E L Thomas
Affiliation: National Institute for Medical Research
- Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trialYuen Li Chung
King s College London School of Medicine, and the MRC Clinical Science Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
Arthritis Rheum 57:694-702. 2007....
- Whole body fat: content and distributionE L Thomas
Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
Prog Nucl Magn Reson Spectrosc 73:56-80. 2013..Finally, we will discuss how MRI/MRS techniques are helping in changing the perception of what is healthy and what is normal and desirable body-fat content and distribution. ..
- Pragmatic study of orlistat 60 mg on abdominal obesityE L Thomas
Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
Eur J Clin Nutr 65:1256-62. 2011....
- Excess body fat in obese and normal-weight subjectsE Louise Thomas
Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Nutr Res Rev 25:150-61. 2012..Here, examples of these phenotypes are presented and the value of carrying out enhanced phenotypical characterisation of subjects in interventional studies discussed...
- The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fatE Louise Thomas
Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
Obesity (Silver Spring) 20:76-87. 2012..From these data we propose the thin-on-the-outside fat-on-the-inside (TOFI) as a subphenotype for individuals at increased metabolic risk...
- Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissueE L Thomas
The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College of Medicine, London, UK
Int J Obes Relat Metab Disord 27:211-8. 2003..To assess the validity of this approach, we have compared single- and multi-slice MRI methods for the measurement of intra-abdominal adipose tissue content...
- Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat contentE Louise Thomas
The Robert Steiner MR Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Atherosclerosis 195:e181-90. 2007..72, p<0.01; r=.0.86, p<0.01, respectively). In patients with FCHL on conventional lipid-lowering therapy, the addition of pioglitazone acts favourably on several metabolic parameters...
- Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver diseaseE Louise Thomas
Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Rd, London W12 0HS, United Kingdom
World J Gastroenterol 12:5813-9. 2006..To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL)...
- Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy studyE L Thomas
Robert Steiner MR Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd, London W12 0HS, UK
Gut 54:122-7. 2005..Proton magnetic resonance spectroscopy (1H MRS) is a non-invasive method for measurement of tissue fat content, including intrahepatocellular lipids (IHCL) and intramyocellular lipids (IMCL)...
- Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imagingE L Thomas
The Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England
Lipids 35:769-76. 2000....
- Magnetic resonance imaging of total body fatE L Thomas
The Robert Steiner Magnetic Resonance Imaging Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, United Kingdom
J Appl Physiol (1985) 85:1778-85. 1998....
- Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRIE L Thomas
Metabolic and Molecular Imaging Group, Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, UK
Eur J Clin Nutr 64:525-33. 2010..The objective of this study was to analyse the validity of the ViScan to assess adult abdominal adiposity across a range of body fatness...
- Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distributionA P Goldstone
Endocrine Unit, MRC Clinical Sciences Centre, London, United Kingdom
J Clin Endocrinol Metab 86:4330-8. 2001..05) but not visceral adiposity (P = 0.3-0.6), supporting their association. The cause of the reduced visceral adiposity in Prader-Willi syndrome may reflect novel hormonal, hypothalamic, and/or genetic influences on body fat distribution...
- Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopyE L Thomas
Robert Steiner MRI Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
Lipids 32:645-51. 1997..Our results demonstrate that 13C MRS can be utilized to assess noninvasively neonatal adipose tissue lipid composition and to monitor the effects of developmental changes due to gestational age and oral feeding...
- Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humansJ Rico-Sanz
Robert Steiner MR Unit, Hammersmith Hospital, Royal Postgraduate Medical School, London, UK
J Physiol 510:615-22. 1998..Energy for this type of muscle contraction may arise primarily from muscle phosphocreatine (PCr) and glycogen breakdown, circulating glucose and fatty acids from triglycerides other than those encountered within and between muscle cells...
- Early nutritional determinants of intrahepatocellular lipid deposition in preterm infants at term ageV Vasu
Section of Neonatal Medicine, Department of Medicine, Imperial College London, Chelsea and Westminster Campus, London, UK
Int J Obes (Lond) 37:500-4. 2013..Preterm nutritional intake is a plausible determinant of these aberrant trajectories of development...
- Neonatal intrahepatocellular lipidE L Thomas
Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
Arch Dis Child Fetal Neonatal Ed 93:F382-3. 2008..In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH2/water median (interquartile range): preterm 1.69 (1.04-3.53), term 0.21 (0-0.54) and adult 0.55 (0.08-1.57)...
- Incidental findings in healthy control research subjects using whole-body MRIS H X Morin
Division of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK
Eur J Radiol 72:529-33. 2009..We aimed to assess the prevalence of incidental findings in a sequential cohort of healthy volunteers undergoing whole-body MRI as part of a normal control database for imaging research studies...
- Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolismF Shojaee-Moradie
Department of Diabetes, Endocrinology and Internal Medicine, GKT School of Medicine, King s College London, London, UK
Diabetologia 50:404-13. 2007..We investigated the effects of 6 weeks of supervised exercise in sedentary men on these variables...
- Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by (1)H-MRSJ Rico-Sanz
The Robert Steiner Magnetic Resonance Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, United Kingdom
J Appl Physiol (1985) 87:2068-72. 1999..4 +/- 19.2 mmol/kg dry wt (TA)]. It is proposed that the differences in metabolite levels may be due to the differences in fiber-type composition and deposition of metabolites due to the adaptation of different muscles during locomotion...
- Fast and reproducible method for the direct quantitation of adipose tissue in newborn infantsT A M Harrington
The Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Lipids 37:95-100. 2002..Furthermore, its noninvasive nature makes it an ideal method for longitudinal and interventional studies in newborn infants...
- Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndromeAnthony P Goldstone
Endocrine Unit, the Department of Dietetics, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Am J Clin Nutr 75:468-75. 2002..Obesity in Prader-Willi syndrome (PWS) may be related to abnormalities in the adipocyte-leptin-hypothalamic pathway and may be exacerbated by reductions in the resting metabolic rate (RMR)...
- Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian IndiansNeena Modi
Section of Neonatal Medicine, Division of Medicine, Chelsca and Westminister Hospital Campus, Imperial College London, London SW10 9NH, UK
Pediatr Res 65:584-7. 2009..175 to 0.034 L, p = 0.2). We conclude that differences in adipose tissue partitioning exist at birth. Investigative, screening, and preventive measures must involve maternal health, intrauterine life, and infancy...
- Altered adiposity after extremely preterm birthSabita Uthaya
Division of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
Pediatr Res 57:211-5. 2005..We suggest that these observations may in part explain the associations between small size at birth and later disease. Preterm infants may be at risk in later life of metabolic complications through increased and aberrant adiposity...
- Non-invasive means of measuring hepatic fat contentSanjeev R Mehta
Department of Metabolic Medicine, Division of Medicine, Imperial College London, St Mary s Campus, 2nd Floor, Mint Wing, St Mary s Hospital, Praed Street, London W2 1NY, United Kingdom
World J Gastroenterol 14:3476-83. 2008..g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions...
- Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipidsLouise M Goff
Department of Nutrition and Dietetics, Hammersmith Hospital, Imperial College School of Medicine, W12 0HS, UK
Br J Nutr 89:365-75. 2003....
- Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infantsNeena Modi
Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
Pediatr Res 60:345-8. 2006..Low total adipose tissue quantity at birth appears to direct nutrition toward head growth. Adipose tissue may be involved in the signaling of catch-up growth...
- Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gammaDavid B Savage
Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
Diabetes 52:910-7. 2003..Although the condition is rare, the study of humans with dominant-negative mutations in PPAR-gamma can provide important insight into the roles of this nuclear receptor in human metabolism...
- Critical role for peptide YY in protein-mediated satiation and body-weight regulationRachel L Batterham
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
Cell Metab 4:223-33. 2006..Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity...
- Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistanceAnthony P Goldstone
Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom EC1A 7BE
J Clin Endocrinol Metab 89:1718-26. 2004..The hyperghrelinemia in PWS adults is therefore not solely explained by their reduced visceral adiposity and relative hypoinsulinemia. Its cause and consequences await further elucidation...
- Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose contentJulia E Ostberg
Department of Endocrinology, University College London Hospitals, United Kingdom
J Clin Endocrinol Metab 90:2631-5. 2005..Elevated IHCL in TS is associated with estrogen deficiency. BI may be useful to estimate total body fat, but does not reliably localize fat depots in TS...