Genomes and Genes
Diane G Newell
- Biosecurity-based interventions and strategies to reduce Campylobacter spp. on poultry farmsD G Newell
Foodborne Zoonoses Consultancy, Silver Birches, Wherwell, Andover SP11 7AW, United Kingdom
Appl Environ Microbiol 77:8605-14. 2011..However, complementary, non-biosecurity-based approaches will also be required in the future to maximize the reduction of Campylobacter-positive flocks at the farm level...
- Food-borne diseases - the challenges of 20 years ago still persist while new ones continue to emergeDiane G Newell
Veterinary Laboratories Agency, Addlestone, UK
Int J Food Microbiol 139:S3-15. 2010..It will also be necessary understand the multiple interactions these pathogens have with their environments during transmission along the food chain in order to develop effective prevention and control strategies...
- Longitudinal molecular epidemiological study of thermophilic campylobacters on one conventional broiler chicken farmAnne M Ridley
Department for Food and Environmental Safety, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, United Kingdom
Appl Environ Microbiol 77:98-107. 2011....
- An aflagellate mutant Yersinia enterocolitica biotype 1A strain displays altered invasion of epithelial cells, persistence in macrophages, and cytokine secretion profiles in vitroAlan McNally
Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Surrey, UK
Microbiology 153:1339-49. 2007..Preliminary studies using porcine in vitro organ culture (IVOC) tissue suggested that the flagella mutant was also attenuated in its ability to colonize intestinal tissue...
- Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickensManal Abuoun
Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Infect Immun 73:3053-62. 2005..However, no neutralizing antibodies were detected in colonized chickens despite the expression of CDT in the avian gut as indicated by reverse transcription-PCR...
- Identification of hyperinvasive Campylobacter jejuni strains isolated from poultry and human clinical sourcesCatherine Fearnley
Veterinary Laboratories Agency, Weybridge, Surrey KT15 3NB, UK
J Med Microbiol 57:570-80. 2008..This trend was stronger when the two genes were analysed together, thus ciaB(-) cj0486(+) was over-represented in high and hyperinvasive strains, with low invaders more commonly found to lack these genes (P=0.0064)...
- Yersinia enterocolitica isolates of differing biotypes from humans and animals are adherent, invasive and persist in macrophages, but differ in cytokine secretion profiles in vitroAlan McNally
Veterinary Laboratories Agency, Woodham Lane, New Haw, Surrey KT15 3NB, UK
J Med Microbiol 55:1725-34. 2006..Infections of porcine tissue also suggested the possibility of host-tissue tropism within Y. enterocolitica subtypes...
- Application of fluorescent amplified fragment length polymorphism for comparison of human and animal isolates of Yersinia enterocoliticaCatherine Fearnley
Department of Food and Environmental Safety, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Appl Environ Microbiol 71:4960-5. 2005..The distribution of some BT1A isolates within cluster A raises questions about the relationship between virulence potential and biotype...
- Real-time PCR approach for detection of environmental sources of Campylobacter strains colonizing broiler flocksAnne M Ridley
Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom
Appl Environ Microbiol 74:2492-504. 2008..The strategy may also have wider applications for the tracking of specific campylobacter strains in heavily contaminated environments...
- Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuniIf H A Barnes
Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
Microb Pathog 43:198-207. 2007..In vivo studies showed that, although GGT activity was not required for initial colonization of 1-day-old chicks, the enzyme was required for persistent colonization of the avian gut...
- Multilocus sequence typing for comparison of veterinary and human isolates of Campylobacter jejuniGeorgina Manning
Veterinary Laboratories Agency (Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Appl Environ Microbiol 69:6370-9. 2003..In addition to isolates from human outbreaks, one group of isolates that were not epidemiologically linked was also identical at all 12 loci. This group of isolates is believed to represent another stable strain of C. jejuni...
- Gene expression profiles induced by Salmonella infection in resistant and susceptible miceShaun Cawthraw
Department of Bacteriology, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
Microbes Infect 13:383-93. 2011..Taken together these data indicate that in vivo responses to Salmonella, at the level of the intestine, are tightly regulated by the host...
- Campylobacter concisus: an emerging pathogen?Diane G Newell
MED VET NET, Veterinary Laboratories Agency, Addlestone, Surrey, UK
Eur J Gastroenterol Hepatol 17:1013-4. 2005..However, considerable further work is needed with more discriminatory genotyping methods, before accurate assessment of the risk of C. concisus infection to human health can be determined...
- Identification of genetic differences between two Campylobacter jejuni strains with different colonization potentialsIf H Ahmed
Veterinary Laboratories Agency (Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
Microbiology 148:1203-12. 2002..These results indicate that subtractive hybridization can successfully identify genes that are absent from the only C. jejuni strain for which the genome sequence is currently available...