Lorna M Williamson

Summary

Affiliation: National Blood Service
Country: UK

Publications

  1. ncbi request reprint Screening programmes for foetomaternal alloimmune thrombocytopenia
    L M Williamson
    University of Cambridge, Division of Transfusion Medicine, East Anglia Centre, Cambridge, UK
    Vox Sang 74:385-9. 1998
  2. ncbi request reprint Methylene blue-treated fresh-frozen plasma: what is its contribution to blood safety?
    Lorna M Williamson
    University of Cambridge and National Blood Service, Cambridge, United Kingdom
    Transfusion 43:1322-9. 2003
  3. ncbi request reprint Correcting haemostasis
    L M Williamson
    University of Cambridge, Division of Transfusion Medicine National Blood Service, Long Road, Cambridge CB2 2PT, UK
    Vox Sang 87:51-7. 2004
  4. ncbi request reprint Leucocyte-depleted blood in prevention of post-operative infections following elective orthopaedic and cardiac procedures
    L M Williamson
    National Blood Service, and University of Cambridge
    Vox Sang 83:457-60. 2002
  5. ncbi request reprint Transfusion triggers in the UK
    Lorna M Williamson
    University of Cambridge National Blood Service, Cambridge, UK
    Vox Sang 83:217-9. 2002
  6. ncbi request reprint Using haemovigilance data to set blood safety priorities
    Lorna M Williamson
    University of Cambridge, National Blood Service, England
    Vox Sang 83:65-9. 2002
  7. ncbi request reprint The impact of universal leukodepletion of the blood supply on hemovigilance reports of posttransfusion purpura and transfusion-associated graft-versus-host disease
    Lorna M Williamson
    Department of Haematology, University of Cambridge, and NHS Blood and Transplant, Long Road, Cambridge, United Kingdom
    Transfusion 47:1455-67. 2007
  8. ncbi request reprint A randomized trial of solvent/detergent-treated and standard fresh-frozen plasma in the coagulopathy of liver disease and liver transplantation
    L M Williamson
    Division of Transfusion Medicine, University of Cambridge, UK
    Transfusion 39:1227-34. 1999
  9. ncbi request reprint Systems contributing to the assurance of transfusion safety in the United Kingdom
    L M Williamson
    Division of Transfusion Medicine, University of Cambridge National Blood Service, East Anglia Centre, Cambridge, UK
    Vox Sang 77:82-7. 1999
  10. ncbi request reprint Evaluation of plasma and red cells obtained after leucocyte depletion of whole blood
    L M Williamson
    National Blood Service, East Anglia Centre, Cambridge, UK
    Transfus Med 9:51-61. 1999

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Screening programmes for foetomaternal alloimmune thrombocytopenia
    L M Williamson
    University of Cambridge, Division of Transfusion Medicine, East Anglia Centre, Cambridge, UK
    Vox Sang 74:385-9. 1998
    ....
  2. ncbi request reprint Methylene blue-treated fresh-frozen plasma: what is its contribution to blood safety?
    Lorna M Williamson
    University of Cambridge and National Blood Service, Cambridge, United Kingdom
    Transfusion 43:1322-9. 2003
  3. ncbi request reprint Correcting haemostasis
    L M Williamson
    University of Cambridge, Division of Transfusion Medicine National Blood Service, Long Road, Cambridge CB2 2PT, UK
    Vox Sang 87:51-7. 2004
  4. ncbi request reprint Leucocyte-depleted blood in prevention of post-operative infections following elective orthopaedic and cardiac procedures
    L M Williamson
    National Blood Service, and University of Cambridge
    Vox Sang 83:457-60. 2002
  5. ncbi request reprint Transfusion triggers in the UK
    Lorna M Williamson
    University of Cambridge National Blood Service, Cambridge, UK
    Vox Sang 83:217-9. 2002
  6. ncbi request reprint Using haemovigilance data to set blood safety priorities
    Lorna M Williamson
    University of Cambridge, National Blood Service, England
    Vox Sang 83:65-9. 2002
  7. ncbi request reprint The impact of universal leukodepletion of the blood supply on hemovigilance reports of posttransfusion purpura and transfusion-associated graft-versus-host disease
    Lorna M Williamson
    Department of Haematology, University of Cambridge, and NHS Blood and Transplant, Long Road, Cambridge, United Kingdom
    Transfusion 47:1455-67. 2007
    ....
  8. ncbi request reprint A randomized trial of solvent/detergent-treated and standard fresh-frozen plasma in the coagulopathy of liver disease and liver transplantation
    L M Williamson
    Division of Transfusion Medicine, University of Cambridge, UK
    Transfusion 39:1227-34. 1999
    ..This study aimed to assess the efficacy of SD-treated plasma in correcting the coagulopathy associated with liver disease and liver transplantation...
  9. ncbi request reprint Systems contributing to the assurance of transfusion safety in the United Kingdom
    L M Williamson
    Division of Transfusion Medicine, University of Cambridge National Blood Service, East Anglia Centre, Cambridge, UK
    Vox Sang 77:82-7. 1999
    ..A number of other initiatives exist in the UK which also have importance in contributing to transfusion safety. This article reviews these other key contributors, allowing SHOT to be placed in context...
  10. ncbi request reprint Evaluation of plasma and red cells obtained after leucocyte depletion of whole blood
    L M Williamson
    National Blood Service, East Anglia Centre, Cambridge, UK
    Transfus Med 9:51-61. 1999
    ..There was no evidence of complement or coagulation activation with significant removal of preformed C3a in cold hold units. Plasma storage parameters were maintained at control levels for 12 months...
  11. ncbi request reprint The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening
    L M Williamson
    Division of Transfusion Medicine, University of Cambridge, Cambridge, UK
    Blood 92:2280-7. 1998
    ..HPA-1a and HLA-DRB3*0101 typing combined with anti-HPA-1a titration allows selection of the majority of pregnancies at risk of severe thrombocytopenia...
  12. ncbi request reprint HPA-1a antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia
    Cedric Ghevaert
    National Blood Service, Department of Haematology, University of Cambridge, Cambridge, UK
    Transfusion 47:1296-305. 2007
    ..The antenatal management of fetomaternal alloimmune thrombocytopenia (FMAIT) due to HPA-1a antibodies remains controversial, and a test identifying pregnancies that do not require therapy would be of clinical value...
  13. pmc Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia
    Cedric Ghevaert
    NHS Blood and Transplant, Department of Haematology, University of Cambridge, Cambridge, United Kingdom
    J Clin Invest 118:2929-38. 2008
    ..These results provide rationale for human clinical studies...
  14. ncbi request reprint Low-affinity FcγR interactions can decide the fate of novel human IgG-sensitised red blood cells and platelets
    Kathryn L Armour
    Department of Pathology, University of Cambridge, Cambridge, UK
    Eur J Immunol 44:905-14. 2014
    ..Considering therapeutic blocking Abs, G1Δnab offers lower FcγR binding and a greater bias towards inhibition than IgG2 and IgG4 constant regions. ..
  15. ncbi request reprint The effect of methylene blue photoinactivation and methylene blue removal on the quality of fresh-frozen plasma
    Margaret Garwood
    National Blood Service, England and North Wales, United Kingdom
    Transfusion 43:1238-47. 2003
    ..T: he effects of using fresh or frozen-thawed plasma, WBC reduction of plasma before freezing, and the use of two different methylene blue (MB) removal filters on the quality of MB-treated plasma were compared...
  16. ncbi request reprint The effect of universal leukoreduction on postoperative infections and length of hospital stay in elective orthopedic and cardiac surgery
    Charlotte A Llewelyn
    National Blood Service, Cambridge and Oxford Centres, England, UK
    Transfusion 44:489-500. 2004
    ..A before and after study was undertaken to investigate the effect of universal leukoreduction (ULR) in the UK on postoperative length of hospital stay (LOS) and infections...
  17. pmc Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers
    Cedric Ghevaert
    National Health Service NHS Blood and Transplant, Cambridge, United Kingdom
    Blood 122:313-20. 2013
    ..This confirms the therapeutic potential of B2G1Δnab. The efficient clearance of platelets sensitized with B2G1 also opens up the opportunity to carry out studies of prophylaxis to prevent alloimmunization in HPA-1a-negative mothers. ..
  18. ncbi request reprint Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia
    Cedric Ghevaert
    National Blood Service Cambridge, Cambridge and Oxford, Department of Haematology, University of Cambridge, Cambridge, UK
    Transfusion 47:901-10. 2007
    ..Fetomaternal alloimmune thrombocytopenia (FMAIT) is the commonest cause of severe thrombocytopenia in term neonates but its management remains controversial...
  19. ncbi request reprint Assessment of removal of human cytomegalovirus from blood components by leukocyte depletion filters using real-time quantitative PCR
    Micaela Rios Visconti
    Division of Transfusion Medicine, National Blood Service, Long Rd, Cambridge CB2 2PT, England
    Blood 103:1137-9. 2004
    ..81(10)log reduction) and from 3.8 x 10(2) to 4.77 copies per microliter (1.9(10)log reduction) in platelets. These results suggest that LD by filtration reduces viral burden but does not completely remove CMV from blood components...
  20. ncbi request reprint Intravascular survival of red cells coated with a mutated human anti-D antibody engineered to lack destructive activity
    Kathryn L Armour
    Department of Pathology, University of Cambridge, Cambridge CB2 2PT, United Kingdom
    Blood 107:2619-26. 2006
    ..These findings suggest that G1Deltanab-coated RBCs were not hemolysed but temporarily sequestered in the spleen and that our approach merits investigation in larger studies...
  21. doi request reprint The Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trial
    Jo Howard
    Department of Haematology, Guy s and St Thomas Hospital, London, UK
    Lancet 381:930-8. 2013
    ..No consensus exists on whether preoperative blood transfusions are beneficial in patients with sickle-cell disease. We assessed whether perioperative complication rates would be altered by preoperative transfusion...
  22. ncbi request reprint Variables determining blockage of WBC-depleting filters by Hb sickle cell trait donations
    Martin J Beard
    National Blood Service, Crescent Drive, Brentwood, Essex CM15 8DP, UK
    Transfusion 44:422-30. 2004
    ..Sickle cell trait donations can block leukodepletion (LD) filters or fail to LD, but the variables affecting blockage are unclear...
  23. ncbi request reprint The quality of fresh-frozen plasma produced from whole blood stored at 4 degrees C overnight
    Rebecca Cardigan
    National Blood Service, England and North Wales, UK
    Transfusion 45:1342-8. 2005
    ..The aim of this study was to assess whether the quality of FFP produced from whole blood stored at 4 degrees C overnight is adequate for its intended purpose...
  24. ncbi request reprint Tracking and characterisation of transfused platelets by two colour, whole blood flow cytometry
    Darren L Hughes
    Department of Haematology, University of Cambridge, Cambridge, UK
    Br J Haematol 130:791-4. 2005
    ..1 +/- 6.7 to 7.3 +/- 3.3% at 6 h. This method avoids radio or chemical labelling, and could be used to assess novel platelet preparations post-transfusion...
  25. ncbi request reprint Serious hazards of transfusion: a decade of hemovigilance in the UK
    Dorothy Stainsby
    Transfus Med Rev 20:273-82. 2006
    ..The UK blood services have developed strategies to reduce these risks. Future SHOT data will evaluate the success of these and other blood safety improvements...
  26. ncbi request reprint Tracing blood units to their recipients: results of a two-centre study
    S Ballard
    National Blood Service Medical Research Council Clinical Studies Unit, Cambridge, UK
    Transfus Med 13:127-30. 2003
    ..These results have implications for 'lookback studies' involving blood transfusion. Further efforts are required to educate those involved in transfusing blood about the need for accurate documentation...
  27. ncbi request reprint Risks of fresh frozen plasma and platelets
    Sheila MacLennan
    National Blood Service, Leeds Centre, England
    J Trauma 60:S46-50. 2006
    ..Amotosalen is also licensed for platelet concentrates, with the added benefit of bacterial killing. In the UK, concern regarding vCJD has led to importation of US FFP for children...
  28. ncbi request reprint Transfusion of prion-filtered red cells does not increase the rate of alloimmunization or transfusion reactions in patients: results of the UK trial of prion-filtered versus standard red cells in surgical patients (PRISM A)
    Modupe O Elebute
    Department of Haematology, King s College Hospital, London, UK
    Br J Haematol 160:701-8. 2013
    ..These data suggest that prion filtration of red cells does not reduce overall transfusion safety. This finding requires confirmation in large populations of transfused patients...
  29. ncbi request reprint Persistence of HTLV-I in blood components after leukocyte depletion
    Joanne Pennington
    Department of Haematology, Division of Transfusion Medicine, University of Cambridge, United Kingdom
    Blood 100:677-81. 2002
    ..These results suggest that LD alone may not provide complete protection from HTLV-I transmission by transfusion...
  30. ncbi request reprint Neonatal transfusion
    Anne M Kelly
    University of Cambridge, NHS Blood and Transplant, Department of Haematology Division of Transfusion Medicine, Long Road, Cambridge, CB2 0PT, United Kingdom Electronic address
    Early Hum Dev 89:855-60. 2013
    ..Indications for transfusion of specific products including red cells, platelets, and plasma are discussed, and their use is illustrated by case examples. ..
  31. ncbi request reprint The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function
    Lotta Joutsi-Korhonen
    University of Cambridge Department of Haematology, National Blood Service Cambridge, Long Road, Cambridge, UK
    Thromb Haemost 91:743-54. 2004
    ..As the effect on platelet function is modest with HPA-1a1b (fetal type) platelets, the mutated HPA-1a antibodies described here could be developed further for FMAIT therapy...
  32. ncbi request reprint Transfusion hazard reporting: powerful data, but do we know how best to use it?
    Lorna M Williamson
    Transfusion 42:1249-52. 2002