W G McCluggage


Affiliation: Northern Ireland
Country: UK


  1. request reprint
    McCluggage W, Young R. Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. Semin Diagn Pathol. 2005;22:3-32 pubmed
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    McCluggage W. A review and update of morphologically bland vulvovaginal mesenchymal lesions. Int J Gynecol Pathol. 2005;24:26-38 pubmed
  3. McCluggage W. My approach to the interpretation of endometrial biopsies and curettings. J Clin Pathol. 2006;59:801-12 pubmed
    ..The value of ancillary techniques, especially immunohistochemistry, is discussed where appropriate. ..
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    McCluggage W. Ovarian neoplasms composed of small round cells: a review. Adv Anat Pathol. 2004;11:288-96 pubmed
    ..In this review, the morphologic features of some of these neoplasms are described, as is the value of immunohistochemistry and other ancillary techniques in establishing a diagnosis. ..
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    McCluggage W, Jamieson T, Dobbs S, Grey A. Aggressive angiomyxoma of the vulva: Dramatic response to gonadotropin-releasing hormone agonist therapy. Gynecol Oncol. 2006;100:623-5 pubmed
    ..These agents may also be used to effect a reduction in size, so that more conservative surgery can be undertaken. ..
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    McCluggage W, McKenna M, McBride H. CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 2007;26:322-7 pubmed
  7. McCluggage W, Sumathi V, Nucci M, Hirsch M, Dal Cin P, Wells M, et al. Ewing family of tumours involving the vulva and vagina: report of a series of four cases. J Clin Pathol. 2007;60:674-80 pubmed
    ..This report expands the published literature regarding EFTs involving the vulva and vagina and stresses the importance of molecular techniques in firmly establishing the diagnosis, especially when these neoplasms arise at unusual sites. ..
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    McCluggage W, Young R. Paraganglioma of the ovary: report of three cases of a rare ovarian neoplasm, including two exhibiting inhibin positivity. Am J Surg Pathol. 2006;30:600-5 pubmed
    ..Possible theories of histogenesis of primary ovarian paraganglioma include an origin from extra-adrenal paraganglia in the region of the ovary or unidirectional differentiation within a teratoma. ..
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    McCluggage W. A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms. Adv Anat Pathol. 2004;11:162-71 pubmed

More Information


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    McCluggage W, Oliva E, Connolly L, McBride H, Young R. An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. Int J Gynecol Pathol. 2004;23:330-6 pubmed
    ..Germ cell and neuroendocrine origins seem highly unlikely. ..
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    McCluggage W, Ganesan R, Hirschowitz L, Miller K, Rollason T. Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis. Am J Surg Pathol. 2006;30:209-15 pubmed
    ..Possible theories of histogenesis include a developmental anomaly, metaplasia of preexisting endocervical glands, and derivation from mesonephric remnants. ..
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    McCluggage W, Strand K, Abdulkadir A. Immunohistochemical localization of metallothionein in benign and malignant epithelial ovarian tumors. Int J Gynecol Cancer. 2002;12:62-5 pubmed
    ..Whether high MT expression is an independent prognostic factor and increased expression indicates chemotherapy resistance in ovarian cancer, as has been previously suggested, should be determined by further studies. ..
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    McCluggage W. Recent advances in immunohistochemistry in gynaecological pathology. Histopathology. 2002;40:309-26 pubmed
    ..A newly developed monoclonal antibody HMGIC which is expressed in vulvovaginal aggressive angiomyxoma may prove to be of value in the often difficult distinction of this lesion from its histological mimics. ..
  5. McCluggage W. Lymphoepithelioma-like carcinoma of the vagina. J Clin Pathol. 2001;54:964-5 pubmed
    ..In situ hybridisation and immunohistochemistry for Epstein-Barr virus were negative. A review of the literature reveals that such neoplasms appear to be extremely rare within the female genital tract outside of the cervix. ..
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    McCluggage W, Boyde A. Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant. Int J Surg Pathol. 2007;15:262-5 pubmed
    ..Uterine angioleiomyoma has a close morphological resemblance to the similarly named skin tumor. We review uterine smooth-muscle and other mesenchymal neoplasms in which prominent vascular channels are a feature. ..
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    McCluggage W, Shah R, Connolly L, McBride H. Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2. Int J Gynecol Pathol. 2008;27:92-100 pubmed
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    McCluggage W, Ganesan R, Hirschowitz L, Rollason T. Cellular angiofibroma and related fibromatous lesions of the vulva: report of a series of cases with a morphological spectrum wider than previously described. Histopathology. 2004;45:360-8 pubmed
    ..We believe these lesions fall within the broad spectrum of fibromatous lesions of the vulva...
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    McCluggage W, Oliva E, Herrington C, McBride H, Young R. CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endome. Histopathology. 2003;43:144-50 pubmed
    ..In this study the specificity of these two antibodies in evaluating cervical and uterine glandular lesions and the value of CD10 in determining whether stroma is endometriotic or not were investigated...
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    McCluggage W. Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas. Int J Gynecol Cancer. 2002;12:687-90 pubmed
    ..Prospective studies should be performed to ascertain whether such adjuvant therapies are more effective than traditional sarcoma based therapies in the treatment of these aggressive neoplasms...
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    McCluggage W, Young R. Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors). Am J Surg Pathol. 2007;31:592-7 pubmed
    ..The presence of more typical Sertoli cell elements and Leydig cells, an absence of squamous elements, endometriosis or associated adenofibroma, and the characteristic immunophenotype assist in diagnosis...
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    McCluggage W, Young R. Tubulo-squamous polyp: a report of ten cases of a distinctive hitherto uncharacterized vaginal polyp. Am J Surg Pathol. 2007;31:1013-9 pubmed