James F Wilson

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Genomic runs of homozygosity record population history and consanguinity
    Mirna Kirin
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e13996. 2010
  2. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
  3. pmc A combined long-range phasing and long haplotype imputation method to impute phase for SNP genotypes
    John M Hickey
    University of New England, Armidale, Australia
    Genet Sel Evol 43:12. 2011
  4. pmc A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    BMC Med Genet 11:41. 2010
  5. pmc Uncovering networks from genome-wide association studies via circular genomic permutation
    Claudia P Cabrera
    MRC Human Genetics Unit, Medical Research Council, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland, United Kingdom
    G3 (Bethesda) 2:1067-75. 2012
  6. pmc Inference of identity by descent in population isolates and optimal sequencing studies
    Dominik Glodzik
    MRC Institute of Genetics and Molecular Medicine MRC IGMM, MRC Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Eur J Hum Genet 21:1140-5. 2013
  7. pmc Local exome sequences facilitate imputation of less common variants and increase power of genome wide association studies
    Peter K Joshi
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS ONE 8:e68604. 2013
  8. pmc Copy number variation across European populations
    Wanting Chen
    Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, United Kingdom
    PLoS ONE 6:e23087. 2011
  9. pmc Genome-wide analysis of epistasis in body mass index using multiple human populations
    Wen Hua Wei
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Eur J Hum Genet 20:857-62. 2012
  10. doi request reprint The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis
    Christopher S Franklin
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    Ann Hum Genet 74:471-8. 2010

Collaborators

Detail Information

Publications16

  1. pmc Genomic runs of homozygosity record population history and consanguinity
    Mirna Kirin
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e13996. 2010
    ..Individual ROH measures will also allow quantification of the disease risk arising from polygenic recessive effects...
  2. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
    ....
  3. pmc A combined long-range phasing and long haplotype imputation method to impute phase for SNP genotypes
    John M Hickey
    University of New England, Armidale, Australia
    Genet Sel Evol 43:12. 2011
    ..Long-range phasing and haplotype library imputation constitute a fast and accurate method to impute phase for SNP data...
  4. pmc A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    BMC Med Genet 11:41. 2010
    ..A substantial proportion of the inter-individual variability in S CR level is explicable by genetic factors...
  5. pmc Uncovering networks from genome-wide association studies via circular genomic permutation
    Claudia P Cabrera
    MRC Human Genetics Unit, Medical Research Council, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland, United Kingdom
    G3 (Bethesda) 2:1067-75. 2012
    ..05, whereas applying circular genomic permutation reduces the number of significant results to a more credible 40% of that value. The circular permutation software ("genomicper") is available as an R package at http://cran.r-project.org/...
  6. pmc Inference of identity by descent in population isolates and optimal sequencing studies
    Dominik Glodzik
    MRC Institute of Genetics and Molecular Medicine MRC IGMM, MRC Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Eur J Hum Genet 21:1140-5. 2013
    ..We find that with sample sizes of 1000 individuals from an isolated population genotyped using a dense SNP array, and with 20% of these individuals sequenced, 65% of sequences of the unsequenced subjects can be partially inferred...
  7. pmc Local exome sequences facilitate imputation of less common variants and increase power of genome wide association studies
    Peter K Joshi
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS ONE 8:e68604. 2013
    ..The imputation improvement corresponds to an increase in effective sample size of 28-38%, for SNPs with a minor allele frequency in the range 1-3%. ..
  8. pmc Copy number variation across European populations
    Wanting Chen
    Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, United Kingdom
    PLoS ONE 6:e23087. 2011
    ....
  9. pmc Genome-wide analysis of epistasis in body mass index using multiple human populations
    Wen Hua Wei
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Eur J Hum Genet 20:857-62. 2012
    ..We conclude that genome-wide analysis of epistasis in multiple populations is an effective approach to provide new insights into the genetic regulation of BMI but requires additional efforts to confirm the findings...
  10. doi request reprint The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis
    Christopher S Franklin
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    Ann Hum Genet 74:471-8. 2010
    ..The strongest association was with the TCF7L2 gene (rs7903146, P= 1.48 × 10⁻⁷). This is also the strongest common genetic risk factor for T2D but it has not been identified in previous genome-wide studies of glycated haemoglobin...
  11. pmc Evidence of inbreeding depression on human height
    Ruth McQuillan
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS Genet 8:e1002655. 2012
    ....
  12. pmc Genome-wide association uncovers shared genetic effects among personality traits and mood states
    Michelle Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 159:684-95. 2012
    ..The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits...
  13. pmc Characterisation of genome-wide association epistasis signals for serum uric acid in human population isolates
    Wenhua Wei
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
    PLoS ONE 6:e23836. 2011
    ..We conclude that GWA epistasis analysis is useful despite relatively low power in small isolated populations...
  14. ncbi request reprint Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin
    Jennifer L Bolton
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 10:e1004474. 2014
    ..In turn this genetic variation may contribute to cortisol-associated degenerative diseases. ..
  15. pmc Genome-wide homozygosity and multiple sclerosis in Orkney and Shetland Islanders
    Rebekah E McWhirter
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Hum Genet 20:198-202. 2012
    ..No effect of genome-wide homozygosity was detected, indicating that inbreeding and consanguinity are not risk factors for MS in this population...
  16. pmc Comparative assessment of methods for estimating individual genome-wide homozygosity-by-descent from human genomic data
    Ozren Polasek
    Public Health Sciences, University of Edinburgh, Edinburgh, UK
    BMC Genomics 11:139. 2010
    ..0625) were included in this study. All individuals were genotyped with the Illumina HumanHap300 array with 317,503 SNP markers...