Research Topics
| N WinSummaryAffiliation: National Blood Service Country: UK Publications
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Detail Information
Publications
Severe gestational (incidental) thrombocytopenia: to treat or not to treatN Win
National Blood Service, Tooting Centre, 75 Cranmer Terrace, London, SW17 ORB, UK
Hematology 10:69-72. 2005..The severe form of gestational thrombocytopenia appears to be rare, and recognition is important, as it may recur in subsequent pregnancies and does not require any therapeutic intervention...- Hyperhemolytic transfusion reaction in sickle cell diseaseN Win
Red Cell Immunohaematology, National Blood Service South Thames Centre, London, UK
Transfusion 41:323-8. 2001..Continuation of blood transfusion may be lethal, as it can further exacerbate hemolysis. The pathophysiologic mechanism of HTR is not well understood... - Platelet apheresis for digital gangrene due to thrombocytosis in chronic myeloid leukaemiaN Win
National Blood Service South London Centre, UK
Clin Lab Haematol 23:65-6. 2001..We describe a case of CML which presented with digital gangrene due to thrombocytosis. Reduction of the platelet count by plateletpheresis lead to rapid symptomatic relief and recovery from the gangrene... - Recurrent transfusion-related acute lung injuryN Win
Department of Immunohaematology, National Blood Service, South Thames Centre, London, UK
Transfusion 41:1421-5. 2001..Biologically active lipids that accumulate during storage of RBCs and platelets may also cause TRALI. There has been only one previously reported case of recurrent TRALI... - Intravenous immunoglobulin given to lymphoma patients with recurrent haemolytic transfusion reactions after transfusion of compatible bloodN Win
Red Cell Immunohaematology, National Blood Service Tooting Centre, 75 Cranmer Terr, London, ORB, UK
Hematology 10:375-8. 2005..The response to IVIg in these cases suggests that IVIg should be tried when recurrent non-antibody mediated haemolytic transfusion reactions occur in patients with a lymphoid malignancy... - Use of intravenous immunoglobulin and intravenous methylprednisolone in hyperhaemolysis syndrome in sickle cell diseaseNay Win
Red Cell Immunohaematology, National Blood Service Tooting Centre, London, UK
Hematology 9:433-6. 2004..IVIg and methylprednisolone appear to have a synergistic effect on suppressing the activity of macrophages... - Use of red cells preserved in extended storage media for exchange transfusion in anti-k haemolytic disease of the newbornN Win
Red Cell Immunohaematology, National Blood Service, Tooting Centre, London, UK
Transfus Med 15:157-60. 2005..Caution should be taken, however, and renal function and electrolyte levels should be monitored closely. More information is required regarding the safety of SAGM units for exchange transfusion... 
How much residual plasma may cause TRALI?N Win
Red Cell Immunology Department, National Blood Service, Tooting Centre, London
Transfus Med 18:276-80. 2008..The risk of TRALI remains, despite providing pooled platelets suspended in male donor plasma. The significance of multiple HLA antigen/antibody matching between donor and recipient in immune TRALI warrants further study...- Management of pregnancy complicated by anti-hrB/anti-HrBN Win
Red Cell Immunohaematology, National Blood Service Tooting Centre, London SW17 ORB, UK
Immunohematology 23:143-5. 2007..Further information and publications are warranted to gain more knowledge of these rare antibodies... - Measurement of macrophage marker in hyperhaemolytic transfusion reaction: a case reportN Win
Department of Red Cell Immunology RCI, NHS Blood and Transplant, Tooting Centre, London, UK
Transfus Med 22:137-41. 2012.... - Transfusion-related acute lung injury associated with interdonor incompatibility for the neutrophil-specific antigen HNA-1aG Lucas
International Blood Group Reference Laboratory, Bristol, UK
Vox Sang 79:112-5. 2000..Bilateral infiltrates were seen on chest X-ray. A diagnosis of transfusion-related acute lung injury (TRALI) was made. The patient received 100% oxygen and recovered after 5 days... - Mixed-type autoimmune haemolytic anaemia: unusual cases and a case associated with splenic T-cell angioimmunoblastic non-Hodgkin's lymphomaNay Win
NBS Tooting Centre, Cranmer Terrace, London, UK
Hematology 12:159-62. 2007..Awareness of this condition is important as management may be different from either treating warm AIHA or CHAD... - Do patients with autoantibodies or clinically insignificant alloantibodies require an indirect antiglobulin test crossmatch?Edmond Lee
Red Cell Immunohematology, National Blood Service, London, UK
Transfusion 47:1290-5. 2007..Performing an IAT XM will give a mismatched result anyway, delays the supply of blood to the patient, and provides no additional benefit or safety... - Hyperhemolysis syndrome in sickle cell disease: case report (recurrent episode) and literature reviewNay Win
Red Cell Immunohaematology, National Blood Service, Tooting Center, London, UK
Transfusion 48:1231-8. 2008..The pathogenesis remains unclear. The possible mechanisms include bystander hemolysis, suppression of erythropoiesis, and destruction of red cells (RBCs) due to contact lysis via activated macrophages... - Hyperhaemolysis syndrome in a patient with myelofibrosisJennifer G Treleaven
Department of Haematology Royal Marsden Hospital, Sutton Surrey, UK
Hematology 9:147-9. 2004.... - Anti-Cr(a): pregnancy and transfusion supportNay Win
Immunohematology 22:203-4. 2006 - Ninety-six suspected transfusion related acute lung injury cases: investigation findings and clinical outcomeNay Win
Red Cell Immunohaematology, National Health Service Blood and Transplant NHSBT, Tooting Centre, London, UK
Hematology 12:461-9. 2007..By applying strict clinical criteria and using sensitive techniques a white blood cell antibody mediated immunological pathophysiology can be implicated in the majority TRALI cases... - Management of pregnancy complicated by anti-DibNay Win
Transfusion 43:1642-3. 2003 - TRALI associated with HLA class II antibodiesNay Win
Transfusion 43:545-6. 2003