James M A Turner

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Sex chromosomes make their mark
    James M A Turner
    MRC National Institute for Medical Research Division, Stem Cell Research and Developmental Genetics, London, UK
    Chromosoma 114:300-6. 2005
  2. ncbi request reprint X-inactivation: close encounters of the X kind
    James M A Turner
    Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Curr Biol 16:R259-61. 2006
  3. ncbi request reprint Meiotic sex chromosome inactivation
    James M A Turner
    Division of Stem Cell Biology and Developmental Genetics, MRC NIMR, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:1823-31. 2007
  4. pmc Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation
    Jennifer Grant
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 487:254-8. 2012
  5. ncbi request reprint Meiosis 2007--where have we got to and where are we going?
    James M A Turner
    MRC Biomedical NMR Centre, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Chromosome Res 15:517-21. 2007
  6. ncbi request reprint Silencing of unsynapsed meiotic chromosomes in the mouse
    James M A Turner
    Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Genet 37:41-7. 2005
  7. pmc Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation
    Shantha K Mahadevaiah
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Cell Biol 182:263-76. 2008
  8. pmc ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing
    Helene Royo
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Genes Dev 27:1484-94. 2013
  9. ncbi request reprint BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation
    James M A Turner
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Curr Biol 14:2135-42. 2004
  10. ncbi request reprint Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids
    James M A Turner
    Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Dev Cell 10:521-9. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Sex chromosomes make their mark
    James M A Turner
    MRC National Institute for Medical Research Division, Stem Cell Research and Developmental Genetics, London, UK
    Chromosoma 114:300-6. 2005
  2. ncbi request reprint X-inactivation: close encounters of the X kind
    James M A Turner
    Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Curr Biol 16:R259-61. 2006
    ..Two new studies have shown that the initiation of inactivation is preceded by X chromosome pairing; their results implicate this pairing in the choice and counting functions of X chromosome inactivation...
  3. ncbi request reprint Meiotic sex chromosome inactivation
    James M A Turner
    Division of Stem Cell Biology and Developmental Genetics, MRC NIMR, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:1823-31. 2007
    ..Furthermore, failure in MSCI is emerging as an important etiological factor in meiotic sterility...
  4. pmc Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation
    Jennifer Grant
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 487:254-8. 2012
    ..Our findings permit comparative studies of X-chromosome inactivation in mammals and pose questions about the mechanisms by which X-chromosome inactivation is achieved in eutherians...
  5. ncbi request reprint Meiosis 2007--where have we got to and where are we going?
    James M A Turner
    MRC Biomedical NMR Centre, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Chromosome Res 15:517-21. 2007
  6. ncbi request reprint Silencing of unsynapsed meiotic chromosomes in the mouse
    James M A Turner
    Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Genet 37:41-7. 2005
    ..These findings impact on the interpretation of the relationship between synaptic errors and sterility in mammals and extend our understanding of the biology of Brca1...
  7. pmc Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation
    Shantha K Mahadevaiah
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Cell Biol 182:263-76. 2008
    ..Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI...
  8. pmc ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing
    Helene Royo
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Genes Dev 27:1484-94. 2013
    ..Our work identifies a role for ATR in the epigenetic regulation of gene expression and presents a new technique for ablating gene function in the germline. ..
  9. ncbi request reprint BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation
    James M A Turner
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Curr Biol 14:2135-42. 2004
    ..These observations highlight an important role for BRCA1 in recruiting the kinase ATR to XY chromatin at the onset of MSCI and provide compelling evidence that it is ATR that phosphorylates H2AX and triggers MSCI...
  10. ncbi request reprint Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids
    James M A Turner
    Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Dev Cell 10:521-9. 2006
    ..While this postmeiotic repression occurs after the loss of MSUC-related proteins at the end of prophase, other histone modifications associated with transcriptional repression have by then become established...
  11. doi request reprint Evidence that meiotic sex chromosome inactivation is essential for male fertility
    Helene Royo
    Department of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Curr Biol 20:2117-23. 2010
    ..Our findings show that MSCI is essential for male meiosis and, as such, provide insight into the differential severity of meiotic mutations' effects on male and female meiosis...
  12. ncbi request reprint Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist
    James M A Turner
    Division of Developmental Genetics, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Cell Sci 115:4097-105. 2002
    ..However, our finding that MSCI and sex-body formation are unaltered in mice with targeted mutations of Xist that prevent somatic X inactivation suggests that somatic X-inactivation and MSCI occur by fundamentally different mechanisms...
  13. pmc Error-prone ZW pairing and no evidence for meiotic sex chromosome inactivation in the chicken germ line
    Silvana Guioli
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, London, United Kingdom
    PLoS Genet 8:e1002560. 2012
    ..The lack of conservation of MSCI in the chicken reopens the debate about the evolution of MSCI and its driving forces...
  14. ncbi request reprint Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR
    Louise N Reynard
    MRC National Institute for Medical Research, London NW7 1AA, United Kingdom
    Biol Reprod 77:329-35. 2007
    ..As a result of these findings, the gene previously known as Xmr is now officially know as Slx, Sycp3-like, X-linked...
  15. doi request reprint Key features of the X inactivation process are conserved between marsupials and eutherians
    Shantha K Mahadevaiah
    MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Curr Biol 19:1478-84. 2009
    ..We conclude that aspects of the XCI process are more highly conserved in therian mammals than previously thought...
  16. pmc Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions
    Louise N Reynard
    MRC National Institute for Medical Research, London NW7 1AA, UK
    J Cell Sci 122:4239-48. 2009
    ..Together, these data show that an MSYq gene regulates sex chromosome gene expression as well as chromatin remodelling in spermatids...
  17. ncbi request reprint The management of DNA double-strand breaks in mitotic G2, and in mammalian meiosis viewed from a mitotic G2 perspective
    Paul S Burgoyne
    Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Bioessays 29:974-86. 2007
    ....
  18. doi request reprint The consequences of asynapsis for mammalian meiosis
    Paul S Burgoyne
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
    Nat Rev Genet 10:207-16. 2009
    ..Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into the connection between asynapsis and meiotic impairment...
  19. doi request reprint Using RNA FISH to study gene expression during mammalian meiosis
    Shantha K Mahadevaiah
    Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Methods Mol Biol 558:433-44. 2009
    ..Here we describe a protocol for carrying out RNA FISH on male meiotic cells, together with detail on the important controls and common problems associated with this technique...
  20. pmc Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development
    Carles Gaston-Massuet
    Neural Development Unit, Institute of Child Health, University College London, London, UK
    Dev Biol 324:322-33. 2008
    ..Our research has revealed a role for Six3 in normal pituitary development, which has likely been conserved during evolution as SIX3 is also expressed in the pituitary gland of the human embryo...
  21. pmc The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression
    Jacob L Mueller
    Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:794-9. 2008
    ..Thus, not only is the mouse X chromosome enriched for spermatogenesis genes functioning before meiosis, but in addition, approximately 18% of mouse X-linked genes are expressed in postmeiotic cells...
  22. ncbi request reprint Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes
    Yuki Takada
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Yokohama, Japan
    Development 134:579-90. 2007
    ..Therefore, for the first time, we are able to indicate a functional involvement of Prc1 during the meiotic prophase of male germ cells and a regulatory role of Scmh1 for Prc1, which involves sex chromosomes...
  23. ncbi request reprint Localisation of histone macroH2A1.2 to the XY-body is not a response to the presence of asynapsed chromosome axes
    Sigrid Hoyer-Fender
    III Department of Zoology Developmental Biology, University of Gottingen, Humboldtallee 34A, 37073 Gottingen, Germany
    J Cell Sci 117:189-98. 2004
    ..MacroH2A1.2 and HP1 beta co-localise to autosomal pericentromeric heterochromatin in spermatocytes. However, the two proteins show temporally and spatially distinct patterns of association to X and Y chromatin...
  24. ncbi request reprint Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
    Yael Costa
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 15:2324-34. 2006
    ..The presence of MAEL in these critical compartments of male germ cells and its interactions provide a link suggesting the involvement of the miRNA pathway in MSUC...
  25. ncbi request reprint Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids
    Peter J I Ellis
    Department of Pathology, Mammalian Molecular Genetics Group, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Hum Mol Genet 14:2705-15. 2005
    ..We therefore propose that this repression and MSCI itself are evolutionary adaptations to maintain a normal sex ratio in the face of X/Y antagonism...