S J Thorpe

Summary

Affiliation: National Institute for Biological Standards and Control
Country: UK

Publications

  1. ncbi request reprint An International Standard for specifying the minimum potency of anti-D blood-grouping reagents: evaluation of a candidate preparation in an international collaborative study
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 90:131-9. 2006
  2. ncbi request reprint International collaborative study to evaluate a recombinant L ferritin preparation as an International Standard
    S J Thorpe
    National Institute for Biological Standards and Control, Herts UK
    Clin Chem 43:1582-7. 1997
  3. ncbi request reprint A global standard for anti-D immunoglobulin: international collaborative study to evaluate a candidate preparation
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 85:313-21. 2003
  4. ncbi request reprint An International Standard for whole blood folate: evaluation of a lyophilised haemolysate in an international collaborative study
    Susan J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Clin Chem Lab Med 42:533-9. 2004
  5. ncbi request reprint Anti-A and anti-B activity in batches of different intravenous immunoglobulin products determined using a direct haemagglutination method
    Susan J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK
    Biologicals 33:111-6. 2005
  6. ncbi request reprint International collaborative study to assess candidate reference preparations to control the level of anti-D in IVIG for use in Europe and the United States
    Susan J Thorpe
    National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    Biologicals 34:209-12. 2006
  7. ncbi request reprint International standards for minimum potency of anti-A and anti-B blood grouping reagents: evaluation of candidate preparations in an international collaborative study
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Vox Sang 91:336-44. 2006
  8. ncbi request reprint International Standard for serum vitamin B(12) and serum folate: international collaborative study to evaluate a batch of lyophilised serum for B(12) and folate content
    Susan J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Clin Chem Lab Med 45:380-6. 2007
  9. doi request reprint Anti-D and anti-i activities are inseparable in V4-34-encoded monoclonal anti-D: the same framework 1 residues are required for both reactivities
    Susan J Thorpe
    Biotherapeutics Group and Technology Development and Infrastructure Group, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Transfusion 48:930-40. 2008
  10. ncbi request reprint Batches of intravenous immunoglobulin associated with adverse reactions in recipients contain atypically high anti-Rh D activity
    S J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 85:80-4. 2003

Collaborators

Detail Information

Publications28

  1. ncbi request reprint An International Standard for specifying the minimum potency of anti-D blood-grouping reagents: evaluation of a candidate preparation in an international collaborative study
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 90:131-9. 2006
    ..The aim of this study was to evaluate a lyophilized monoclonal immunoglobulin M (IgM) anti-D preparation for use as an International Standard to specify a recommended minimum acceptable potency of anti-D blood-grouping reagents...
  2. ncbi request reprint International collaborative study to evaluate a recombinant L ferritin preparation as an International Standard
    S J Thorpe
    National Institute for Biological Standards and Control, Herts UK
    Clin Chem 43:1582-7. 1997
    ..On the basis of the results presented here, the WHO Expert Committee on Biological Standardization established 94/572 as the 3rd IS for ferritin, recombinant...
  3. ncbi request reprint A global standard for anti-D immunoglobulin: international collaborative study to evaluate a candidate preparation
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 85:313-21. 2003
    ..The aim of the study was to evaluate a lyophilized anti-D immunoglobulin preparation to serve as a global standard for potency assays of anti-D immunoglobulin products...
  4. ncbi request reprint An International Standard for whole blood folate: evaluation of a lyophilised haemolysate in an international collaborative study
    Susan J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Clin Chem Lab Med 42:533-9. 2004
    ..On the basis of the results presented here, the World Health Organization Expert Committee on Biological Standardization established 95/528 as an IS for whole blood folate...
  5. ncbi request reprint Anti-A and anti-B activity in batches of different intravenous immunoglobulin products determined using a direct haemagglutination method
    Susan J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK
    Biologicals 33:111-6. 2005
    ....
  6. ncbi request reprint International collaborative study to assess candidate reference preparations to control the level of anti-D in IVIG for use in Europe and the United States
    Susan J Thorpe
    National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    Biologicals 34:209-12. 2006
    ....
  7. ncbi request reprint International standards for minimum potency of anti-A and anti-B blood grouping reagents: evaluation of candidate preparations in an international collaborative study
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Vox Sang 91:336-44. 2006
    ..The aim of the study was to evaluate lyophilized monoclonal IgM anti-A and anti-B preparations for use as international standards (IS) to specify recommended minimum potencies of anti-A and anti-B blood grouping reagents in tube tests...
  8. ncbi request reprint International Standard for serum vitamin B(12) and serum folate: international collaborative study to evaluate a batch of lyophilised serum for B(12) and folate content
    Susan J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Clin Chem Lab Med 45:380-6. 2007
    ..Pooled human serum, lyophilised in ampoules and designated 03/178, was therefore evaluated by 24 laboratories in seven countries for its suitability to serve as an International Standard (IS) for B(12) and folate...
  9. doi request reprint Anti-D and anti-i activities are inseparable in V4-34-encoded monoclonal anti-D: the same framework 1 residues are required for both reactivities
    Susan J Thorpe
    Biotherapeutics Group and Technology Development and Infrastructure Group, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
    Transfusion 48:930-40. 2008
    ..V4-34 framework 1 (FR1) sequence is believed to be critical for cold agglutinin activity of cold agglutinins...
  10. ncbi request reprint Batches of intravenous immunoglobulin associated with adverse reactions in recipients contain atypically high anti-Rh D activity
    S J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 85:80-4. 2003
    ..Two reports of haemolysis occurring in recipients of IVIG manufactured from US plasma provided a rare opportunity to investigate whether high anti-D levels could have induced the haemolysis...
  11. ncbi request reprint Competitive enzyme-linked immunoassay of monoclonal immunoglobulin G anti-D preparations
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Transfus Med 13:153-9. 2003
    ..The results show that competitive EIA is suitable for quantitating most monoclonal anti-D for development and quality control purposes, regardless of their D epitope reactivity...
  12. ncbi request reprint A stable lyophilized reagent for use in a potential reference assay for quantitation of anti-D in immunoglobulin products
    Susan J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    Biologicals 30:315-21. 2002
    ..We also describe the use of trehalose for stabilization of dried erythrocyte-coated microtitre plates...
  13. ncbi request reprint International collaborative study to evaluate methods for quantification of anti-D in immunoglobulin preparations
    S J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 83:42-50. 2002
    ..The aim of this study was to carry out a direct comparison of autoanalyser methodology, competitive enzyme-linked immunoassay (EIA) and flow cytometry...
  14. ncbi request reprint Immunochemical characterization of the Rh CW antigen using human monoclonal antibodies
    S J Thorpe
    National Institute for Biological Standards and Control, South Mimms, Potters Bar, UK
    Vox Sang 73:174-81. 1997
    ..Human monoclonal antibodies have been produced against various Rh antigens. We report here the production of another one against Rh C and the first such antibody against Rh CW...
  15. ncbi request reprint A competitive enzyme-linked immunoassay using erythrocytes fixed to microtitre plates for anti-D quantitation in immunoglobulin products
    S J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control NIBSC, Potters Bar, UK
    Vox Sang 79:100-7. 2000
    ..Anti-D quantitation is usually performed using automated haemagglutination methodology although this can only be carried out in specialist centres. The aim of this study was to develop a simple and robust assay for anti-D quantitation...
  16. ncbi request reprint International collaborative study to establish reference preparations to standardise haemagglutination testing for anti-A and anti-B in normal intravenous immunoglobulins by the direct method
    S J Thorpe
    National Institute for Biological Standards and Control NIBSC, Health Protection Agency, Potters Bar, EN6 3QG Hertfordshire, UK
    Pharmeur Bio Sci Notes 2010:39-50. 2010
    ....
  17. doi request reprint International collaborative study to evaluate candidate reference reagents to standardize haemagglutination testing for anti-A and anti-B in normal intravenous immunoglobulin products
    S J Thorpe
    Biotherapeutics Group, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, UK
    Vox Sang 97:160-8. 2009
    ....
  18. ncbi request reprint International collaborative study to establish immunoglobulin (anti-D test) BRP batch 1
    S J Thorpe
    NIBSC, Potters Bar, Herts EN6 3QG, UK
    Pharmeuropa Bio 2006:49-56. 2006
    ..Further to completion of the study, the materials assayed in the study were granted the status of Ph. Eur. and US FDA reference preparations for controlling the levels of anti-D in IGIV...
  19. ncbi request reprint Collaborative study for establishment of a global standard for the potency assay of human anti-D immunoglobulin
    S J Thorpe
    National Institute for Biological Standards and Control NIBSC, Potters Bar, United Kingdom
    Pharmeuropa Bio 2003:9-26. 2004
    ..Sample A was adopted by the Ph. Eur. Commission at its 115th session (March 2003) as the first Ph. Eur. BRP (available from the EDQM: catalog number Y0000219) with the assigned potency of 285 IU/ampoule...
  20. pmc Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Immunology 93:129-36. 1998
    ..The involvement of charge interactions was further indicated by the effects of pH and ionic strength on the immunofluorescence staining patterns...
  21. ncbi request reprint Cold agglutinin activity is common among human monoclonal IgM Rh system antibodies using the V4-34 heavy chain variable gene segment
    S J Thorpe
    Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, UK
    Transfusion 37:1111-6. 1997
    ..CONCLUSION: Anti-I/i reactivity is common among IgM Rh system MoAbs and is shown only by the V4-34-encoded subset. This finding has implications for the use of MoAbs for Rh system typing of blood...
  22. ncbi request reprint International collaborative study to evaluate a candidate reference preparation to define an appropriate specified limit of anti-D in intravenous immunoglobulin products
    S J Thorpe
    National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    Vox Sang 88:278-87. 2005
    ....
  23. ncbi request reprint Clonal analysis of a human antimouse antibody (HAMA) response
    S J Thorpe
    Division of Haematology Division of Bacteriology, National Institute for Biological Standards and Control, Herts, UK
    Scand J Immunol 57:85-92. 2003
    ....
  24. ncbi request reprint Enhanced efficacy of anti-D immunoglobulin for treating ITP is not explained by higher immunoglobulin polymer content
    C Dolman
    Division of Immunobiology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Herts, EN6 3QG, UK
    Biologicals 29:75-9. 2001
    ..Therefore, higher immunoglobulin dimer and/or aggregate content cannot explain the increased efficacy of anti-D immunoglobulin for treatment of ITP. The role of polymeric Ig in efficacy for treatment of ITP is unclear...
  25. doi request reprint International reference reagents to standardise blood group genotyping: evaluation of candidate preparations in an international collaborative study
    J Boyle
    National Institute for Biological Standards and Control NIBSC, Potters Bar, Herts, UK
    Vox Sang 104:144-52. 2013
    ....
  26. ncbi request reprint A VH4-34+ myeloma protein with weak autoreactivity
    Marianne Fr√łyland
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Haematologica 92:690-3. 2007
    ..Thus, counter-selection of VH4-34 is pronounced but not absolute in MM. Mechanisms of how VH4-34 can occasionally be expressed in MM and clinical implications are discussed...
  27. ncbi request reprint "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics
    Richard Stebbings
    Biotherapeutics Group, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom
    J Immunol 179:3325-31. 2007
    ....
  28. ncbi request reprint Selective cleavage of human IgG by the matrix metalloproteinases, matrilysin and stromelysin
    Andrew J H Gearing
    British Biotech Pharmaceuticals Ltd, Oxford OX4 5LY, UK
    Immunol Lett 81:41-8. 2002
    ..In inflamed or damaged tissues where plasma protein leakage occurs, degradation by MMPs may be a mechanism for clearance of IgG...