James W Neal

Summary

Country: UK

Publications

  1. doi Flaviviruses are neurotropic, but how do they invade the CNS?
    J W Neal
    Institute of Infection and Immunity, Henry Wellcome Building, University Hospital of Wales, Cardiff University, Cardiff CF14 4XN, United Kingdom Electronic address
    J Infect 69:203-15. 2014
  2. pmc The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review
    M R Griffiths
    Deptartment of Medical Biochemistry, University Hospital of Wales, Cardiff University Medical School, Cardiff CF14 4XN, UK
    Int J Inflam 2010:151097. 2010
  3. doi How does the brain limit the severity of inflammation and tissue injury during bacterial meningitis?
    James W Neal
    Neuropathology Laboratory, Department of Cellular Pathology, Cardiff University Medical School, Cardiff, Wales, United Kingdom
    J Neuropathol Exp Neurol 72:370-85. 2013
  4. pmc Complement activation in multiple sclerosis plaques: an immunohistochemical analysis
    Gillian Ingram
    Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK
    Acta Neuropathol Commun 2:53. 2014
  5. pmc C3-dependent mechanism of microglial priming relevant to multiple sclerosis
    Valeria Ramaglia
    Department of Infection, Immunity, and Biochemistry, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 109:965-70. 2012
  6. doi The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain
    Mark R Griffiths
    Departments of Medical Biochemistry, University of Cardiff Medical School, Cardiff, United Kingdom
    J Neuropathol Exp Neurol 68:217-26. 2009

Collaborators

  • Inge Huitinga
  • Owain W Howell
  • P Gasque
  • Gillian Ingram
  • B Paul Morgan
  • Valeria Ramaglia
  • M R Griffiths
  • Mark R Griffiths
  • Neil P Robertson
  • Bethan Dancey
  • Svetlana Hakobyan
  • Sam Loveless
  • Claire L Harris
  • Rossen M Donev
  • Frank Baas
  • Xiaobo Wu
  • Timothy R Hughes
  • Marieta M Ruseva

Detail Information

Publications6

  1. doi Flaviviruses are neurotropic, but how do they invade the CNS?
    J W Neal
    Institute of Infection and Immunity, Henry Wellcome Building, University Hospital of Wales, Cardiff University, Cardiff CF14 4XN, United Kingdom Electronic address
    J Infect 69:203-15. 2014
    ..The FV also crosses epithelial and endothelial barriers by disrupting Tight Junction complexes to increase BBB permeability. This review describes the multiple pathways responsible for the neuroinvasive properties of the Flaviviruses. ..
  2. pmc The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review
    M R Griffiths
    Deptartment of Medical Biochemistry, University Hospital of Wales, Cardiff University Medical School, Cardiff CF14 4XN, UK
    Int J Inflam 2010:151097. 2010
    ..Stem cells also interact with the chemoattractants C3a, C5a, SDF-1, and thrombin to promote stem cell migration into damaged tissue to support tissue homeostasis...
  3. doi How does the brain limit the severity of inflammation and tissue injury during bacterial meningitis?
    James W Neal
    Neuropathology Laboratory, Department of Cellular Pathology, Cardiff University Medical School, Cardiff, Wales, United Kingdom
    J Neuropathol Exp Neurol 72:370-85. 2013
    ..The neuroimmunoregulatory molecules and other CNS anti-inflammatory pathways represent potential therapeutic targets capable of reducing brain injury caused by bacterial infection...
  4. pmc Complement activation in multiple sclerosis plaques: an immunohistochemical analysis
    Gillian Ingram
    Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK
    Acta Neuropathol Commun 2:53. 2014
    ..This study aims to bring clarity to these questions...
  5. pmc C3-dependent mechanism of microglial priming relevant to multiple sclerosis
    Valeria Ramaglia
    Department of Infection, Immunity, and Biochemistry, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 109:965-70. 2012
    ..In summary, C3-dependent microglial priming confers susceptibility to other challenges. Our observations are relevant to progression in MS and other neurological diseases exacerbated by acute insults...
  6. doi The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain
    Mark R Griffiths
    Departments of Medical Biochemistry, University of Cardiff Medical School, Cardiff, United Kingdom
    J Neuropathol Exp Neurol 68:217-26. 2009
    ..This review outlines the cellular pathways used for the detection and phagocytosis of apoptotic cells in vitro and in experimental models of CNS inflammation...