Martin Vordermeier

Summary

Affiliation: New Haw
Country: UK

Publications

  1. pmc Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    H Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 70:3026-32. 2002
  2. ncbi request reprint Toward the development of diagnostic assays to discriminate between Mycobacterium bovis infection and bacille Calmette-Guérin vaccination in cattle
    H M Vordermeier
    Tuberculosis Research Group, Bacteriology Department, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Infect Dis 30:S291-8. 2000
  3. ncbi request reprint Improved immunogenicity of DNA vaccination with mycobacterial HSP65 against bovine tuberculosis by protein boosting
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Vet Microbiol 93:349-59. 2003
  4. pmc Recognition of mycobacterial epitopes by T cells across mammalian species and use of a program that predicts human HLA-DR binding peptides to predict bovine epitopes
    Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 71:1980-7. 2003
  5. pmc Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratory Agency, Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UK
    Infect Immun 72:6255-61. 2004
  6. pmc Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle
    H M Vordermeier
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Diagn Lab Immunol 8:571-8. 2001
  7. ncbi request reprint Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test
    H M Vordermeier
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Surrey KT15 3NB, Addlestone, UK
    Vaccine 19:1246-55. 2000
  8. pmc The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia
    Martin Vordermeier
    Animal Health and Veterinary Laboratories Agency, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Comp Immunol Microbiol Infect Dis 35:227-32. 2012
  9. pmc Development of diagnostic reagents to differentiate between Mycobacterium bovis BCG vaccination and M. bovis infection in cattle
    H M Vordermeier
    TB Research Group, Bacteriology Department, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, KT15 3NB, United Kingdom
    Clin Diagn Lab Immunol 6:675-82. 1999
  10. ncbi request reprint Low-dose Mycobacterium bovis infection in cattle results in pathology indistinguishable from that of high-dose infection
    Linda Johnson
    Department of Pathology, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Tuberculosis (Edinb) 87:71-6. 2007

Detail Information

Publications62

  1. pmc Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    H Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 70:3026-32. 2002
    ....
  2. ncbi request reprint Toward the development of diagnostic assays to discriminate between Mycobacterium bovis infection and bacille Calmette-Guérin vaccination in cattle
    H M Vordermeier
    Tuberculosis Research Group, Bacteriology Department, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Infect Dis 30:S291-8. 2000
    ..bovis from those vaccinated with BCG and from those sensitized to avian tuberculin in lymphocyte transformation and interferon-gamma assays...
  3. ncbi request reprint Improved immunogenicity of DNA vaccination with mycobacterial HSP65 against bovine tuberculosis by protein boosting
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Vet Microbiol 93:349-59. 2003
    ....
  4. pmc Recognition of mycobacterial epitopes by T cells across mammalian species and use of a program that predicts human HLA-DR binding peptides to predict bovine epitopes
    Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 71:1980-7. 2003
    ..bovis-infected cattle. The results obtained in this study support the approach of using bioinformatics to increase the efficiency of epitope screening and selection...
  5. pmc Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratory Agency, Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UK
    Infect Immun 72:6255-61. 2004
    ..In conclusion, the use of CyaA fusion proteins with ESAT-6 and CFP10 has the potential to improve the sensitivity of immunodiagnostic tests detecting bovine tuberculosis in cattle...
  6. pmc Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle
    H M Vordermeier
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Diagn Lab Immunol 8:571-8. 2001
    ..In summary, our results demonstrate that this peptide cocktail can discriminate between M. bovis infection and BCG vaccination with a high degree of sensitivity and specificity...
  7. ncbi request reprint Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test
    H M Vordermeier
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Surrey KT15 3NB, Addlestone, UK
    Vaccine 19:1246-55. 2000
    ..Significantly, the specificity of tuberculin skin testing was not compromised by DNA vaccination since none of the vaccinated calves showed positive skin test reactivity...
  8. pmc The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia
    Martin Vordermeier
    Animal Health and Veterinary Laboratories Agency, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Comp Immunol Microbiol Infect Dis 35:227-32. 2012
    ....
  9. pmc Development of diagnostic reagents to differentiate between Mycobacterium bovis BCG vaccination and M. bovis infection in cattle
    H M Vordermeier
    TB Research Group, Bacteriology Department, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, KT15 3NB, United Kingdom
    Clin Diagn Lab Immunol 6:675-82. 1999
    ..avium-sensitized animals did not respond. In summary, our results suggest that peptide and protein cocktails can be designed to discriminate between M. bovis infection and BCG vaccination...
  10. ncbi request reprint Low-dose Mycobacterium bovis infection in cattle results in pathology indistinguishable from that of high-dose infection
    Linda Johnson
    Department of Pathology, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Tuberculosis (Edinb) 87:71-6. 2007
    ..These studies confirm that within the same time period, the smallest possible infective dose, properly administered, can produce pathology indistinguishable from a dose 1000-fold greater...
  11. pmc Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle
    Adam O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, United Kingdom
    PLoS ONE 5:e8527. 2010
    ..This work will serve as a baseline for future studies into the genetic basis of host preference, and in particular the molecular basis of virulence in M. bovis...
  12. ncbi request reprint Development of cattle TB vaccines in the UK
    Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet Immunol Immunopathol 112:38-48. 2006
    ..These significant advances are detailed in this review with a summary of future directions that TB vaccine development for cattle is likely to take...
  13. pmc Field evaluation of the efficacy of Mycobacterium bovis bacillus Calmette-Guerin against bovine tuberculosis in neonatal calves in Ethiopia
    Gobena Ameni
    Veterinary Laboratories Agency, TB Research Group, New Haw, Addelstone, Surrey, United Kingdom
    Clin Vaccine Immunol 17:1533-8. 2010
    ..In conclusion, the present trial demonstrated an encouraging protective effect of BCG against bTB in a natural transmission setting in Ethiopia...
  14. doi request reprint Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle
    Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet Microbiol 151:8-13. 2011
    ..Finally, we present an up-date of our current approaches in this area...
  15. ncbi request reprint Immunohistochemical markers augment evaluation of vaccine efficacy and disease severity in bacillus Calmette-Guerin (BCG) vaccinated cattle challenged with Mycobacterium bovis
    Linda Johnson
    Department of Pathology, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK
    Vet Immunol Immunopathol 111:219-29. 2006
    ..Lymph node evaluation using light microscopy and immunohistochemical markers is useful to assess the immune response and discriminate granulomas to determine vaccine efficacy and disease severity...
  16. pmc Evaluation of gamma interferon and antibody tuberculosis tests in alpacas
    Shelley Rhodes
    Animal Health and Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, United Kingdom
    Clin Vaccine Immunol 19:1677-83. 2012
    ....
  17. doi request reprint Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection
    Martin Vordermeier
    TB Research Group, Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Trop Anim Health Prod 44:651-5. 2012
    ..Our results suggested subtle differences in the cytokine profile because only infection-induced IL-6 production was significantly increased in monocytes from the more susceptible Holstein cattle...
  18. doi request reprint DIVA reagents for bovine tuberculosis vaccines in cattle
    Martin Vordermeier
    Animal Health and Veterinary Laboratories Agency, Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Expert Rev Vaccines 10:1083-91. 2011
    ..We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program...
  19. pmc Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics
    P J Cockle
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, United Kingdom
    Infect Immun 70:6996-7003. 2002
    ..In particular, eight highly immunogenic antigens were identified whose potentials as diagnostic reagents or as subunit vaccines warrant further study (Rv1983, Rv1986, Rv3872, Rv3873, Rv3878, Rv3879c, Rv1979c, and Rv1769)...
  20. doi request reprint ELISPOT assays to enumerate bovine IFN-γ-secreting cells for the development of novel vaccines against bovine tuberculosis
    Martin Vordermeier
    Department of Bacteriology, TB Research Group, Veterinary Laboratories Agency, WeybridgeAddlestone, Surrey, UK
    Methods Mol Biol 792:219-27. 2012
    ..This is particularly the case for vaccines against diseases that require protective cell-mediated immunity, such as tuberculosis. This chapter describes ELISPOT assays detecting bovine IFN-γ...
  21. doi request reprint Isoniazid treatment of Mycobacterium bovis in cattle as a model for human tuberculosis
    G S Dean
    TB Research Group, Veterinary Laboratories Agency, Woodham Lane, Weybridge, KT15 3NB, UK
    Tuberculosis (Edinb) 88:586-94. 2008
    ..Specific IL-10 responses were observed in all calves following treatment with INH suggesting a role for IL-10 in the resolution of infection...
  22. pmc 1,25-dihydroxyvitamin D3 and development of tuberculosis in cattle
    S G Rhodes
    TB Research Group, Veterinary Laboratories Agency, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Diagn Lab Immunol 10:1129-35. 2003
    ....
  23. ncbi request reprint Antigen recognition and immunomodulation by gamma delta T cells in bovine tuberculosis
    S G Rhodes
    TB Research Group, Veterinary Laboratories Agency, Surrey, United Kingdom
    J Immunol 166:5604-10. 2001
    ....
  24. pmc Distinct response kinetics of gamma interferon and interleukin-4 in bovine tuberculosis
    S G Rhodes
    TB Research Group, Veterinary Laboratories Agency, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 68:5393-400. 2000
    ....
  25. pmc Antigen specificity in experimental bovine tuberculosis
    S G Rhodes
    TB Research Group, Veterinary Laboratories Agency, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 68:2573-8. 2000
    ..bovis infection in cattle...
  26. pmc Antigen mining with iterative genome screens identifies novel diagnostics for the Mycobacterium tuberculosis complex
    Katie Ewer
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Vaccine Immunol 13:90-7. 2006
    ..Evaluation of the peptides identified from the three dominant antigens by use of larger field studies is now a priority...
  27. doi request reprint Gene expression profiling and antigen mining of the tuberculin production strain Mycobacterium bovis AN5
    M Carmen Garcia Pelayo
    TB Research Group, VLA Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, UK
    Vet Microbiol 133:272-7. 2009
    ..Our results show that field strains of M. bovis show some significant differences in gene expression to AN5, and that this differential gene expression may impact on the antigen profiles expressed by AN5 during in vitro culture...
  28. pmc The burden of mycobacterial disease in ethiopian cattle: implications for public health
    Stefan Berg
    TB Research Group, Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    PLoS ONE 4:e5068. 2009
    ..Furthermore, Ethiopia has one of the highest incidence rates of human extrapulmonary TB in the world, a clinical presentation that is often associated with transmission of M. bovis from cattle to humans...
  29. ncbi request reprint Distribution and activation of T-lymphocyte subsets in tuberculous bovine lymph-node granulomas
    E Liebana
    Department of Pathology, Veterinary Laboratories Agency Weybridge, Addlestone, KT15 3NB Surrey, England, UK
    Vet Pathol 44:366-72. 2007
    ..In general terms, there was a higher density of CD8(+) cells compared with CD4(+) cells. However, there was no sense of rimming effect for any of the investigated cell populations...
  30. pmc Modulation of the bovine delayed-type hypersensitivity responses to defined mycobacterial antigens by a synthetic bacterial lipopeptide
    A O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Infect Immun 71:6420-5. 2003
    ..This lipopeptide stimulated the release of the proinflammatory cytokine tumor necrosis factor alpha from monocyte-derived bovine dendritic cells in vitro, thereby providing a possible mechanism for its DTH-enhancing properties...
  31. ncbi request reprint Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattle
    H M Vordermeier
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet J 171:229-44. 2006
    ....
  32. ncbi request reprint Influence of skin testing and overnight sample storage on blood-based diagnosis of bovine tuberculosis
    A O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone
    Vet Rec 155:204-6. 2004
  33. ncbi request reprint Blood-based assays to detect Mycobacterium bovis-infected cattle missed by tuberculin skin testing
    M Coad
    TB Research Group, Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB
    Vet Rec 162:382-4. 2008
  34. ncbi request reprint Influence of skin testing and blood storage on interferon-gamma production in cattle affected naturally with Mycobacterium bovis
    M Coad
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB
    Vet Rec 160:660-2. 2007
  35. pmc Field evaluation of a novel differential diagnostic reagent for detection of Mycobacterium bovis in cattle
    P J Cockle
    TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Vaccine Immunol 13:1119-24. 2006
    ..In addition, the specificity of this cocktail was not compromised by Mycobacterium bovis BCG vaccination. In summary, our results prioritize this peptide-based, fully synthetic reagent for assessment in larger trials...
  36. ncbi request reprint Immunogenicity comparison of the intradermal or endobronchial boosting of BCG vaccinates with Ad5-85A
    Adam Whelan
    TB Research Group, Animal Health and Veterinary Laboratories Agency, Weybridge, Surrey KT 15 3NB, UK
    Vaccine 30:6294-300. 2012
    ..These results contribute to our understanding on how different vaccination strategies may affect different compartments of the immune response and in turn to the development of safer and more effective vaccines...
  37. ncbi request reprint Use of the bovine model of tuberculosis for the development of improved vaccines and diagnostics
    R G Hewinson
    TB Research Group, Department of Bacterial Diseases, VLA Weybridge, Addlestone, Surrey KT15 3NB, UK
    Tuberculosis (Edinb) 83:119-30. 2003
    ..Finally we have been able to use the model to develop a vaccine that improves the efficacy of BCG against M. bovis challenge...
  38. ncbi request reprint Development of vaccines against bovine tuberculosis
    P J Hogarth
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, UK
    J Pharm Pharmacol 58:749-57. 2006
    ..Here, we present a review of progress toward that goal, and discuss how this progress has shaped our research strategy for the development of a vaccine...
  39. ncbi request reprint Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations
    Adam O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 26:166-73. 2008
    ..Measurement of central memory responses induced by TB vaccine candidates in cattle may provide a useful correlate of protection and warrants further investigation in challenge experiments...
  40. pmc Enhanced protection against bovine tuberculosis after coadministration of Mycobacterium bovis BCG with a Mycobacterial protein vaccine-adjuvant combination but not after coadministration of adjuvant alone
    D Neil Wedlock
    AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand
    Clin Vaccine Immunol 15:765-72. 2008
    ..Vaccination of cattle with a combination of BCG and protein tuberculosis vaccine enhances protection against tuberculosis...
  41. pmc Characterization of two in vivo-expressed methyltransferases of the Mycobacterium tuberculosis complex: antigenicity and genetic regulation
    Paul Golby
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, UK
    Microbiology 154:1059-67. 2008
    ....
  42. pmc Screening of highly expressed mycobacterial genes identifies Rv3615c as a useful differential diagnostic antigen for the Mycobacterium tuberculosis complex
    Ben Sidders
    Department of Pathology and Infectious Disease, The Royal Veterinary College, London, United Kingdom
    Infect Immun 76:3932-9. 2008
    ....
  43. ncbi request reprint Protective immunity against Mycobacterium bovis induced by vaccination with Rv3109c--a member of the esat-6 gene family
    Philip J Hogarth
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 23:2557-64. 2005
    ..Significantly, Rv3019c also stimulated IFN-gamma responses in PBMC from BCG vaccinated cattle, indicating its potential for use in a heterologous prime-boost strategy in conjunction with BCG in the target species...
  44. pmc Enhancement of the sensitivity of the whole-blood gamma interferon assay for diagnosis of Mycobacterium bovis infections in cattle
    Michel Denis
    AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand
    Clin Vaccine Immunol 14:1483-9. 2007
    ..Therefore, the use of ESAT-6/CFP-10 with anti-IL-10 could be useful to detect cattle potentially infected with tuberculosis, which are not detected using current procedures...
  45. pmc Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level
    H Martin Vordermeier
    TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Vaccine Immunol 14:1203-9. 2007
    ....
  46. pmc Association of tuberculin-boosted antibody responses with pathology and cell-mediated immunity in cattle vaccinated with Mycobacterium bovis BCG and infected with M. bovis
    Konstantin Lyashchenko
    Chembio Diagnostic Systems, Inc, Medford, New York, USA
    Infect Immun 72:2462-7. 2004
    ....
  47. ncbi request reprint Cattle as a model for development of vaccines against human tuberculosis
    Bryce M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 85:19-24. 2005
    ....
  48. ncbi request reprint Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine and Department of Pediatric Infectious Diseases, Faculty of Medicine, Imperial College London, Wright Fleming Institute, UK
    J Immunol 174:4237-43. 2005
    ..The demonstration that there is infection stage-specific immunity to tuberculosis has implications for vaccine design...
  49. pmc Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Imperial College London, Wright Fleming Institute, Norfolk Place, London W2 1PG, United Kingdom
    Infect Immun 73:2991-8. 2005
    ....
  50. ncbi request reprint Effect of oral vaccination of cattle with lipid-formulated BCG on immune responses and protection against bovine tuberculosis
    Bryce M Buddle
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vaccine 23:3581-9. 2005
    ..Oral vaccination of BCG in a lipid-formulation to calves was shown to induce some positive tuberculin skin test reactions, but could also induce protection against bovine tuberculosis...
  51. pmc Vaccination of cattle with a CpG oligodeoxynucleotide-formulated mycobacterial protein vaccine and Mycobacterium bovis BCG induces levels of protection against bovine tuberculosis superior to those induced by vaccination with BCG alone
    D Neil Wedlock
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Infect Immun 73:3540-6. 2005
    ..These results suggest that a combination of a CpG ODN-formulated protein vaccine and BCG offers better protection against bovine tuberculosis than does BCG alone...
  52. pmc The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis
    Margot A Skinner
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Infect Immun 73:4441-4. 2005
    ..bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity...
  53. pmc Minimum infective dose of Mycobacterium bovis in cattle
    Gillian S Dean
    TB Research Group, Veterinary Laboratories Agency, Weybridge, UK
    Infect Immun 73:6467-71. 2005
    ..bovis infection regardless of the dose. This information should be useful in modeling the dynamics of bovine tuberculosis in cattle and in assessing the risk of transmission...
  54. ncbi request reprint Vaccines for bovine tuberculosis: current views and future prospects
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, RG207NN, UK
    Expert Rev Vaccines 4:891-903. 2005
    ..These strategies are also highly applicable to the fight against tuberculosis in humans...
  55. ncbi request reprint Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organism
    R Glyn Hewinson
    TB Research Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
    Vet Microbiol 112:127-39. 2006
    ..bovis and BCG will allow insight into how BCG became attenuated following serial passage on artificial growth media and reveal clues into how to improve the vaccine efficacy of BCG...
  56. pmc Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG
    H Martin Vordermeier
    TB Research Group, VLA Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 74:1416-8. 2006
    ..Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination...
  57. pmc A DNA prime-Mycobacterium bovis BCG boost vaccination strategy for cattle induces protection against bovine tuberculosis
    Margot A Skinner
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 71:4901-7. 2003
    ..The use of the prime-boost strategy suggested that a combination of vaccines may be better than a single vaccine for protection against tuberculosis...
  58. ncbi request reprint Synthetic peptide vaccination in cattle: induction of strong cellular immune responses against peptides derived from the Mycobacterium bovis antigen Rv3019c
    H Martin Vordermeier
    Veterinary Labortories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 23:4375-84. 2005
    ..Peptide vaccination boosted responses primed by DNA vaccination. In conclusion, emulsigen and CpG motif containing ODN constitute a promising adjuvant formulation to deliver peptides to veterinary species...
  59. pmc Is interleukin-4delta3 splice variant expression in bovine tuberculosis a marker of protective immunity?
    Shelley G Rhodes
    Veterinary Laboratories Agency, Surrey KT15 3NB, United Kingdom
    Infect Immun 75:3006-13. 2007
    ..bovis infection in cattle and are in accordance with clinical studies that have suggested a role for IL-4 splice variants in protective immunity in tuberculosis...
  60. ncbi request reprint Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFNgamma post-vaccination, but induce similar levels of protection against bovine tuberculosis
    D Neil Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 118:50-8. 2007
    ..The results also show that post-vaccination antigen-specific IFN-gamma levels in whole blood is not always a reliable indicator of protection against a subsequent virulent challenge...
  61. pmc Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guérin
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, UK
    Immunology 112:461-70. 2004
    ....
  62. ncbi request reprint Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines
    Zhou Xing
    Infectious Diseases Division, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Gene Ther 5:485-92. 2005
    ..Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines...