Peter S Zammit

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Kinetics of myoblast proliferation show that resident satellite cells are competent to fully regenerate skeletal muscle fibers
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, United Kingdom
    Exp Cell Res 281:39-49. 2002
  2. pmc Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    J Cell Biol 166:347-57. 2004
  3. ncbi request reprint Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, W12 0NN, UK
    Dev Biol 273:454-65. 2004
  4. pmc Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation
    Charlotte A Collins
    Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, United Kingdom
    PLoS ONE 4:e4475. 2009
  5. ncbi request reprint Pax7 and myogenic progression in skeletal muscle satellite cells
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK
    J Cell Sci 119:1824-32. 2006
  6. pmc Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells
    Viola F Gnocchi
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London, UK
    PLoS ONE 4:e5205. 2009
  7. doi request reprint Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells
    Mathieu Fortier
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Dev Biol 382:504-16. 2013
  8. ncbi request reprint Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche
    Charlotte A Collins
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cell 122:289-301. 2005
  9. ncbi request reprint Heparin-binding EGF-like growth factor shows transient left-right asymmetrical expression in mouse myotome pairs
    Jon P Golding
    Muscle Cell Biology Group, MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, UK
    Gene Expr Patterns 5:3-9. 2004
  10. ncbi request reprint Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin
    Jon P Golding
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, London, United Kingdom
    Dev Dyn 231:795-800. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Kinetics of myoblast proliferation show that resident satellite cells are competent to fully regenerate skeletal muscle fibers
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, United Kingdom
    Exp Cell Res 281:39-49. 2002
    ..This time course is similar to that observed in vivo following acute injury and indicates that cells other than satellite cells are not required for complete myofiber regeneration...
  2. pmc Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    J Cell Biol 166:347-57. 2004
    ..These observations suggest that satellite cells either differentiate or switch from terminal myogenesis to maintain the satellite cell pool...
  3. ncbi request reprint Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, W12 0NN, UK
    Dev Biol 273:454-65. 2004
    ..These studies are a first step towards identifying cognate transcription factors involved in muscle stem cell regulation...
  4. pmc Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation
    Charlotte A Collins
    Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, United Kingdom
    PLoS ONE 4:e4475. 2009
    ..Our results show that in muscle progenitor cells, Pax3 and Pax7 function to maintain expression of myogenic regulatory factors, and promote population expansion, but are also required for myogenic differentiation to proceed...
  5. ncbi request reprint Pax7 and myogenic progression in skeletal muscle satellite cells
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK
    J Cell Sci 119:1824-32. 2006
    ..Therefore Pax7 may be involved in maintaining proliferation and preventing precocious differentiation, but does not promote quiescence...
  6. pmc Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells
    Viola F Gnocchi
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London, UK
    PLoS ONE 4:e5205. 2009
    ..Conversely, Jagged-1, a Notch ligand, was not expressed in quiescent satellite cells but was induced upon activation. These findings further contribute to defining the molecular signature of muscle satellite cells...
  7. doi request reprint Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells
    Mathieu Fortier
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Dev Biol 382:504-16. 2013
    ..In conclusion, signalling though S1PR3 suppresses cell cycle progression to regulate function in muscle satellite cells. ..
  8. ncbi request reprint Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche
    Charlotte A Collins
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cell 122:289-301. 2005
    ..Thus, within a normally stable tissue, the satellite cell exhibits archetypal stem cell properties and is competent to form the basal origin of adult muscle regeneration...
  9. ncbi request reprint Heparin-binding EGF-like growth factor shows transient left-right asymmetrical expression in mouse myotome pairs
    Jon P Golding
    Muscle Cell Biology Group, MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, UK
    Gene Expr Patterns 5:3-9. 2004
    ..Thus, the expression of HB-EGF in myotome pairs is regulated by global cues that define the left-right body axis...
  10. ncbi request reprint Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin
    Jon P Golding
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, London, United Kingdom
    Dev Dyn 231:795-800. 2004
    ..Myotome asymmetry, therefore, is downstream of the iv mutation but upstream of, or unrelated to, the Pitx2c pathway...
  11. pmc Uncoordinated transcription and compromised muscle function in the lmna-null mouse model of Emery- Emery-Dreyfuss muscular dystrophy
    Viola F Gnocchi
    The Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London, United Kingdom
    PLoS ONE 6:e16651. 2011
    ....
  12. doi request reprint beta-Catenin promotes self-renewal of skeletal-muscle satellite cells
    Ana Perez-Ruiz
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London, UK
    J Cell Sci 121:1373-82. 2008
    ..Thus, beta-catenin signalling in proliferating satellite cells directs these cells towards the self-renewal pathway and, so, contributes to the maintenance of this stem-cell pool in adult skeletal muscle...
  13. doi request reprint Pitx genes are redeployed in adult myogenesis where they can act to promote myogenic differentiation in muscle satellite cells
    Paul Knopp
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London, SE1 1UL, England, UK
    Dev Biol 377:293-304. 2013
    ..Together, our results show that Pitx genes play a role in regulating satellite cell function during myogenesis in adult...
  14. pmc Donor satellite cell engraftment is significantly augmented when the host niche is preserved and endogenous satellite cells are incapacitated
    Luisa Boldrin
    The Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, United Kingdom
    Stem Cells 30:1971-84. 2012
    ..Thus preservation of the satellite cell niche, concomitant with functional impairment of the majority of satellite cells within dystrophic human muscles, may improve the efficiency of stem cell therapy...
  15. pmc Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner
    Yusuke Ono
    King s College London, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London, UK
    J Cell Sci 122:4427-38. 2009
    ..Taken together, our observations show that PS1 is a key player in the choice of satellite cell fate, acting through both gamma-secretase-dependent and gamma-secretase-independent mechanisms...
  16. doi request reprint Does satellite cell dysfunction contribute to disease progression in Emery-Dreifuss muscular dystrophy?
    Viola F Gnocchi
    King s College London, Randall Division of Cell and Molecular Biophysics, London, UK
    Biochem Soc Trans 36:1344-9. 2008
    ....
  17. doi request reprint Direct effects of the pathogenic mutation on satellite cell function in muscular dystrophy
    Jennifer E Morgan
    Dubowitz Neuromuscular Centre, UCL Institute of Child Health, University College London, London, UK
    Exp Cell Res 316:3100-8. 2010
    ..Here, we review whether the pathogenic mutation can directly contribute to satellite cell dysfunction in a number of muscular dystrophies...
  18. pmc The muscle satellite cell at 50: the formative years
    Juergen Scharner
    Randall Division of Cell and Molecular Biophysics, King s College London, London, SE1 1UL, UK
    Skelet Muscle 1:28. 2011
    ..Finally, the rapid progress in the age of molecular biology is briefly discussed, and some ongoing debates on satellite cell function highlighted...
  19. ncbi request reprint Sphingomyelin levels in the plasma membrane correlate with the activation state of muscle satellite cells
    Yosuke Nagata
    Department of Life Sciences, The University of Tokyo, Meguro ku, Tokyo 153 8902, Japan
    J Histochem Cytochem 54:375-84. 2006
    ..Our observations show that quiescent satellite cells are characterized by high levels of sphingomyelin in their plasma membranes and that lysenin provides a novel marker of myogenic quiescence...
  20. ncbi request reprint Integration of embryonic and fetal skeletal myogenic programs at the myosin light chain 1f/3f locus
    Peter S Zammit
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 313:420-33. 2008
    ..Together our observations provide insights into the regulation of fetal myogenesis and the mechanisms by which temporally distinct genetic programs are integrated at a single locus...
  21. ncbi request reprint The A17 enhancer directs expression of Myf5 to muscle satellite cells but Mrf4 to myonuclei
    Ted Hung Tse Chang
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, Paris, France
    Dev Dyn 236:3419-26. 2007
    ..Importantly, therefore, this promoter-specific activity directed by A17 reflects aspects of the expression profiles of the endogenous Myf5 and Mrf4 genes...
  22. ncbi request reprint Control of Myf5 activation in adult skeletal myonuclei requires ERK signalling
    Ana Perez-Ruiz
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    Cell Signal 19:1671-80. 2007
    ..Together these observations show that Myf5 activation in adult muscle is accomplished by a complex signalling pathway, and provides candidates that can be examined for their role in Myf5 regulation during development...
  23. ncbi request reprint A population of myogenic stem cells that survives skeletal muscle aging
    Charlotte A Collins
    The Dubowitz Neuromuscular Unit, Department of Paediatrics, Imperial College London, Hammersmith Hospital, London, U K
    Stem Cells 25:885-94. 2007
    ..Thus, the effectiveness of stem-cell-mediated muscle regeneration is determined by both extrinsic environmental influences and diversity in intrinsic potential of the stem cells themselves...
  24. ncbi request reprint The skeletal muscle satellite cell: the stem cell that came in from the cold
    Peter S Zammit
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL England
    J Histochem Cytochem 54:1177-91. 2006
    ..This is a fast-moving and dynamic field, however, and in this review we discuss the evidence that we think puts this enigmatic cell firmly back at the center of adult myogenesis...
  25. pmc Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling
    Yosuke Nagata
    Department of Life Sciences, The University of Tokyo, Meguro ku, Tokyo 153 8902, Japan
    J Cell Biol 174:245-53. 2006
    ..Together, our observations show that sphingolipid signaling is involved in the induction of proliferation in an adult stem cell and a key component of muscle regeneration...
  26. ncbi request reprint A role for the myogenic determination gene Myf5 in adult regenerative myogenesis
    Barbara Gayraud-Morel
    Stem Cells and Development, Dept of Developmental Biology, Pasteur Institute, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 312:13-28. 2007
    ..Therefore, we show that Myf5 is a regulator of regenerative myogenesis and homeostasis, with functions distinct from those of Myod and Mrf4...