V Jairath

Summary

Affiliation: NHS Blood and Transplant
Country: UK

Publications

  1. doi request reprint Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial
    Vipul Jairath
    NHS Blood and Transplant, Oxford, UK Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK Electronic address
    Lancet 386:137-44. 2015
  2. pmc HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial
    Ian Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trials 15:450. 2014
  3. pmc Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials
    Brennan C Kahan
    Pragmatic Clinical Trials Unit, Queen Mary University of London, E1 2AB London, UK
    Trials 15:456. 2014
  4. pmc The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies
    Brennan C Kahan
    Pragmatic Clinical Trials Unit, Queen Mary University of London, London E1 2AB, UK
    Trials 15:139. 2014
  5. doi request reprint Acute variceal haemorrhage in the United Kingdom: patient characteristics, management and outcomes in a nationwide audit
    Vipul Jairath
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK Electronic address
    Dig Liver Dis 46:419-26. 2014
  6. pmc Update on the transfusion in gastrointestinal bleeding (TRIGGER) trial: statistical analysis plan for a cluster-randomised feasibility trial
    Brennan C Kahan
    MRC Clinical Trials Unit, Aviation House 125 Kingsway, London WC2B 6NH, UK
    Trials 14:206. 2013
  7. pmc Restrictive vs liberal blood transfusion for acute upper gastrointestinal bleeding: rationale and protocol for a cluster randomized feasibility trial
    Vipul Jairath
    NHS Blood and Transplant, Oxford, United Kingdom
    Transfus Med Rev 27:146-53. 2013
  8. doi request reprint Prevalence, management, and outcomes of patients with coagulopathy after acute nonvariceal upper gastrointestinal bleeding in the United Kingdom
    Vipul Jairath
    NHS Blood and Transplant and the Translational Gastroenterology Unit, Oxford University Hospitals, Oxford, UK
    Transfusion 53:1069-76. 2013
  9. doi request reprint National audit of the use of surgery and radiological embolization after failed endoscopic haemostasis for non-variceal upper gastrointestinal bleeding
    V Jairath
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
    Br J Surg 99:1672-80. 2012
  10. doi request reprint Outcomes following acute nonvariceal upper gastrointestinal bleeding in relation to time to endoscopy: results from a nationwide study
    V Jairath
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
    Endoscopy 44:723-30. 2012

Collaborators

Detail Information

Publications13

  1. doi request reprint Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial
    Vipul Jairath
    NHS Blood and Transplant, Oxford, UK Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK Electronic address
    Lancet 386:137-44. 2015
    ..We aimed to assess whether a multicentre, cluster randomised trial is a feasible method to substantiate or refute this finding...
  2. pmc HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial
    Ian Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trials 15:450. 2014
    ..The trials were also too small to assess the effect of tranexamic acid on thromboembolic events...
  3. pmc Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials
    Brennan C Kahan
    Pragmatic Clinical Trials Unit, Queen Mary University of London, E1 2AB London, UK
    Trials 15:456. 2014
    ..Blinded outcome assessment is recommended in open-label trials to reduce bias, however it is not always feasible. It is therefore important to find other means of reducing bias in these scenarios...
  4. pmc The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies
    Brennan C Kahan
    Pragmatic Clinical Trials Unit, Queen Mary University of London, London E1 2AB, UK
    Trials 15:139. 2014
    ..Adjustment for prognostic covariates can lead to increased power in the analysis of randomized trials. However, adjusted analyses are not often performed in practice...
  5. doi request reprint Acute variceal haemorrhage in the United Kingdom: patient characteristics, management and outcomes in a nationwide audit
    Vipul Jairath
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK Electronic address
    Dig Liver Dis 46:419-26. 2014
    ..Despite advances in treatment, acute variceal haemorrhage remains life-threatening...
  6. pmc Update on the transfusion in gastrointestinal bleeding (TRIGGER) trial: statistical analysis plan for a cluster-randomised feasibility trial
    Brennan C Kahan
    MRC Clinical Trials Unit, Aviation House 125 Kingsway, London WC2B 6NH, UK
    Trials 14:206. 2013
    ..Previous research has suggested an association between more liberal red blood cell (RBC) transfusion and greater risk of further bleeding and mortality following acute upper gastrointestinal bleeding (AUGIB)...
  7. pmc Restrictive vs liberal blood transfusion for acute upper gastrointestinal bleeding: rationale and protocol for a cluster randomized feasibility trial
    Vipul Jairath
    NHS Blood and Transplant, Oxford, United Kingdom
    Transfus Med Rev 27:146-53. 2013
    ..The results of this study will inform the feasibility and design of a phase III randomized trial. ..
  8. doi request reprint Prevalence, management, and outcomes of patients with coagulopathy after acute nonvariceal upper gastrointestinal bleeding in the United Kingdom
    Vipul Jairath
    NHS Blood and Transplant and the Translational Gastroenterology Unit, Oxford University Hospitals, Oxford, UK
    Transfusion 53:1069-76. 2013
    ..We describe the prevalence, use of plasma, and outcomes of patients with coagulopathy after acute nonvariceal upper gastrointestinal bleeding (NVUGIB)...
  9. doi request reprint National audit of the use of surgery and radiological embolization after failed endoscopic haemostasis for non-variceal upper gastrointestinal bleeding
    V Jairath
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
    Br J Surg 99:1672-80. 2012
    ..This study examined the use, clinical characteristics and outcomes of patients receiving salvage surgery or TAE after failed endoscopic haemostasis for NVUGIB...
  10. doi request reprint Outcomes following acute nonvariceal upper gastrointestinal bleeding in relation to time to endoscopy: results from a nationwide study
    V Jairath
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
    Endoscopy 44:723-30. 2012
    ..The aim of the current audit study was to examine the relationship between time to endoscopy and clinical outcomes in patients presenting with NVUGIB...
  11. pmc Why do mortality rates for nonvariceal upper gastrointestinal bleeding differ around the world? A systematic review of cohort studies
    Vipul Jairath
    Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
    Can J Gastroenterol 26:537-43. 2012
    ..Discrepancies exist in reported mortality rates of nonvariceal upper gastrointestinal bleeding (NVUGIB)...
  12. doi request reprint Mortality from acute upper gastrointestinal bleeding in the United kingdom: does it display a "weekend effect"?
    V Jairath
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
    Am J Gastroenterol 106:1621-8. 2011
    ..The aim of this study is to examine the relationship between weekend presentation to hospital following acute upper gastrointestinal bleeding and mortality...
  13. doi request reprint Red blood cell transfusion practice in patients presenting with acute upper gastrointestinal bleeding: a survey of 815 UK clinicians
    Vipul Jairath
    NHS Blood and Transplant and Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
    Transfusion 51:1940-8. 2011
    ..We aimed to survey UK clinicians about their RBC transfusion practice in AUGIB...