E L Thomas

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
    Yuen Li Chung
    King s College London School of Medicine, and the MRC Clinical Science Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Arthritis Rheum 57:694-702. 2007
  2. doi Whole body fat: content and distribution
    E L Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Prog Nucl Magn Reson Spectrosc 73:56-80. 2013
  3. doi Pragmatic study of orlistat 60 mg on abdominal obesity
    E L Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Eur J Clin Nutr 65:1256-62. 2011
  4. doi Excess body fat in obese and normal-weight subjects
    E Louise Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Nutr Res Rev 25:150-61. 2012
  5. doi The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
    E Louise Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Obesity (Silver Spring) 20:76-87. 2012
  6. ncbi Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue
    E L Thomas
    The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College of Medicine, London, UK
    Int J Obes Relat Metab Disord 27:211-8. 2003
  7. ncbi Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content
    E Louise Thomas
    The Robert Steiner MR Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Atherosclerosis 195:e181-90. 2007
  8. ncbi Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease
    E Louise Thomas
    Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Rd, London W12 0HS, United Kingdom
    World J Gastroenterol 12:5813-9. 2006
  9. pmc Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study
    E L Thomas
    Robert Steiner MR Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd, London W12 0HS, UK
    Gut 54:122-7. 2005
  10. ncbi Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging
    E L Thomas
    The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England
    Lipids 35:769-76. 2000

Collaborators

Detail Information

Publications31

  1. ncbi Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
    Yuen Li Chung
    King s College London School of Medicine, and the MRC Clinical Science Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Arthritis Rheum 57:694-702. 2007
    ....
  2. doi Whole body fat: content and distribution
    E L Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Prog Nucl Magn Reson Spectrosc 73:56-80. 2013
    ..Finally, we will discuss how MRI/MRS techniques are helping in changing the perception of what is healthy and what is normal and desirable body-fat content and distribution. ..
  3. doi Pragmatic study of orlistat 60 mg on abdominal obesity
    E L Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Eur J Clin Nutr 65:1256-62. 2011
    ....
  4. doi Excess body fat in obese and normal-weight subjects
    E Louise Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Nutr Res Rev 25:150-61. 2012
    ..Here, examples of these phenotypes are presented and the value of carrying out enhanced phenotypical characterisation of subjects in interventional studies discussed...
  5. doi The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
    E Louise Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Obesity (Silver Spring) 20:76-87. 2012
    ..From these data we propose the thin-on-the-outside fat-on-the-inside (TOFI) as a subphenotype for individuals at increased metabolic risk...
  6. ncbi Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue
    E L Thomas
    The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College of Medicine, London, UK
    Int J Obes Relat Metab Disord 27:211-8. 2003
    ..To assess the validity of this approach, we have compared single- and multi-slice MRI methods for the measurement of intra-abdominal adipose tissue content...
  7. ncbi Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content
    E Louise Thomas
    The Robert Steiner MR Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Atherosclerosis 195:e181-90. 2007
    ..72, p<0.01; r=.0.86, p<0.01, respectively). In patients with FCHL on conventional lipid-lowering therapy, the addition of pioglitazone acts favourably on several metabolic parameters...
  8. ncbi Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease
    E Louise Thomas
    Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Rd, London W12 0HS, United Kingdom
    World J Gastroenterol 12:5813-9. 2006
    ..To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL)...
  9. pmc Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study
    E L Thomas
    Robert Steiner MR Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd, London W12 0HS, UK
    Gut 54:122-7. 2005
    ..Proton magnetic resonance spectroscopy (1H MRS) is a non-invasive method for measurement of tissue fat content, including intrahepatocellular lipids (IHCL) and intramyocellular lipids (IMCL)...
  10. ncbi Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging
    E L Thomas
    The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England
    Lipids 35:769-76. 2000
    ....
  11. ncbi Magnetic resonance imaging of total body fat
    E L Thomas
    The Robert Steiner Magnetic Resonance Imaging Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, United Kingdom
    J Appl Physiol (1985) 85:1778-85. 1998
    ....
  12. doi Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI
    E L Thomas
    Metabolic and Molecular Imaging Group, Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, UK
    Eur J Clin Nutr 64:525-33. 2010
    ..The objective of this study was to analyse the validity of the ViScan to assess adult abdominal adiposity across a range of body fatness...
  13. ncbi Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution
    A P Goldstone
    Endocrine Unit, MRC Clinical Sciences Centre, London, United Kingdom
    J Clin Endocrinol Metab 86:4330-8. 2001
    ..05) but not visceral adiposity (P = 0.3-0.6), supporting their association. The cause of the reduced visceral adiposity in Prader-Willi syndrome may reflect novel hormonal, hypothalamic, and/or genetic influences on body fat distribution...
  14. ncbi Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopy
    E L Thomas
    Robert Steiner MRI Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Lipids 32:645-51. 1997
    ..Our results demonstrate that 13C MRS can be utilized to assess noninvasively neonatal adipose tissue lipid composition and to monitor the effects of developmental changes due to gestational age and oral feeding...
  15. pmc Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans
    J Rico-Sanz
    Robert Steiner MR Unit, Hammersmith Hospital, Royal Postgraduate Medical School, London, UK
    J Physiol 510:615-22. 1998
    ..Energy for this type of muscle contraction may arise primarily from muscle phosphocreatine (PCr) and glycogen breakdown, circulating glucose and fatty acids from triglycerides other than those encountered within and between muscle cells...
  16. doi Early nutritional determinants of intrahepatocellular lipid deposition in preterm infants at term age
    V Vasu
    Section of Neonatal Medicine, Department of Medicine, Imperial College London, Chelsea and Westminster Campus, London, UK
    Int J Obes (Lond) 37:500-4. 2013
    ..Preterm nutritional intake is a plausible determinant of these aberrant trajectories of development...
  17. doi Neonatal intrahepatocellular lipid
    E L Thomas
    Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Arch Dis Child Fetal Neonatal Ed 93:F382-3. 2008
    ..In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH2/water median (interquartile range): preterm 1.69 (1.04-3.53), term 0.21 (0-0.54) and adult 0.55 (0.08-1.57)...
  18. doi Incidental findings in healthy control research subjects using whole-body MRI
    S H X Morin
    Division of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Eur J Radiol 72:529-33. 2009
    ..We aimed to assess the prevalence of incidental findings in a sequential cohort of healthy volunteers undergoing whole-body MRI as part of a normal control database for imaging research studies...
  19. ncbi Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism
    F Shojaee-Moradie
    Department of Diabetes, Endocrinology and Internal Medicine, GKT School of Medicine, King s College London, London, UK
    Diabetologia 50:404-13. 2007
    ..We investigated the effects of 6 weeks of supervised exercise in sedentary men on these variables...
  20. ncbi Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by (1)H-MRS
    J Rico-Sanz
    The Robert Steiner Magnetic Resonance Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, United Kingdom
    J Appl Physiol (1985) 87:2068-72. 1999
    ..4 +/- 19.2 mmol/kg dry wt (TA)]. It is proposed that the differences in metabolite levels may be due to the differences in fiber-type composition and deposition of metabolites due to the adaptation of different muscles during locomotion...
  21. ncbi Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants
    T A M Harrington
    The Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Lipids 37:95-100. 2002
    ..Furthermore, its noninvasive nature makes it an ideal method for longitudinal and interventional studies in newborn infants...
  22. ncbi Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
    Anthony P Goldstone
    Endocrine Unit, the Department of Dietetics, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Clin Nutr 75:468-75. 2002
    ..Obesity in Prader-Willi syndrome (PWS) may be related to abnormalities in the adipocyte-leptin-hypothalamic pathway and may be exacerbated by reductions in the resting metabolic rate (RMR)...
  23. doi Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian Indians
    Neena Modi
    Section of Neonatal Medicine, Division of Medicine, Chelsca and Westminister Hospital Campus, Imperial College London, London SW10 9NH, UK
    Pediatr Res 65:584-7. 2009
    ..175 to 0.034 L, p = 0.2). We conclude that differences in adipose tissue partitioning exist at birth. Investigative, screening, and preventive measures must involve maternal health, intrauterine life, and infancy...
  24. ncbi Altered adiposity after extremely preterm birth
    Sabita Uthaya
    Division of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    Pediatr Res 57:211-5. 2005
    ..We suggest that these observations may in part explain the associations between small size at birth and later disease. Preterm infants may be at risk in later life of metabolic complications through increased and aberrant adiposity...
  25. pmc Non-invasive means of measuring hepatic fat content
    Sanjeev R Mehta
    Department of Metabolic Medicine, Division of Medicine, Imperial College London, St Mary s Campus, 2nd Floor, Mint Wing, St Mary s Hospital, Praed Street, London W2 1NY, United Kingdom
    World J Gastroenterol 14:3476-83. 2008
    ..g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions...
  26. ncbi Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids
    Louise M Goff
    Department of Nutrition and Dietetics, Hammersmith Hospital, Imperial College School of Medicine, W12 0HS, UK
    Br J Nutr 89:365-75. 2003
    ....
  27. ncbi Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants
    Neena Modi
    Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Pediatr Res 60:345-8. 2006
    ..Low total adipose tissue quantity at birth appears to direct nutrition toward head growth. Adipose tissue may be involved in the signaling of catch-up growth...
  28. ncbi Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
    David B Savage
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 52:910-7. 2003
    ..Although the condition is rare, the study of humans with dominant-negative mutations in PPAR-gamma can provide important insight into the roles of this nuclear receptor in human metabolism...
  29. ncbi Critical role for peptide YY in protein-mediated satiation and body-weight regulation
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
    Cell Metab 4:223-33. 2006
    ..Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity...
  30. ncbi Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 89:1718-26. 2004
    ..The hyperghrelinemia in PWS adults is therefore not solely explained by their reduced visceral adiposity and relative hypoinsulinemia. Its cause and consequences await further elucidation...
  31. ncbi Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose content
    Julia E Ostberg
    Department of Endocrinology, University College London Hospitals, United Kingdom
    J Clin Endocrinol Metab 90:2631-5. 2005
    ..Elevated IHCL in TS is associated with estrogen deficiency. BI may be useful to estimate total body fat, but does not reliably localize fat depots in TS...