Julia L Newton

Summary

Country: UK

Publications

  1. ncbi request reprint Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope
    Julia L Newton
    Cardiovascular Investigation Unit Institute for Ageing and Health, Care of the Elderly Offices, Royal Victoria Infirmary, University of Newcastle, Newcastle NE1 4LP, United Kingdom
    Europace 7:396-9. 2005
  2. ncbi request reprint The diurnal profile of gastric pepsin activity is reduced with Helicobacter pylori infection
    J L Newton
    Department of Physiological Sciences, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Dig Dis Sci 49:1103-8. 2004
  3. ncbi request reprint Review article: the ageing bowel and intolerance to aspirin
    J L Newton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Aliment Pharmacol Ther 19:39-45. 2004
  4. ncbi request reprint A prospective evaluation of bone mineral density measurement in females who have fallen
    Julia L Newton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Age Ageing 32:497-502. 2003
  5. ncbi request reprint Cognitive behavioural therapy as a potential treatment for vasovagal/neurocardiogenic syncope--a pilot study
    J L Newton
    Cardiovascular Investigation Unit Falls and Syncope Service, Royal Victoria Infirmary, University of Newcastle upon Tyne, UK
    Europace 5:299-301. 2003
  6. ncbi request reprint Familial neurocardiogenic (vasovagal) syncope
    Julia L Newton
    Cardiovascular Investigation Unit Institute for Ageing and Health, School of Clinical Medical Sciences, Newcastle, United Kingdom
    Am J Med Genet A 133:176-9. 2005
  7. ncbi request reprint Reduced heart rate variability and baroreflex sensitivity in primary biliary cirrhosis
    Julia L Newton
    Cardiovascular Investigation Unit, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Liver Int 26:197-202. 2006
  8. ncbi request reprint Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity
    Julia L Newton
    Cardiovascular Investigation Unit, University of Newcastle, Care of the Elderly Offices, Royal Victoria Infirmary, UK
    Eur J Gastroenterol Hepatol 19:125-32. 2007
  9. pmc Improving the gastrointestinal tolerability of aspirin in older people
    Julia L Newton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Clin Interv Aging 1:33-9. 2006
  10. doi request reprint Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Liver Int 30:878-85. 2010

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope
    Julia L Newton
    Cardiovascular Investigation Unit Institute for Ageing and Health, Care of the Elderly Offices, Royal Victoria Infirmary, University of Newcastle, Newcastle NE1 4LP, United Kingdom
    Europace 7:396-9. 2005
    ..Here we present the first study examining a potential genetic abnormality in VVS...
  2. ncbi request reprint The diurnal profile of gastric pepsin activity is reduced with Helicobacter pylori infection
    J L Newton
    Department of Physiological Sciences, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Dig Dis Sci 49:1103-8. 2004
    ..001). There is significant pepsin activity in the stomach throughout the 24-hr period, with a trend for the highest activity through the night. Subjects with H. pylori infection have lower luminal pepsin activity...
  3. ncbi request reprint Review article: the ageing bowel and intolerance to aspirin
    J L Newton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Aliment Pharmacol Ther 19:39-45. 2004
    ..This would allow greater numbers of older subjects to gain the benefits associated with aspirin use...
  4. ncbi request reprint A prospective evaluation of bone mineral density measurement in females who have fallen
    Julia L Newton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Age Ageing 32:497-502. 2003
    ..This predicts overall fracture risk as effectively as dual X-ray at the spine and hip, although site specific measurements provide the best estimate of fracture risk at a particular location...
  5. ncbi request reprint Cognitive behavioural therapy as a potential treatment for vasovagal/neurocardiogenic syncope--a pilot study
    J L Newton
    Cardiovascular Investigation Unit Falls and Syncope Service, Royal Victoria Infirmary, University of Newcastle upon Tyne, UK
    Europace 5:299-301. 2003
    ..All subjects post-intervention were able to return to work or schooling. CBT is an effective treatment in those with difficult to manage VVS. Randomized controlled trials are needed...
  6. ncbi request reprint Familial neurocardiogenic (vasovagal) syncope
    Julia L Newton
    Cardiovascular Investigation Unit Institute for Ageing and Health, School of Clinical Medical Sciences, Newcastle, United Kingdom
    Am J Med Genet A 133:176-9. 2005
    ..Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members...
  7. ncbi request reprint Reduced heart rate variability and baroreflex sensitivity in primary biliary cirrhosis
    Julia L Newton
    Cardiovascular Investigation Unit, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Liver Int 26:197-202. 2006
    ..We have assessed heart rate variability (HRV) and baroreflex sensitivity (BRS) risk factors associated with cardiovascular mortality, in 57 PBC patients and age- and sex-matched normal controls...
  8. ncbi request reprint Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity
    Julia L Newton
    Cardiovascular Investigation Unit, University of Newcastle, Care of the Elderly Offices, Royal Victoria Infirmary, UK
    Eur J Gastroenterol Hepatol 19:125-32. 2007
    ..Here, we investigate the prevalence of autonomic dysfunction using highly sensitive detection modalities and its relationship with fatigue in both noncirrhotic and cirrhotic primary biliary cirrhosis patients...
  9. pmc Improving the gastrointestinal tolerability of aspirin in older people
    Julia L Newton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Clin Interv Aging 1:33-9. 2006
    ....
  10. doi request reprint Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Liver Int 30:878-85. 2010
    ..Cognitive impairment is recognised in the early stages of primary biliary cirrhosis (PBC)...
  11. doi request reprint Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease
    James Frith
    UK NIHR Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    J Hepatol 52:112-6. 2010
    ..To increase exercise in NAFLD it is important to understand the barriers to performing it...
  12. doi request reprint Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:541-9. 2008
    ..Cognitive impairment is, in turn, associated with structural brain lesions and autonomic dysfunction, which may predict risk of cognitive decline...
  13. doi request reprint Home orthostatic training in vasovagal syncope modifies autonomic tone: results of a randomized, placebo-controlled pilot study
    Maw Pin Tan
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Europace 12:240-6. 2010
    ..To detect possible autonomic changes due to home orthostatic training (HOT) and to assess the feasibility of a larger, placebo-controlled study of HOT in vasovagal syncope (VVS)...
  14. ncbi request reprint Falls and fall-related injury are common in older people with chronic liver disease
    James Frith
    UK National Institute for Health Research, Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle, NE1 7RU, UK
    Dig Dis Sci 57:2697-702. 2012
    ..With risk factors such as autonomic dysfunction, cognitive impairment, and muscle abnormalities in CLD it is expected that falls and injury will be common...
  15. doi request reprint The relationship between carotid sinus hypersensitivity, orthostatic hypotension, and vasovagal syncope: a case-control study
    Maw Pin Tan
    Institute for Ageing and Health, Wolfson Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Europace 10:1400-5. 2008
    ..We conducted a case-control study evaluating this relationship in a large patient cohort...
  16. doi request reprint Impedance cardiography: a role in vasovagal syncope diagnosis?
    Steve W Parry
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Age Ageing 38:718-23. 2009
    ..Alternative methods of diagnosing vasovagal syncope would thus be useful...
  17. doi request reprint Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease
    Julia L Newton
    Institute of Cellular Medicine, University of Newcastle, UK
    Clin Auton Res 19:319-26. 2009
    ..We examined the relationship between parameters of blood pressure regulation with perception of fatigue in NAFLD...
  18. doi request reprint Reduction in functional ability is significant postliver transplantation compared with matched liver disease and community dwelling controls
    Chris Elliott
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK
    Transpl Int 24:588-95. 2011
    ..Further study is warranted to address the mechanisms responsible for post-transplant functional impairment and to develop effective rehabilitation regimes to maximize function following liver transplantation...
  19. ncbi request reprint Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 45:1496-505. 2007
    ..Autonomic dysfunction is independently associated with both fatigue and, importantly, symptoms of cognitive dysfunction, suggesting the potential for significant organic sequelae...
  20. ncbi request reprint The role of psychological factors in the fatigue of primary biliary cirrhosis
    Peter Blackburn
    Department of Health Psychology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Liver Int 27:654-61. 2007
    ....
  21. ncbi request reprint Human pancreatic polypeptide has a marked diurnal rhythm that is affected by ageing and is associated with the gastric TFF2 circadian rhythm
    C Emma Johns
    Department of Pathology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Peptides 27:1341-8. 2006
    ..These results identify potential therapies for treatment of gastric mucosal morbidity and age-associated loss of appetite...
  22. pmc Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Appl Physiol 112:2043-8. 2012
    ..This is analogous to the changes found in healthy aging for subjects ∼16 yr older than the fatigued PBC patients. Hence the hearts of fatigued PBC patients may be subject to processes of accelerated aging...
  23. doi request reprint Managing systemic symptoms in chronic liver disease
    Julia L Newton
    UK NIHR Biomedical Research Centre in Ageing and Age Related Diseases, Newcastle University, Newcastle, UK
    J Hepatol 56:S46-55. 2012
    ..We believe that such a systematic approach, when applied to research as well as to clinical management, will allow us to reduce the overall burden of chronic liver disease, improve quality of life and enhance functional ability...
  24. doi request reprint Fatigue is significant in vasovagal syncope and is associated with autonomic symptoms
    Henrietta Legge
    Falls and Syncope Service, Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    Europace 10:1095-101. 2008
    ..To quantify the prevalence of fatigue and its severity in vasovagal syncope (VVS) and to examine whether fatigue severity associates with symptoms of autonomic dysfunction...
  25. doi request reprint Impaired cardiovascular response to standing in chronic fatigue syndrome
    Kieren G Hollingsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Eur J Clin Invest 40:608-15. 2010
    ..This study examined the relationship between skeletal and cardiac muscle function and symptoms on standing in CFS using magnetic resonance spectroscopy (MRS) and impedance cardiography...
  26. doi request reprint Level of psychosocial impairment predicts early response to treatment in vasovagal syncope
    Bev Flint
    Department of Clinical Health Psychology, Royal Victoria Infirmary, Newcastle, UK
    Europace 11:231-6. 2009
    ..To investigate whether levels of psychosocial impairment and psychological distress at diagnosis in those with vasovagal syncope (VVS) predict subsequent response to conventional treatment...
  27. doi request reprint Lower ambulatory blood pressure in chronic fatigue syndrome
    Julia L Newton
    Cardiovascular Investigation Unit, Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK
    Psychosom Med 71:361-5. 2009
    ..The cause of CFS remains unknown and there are no effective treatments...
  28. doi request reprint Systemic symptoms in non-alcoholic fatty liver disease
    Julia L Newton
    Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle, UK
    Dig Dis 28:214-9. 2010
    ..Consideration of these symptoms affecting patients with NAFLD and, where possible, effective treatment will lead to improvements in quality of life and enhance the ability of those with NAFLD to function in their daily lives...
  29. doi request reprint Functional capacity is significantly impaired in primary biliary cirrhosis and is related to orthostatic symptoms
    Julia L Newton
    Institute of Cellular Medicine, Newcastle University, NIHR Biomedical Research Centre in Ageing Liver Theme, Newcastle upon Tyne, UK
    Eur J Gastroenterol Hepatol 23:566-72. 2011
    ..To assess patient-reported functional ability and its relationship with symptoms in primary biliary cirrhosis (PBC)...
  30. doi request reprint Is chronic fatigue syndrome in older patients a different disease? -- a clinical cohort study
    Ieuan Lewis
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Eur J Clin Invest 43:302-8. 2013
    ..Therefore, we performed a clinical cohort study to examine and differentiate the clinical and autonomic features in CFS patients aged over 50...
  31. doi request reprint Impaired functional status in primary Sjögren's syndrome
    Katie L Hackett
    National Institute of Health Research Biomedical Research Centre in Ageing and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Arthritis Care Res (Hoboken) 64:1760-4. 2012
    ....
  32. doi request reprint 'Front-loaded' head-up tilt table testing: validation of a rapid first line nitrate-provoked tilt protocol for the diagnosis of vasovagal syncope
    Steve W Parry
    Falls and Syncope Service and Institute for Ageing and Health, Newcastle University, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
    Age Ageing 37:411-5. 2008
    ..06, 27.4). The front-loaded GTN protocol provided a higher diagnostic rate than passive tilt testing, and provides a rapid alternative to conventional methods, though false positivity rates are higher...
  33. doi request reprint Results of carotid sinus massage in a tertiary referral unit--is carotid sinus syndrome still relevant?
    Maw Pin Tan
    Institute for Ageing and Health, Wolfson Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Age Ageing 38:680-6. 2009
    ..carotid sinus hypersensitivity (CSH) is associated with syncope, drop attacks and unexplained falls in older people. However, a recent study has also reported a prevalence of 35% in asymptomatic community-dwelling older people...
  34. doi request reprint Vasovagal syncope in the older person: differences in presentation between older and younger patients
    Gordon W Duncan
    Institute for Ageing and Health, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Age Ageing 39:465-70. 2010
    ..To address this issue, we investigated the age distribution and differences in clinical characteristics associated with age in patients diagnosed with VVS by HUTT at our tertiary referral centre...
  35. doi request reprint Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Gastroenterol Hepatol 6:1041-8. 2008
    ..Although anti-PDC inhibits PDC function in vitro, mitochondrial function in vivo in PBC has not been examined...
  36. doi request reprint Non-alcoholic fatty liver disease in older people
    James Frith
    Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle, UK
    Gerontology 55:607-13. 2009
    ..Non-alcoholic fatty liver disease (NAFLD) is principally a disease of middle and old age. Previous studies reported it to be benign in old age, however more recent studies suggest an increased mortality in the >60-year-olds...
  37. ncbi request reprint Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure
    Julia L Newton
    School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    J Hepatol 44:776-83. 2006
    ..Studies to date examining relative contributions of different symptoms to QOL impairment in PBC, and biological associations have been limited by the unavailability of appropriate disease specific symptom quantification modalities...
  38. pmc Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome
    Julia L Newton
    Institute of Ageing and Health and NIHR Biomedical Research Centre for Ageing, Newcastle University, Newcastle upon Tyne, UK
    Ann Rheum Dis 71:1973-9. 2012
    ..To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS...
  39. pmc The personal and health service impact of falls in 85 year olds: cross-sectional findings from the Newcastle 85+ cohort study
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e33078. 2012
    ..We investigated the prevalence and impact of falls, and the overlap between falls, dizziness and blackouts, in a population-based sample of 85 year olds...
  40. doi request reprint Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case-control study
    David E J Jones
    Institute of Cellular Medicine Newcastle, Newcastle University, Newcastle, UK
    Eur J Clin Invest 42:186-94. 2012
    ..Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of exercise...
  41. doi request reprint Liver disease in older women
    James Frith
    UK NIHR Biomedical Research Centre for Ageing and Age related disease, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Maturitas 65:210-4. 2010
    ..Management strategies are similar irrespective of age or gender, but evidence is lacking specific to older populations...
  42. pmc Single centre experience of ivabradine in postural orthostatic tachycardia syndrome
    Claire McDonald
    Institute for Ageing and Health, UK NIHR Biomedical Research Centre in Ageing and Age related Diseases Cardiovascular theme and Falls and Syncope Service, Newcastle University, Newcastle, UK
    Europace 13:427-30. 2011
    ..Conventional therapy is effective in less than 60%. Case reports suggest ivabradine (a selective sinus node blocker, with no effect on blood pressure) may alleviate POTS-related symptoms. This is a retrospective case-series...
  43. ncbi request reprint Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence
    Julia L Newton
    Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Hepatology 44:91-8. 2006
    ..Existing agents effective at reducing daytime somnolence (such as modafinil) hold potential for the treatment of fatigue in PBC...
  44. ncbi request reprint A functional polymorphism in the interleukin-1 receptor-1 gene is associated with increased risk of Helicobacter pylori infection but not with gastric cancer
    Steve Hartland
    School of Clinical Medical Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Dig Dis Sci 49:1545-50. 2004
    ..27 vs 0.156; P = 0.009; OR = 2.01). Our results suggest that the relationship among IL-1 gene polymorphism, H. pylori, and disease is more complex than initially proposed. More detailed studies of the IL-1 gene cluster are needed...
  45. doi request reprint Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up
    Chris Elliott
    UK NIHR Biomedical Research Centre in Ageing, Liver Theme, Clinical Academic Office, Medical School, Newcastle University, Newcastle, NE2 4HH, UK
    Dig Dis Sci 58:2383-91. 2013
    ..We examined prevalence and predictors of functional impairment in biopsy-proven ALD and NAFLD. Change in function over 3 years was explored...
  46. doi request reprint Restless leg syndrome is a treatable cause of sleep disturbance and fatigue in primary biliary cirrhosis
    Kirstie Anderson
    Newcastle Hospitals NHS Foundation Trust, Newcastle University, Newcastle, UK
    Liver Int 33:239-43. 2013
    ..The cause remains unclear and treatment is challenging. Restless leg syndrome (RLS) is a common sleep disorder. In this study, we systematically screened PBC patients for the presence of RLS...
  47. doi request reprint Cognitive symptoms are common in immune thrombocytopenia and associate with autonomic symptom burden
    James Frith
    Institute for Ageing and Health and UK NIHR Biomedical Research Centre in Ageing, Newcastle University, Newcastle upon Tyne, UK
    Eur J Haematol 88:224-8. 2012
    ..Cognitive impairment commonly associates with autonomic dysfunction. Here, we quantified cognitive symptoms in a large cohort of patients with ITP compared with controls and explored the relationship with autonomic symptoms...
  48. ncbi request reprint The diurnal rhythm of the cytoprotective human trefoil protein TFF2 is reduced by factors associated with gastric mucosal damage: ageing, Helicobacter pylori infection, and sleep deprivation
    C Emma Johns
    Department of Pathology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK
    Am J Gastroenterol 100:1491-7. 2005
    ..TFF2 is considered the major cytoprotective gastric trefoil protein. There is a marked circadian variation in gastric luminal TFF2 in young healthy volunteers with peak levels present during the night...
  49. ncbi request reprint Abnormalities of sympathetic and parasympathetic autonomic function in subjects with defaecation syncope
    Louise Allan
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Europace 6:192-8. 2004
    ..It is associated with increased mortality; however, patients rarely voluntarily report symptoms. We have examined autonomic function in a cohort of patients with defaecation syncope...
  50. pmc Reduced thoracic fluid content in early-stage primary biliary cirrhosis that associates with impaired cardiac inotropy
    Pawel Zalewski
    Institute for Ageing and Health, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Am J Physiol Gastrointest Liver Physiol 305:G393-7. 2013
    ..037; β 0.5). This study has confirmed that TFC is reduced in those with PBC, that this is specific to PBC, and that it associates independently with markers of cardiac inotropy. ..
  51. ncbi request reprint Evidence-based algorithms and the management of falls and syncope presenting to acute medical services
    Steve W Parry
    Falls and Syncope Service and Institute for Ageing and Health, Royal Victoria Infirmary, Newcastle upon Tyne
    Clin Med 8:157-62. 2008
    ..Easy-to-use algorithms can help reduce the number of patients admitted to acute medical services with falls and syncope while optimising the care of those managed as inpatients. The algorithms are provided for use by interested parties...
  52. ncbi request reprint Prevalence of family history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives: preliminary data for the Newcastle cohort
    Julia L Newton
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Auton Res 13:22-6. 2003
    ..Vasovagal syncope is an exaggerated form of the common faint affecting all age groups. Aetiology is unknown but the tendency for the disease to run in families has previously been noted...
  53. doi request reprint The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: results of a 9 year follow-up
    David E Jones
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 53:911-7. 2010
    ..The aim of this study was to explore the inter-relationship between UDCA use, response, and fatigue in determining outcome over 9 years in a unique, comprehensive patient cohort...
  54. doi request reprint Fatigue in primary biliary cirrhosis
    Julia L Newton
    Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, United Kingdom, NE2 4HH
    Clin Liver Dis 12:367-83; ix. 2008
    ..Comprehensive studies investigating the pathogenesis of fatigue in PBC are urgently needed as are large-scale prospective outcome studies...
  55. ncbi request reprint The role of psychological factors in response to treatment in neurocardiogenic (vasovagal) syncope
    Jennifer Gracie
    Department of Psychology, Royal Victoria Infirmary, Newcastle NE1 4LP, UK
    Europace 8:636-43. 2006
    ..This study examines the prevalence of psychological problems in patients with VVS and whether non-responders are psychologically different from those whose symptoms respond to conservative treatment...
  56. doi request reprint Managing fatigue in the syncope unit
    Julia L Newton
    UK NIHR Biomedical Centre in Ageing, Institute of Cellular Medicine, Institute for Ageing and Health, Medical School, Newcastle University, Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Europace 14:1696-9. 2012
    ..Managing this debilitating symptom can often be challenging but, with a structured approach, immensely rewarding, and as a result improve how patients cope with their disease...
  57. ncbi request reprint Heart Rate and Blood Pressure Changes during Gastroscopy in Healthy Older Subjects
    Ruth Ross
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Gerontology 50:182-6. 2004
    ..One previous study of selected younger patients suggested that changes in blood pressure were more pronounced in non-premedicated patients...
  58. doi request reprint Fatigue in adult patients with primary immune thrombocytopenia
    Julia L Newton
    Institute for Ageing and Health and UK NIHR Biomedical Research Centre in Ageing, Newcastle University, Newcastle upon Tyne, UK
    Eur J Haematol 86:420-9. 2011
    ..Patients with primary immune thrombocytopenia (ITP) commonly describe symptoms of fatigue. However, hematologists rarely consider fatigue a manifestation of ITP...
  59. doi request reprint Autonomic dysfunction in chronic liver disease
    James Frith
    Biomedical Research Centre in Ageing Liver theme and Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    Liver Int 29:483-9. 2009
    ..As morbidity and mortality is increased in CLD patients with AD its recognition, investigation and management is important to all who encounter such patients...
  60. ncbi request reprint Effect of age-related changes in gastric physiology on tolerability of medications for older people
    Julia L Newton
    Institute for Ageing and Health, University of Newcastle, Newcastle, UK
    Drugs Aging 22:655-61. 2005
    ..This review emphasises how the stomach changes with age, and how understanding this will aid clinicians when prescribing medications with potential gastrointestinal adverse effects to older people...
  61. ncbi request reprint The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori
    J L Newton
    Department of Medicine Geriatrics, Medical School, University of Newcastle upon Tyne, UK
    Gerontology 46:153-7. 2000
    ..Peptic ulceration and Helicobacter pylori infection increase with advancing age. In the upper gastro-intestinal tract the first line of mucosal defence is the adherent mucus gel layer...
  62. pmc Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice
    J I Semple
    Department of Pathology, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Gut 48:648-55. 2001
    ..TFF2 secretion increases during inactivity and sleep. These results suggest that secretion of TFF2 in the stomach is highest during the night and that the cytoprotective effects of TFF2 on the gastric mucosa occur mainly during sleep...
  63. ncbi request reprint Care of the elderly with gastrointestinal problems in family practice
    J L Newton
    Institute for the Health of the Elderly, Care of the Elderly Offices, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 4LP, UK
    Best Pract Res Clin Gastroenterol 15:1013-25. 2001
    ..The role of family practitioners in the on-going maintenance of gastrointestinal diseases and in the management of Helicobacter pylori in community dwelling older people is also considered...
  64. doi request reprint Development of an evidence-based patient information medium: empowering newly diagnosed patients with primary biliary cirrhosis
    Ruth M Pearce
    UK NIHR Biomedical Research Centre in Ageing Liver Theme, Newcastle University, Newcastle upon Tyne, UK
    J Vis Commun Med 34:4-13. 2011
    ..We believe that introducing such a DVD into clinical practice, following diagnosis, will make a real difference to the quality of life of newly-diagnosed PBC patients...
  65. doi request reprint Self-reported symptom burden; outcome in 418 patients from the Newcastle Vasovagal (Neurocardiogenic) cohort
    R Ross
    Falls and Syncope Service, University of Newcastle, Royal Victoria Infirmary, Newcastle NE1 4LP, UK
    QJM 101:127-35. 2008
    ..Natural history of Vasovagal syndrome (Neurocardiogenic; NCS) is unclear...
  66. pmc The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach
    F E May
    Department of Pathology, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Gut 46:454-9. 2000
    ..TFF2 is also detected at high concentrations around sites of ulceration. It is protective against mucosal damaging agents and stimulates cell motility...
  67. doi request reprint A predictive model for fatigue and its etiologic associations in primary biliary cirrhosis
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, United Kingdom
    Clin Gastroenterol Hepatol 6:228-33. 2008
    ..Here we explore how these biological associates inter-relate, and their cumulative impact upon typical clinical cohorts...
  68. ncbi request reprint Molecular genetics of rheumatoid arthritis
    Sinead M J Harney
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 8BN, UK
    Curr Opin Pharmacol 3:280-5. 2003
    ..However, preliminary experience suggests that unravelling the genetic component of common inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus, might be a harder nut to crack...
  69. ncbi request reprint Are some antihypertensives more prone to induce hypotensive side effects than others?
    Lauren Burton
    Age Ageing 33:626-8. 2004
  70. ncbi request reprint Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: a review of 10 years' experience
    Zbigniew J Gieroba
    Flinders University Department of Rehabilitation and Aged Care, Repatriation General Hospital, Daw Park, South Australia
    J Am Geriatr Soc 52:1913-5. 2004
    ..To test the safety of the head-up tilt test (HUT) in older adults...
  71. ncbi request reprint Symptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradine
    Victoria Ewan
    Falls and Syncope Service, Institute for Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK
    Europace 9:1202. 2007
  72. ncbi request reprint The v-MFG test: investigating maternal, offspring and maternal-fetal genetic incompatibility effects on disease and viability
    Hsin Ju Hsieh
    Biostatistics, University of California, Los Angeles, CA, USA
    Genet Epidemiol 30:333-47. 2006
    ....
  73. pmc Effective interventions to prevent falls in older people
    Joanna L Hampton
    Br J Gen Pract 52:884-6. 2002
  74. ncbi request reprint Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis
    Julia L Newton
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Arthritis Rheum 50:2122-9. 2004
    ..To refine this association, we performed a case-control association study using both SNPs and microsatellite markers in haplotypes matched either for HLA-DRB1*0404 or for HLA-DRB1*0401...
  75. doi request reprint An integrated care pathway improves quality of life in Primary Biliary Cirrhosis
    David E J Jones
    Institute of Cellular Medicine, Newcastle University, Newcastle NE24HH, UK
    QJM 101:535-43. 2008
    ..We have formally explored how these two perspectives of chronic disease management can be combined into a clinic consultation and impact upon quality of life (QOL) in PBC...
  76. ncbi request reprint Upper gastrointestinal alarms in older people
    Neeraj Bhala
    Lancet 366:982-3. 2005
  77. ncbi request reprint Reflections on therapeutic trials in primary biliary cirrhosis: a quality of life oriented counter-view
    David E J Jones
    Hepatology 43:633; author reply 634. 2006