department of Gynaecological Oncology, Belfast City Hospital, Belfast, Northern Ireland
    Int J Gynecol Cancer 16:780-5. 2006

Collaborators

Detail Information

Publications84

  1. pmc Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    J Clin Pathol 53:603-5. 2000
    ..We also wished to ascertain whether positivity may be found in the stromal cells of normal vulval skin and in other lesions at this site that can cause diagnostic confusion with aggressive angiomyxoma...
  2. ncbi request reprint Primary adenocarcinoma of the vagina arising in endocervicosis
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BL, Northern Ireland
    Int J Gynecol Pathol 20:399-402. 2001
    ..This is the second reported case of vaginal endocervicosis and the first documented report of adenocarcinoma arising in endocervicosis at any site...
  3. ncbi request reprint An immunohistochemical and morphological analysis of post-chemotherapy ovarian carcinoma
    K Miller
    Department of Pathology, Belfast City Hospital Trust, Belfast, UK
    J Clin Pathol 61:652-7. 2008
    ..The morphology of ovarian carcinoma following chemotherapy often differs markedly from native tumour. This study aimed to compare the immunophenotype of post-chemotherapy ovarian carcinomas with that of untreated tumour...
  4. ncbi request reprint Superficial myofibroblastoma of the lower female genital tract: report of a series including tumours with a vulval location
    R Ganesan
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Histopathology 46:137-43. 2005
    ....
  5. doi request reprint Morules in endometrioid proliferations of the uterus and ovary consistently express the intestinal transcription factor CDX2
    O Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 53:156-65. 2008
    ..To undertake an immunohistochemical analysis of squamous elements in endometrioid proliferations of the uterus and ovary and to compare the immunophenotype of typical squamous elements and so-called squamous morules...
  6. doi request reprint Peritoneal stromal endometriosis: a detailed morphological analysis of a large series of cases of a common and under-recognised form of endometriosis
    D P Boyle
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 62:530-3. 2009
    ..This form of endometriosis has been previously referred to as stromal or micronodular stromal endometriosis. However, there has been little reference to this condition in the literature...
  7. ncbi request reprint Uterine serous carcinoma and endometrial intraepithelial carcinoma arising in endometrial polyps: report of 5 cases, including 2 associated with tamoxifen therapy
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Hum Pathol 34:939-43. 2003
    ..Because 2 of the patients had been taking tamoxifen, this raises the possibility of an association between tamoxifen and the development of USC and EIC in the endometrial polyps that are characteristic of this medication...
  8. doi request reprint Intestinal endometriosis morphologically mimicking colonic adenocarcinoma
    P Kelly
    Department of Pathology, Royal Group of Hospitals, Belfast, UK
    Histopathology 52:510-4. 2008
  9. pmc Thyroglobulin immunoreactivity in lymph node histiocytes: a potential diagnostic pitfall
    L Venkatraman
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 54:314-6. 2001
    ..This prompted the investigation of whether thyroglobulin immunoreactivity is common in regional lymph nodes in cases of thyroid malignancy...
  10. ncbi request reprint the management of vulval intraepithelial neoplasia in Northern Ireland
    A A Zawislak
    Department of Gynaecological Oncology, Belfast City Hospital, Belfast, Northern Ireland
    Int J Gynecol Cancer 16:780-5. 2006
    ..VIN should be managed by clinicians with expertise in this field and who are treating significant numbers of patients according to evidence-based protocols...
  11. ncbi request reprint Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Ireland
    Int J Gynecol Pathol 27:92-100. 2008
    ....
  12. ncbi request reprint Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential
    H A McBride
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 50:851-8. 2007
    ..p16 expression was also compared with that of p53 and MIB1...
  13. doi request reprint Signet ring cells of stromal derivation in the uterine cervix secondary to cauterisation: report of a previously undescribed phenomenon
    M McKenna
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 61:648-51. 2008
    ..To describe the occurrence of signet ring cells of stromal origin within the uterine cervix...
  14. pmc My approach to the interpretation of endometrial biopsies and curettings
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland
    J Clin Pathol 59:801-12. 2006
    ..The value of ancillary techniques, especially immunohistochemistry, is discussed where appropriate...
  15. ncbi request reprint An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 23:330-6. 2004
    ..Germ cell and neuroendocrine origins seem highly unlikely...
  16. ncbi request reprint A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma
    R I Cameron
    Department of Pathalogy, Royal Group of Hospitals Trust, Belfast, Northern Ireland, United Kingdom
    Int J Gynecol Pathol 22:272-6. 2003
    ..Primary ovarian clear cell carcinomas are characterized by CK7 positivity, whereas primary renal neoplasms are characterized by positivity for CD10 and RCC marker and negative staining with CK7...
  17. ncbi request reprint Endometrial hyperplasia involving endometrial polyps: report of a series and discussion of the significance in an endometrial biopsy specimen
    P Kelly
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    BJOG 114:944-50. 2007
    ..Currently, it is not known whether the hyperplasia is likely to be confined to the polyp or also involve nonpolypoid endometrium. We aim to assess the likelihood of hyperplasia being confined to an endometrial polyp...
  18. ncbi request reprint WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma
    M Al-Hussaini
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 44:109-15. 2004
    ..This study aims to document the value of WT-1 in these settings. Cases of ovarian borderline serous tumour, primary peritoneal serous carcinoma (PPSC) and uterine endometrioid carcinoma were also studied...
  19. ncbi request reprint High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour
    C J O'Neill
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland, UK
    Histopathology 50:773-9. 2007
    ..The aim of this study was to compare expression of p16 INK4A (p16) in these two tumour types. We also included cases of serous borderline tumour, since these are considered to represent a precursor lesion of low-grade serous carcinoma...
  20. ncbi request reprint Value of inhibin staining in gynecological pathology
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Int J Gynecol Pathol 20:79-85. 2001
    ....
  21. pmc Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma
    R I Cameron
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 57:888-90. 2004
    ....
  22. ncbi request reprint The large loop excision of the transformation zone cut or blend thermal artefact study: a randomized controlled trial
    H A Nagar
    Department of Gynaecological Oncology, Belfast City Hospital, Belfast, Northern Ireland, UK
    Int J Gynecol Cancer 14:1108-11. 2004
    ....
  23. ncbi request reprint Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord-stromal tumours
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast and The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Histopathology 38:403-8. 2001
    ..The aim of this study was to investigate calretinin staining in a series of these tumours and their histological mimics in order to determine the value of calretinin staining in a diagnostic setting...
  24. ncbi request reprint Monoclonal antibody SM047 as an immunohistochemical marker of ovarian adenocarcinoma
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 38:542-9. 2001
    ..These findings need to be confirmed by further study of larger numbers of cases...
  25. ncbi request reprint Aggressive angiomyxoma of the vulva: Dramatic response to gonadotropin-releasing hormone agonist therapy
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    Gynecol Oncol 100:623-5. 2006
    ..Most cases exhibit positive immunohistochemical staining with oestrogen receptor (ER) and, or, progesterone receptor (PR)...
  26. pmc Uterine tumour resembling ovarian sex cord tumour is an immunohistochemically polyphenotypic neoplasm which exhibits coexpression of epithelial, myoid and sex cord markers
    D P Hurrell
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 60:1148-54. 2007
    ..To describe the clinicopathological and immunohistochemical findings in four cases of uterine tumour resembling ovarian sex cord tumour (UTROSCT)...
  27. ncbi request reprint Endometrial stromal neoplasms are immunoreactive with WT-1 antibody
    V P Sumathi
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Int J Gynecol Pathol 23:241-7. 2004
    ..The overlapping immunophenotype of endometrial stromal and leiomyomatous neoplasms may reflect the origin of both cell types from a common progenitor within the uterus...
  28. ncbi request reprint CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Histopathology 39:273-8. 2001
    ..Staining of a range of tumours which can be confused morphologically with endometrial stromal neoplasms was also undertaken to ascertain whether antibodies against CD10 are of value in a diagnostic sense...
  29. doi request reprint Combined actinomycotic and pseudoactinomycotic radiate granules in the female genital tract: description of a series of cases
    D P Boyle
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BA, Northern Ireland, UK
    J Clin Pathol 62:1123-6. 2009
    ..It is important to distinguish between these since the former may result in pelvic inflammatory disease and require antibiotic treatment while the latter is non-infectious and does not require specific treatment...
  30. ncbi request reprint p16 immunoreactivity may assist in the distinction between endometrial and endocervical adenocarcinoma
    W G McCluggage
    Department of Pathology, Royal Group Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 22:231-5. 2003
    ..Diffuse, strong positivity with p16 in endocervical adenocarcinomas is likely caused by inactivation of the retinoblastoma protein by the E7 human papillomavirus oncoprotein, which acts as a p16 transcript repressor...
  31. pmc Non-neoplastic granulosa cells within ovarian vascular channels: a rare potential diagnostic pitfall
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 57:151-4. 2004
    ..To describe six cases seen in consultation in which artefactual vascular involvement within the ovary by benign granulosa cells caused diagnostic confusion...
  32. ncbi request reprint Clear cell struma ovarii
    M B Loughrey
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 43:495-7. 2003
  33. ncbi request reprint CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 43:144-50. 2003
    ..In this study the specificity of these two antibodies in evaluating cervical and uterine glandular lesions and the value of CD10 in determining whether stroma is endometriotic or not were investigated...
  34. pmc Results of a questionnaire regarding criteria for adequacy of endometrial biopsies
    V Phillips
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 58:417-9. 2005
    ..An initial audit showing variation in endometrial biopsy adequacy reporting prompted this assessment of the criteria used by specialist gynaecological pathologists for the classification of adequacy...
  35. ncbi request reprint Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, and Department of Pathology, St James s University Hospital, Leeds, UK
    Histopathology 47:231-47. 2005
    ..We critically discuss the value of immunohistochemistry and associated pitfalls with each tumour type described...
  36. ncbi request reprint Gynandroblastoma of ovary with juvenile granulosa cell component and heterologous intestinal type glands
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Histopathology 29:253-7. 1996
    ..The tumour demonstrates a unique combination of elements which has not previously been described...
  37. pmc Audit and internal quality control in immunohistochemistry
    P Maxwell
    Quantitative Biomarkers Group, Cancer Research Centre, Queens University of Belfast and Institute of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BA, Northern Ireland, UK
    J Clin Pathol 53:929-32. 2000
    ..This study, comprising a retrospective audit, aims to describe a method of internal quality control for immunohistochemistry. A scoring system that allows comparison between cases is described...
  38. ncbi request reprint Immunohistochemical expression of CD10 and t(14;18) chromosomal translocation may be indicators of follicle centre cell origin in nodal diffuse large B-cell lymphoma
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast City Hospital Trust, Belfast, UK
    Histopathology 41:414-20. 2002
    ..We also correlated these parameters with the presence or absence of p53 protein expression by the neoplastic cells...
  39. ncbi request reprint My approach to and thoughts on the typing of ovarian carcinomas
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT126BL, Northern Ireland, UK
    J Clin Pathol 61:152-63. 2008
    ....
  40. ncbi request reprint Lesson of the month: neuroendocrine carcinoma of the caecum
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, N Ireland, UK
    Histopathology 41:556-8. 2002
  41. ncbi request reprint SM047 immunoreactivity in peritoneal fluids
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Cytopathology 14:32-6. 2003
    ..The small numbers of other malignancies in the study precludes a judgement of the value of SM047 staining in these neoplasms. SM047 staining may be useful, as part of a larger panel, in the work up of patients with peritoneal effusions...
  42. pmc Endocervical glandular lesions: controversial aspects and ancillary techniques
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    J Clin Pathol 56:164-73. 2003
    ....
  43. ncbi request reprint Soft tissue myoepithelioma: a case report
    L Venkatraman
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Pathology 34:451-4. 2002
    ..This case report highlights the rare occurrence of myoepitheliomas in deep soft tissues. Pathologists should be aware of this and should consider a myoepithelioma in the differential diagnosis of a soft tissue spindle cell neoplasm...
  44. pmc Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    J Clin Pathol 53:327-34. 2000
    ..Of these, anti-alpha inhibin appears to be of most diagnostic value. It is stressed that these antibodies should always be used as part of a larger panel and not in isolation...
  45. pmc Lymphoepithelioma-like carcinoma of the vagina
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 54:964-5. 2001
    ..In situ hybridisation and immunohistochemistry for Epstein-Barr virus were negative. A review of the literature reveals that such neoplasms appear to be extremely rare within the female genital tract outside of the cervix...
  46. doi request reprint Enterobious vermicularis (pinworm) infestation of the vulva: report of 2 cases of a pseudoneoplastic lesion mimicking squamous carcinoma
    P Konanahalli
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 29:490-3. 2010
    ....
  47. pmc Soft tissue, pelvic, and urinary bladder leiomyosarcoma as second neoplasm following hereditary retinoblastoma
    L Venkatraman
    Department of Pathology, Belfast City Hospital Trust, Belfast BT9 7AD, Northern Ireland, UK
    J Clin Pathol 56:233-6. 2003
    ..Leiomyosarcoma developing as a second malignancy has rarely been reported and most have occurred in the field of previous radiotherapy. The literature on leiomyosarcoma occurring as a second neoplasm following retinoblastoma is reviewed...
  48. ncbi request reprint Radiation-induced atypical squamous metaplasia of the urinary bladder mucosa with involvement of subepithelial tissue mimicking metastatic cervical squamous carcinoma
    K M Dillon
    Department of Pathology, Royal Group of Hospital Trust, Belfast, Northern Ireland
    Histopathology 46:105-6. 2005
  49. pmc Embryonal rhabdomyosarcoma of the cervix with focal pleomorphic areas
    J P Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    J Clin Pathol 60:88-9. 2007
    ..The significance of this finding is uncertain. These foci may represent areas of dedifferentiation in an embryonal rhabdomyosarcoma...
  50. pmc A simple method for the prevention of endometrial autolysis in hysterectomy specimens
    J P Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 57:332-3. 2004
    ..Assessment of the endometrium is often difficult because of pronounced tissue autolysis. This study describes a simple method to prevent endometrial autolysis and aid in interpretation of the endometrium...
  51. ncbi request reprint Unusual morphologic features of uterine leiomyomas treated with gonadotropin-releasing hormone agonists: massive lymphoid infiltration and vasculitis
    G McClean
    Department of Pathology, Royal Hospitals Trust, Belfast, Northern Ireland
    Int J Surg Pathol 11:339-44. 2003
    ..Since GnRH agonists are increasingly being used in the management of uterine leiomyomas, pathologists should be aware of these unusual morphologic features in order to avoid diagnostic confusion...
  52. ncbi request reprint Current concepts in ovarian epithelial tumorigenesis: correlation between morphological and molecular data
    M Scott
    Department of Pathology, Royal Group of Hospitals Trust, Belfast
    Histol Histopathol 21:81-92. 2006
    ..It can be anticipated that this will lead to the development of specific therapeutic agents of value against a specific tumour type...
  53. ncbi request reprint Atypical carcinoid tumor of the larynx: an immunohistochemical, ultrastructural, and flow cytometric analysis
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Ultrastruct Pathol 21:431-8. 1997
    ..Further study is necessary to determine whether mutation of the p53 gene is important in the evolution of laryngeal neuroendocrine tumors and whether DNA aneuploidy or polyploidy identifies a subset of these tumors with a poor prognosis...
  54. ncbi request reprint Cellular angiofibroma and related fibromatous lesions of the vulva: report of a series of cases with a morphological spectrum wider than previously described
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 45:360-8. 2004
    ..We believe these lesions fall within the broad spectrum of fibromatous lesions of the vulva...
  55. pmc Uterine endometrial stromal sarcoma with smooth muscle and glandular differentiation
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 54:481-3. 2001
    ..This report discusses the differential diagnosis of this lesion, which has been designated a low grade endometrial stromal sarcoma with smooth muscle and glandular differentiation...
  56. ncbi request reprint Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia
    R I Cameron
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northen Ireland
    Histopathology 41:313-21. 2002
    ..This study investigates the value of immunohistochemical staining with MIB1, bcl2 and p16 in the distinction of cervical glandular intraepithelial neoplasia from these benign mimics...
  57. pmc Cytomegalovirus infection of the cervix: morphological observations in five cases of a possibly under-recognised condition
    C E McGalie
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 57:691-4. 2004
    ..This study describes histopathological findings in five biopsies from four patients with CMV cervicitis...
  58. ncbi request reprint Extragenital müllerian carcinosarcoma arising from the peritoneum: report of two cases
    V P Sumathi
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Cancer 12:764-7. 2002
    ..We wish to highlight the fact that these aggressive neoplasms may occasionally have a peritoneal origin, similar to primary peritoneal serous carcinomas...
  59. ncbi request reprint Serous carcinoma arising in an adenofibroma of the endometrium
    L Venkatraman
    Department of Pathology, Belfast City Hospital Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 22:194-7. 2003
    ..The carcinoma involved the myometrium and cervix (stage IIa). To our knowledge, this is the third documented case of an adenocarcinoma and the first serous carcinoma involving a uterine adenofibroma...
  60. doi request reprint Bone marrow micrometastases in esophageal carcinoma: a 10-year follow-up study
    R T Gray
    Department of Upper Gastrointestinal Surgery, Ulster Hospital, Dundonald, UK
    Dis Esophagus 25:709-15. 2012
    ..Although the presence of BMMs correlates with recognized adverse tumor characteristics in patients with esophageal cancer, micrometastases detected in the bone marrow at time of surgery does not influence long-term survival...
  61. pmc The effects of the levonorgestrel intrauterine system (Mirena coil) on endometrial morphology
    V Phillips
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 56:305-7. 2003
    ..The Mirena coil is a levonorgestrel releasing intrauterine device that is in widespread use. This study aims to document the endometrial morphology associated with this device...
  62. ncbi request reprint Ovarian fibrosarcoma with androgenic manifestations: a rare association
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    BJOG 109:1079-80. 2002
  63. ncbi request reprint Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas
    W G McCluggage
    Department of Pathology, Royal Groups of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Cancer 12:687-90. 2002
    ..Prospective studies should be performed to ascertain whether such adjuvant therapies are more effective than traditional sarcoma based therapies in the treatment of these aggressive neoplasms...
  64. pmc Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas?
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    J Clin Pathol 55:321-5. 2002
    ..Importantly, a small proportion of uterine carcinosarcomas are true collision tumours and should be recognised as such because, in some instances, the prognosis may be better than for a similar stage carcinosarcoma...
  65. pmc CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis
    V P Sumathi
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 55:391-2. 2002
    ..The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in confirming a diagnosis of endometriosis...
  66. doi request reprint Application of immunohistochemistry to gynecologic pathology
    Khush Mittal
    Department of Pathology, NYU School of Medicine and Surgical and Ob Gyn Pathology, Bellevue Hospital, Room 4 west 1, 462 First Ave, New York, NY 10016, USA
    Arch Pathol Lab Med 132:402-23. 2008
    ..Immunohistochemical stains are extremely useful in resolving many of these problematic cases. As the knowledge in this area is constantly expanding, it is useful to have this updated information in a review form for easy access...
  67. ncbi request reprint Recent advances in immunohistochemistry in gynaecological pathology
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 40:309-26. 2002
    ..A newly developed monoclonal antibody HMGIC which is expressed in vulvovaginal aggressive angiomyxoma may prove to be of value in the often difficult distinction of this lesion from its histological mimics...
  68. doi request reprint WT-1 immunohistochemical expression in small round blue cell tumours
    W G McCluggage
    Histopathology 52:631-2. 2008
  69. ncbi request reprint Placental site nodule of the ovary
    M Al-Hussaini
    Histopathology 41:471-2. 2002
  70. pmc Morphological effects of chemotherapy on ovarian carcinoma
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 55:27-31. 2002
    ..This study aims to describe the morphological features found in ovarian carcinoma after chemotherapy because these have not been detailed previously...
  71. pmc Role of polymerase chain reaction and immunocytochemistry in the cytological assessment of lymphoid proliferations
    L Venkatraman
    Department of Histopathology, Royal Victoria Hospital, Belfast, UK
    J Clin Pathol 59:1160-5. 2006
    ..The combined use of genetic analysis and flow cytometry for immunophenotyping has increased the accuracy of diagnosis and correct categorisation of lymphomas on cytological preparations...
  72. ncbi request reprint Uterine leiomyosarcoma with HMB45+ clear cell areas: report of two cases
    D P Hurrell
    Histopathology 47:540-2. 2005
  73. pmc Inhibin is more specific than calretinin as an immunohistochemical marker for differentiating sarcomatoid granulosa cell tumour of the ovary from other spindle cell neoplasms
    V I Shah
    Department of Histopathology, Singleton Hospital, Sketty, Swansea SA2 8QA, Wales, UK
    J Clin Pathol 56:221-4. 2003
    ..To describe a case of recurrent sarcomatoid adult granulosa cell tumour (AGCT) of the ovary and to evaluate the usefulness of two ovarian sex cord stromal markers (inhibin and calretinin) in separating sarcomatoid AGCT from true sarcomas...
  74. ncbi request reprint [Uterine carcinosarcoma related to tamoxifen]
    W G McCluggage
    Int J Gynecol Cancer 13:697-8; author reply 697-8. 2003
  75. ncbi request reprint Differentiation and proliferation related proteins in the epithelium of prophylactically removed ovaries from women with a hereditary female adnexal cancer predisposition
    W G McCluggage
    Histopathology 45:298-9. 2004
  76. pmc Early experience with chronic hepatitis C in Northern Ireland: epidemiology and response to monotherapy
    N I McDougall
    The Liver Unit, Royal Victoria Hospital, 1st Floor, East Wing, Grosvenor Road, Belfast
    Ulster Med J 73:25-31. 2004
    ..Only a minority of anti-HCV positive non-haemophiliac patients progress to have interferon therapy suggesting that the cost of treating chronic HCV may not be as great as initially thought...
  77. ncbi request reprint Simple clefts, complex problems: reflections on glandular lesions of the uterine cervix
    W G McCluggage
    Int J Gynecol Pathol 22:103-4. 2003
  78. pmc Recurrent cellular angiofibroma of the vulva
    W G McCluggage
    J Clin Pathol 55:477-9. 2002
  79. pmc MR staging in carcinoma of the endometrium and carcinoma of the cervix
    M V Pakkal
    Department of Radiology, Royal Victoria Hospital, Grosvenor Road, Belfast
    Ulster Med J 73:20-4. 2004
    ..It helps decide operability, the type of operation and aids in the selection of patients who need to be considered for specialist referral to a gynaecologist oncologist...
  80. ncbi request reprint Ischemic fasciitis: an unusual vulvovaginal spindle cell lesion
    R Scanlon
    Department of Pathology, National Maternity Hospital, Dublin, Ireland
    Int J Gynecol Pathol 23:65-7. 2004
    ..Histologic examination showed surface ulceration and underlying fibrinoid necrosis with surrounding reactive atypical fibroblast-like cells and small blood vessels, the characteristic histologic features of ischemic fasciitis...
  81. ncbi request reprint Computerized diagnostic decision support system for the classification of preinvasive cervical squamous lesions
    G J Price
    Quantitative Pathology Laboratory, Cancer Research Centre and Centre for Health Care Informatics, The Queen s University, Belfast, United Kingdom
    Hum Pathol 34:1193-203. 2003
    ..DSSs such as this therefore not only have a role to play in enhancing decision making but also in the study of diagnostic protocol, education, self-assessment, and quality control...
  82. ncbi request reprint Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen-associated polypoid uterine lesions
    J P Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Mod Pathol 16:395-8. 2003
    ..Because primary endometrial carcinomas may also arise within tamoxifen polyps, these should be extensively sampled. We briefly review polypoid uterine lesions that may occur secondary to tamoxifen therapy...
  83. ncbi request reprint Large cell neuroendocrine carcinoma of the uterine cervix exhibiting TTF1 immunoreactivity
    W G McCluggage
    Histopathology 51:405-7. 2007
  84. ncbi request reprint Immunoreactivity of ovarian juvenile granulosa cell tumours with epithelial membrane antigen
    W G McCluggage
    Histopathology 46:235-6. 2005