Diane G Newell

Summary

Country: UK

Publications

  1. pmc Biosecurity-based interventions and strategies to reduce Campylobacter spp. on poultry farms
    D G Newell
    Foodborne Zoonoses Consultancy, Silver Birches, Wherwell, Andover SP11 7AW, United Kingdom
    Appl Environ Microbiol 77:8605-14. 2011
  2. doi request reprint Food-borne diseases - the challenges of 20 years ago still persist while new ones continue to emerge
    Diane G Newell
    Veterinary Laboratories Agency, Addlestone, UK
    Int J Food Microbiol 139:S3-15. 2010
  3. pmc Longitudinal molecular epidemiological study of thermophilic campylobacters on one conventional broiler chicken farm
    Anne M Ridley
    Department for Food and Environmental Safety, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, United Kingdom
    Appl Environ Microbiol 77:98-107. 2011
  4. ncbi request reprint An aflagellate mutant Yersinia enterocolitica biotype 1A strain displays altered invasion of epithelial cells, persistence in macrophages, and cytokine secretion profiles in vitro
    Alan McNally
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Surrey, UK
    Microbiology 153:1339-49. 2007
  5. doi request reprint Identification of hyperinvasive Campylobacter jejuni strains isolated from poultry and human clinical sources
    Catherine Fearnley
    Veterinary Laboratories Agency, Weybridge, Surrey KT15 3NB, UK
    J Med Microbiol 57:570-80. 2008
  6. pmc Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickens
    Manal Abuoun
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 73:3053-62. 2005
  7. ncbi request reprint Yersinia enterocolitica isolates of differing biotypes from humans and animals are adherent, invasive and persist in macrophages, but differ in cytokine secretion profiles in vitro
    Alan McNally
    Veterinary Laboratories Agency, Woodham Lane, New Haw, Surrey KT15 3NB, UK
    J Med Microbiol 55:1725-34. 2006
  8. pmc Application of fluorescent amplified fragment length polymorphism for comparison of human and animal isolates of Yersinia enterocolitica
    Catherine Fearnley
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Appl Environ Microbiol 71:4960-5. 2005
  9. pmc Real-time PCR approach for detection of environmental sources of Campylobacter strains colonizing broiler flocks
    Anne M Ridley
    Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom
    Appl Environ Microbiol 74:2492-504. 2008
  10. ncbi request reprint The ecology of Campylobacter jejuni in avian and human hosts and in the environment
    Diane G Newell
    Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, UK
    Int J Infect Dis 6:3S16-20; discussion 3S20-1, 3S53-8. 2002

Collaborators

Detail Information

Publications15

  1. pmc Biosecurity-based interventions and strategies to reduce Campylobacter spp. on poultry farms
    D G Newell
    Foodborne Zoonoses Consultancy, Silver Birches, Wherwell, Andover SP11 7AW, United Kingdom
    Appl Environ Microbiol 77:8605-14. 2011
    ..However, complementary, non-biosecurity-based approaches will also be required in the future to maximize the reduction of Campylobacter-positive flocks at the farm level...
  2. doi request reprint Food-borne diseases - the challenges of 20 years ago still persist while new ones continue to emerge
    Diane G Newell
    Veterinary Laboratories Agency, Addlestone, UK
    Int J Food Microbiol 139:S3-15. 2010
    ..It will also be necessary understand the multiple interactions these pathogens have with their environments during transmission along the food chain in order to develop effective prevention and control strategies...
  3. pmc Longitudinal molecular epidemiological study of thermophilic campylobacters on one conventional broiler chicken farm
    Anne M Ridley
    Department for Food and Environmental Safety, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, United Kingdom
    Appl Environ Microbiol 77:98-107. 2011
    ....
  4. ncbi request reprint An aflagellate mutant Yersinia enterocolitica biotype 1A strain displays altered invasion of epithelial cells, persistence in macrophages, and cytokine secretion profiles in vitro
    Alan McNally
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Surrey, UK
    Microbiology 153:1339-49. 2007
    ..Preliminary studies using porcine in vitro organ culture (IVOC) tissue suggested that the flagella mutant was also attenuated in its ability to colonize intestinal tissue...
  5. doi request reprint Identification of hyperinvasive Campylobacter jejuni strains isolated from poultry and human clinical sources
    Catherine Fearnley
    Veterinary Laboratories Agency, Weybridge, Surrey KT15 3NB, UK
    J Med Microbiol 57:570-80. 2008
    ..This trend was stronger when the two genes were analysed together, thus ciaB(-) cj0486(+) was over-represented in high and hyperinvasive strains, with low invaders more commonly found to lack these genes (P=0.0064)...
  6. pmc Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickens
    Manal Abuoun
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 73:3053-62. 2005
    ..However, no neutralizing antibodies were detected in colonized chickens despite the expression of CDT in the avian gut as indicated by reverse transcription-PCR...
  7. ncbi request reprint Yersinia enterocolitica isolates of differing biotypes from humans and animals are adherent, invasive and persist in macrophages, but differ in cytokine secretion profiles in vitro
    Alan McNally
    Veterinary Laboratories Agency, Woodham Lane, New Haw, Surrey KT15 3NB, UK
    J Med Microbiol 55:1725-34. 2006
    ..Infections of porcine tissue also suggested the possibility of host-tissue tropism within Y. enterocolitica subtypes...
  8. pmc Application of fluorescent amplified fragment length polymorphism for comparison of human and animal isolates of Yersinia enterocolitica
    Catherine Fearnley
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Appl Environ Microbiol 71:4960-5. 2005
    ..The distribution of some BT1A isolates within cluster A raises questions about the relationship between virulence potential and biotype...
  9. pmc Real-time PCR approach for detection of environmental sources of Campylobacter strains colonizing broiler flocks
    Anne M Ridley
    Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom
    Appl Environ Microbiol 74:2492-504. 2008
    ..The strategy may also have wider applications for the tracking of specific campylobacter strains in heavily contaminated environments...
  10. ncbi request reprint The ecology of Campylobacter jejuni in avian and human hosts and in the environment
    Diane G Newell
    Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, UK
    Int J Infect Dis 6:3S16-20; discussion 3S20-1, 3S53-8. 2002
    ....
  11. pmc Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni
    If H A Barnes
    Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Microb Pathog 43:198-207. 2007
    ..In vivo studies showed that, although GGT activity was not required for initial colonization of 1-day-old chicks, the enzyme was required for persistent colonization of the avian gut...
  12. pmc Multilocus sequence typing for comparison of veterinary and human isolates of Campylobacter jejuni
    Georgina Manning
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Appl Environ Microbiol 69:6370-9. 2003
    ..In addition to isolates from human outbreaks, one group of isolates that were not epidemiologically linked was also identical at all 12 loci. This group of isolates is believed to represent another stable strain of C. jejuni...
  13. doi request reprint Gene expression profiles induced by Salmonella infection in resistant and susceptible mice
    Shaun Cawthraw
    Department of Bacteriology, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
    Microbes Infect 13:383-93. 2011
    ..Taken together these data indicate that in vivo responses to Salmonella, at the level of the intestine, are tightly regulated by the host...
  14. ncbi request reprint Campylobacter concisus: an emerging pathogen?
    Diane G Newell
    MED VET NET, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Eur J Gastroenterol Hepatol 17:1013-4. 2005
    ..However, considerable further work is needed with more discriminatory genotyping methods, before accurate assessment of the risk of C. concisus infection to human health can be determined...
  15. ncbi request reprint Identification of genetic differences between two Campylobacter jejuni strains with different colonization potentials
    If H Ahmed
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Microbiology 148:1203-12. 2002
    ..These results indicate that subtractive hybridization can successfully identify genes that are absent from the only C. jejuni strain for which the genome sequence is currently available...