W G McCluggage

Summary

Affiliation: Northern Ireland
Country: UK

Publications

  1. ncbi request reprint Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Semin Diagn Pathol 22:3-32. 2005
  2. pmc My approach to the interpretation of endometrial biopsies and curettings
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland
    J Clin Pathol 59:801-12. 2006
  3. ncbi request reprint A review and update of morphologically bland vulvovaginal mesenchymal lesions
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BL, Northern Ireland
    Int J Gynecol Pathol 24:26-38. 2005
  4. pmc Non-detection of Chlamydia species in carotid atheroma using generic primers by nested PCR in a population with a high prevalence of Chlamydia pneumoniae antibody
    G M Ong
    Regional Virus Laboratory, Royal Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, UK
    BMC Infect Dis 1:12. 2001
  5. ncbi request reprint CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 43:144-50. 2003
  6. pmc Results of a questionnaire regarding criteria for adequacy of endometrial biopsies
    V Phillips
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 58:417-9. 2005
  7. pmc Endocervical glandular lesions: controversial aspects and ancillary techniques
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    J Clin Pathol 56:164-73. 2003
  8. ncbi request reprint SM047 immunoreactivity in peritoneal fluids
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Cytopathology 14:32-6. 2003
  9. ncbi request reprint Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors)
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Am J Surg Pathol 31:592-7. 2007
  10. ncbi request reprint Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, and Department of Pathology, St James s University Hospital, Leeds, UK
    Histopathology 47:231-47. 2005

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Semin Diagn Pathol 22:3-32. 2005
    ....
  2. pmc My approach to the interpretation of endometrial biopsies and curettings
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland
    J Clin Pathol 59:801-12. 2006
    ..The value of ancillary techniques, especially immunohistochemistry, is discussed where appropriate...
  3. ncbi request reprint A review and update of morphologically bland vulvovaginal mesenchymal lesions
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BL, Northern Ireland
    Int J Gynecol Pathol 24:26-38. 2005
    ....
  4. pmc Non-detection of Chlamydia species in carotid atheroma using generic primers by nested PCR in a population with a high prevalence of Chlamydia pneumoniae antibody
    G M Ong
    Regional Virus Laboratory, Royal Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, UK
    BMC Infect Dis 1:12. 2001
    ..The association of Chlamydia pneumoniae with atherosclerosis is controversial. We investigated the presence of C. pneumoniae and other Chlamydia spp. in atheromatous carotid artery tissue...
  5. ncbi request reprint CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 43:144-50. 2003
    ..In this study the specificity of these two antibodies in evaluating cervical and uterine glandular lesions and the value of CD10 in determining whether stroma is endometriotic or not were investigated...
  6. pmc Results of a questionnaire regarding criteria for adequacy of endometrial biopsies
    V Phillips
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 58:417-9. 2005
    ..An initial audit showing variation in endometrial biopsy adequacy reporting prompted this assessment of the criteria used by specialist gynaecological pathologists for the classification of adequacy...
  7. pmc Endocervical glandular lesions: controversial aspects and ancillary techniques
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    J Clin Pathol 56:164-73. 2003
    ....
  8. ncbi request reprint SM047 immunoreactivity in peritoneal fluids
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Cytopathology 14:32-6. 2003
    ..The small numbers of other malignancies in the study precludes a judgement of the value of SM047 staining in these neoplasms. SM047 staining may be useful, as part of a larger panel, in the work up of patients with peritoneal effusions...
  9. ncbi request reprint Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors)
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Am J Surg Pathol 31:592-7. 2007
    ..The presence of more typical Sertoli cell elements and Leydig cells, an absence of squamous elements, endometriosis or associated adenofibroma, and the characteristic immunophenotype assist in diagnosis...
  10. ncbi request reprint Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, and Department of Pathology, St James s University Hospital, Leeds, UK
    Histopathology 47:231-47. 2005
    ..We critically discuss the value of immunohistochemistry and associated pitfalls with each tumour type described...
  11. ncbi request reprint Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas
    W G McCluggage
    Department of Pathology, Royal Groups of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Cancer 12:687-90. 2002
    ..Prospective studies should be performed to ascertain whether such adjuvant therapies are more effective than traditional sarcoma based therapies in the treatment of these aggressive neoplasms...
  12. ncbi request reprint Immunohistochemistry as a diagnostic aid in cervical pathology
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospital Trust, Belfast, Northern Ireland
    Pathology 39:97-111. 2007
    ....
  13. ncbi request reprint Paraganglioma of the ovary: report of three cases of a rare ovarian neoplasm, including two exhibiting inhibin positivity
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland
    Am J Surg Pathol 30:600-5. 2006
    ..Possible theories of histogenesis of primary ovarian paraganglioma include an origin from extra-adrenal paraganglia in the region of the ovary or unidirectional differentiation within a teratoma...
  14. pmc Ewing family of tumours involving the vulva and vagina: report of a series of four cases
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    J Clin Pathol 60:674-80. 2007
    ..In this study, four new cases of EFTs involving the vulva (three cases) or vagina (one case) are reported...
  15. ncbi request reprint Ovarian neoplasms composed of small round cells: a review
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Adv Anat Pathol 11:288-96. 2004
    ..In this review, the morphologic features of some of these neoplasms are described, as is the value of immunohistochemistry and other ancillary techniques in establishing a diagnosis...
  16. ncbi request reprint Cellular angiofibroma and related fibromatous lesions of the vulva: report of a series of cases with a morphological spectrum wider than previously described
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 45:360-8. 2004
    ..We believe these lesions fall within the broad spectrum of fibromatous lesions of the vulva...
  17. ncbi request reprint An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 23:330-6. 2004
    ..Germ cell and neuroendocrine origins seem highly unlikely...
  18. ncbi request reprint CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 26:322-7. 2007
    ....
  19. ncbi request reprint Tubulo-squamous polyp: a report of ten cases of a distinctive hitherto uncharacterized vaginal polyp
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Am J Surg Pathol 31:1013-9. 2007
    ....
  20. ncbi request reprint Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, and University of Wales, Cardiff, UK
    Int J Surg Pathol 15:262-5. 2007
    ..Uterine angioleiomyoma has a close morphological resemblance to the similarly named skin tumor. We review uterine smooth-muscle and other mesenchymal neoplasms in which prominent vascular channels are a feature...
  21. ncbi request reprint A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Adv Anat Pathol 11:162-71. 2004
    ....
  22. ncbi request reprint Immunohistochemical expression of CD10 and t(14;18) chromosomal translocation may be indicators of follicle centre cell origin in nodal diffuse large B-cell lymphoma
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast City Hospital Trust, Belfast, UK
    Histopathology 41:414-20. 2002
    ..We also correlated these parameters with the presence or absence of p53 protein expression by the neoplastic cells...
  23. ncbi request reprint A Strategy for defining biologically relevant levels of p53 protein expression in clinical samples with reference to endometrial neoplasia
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 24:307-12. 2005
    ..Thirdly, standardization between laboratories is necessary if clinical utility is to be attached to markers including p53. We propose a strategy for determining the optimal p53 antibody concentration...
  24. ncbi request reprint Aggressive angiomyxoma of the vulva: Dramatic response to gonadotropin-releasing hormone agonist therapy
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    Gynecol Oncol 100:623-5. 2006
    ..Most cases exhibit positive immunohistochemical staining with oestrogen receptor (ER) and, or, progesterone receptor (PR)...
  25. ncbi request reprint Value of inhibin staining in gynecological pathology
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Int J Gynecol Pathol 20:79-85. 2001
    ....
  26. pmc Thyroglobulin immunoreactivity in lymph node histiocytes: a potential diagnostic pitfall
    L Venkatraman
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 54:314-6. 2001
    ..This prompted the investigation of whether thyroglobulin immunoreactivity is common in regional lymph nodes in cases of thyroid malignancy...
  27. ncbi request reprint Immunohistochemical and functional biomarkers of value in female genital tract lesions
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 25:101-20. 2006
    ..It is stressed that when immunohistochemistry is used diagnostically, panels of markers provide better information than reliance on a single antibody...
  28. ncbi request reprint Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord-stromal tumours
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast and The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Histopathology 38:403-8. 2001
    ..The aim of this study was to investigate calretinin staining in a series of these tumours and their histological mimics in order to determine the value of calretinin staining in a diagnostic setting...
  29. ncbi request reprint CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Histopathology 39:273-8. 2001
    ..Staining of a range of tumours which can be confused morphologically with endometrial stromal neoplasms was also undertaken to ascertain whether antibodies against CD10 are of value in a diagnostic sense...
  30. ncbi request reprint Primary adenocarcinoma of the vagina arising in endocervicosis
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BL, Northern Ireland
    Int J Gynecol Pathol 20:399-402. 2001
    ..This is the second reported case of vaginal endocervicosis and the first documented report of adenocarcinoma arising in endocervicosis at any site...
  31. pmc Lymphoepithelioma-like carcinoma of the vagina
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 54:964-5. 2001
    ..In situ hybridisation and immunohistochemistry for Epstein-Barr virus were negative. A review of the literature reveals that such neoplasms appear to be extremely rare within the female genital tract outside of the cervix...
  32. pmc Morphological effects of chemotherapy on ovarian carcinoma
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 55:27-31. 2002
    ..This study aims to describe the morphological features found in ovarian carcinoma after chemotherapy because these have not been detailed previously...
  33. ncbi request reprint Primary malignant melanoma of the ovary: a report of 9 definite or probable cases with emphasis on their morphologic diversity and mimicry of other primary and secondary ovarian neoplasms
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 25:321-9. 2006
    ..This is an area where electron microscopy can still also contribute useful information...
  34. ncbi request reprint Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Am J Surg Pathol 30:209-15. 2006
    ..Possible theories of histogenesis include a developmental anomaly, metaplasia of preexisting endocervical glands, and derivation from mesonephric remnants...
  35. pmc Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas?
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    J Clin Pathol 55:321-5. 2002
    ..Importantly, a small proportion of uterine carcinosarcomas are true collision tumours and should be recognised as such because, in some instances, the prognosis may be better than for a similar stage carcinosarcoma...
  36. ncbi request reprint Recent advances in immunohistochemistry in gynaecological pathology
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 40:309-26. 2002
    ..A newly developed monoclonal antibody HMGIC which is expressed in vulvovaginal aggressive angiomyxoma may prove to be of value in the often difficult distinction of this lesion from its histological mimics...
  37. ncbi request reprint Rhabdomyosarcoma of the uterus: report of two cases, including one of the spindle cell variant
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Int J Gynecol Cancer 12:128-32. 2002
    ..Immunohistochemical demonstration of skeletal muscle differentiation is necessary for a definitive diagnosis...
  38. ncbi request reprint Immunohistochemical localization of metallothionein in benign and malignant epithelial ovarian tumors
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Int J Gynecol Cancer 12:62-5. 2002
    ..Whether high MT expression is an independent prognostic factor and increased expression indicates chemotherapy resistance in ovarian cancer, as has been previously suggested, should be determined by further studies...
  39. ncbi request reprint Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Ireland
    Int J Gynecol Pathol 27:92-100. 2008
    ....
  40. pmc Role of polymerase chain reaction and immunocytochemistry in the cytological assessment of lymphoid proliferations
    L Venkatraman
    Department of Histopathology, Royal Victoria Hospital, Belfast, UK
    J Clin Pathol 59:1160-5. 2006
    ..The combined use of genetic analysis and flow cytometry for immunophenotyping has increased the accuracy of diagnosis and correct categorisation of lymphomas on cytological preparations...
  41. ncbi request reprint Superficial myofibroblastoma of the lower female genital tract: report of a series including tumours with a vulval location
    R Ganesan
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Histopathology 46:137-43. 2005
    ....
  42. doi request reprint Intestinal endometriosis morphologically mimicking colonic adenocarcinoma
    P Kelly
    Department of Pathology, Royal Group of Hospitals, Belfast, UK
    Histopathology 52:510-4. 2008
  43. ncbi request reprint An immunohistochemical and morphological analysis of post-chemotherapy ovarian carcinoma
    K Miller
    Department of Pathology, Belfast City Hospital Trust, Belfast, UK
    J Clin Pathol 61:652-7. 2008
    ..The morphology of ovarian carcinoma following chemotherapy often differs markedly from native tumour. This study aimed to compare the immunophenotype of post-chemotherapy ovarian carcinomas with that of untreated tumour...
  44. doi request reprint Peritoneal stromal endometriosis: a detailed morphological analysis of a large series of cases of a common and under-recognised form of endometriosis
    D P Boyle
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 62:530-3. 2009
    ..This form of endometriosis has been previously referred to as stromal or micronodular stromal endometriosis. However, there has been little reference to this condition in the literature...
  45. ncbi request reprint A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma
    R I Cameron
    Department of Pathalogy, Royal Group of Hospitals Trust, Belfast, Northern Ireland, United Kingdom
    Int J Gynecol Pathol 22:272-6. 2003
    ..Primary ovarian clear cell carcinomas are characterized by CK7 positivity, whereas primary renal neoplasms are characterized by positivity for CD10 and RCC marker and negative staining with CK7...
  46. ncbi request reprint Uterine serous carcinoma and endometrial intraepithelial carcinoma arising in endometrial polyps: report of 5 cases, including 2 associated with tamoxifen therapy
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Hum Pathol 34:939-43. 2003
    ..Because 2 of the patients had been taking tamoxifen, this raises the possibility of an association between tamoxifen and the development of USC and EIC in the endometrial polyps that are characteristic of this medication...
  47. pmc Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma
    R I Cameron
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 57:888-90. 2004
    ....
  48. doi request reprint Morules in endometrioid proliferations of the uterus and ovary consistently express the intestinal transcription factor CDX2
    O Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 53:156-65. 2008
    ..To undertake an immunohistochemical analysis of squamous elements in endometrioid proliferations of the uterus and ovary and to compare the immunophenotype of typical squamous elements and so-called squamous morules...
  49. ncbi request reprint Endometrial stromal neoplasms are immunoreactive with WT-1 antibody
    V P Sumathi
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Int J Gynecol Pathol 23:241-7. 2004
    ..The overlapping immunophenotype of endometrial stromal and leiomyomatous neoplasms may reflect the origin of both cell types from a common progenitor within the uterus...
  50. pmc Non-neoplastic granulosa cells within ovarian vascular channels: a rare potential diagnostic pitfall
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 57:151-4. 2004
    ..To describe six cases seen in consultation in which artefactual vascular involvement within the ovary by benign granulosa cells caused diagnostic confusion...
  51. ncbi request reprint p16 expression in the female genital tract and its value in diagnosis
    Ciaran J O'Neill
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    Adv Anat Pathol 13:8-15. 2006
    ..Some ovarian serous carcinomas, similar to their uterine counterparts, are p16-positive...
  52. pmc Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    J Clin Pathol 53:603-5. 2000
    ..We also wished to ascertain whether positivity may be found in the stromal cells of normal vulval skin and in other lesions at this site that can cause diagnostic confusion with aggressive angiomyxoma...
  53. ncbi request reprint the management of vulval intraepithelial neoplasia in Northern Ireland
    A A Zawislak
    Department of Gynaecological Oncology, Belfast City Hospital, Belfast, Northern Ireland
    Int J Gynecol Cancer 16:780-5. 2006
    ..VIN should be managed by clinicians with expertise in this field and who are treating significant numbers of patients according to evidence-based protocols...
  54. ncbi request reprint Soft tissue myoepithelioma: a case report
    L Venkatraman
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Pathology 34:451-4. 2002
    ..This case report highlights the rare occurrence of myoepitheliomas in deep soft tissues. Pathologists should be aware of this and should consider a myoepithelioma in the differential diagnosis of a soft tissue spindle cell neoplasm...
  55. ncbi request reprint High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour
    C J O'Neill
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland, UK
    Histopathology 50:773-9. 2007
    ..The aim of this study was to compare expression of p16 INK4A (p16) in these two tumour types. We also included cases of serous borderline tumour, since these are considered to represent a precursor lesion of low-grade serous carcinoma...
  56. ncbi request reprint Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential
    H A McBride
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 50:851-8. 2007
    ..p16 expression was also compared with that of p53 and MIB1...
  57. ncbi request reprint Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia
    R I Cameron
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northen Ireland
    Histopathology 41:313-21. 2002
    ..This study investigates the value of immunohistochemical staining with MIB1, bcl2 and p16 in the distinction of cervical glandular intraepithelial neoplasia from these benign mimics...
  58. doi request reprint Signet ring cells of stromal derivation in the uterine cervix secondary to cauterisation: report of a previously undescribed phenomenon
    M McKenna
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 61:648-51. 2008
    ..To describe the occurrence of signet ring cells of stromal origin within the uterine cervix...
  59. pmc Uterine tumour resembling ovarian sex cord tumour is an immunohistochemically polyphenotypic neoplasm which exhibits coexpression of epithelial, myoid and sex cord markers
    D P Hurrell
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    J Clin Pathol 60:1148-54. 2007
    ..To describe the clinicopathological and immunohistochemical findings in four cases of uterine tumour resembling ovarian sex cord tumour (UTROSCT)...
  60. ncbi request reprint The large loop excision of the transformation zone cut or blend thermal artefact study: a randomized controlled trial
    H A Nagar
    Department of Gynaecological Oncology, Belfast City Hospital, Belfast, Northern Ireland, UK
    Int J Gynecol Cancer 14:1108-11. 2004
    ....
  61. ncbi request reprint WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma
    M Al-Hussaini
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 44:109-15. 2004
    ..This study aims to document the value of WT-1 in these settings. Cases of ovarian borderline serous tumour, primary peritoneal serous carcinoma (PPSC) and uterine endometrioid carcinoma were also studied...
  62. ncbi request reprint Monoclonal antibody SM047 as an immunohistochemical marker of ovarian adenocarcinoma
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 38:542-9. 2001
    ..These findings need to be confirmed by further study of larger numbers of cases...
  63. doi request reprint Combined actinomycotic and pseudoactinomycotic radiate granules in the female genital tract: description of a series of cases
    D P Boyle
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BA, Northern Ireland, UK
    J Clin Pathol 62:1123-6. 2009
    ..It is important to distinguish between these since the former may result in pelvic inflammatory disease and require antibiotic treatment while the latter is non-infectious and does not require specific treatment...
  64. ncbi request reprint Endometrial hyperplasia involving endometrial polyps: report of a series and discussion of the significance in an endometrial biopsy specimen
    P Kelly
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    BJOG 114:944-50. 2007
    ..Currently, it is not known whether the hyperplasia is likely to be confined to the polyp or also involve nonpolypoid endometrium. We aim to assess the likelihood of hyperplasia being confined to an endometrial polyp...
  65. doi request reprint HMGA2 is a sensitive but not specific immunohistochemical marker of vulvovaginal aggressive angiomyxoma
    W Glenn McCluggage
    Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland
    Am J Surg Pathol 34:1037-42. 2010
    ..As well as being of value in primary diagnosis, HMGA2 is useful in evaluating margins and in reexcision specimens of aggressive angiomyxoma in identifying foci of residual or recurrent tumor...
  66. pmc Early experience with chronic hepatitis C in Northern Ireland: epidemiology and response to monotherapy
    N I McDougall
    The Liver Unit, Royal Victoria Hospital, 1st Floor, East Wing, Grosvenor Road, Belfast
    Ulster Med J 73:25-31. 2004
    ..Only a minority of anti-HCV positive non-haemophiliac patients progress to have interferon therapy suggesting that the cost of treating chronic HCV may not be as great as initially thought...
  67. ncbi request reprint Clear cell struma ovarii
    M B Loughrey
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK
    Histopathology 43:495-7. 2003
  68. doi request reprint Metastatic carcinomas in the cervix mimicking primary cervical adenocarcinoma and adenocarcinoma in situ: report of a series of cases
    W Glenn McCluggage
    Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland
    Am J Surg Pathol 34:735-41. 2010
    ..It is important for the pathologist to be aware of the possibility of cervical mucosal metastasis to avoid an erroneous diagnosis of a primary cervical adenocarcinoma or adenocarcinoma in situ...
  69. doi request reprint Endometrial stromal sarcomas with extensive endometrioid glandular differentiation: report of a series with emphasis on the potential for misdiagnosis and discussion of the differential diagnosis
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Histopathology 54:365-73. 2009
    ..To describe a series of endometrial stromal sarcomas with large numbers of endometrioid-type glands...
  70. ncbi request reprint p16 immunoreactivity may assist in the distinction between endometrial and endocervical adenocarcinoma
    W G McCluggage
    Department of Pathology, Royal Group Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 22:231-5. 2003
    ..Diffuse, strong positivity with p16 in endocervical adenocarcinomas is likely caused by inactivation of the retinoblastoma protein by the E7 human papillomavirus oncoprotein, which acts as a p16 transcript repressor...
  71. ncbi request reprint Unusual morphologic features of uterine leiomyomas treated with gonadotropin-releasing hormone agonists: massive lymphoid infiltration and vasculitis
    G McClean
    Department of Pathology, Royal Hospitals Trust, Belfast, Northern Ireland
    Int J Surg Pathol 11:339-44. 2003
    ..Since GnRH agonists are increasingly being used in the management of uterine leiomyomas, pathologists should be aware of these unusual morphologic features in order to avoid diagnostic confusion...
  72. doi request reprint Myxoid change of the myometrium and cervical stroma: description of a hitherto unreported non-neoplastic phenomenon with discussion of myxoid uterine lesions
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 29:351-7. 2010
    ..Pathologists should be aware of this unusual pseudoneoplastic phenomenon to avoid a misdiagnosis of a neoplastic lesion...
  73. doi request reprint The expression and diagnostic utility of p63 in the female genital tract
    Oisin Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Adv Anat Pathol 16:316-21. 2009
    ..p63 is also positive in cervical transitional metaplasia, Walthard rests, vulval Paget disease secondary to an underlying urothelial malignancy, tubulosquamous polyp of the vagina, and ectopic prostatic tissue in the cervix...
  74. doi request reprint Myoepithelial neoplasms involving the vulva and vagina: report of 4 cases
    Meenakshi Meenakshi
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Hum Pathol 40:1747-53. 2009
    ..In reporting these cases, we discuss the criteria for diagnosis and the differential diagnosis...
  75. ncbi request reprint An immunohistochemical comparison between low-grade and high-grade ovarian serous carcinomas: significantly higher expression of p53, MIB1, BCL2, HER-2/neu, and C-KIT in high-grade neoplasms
    Ciaran J O'Neill
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Am J Surg Pathol 29:1034-41. 2005
    ..In particular, the differences in p53 immunoreactivity are in keeping with the observation that p53 gene mutation is more common in high-grade than low-grade OSC...
  76. ncbi request reprint A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 21:11-5. 2002
    ..A panel of immunohistochemical stains, comprising CEA, vimentin, and ER, generally allows confident preoperative distinction between a primary endometrial and endocervical adenocarcinoma...
  77. ncbi request reprint Mullerian papilloma-like proliferation arising in cystic pelvic endosalpingiosis
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, and the Department of Pathology, Belfast City Hospital, Ireland
    Hum Pathol 33:944-6. 2002
    ..The differential diagnosis is discussed. As far as we are aware, this is the first report of such a benign epithelial proliferation involving cystic endosalpingiosis...
  78. doi request reprint Vulval intraepithelial neoplasia with mucinous differentiation: report of 2 cases of a hitherto undescribed phenomenon
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Am J Surg Pathol 33:945-9. 2009
    ..The mucinous cells are likely to be metaplastic and a result of aberrant differentiation in a premalignant squamous lesion...
  79. pmc CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis
    V P Sumathi
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 55:391-2. 2002
    ..The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in confirming a diagnosis of endometriosis...
  80. ncbi request reprint Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series
    J L Hurwitz
    Department of Medical Oncology, Northern Ireland Cancer Centre, Belfast, UK
    BJOG 114:1283-7. 2007
    ..Because of the small numbers of women involved, our knowledge of this rare tumour type is limited. This study aims to further characterise the population of women affected, the disease itself and the most appropriate management strategy...
  81. doi request reprint Enterobious vermicularis (pinworm) infestation of the vulva: report of 2 cases of a pseudoneoplastic lesion mimicking squamous carcinoma
    P Konanahalli
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 29:490-3. 2010
    ....
  82. ncbi request reprint Current concepts in ovarian epithelial tumorigenesis: correlation between morphological and molecular data
    M Scott
    Department of Pathology, Royal Group of Hospitals Trust, Belfast
    Histol Histopathol 21:81-92. 2006
    ..It can be anticipated that this will lead to the development of specific therapeutic agents of value against a specific tumour type...
  83. doi request reprint Uterine gestational choriocarcinoma developing after a long latent period in a postmenopausal woman: the value of DNA polymorphism studies
    Ciaran J O'Neill
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Surg Pathol 16:226-9. 2008
    ..The report discusses the value of DNA polymorphism studies in distinguishing gestational from nongestational choriocarcinoma and from trophoblastic differentiation within a carcinoma...
  84. ncbi request reprint A multistep model for ovarian tumorigenesis: the value of mutation analysis in the KRAS and BRAF genes
    S E Hilary Russell
    Department of Oncology, Queen s University Belfast, Belfast City Hospital, Belfast, UK
    J Pathol 203:617-9. 2004
    ....
  85. doi request reprint Increased p16 expression in high-grade serous and undifferentiated carcinoma compared with other morphologic types of ovarian carcinoma
    V Phillips
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BA, Northern Ireland
    Int J Gynecol Pathol 28:179-86. 2009
    ..This may be useful, in conjunction with WT1, in the classification of problematic neoplasms. p16 may be involved in the pathogenesis of high-grade ovarian serous carcinomas, possibly through inactivation of retinoblastoma protein...
  86. ncbi request reprint Bone marrow micrometastases and markers of angiogenesis in esophageal cancer
    Gary M Spence
    Department of Thoracic Surgery, Royal Victoria Hospital, Belfast, Northern Ireland
    Ann Thorac Surg 78:1944-9; discussion 1950. 2004
    ..We aim to establish if the detection of bone marrow micrometastases associates with elevated markers of angiogenesis and adverse histopathologic features of esophageal cancer...
  87. ncbi request reprint Idiopathic uterine granulomas: report of a series with morphological similarities to idiopathic ovarian cortical granulomas
    Paul Kelly
    From the Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 25:243-6. 2006
    ..quot; Although local and systemic causes of granulomatous inflammation should be excluded, granulomas in the myometrium and cervical stroma may occur without an obvious underlying cause...
  88. doi request reprint An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63
    W Glenn McCluggage
    Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland
    Am J Surg Pathol 34:525-32. 2010
    ..However, the absence of staining with CM2B4 argues against a true Merkel cell tumor. CD99 staining in a cervical neuroendocrine carcinoma should not result in misdiagnosis as a neoplasm in the Ewing family of tumors...
  89. doi request reprint The pathology of and controversial aspects of ovarian borderline tumours
    W Glenn McCluggage
    Department of Pathology, Belfast Health and Social Care Trust, Grosvenor Road, Belfast, Northern Ireland, UK
    Curr Opin Oncol 22:462-72. 2010
    ..Ovarian borderline tumours are relatively uncommon, but not rare, neoplasms. Pathologists and oncologists often struggle with various aspects of borderline tumours which are sometimes controversial and poorly understood...
  90. ncbi request reprint Atypical reactive proliferation of endocervix: a common lesion associated with endometrial carcinoma and likely related to prior endometrial sampling
    Michael Scott
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK
    Mod Pathol 19:470-4. 2006
    ..The vimentin-negative immunophenotype may be of value in cases where the uterine carcinoma is endometrioid in type as these neoplasms are generally vimentin positive...
  91. ncbi request reprint Serous carcinoma arising in an adenofibroma of the endometrium
    L Venkatraman
    Department of Pathology, Belfast City Hospital Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 22:194-7. 2003
    ..The carcinoma involved the myometrium and cervix (stage IIa). To our knowledge, this is the third documented case of an adenocarcinoma and the first serous carcinoma involving a uterine adenofibroma...
  92. ncbi request reprint Ischemic fasciitis: an unusual vulvovaginal spindle cell lesion
    R Scanlon
    Department of Pathology, National Maternity Hospital, Dublin, Ireland
    Int J Gynecol Pathol 23:65-7. 2004
    ..Histologic examination showed surface ulceration and underlying fibrinoid necrosis with surrounding reactive atypical fibroblast-like cells and small blood vessels, the characteristic histologic features of ischemic fasciitis...
  93. ncbi request reprint Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen-associated polypoid uterine lesions
    J P Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Mod Pathol 16:395-8. 2003
    ..Because primary endometrial carcinomas may also arise within tamoxifen polyps, these should be extensively sampled. We briefly review polypoid uterine lesions that may occur secondary to tamoxifen therapy...
  94. ncbi request reprint Extragenital müllerian carcinosarcoma arising from the peritoneum: report of two cases
    V P Sumathi
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Cancer 12:764-7. 2002
    ..We wish to highlight the fact that these aggressive neoplasms may occasionally have a peritoneal origin, similar to primary peritoneal serous carcinomas...
  95. ncbi request reprint Lesson of the month: neuroendocrine carcinoma of the caecum
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, N Ireland, UK
    Histopathology 41:556-8. 2002
  96. doi request reprint Clinical and immunohistochemical assessment of vulval intraepithelial neoplasia following photodynamic therapy using a novel bioadhesive patch-type system loaded with 5-aminolevulinic acid
    A Zawislak
    Department of Gynaecology, Belfast City Hospital Trust, Lisburn Road, Belfast BT9 7AB, UK
    Photodiagnosis Photodyn Ther 6:28-40. 2009
    ..An analysis of changes in expression of apoptotic and cell cycle proteins (p53, p21, Mdm2, Blc-2, Bax, Ki-67) in response to PDT was evaluated...
  97. pmc A simple method for the prevention of endometrial autolysis in hysterectomy specimens
    J P Houghton
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 57:332-3. 2004
    ..Assessment of the endometrium is often difficult because of pronounced tissue autolysis. This study describes a simple method to prevent endometrial autolysis and aid in interpretation of the endometrium...
  98. pmc MR staging in carcinoma of the endometrium and carcinoma of the cervix
    M V Pakkal
    Department of Radiology, Royal Victoria Hospital, Grosvenor Road, Belfast
    Ulster Med J 73:20-4. 2004
    ..It helps decide operability, the type of operation and aids in the selection of patients who need to be considered for specialist referral to a gynaecologist oncologist...
  99. pmc Cytomegalovirus infection of the cervix: morphological observations in five cases of a possibly under-recognised condition
    C E McGalie
    Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland, UK
    J Clin Pathol 57:691-4. 2004
    ..This study describes histopathological findings in five biopsies from four patients with CMV cervicitis...
  100. pmc Uterine endometrial stromal sarcoma with smooth muscle and glandular differentiation
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland
    J Clin Pathol 54:481-3. 2001
    ..This report discusses the differential diagnosis of this lesion, which has been designated a low grade endometrial stromal sarcoma with smooth muscle and glandular differentiation...
  101. ncbi request reprint Pulmonary infarct cytologically mimicking adenocarcinoma of the lung
    Roger E Lawther
    Department of Pathology, Royal Victoria Hospital, Belfast, Northern Ireland
    Ann Thorac Surg 73:1964-5. 2002
    ..A positive sputum specimen should not always be regarded as definitive evidence of malignancy. Instead a full assessment of all available information should be made if unnecessary surgery is to be avoided...