William Taylor

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi A structural pattern-based method for protein fold recognition
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Proteins 56:222-34. 2004
  2. ncbi Decoy models for protein structure comparison score normalisation
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Mol Biol 357:676-99. 2006
  3. ncbi Using scores derived from statistical coupling analysis to distinguish correct and incorrect folds in de-novo protein structure prediction
    Gail J Bartlett
    Division of Mathematical Biology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 4BB, United Kingdom
    Proteins 71:950-9. 2008
  4. pmc Coarse-grained simulation of myosin-V movement
    Zoe Katsimitsoulia
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Math Methods Med 2012:781456. 2012
  5. pmc De novo backbone scaffolds for protein design
    James T MacDonald
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
    Proteins 78:1311-25. 2010
  6. doi Prediction of contacts from correlated sequence substitutions
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Curr Opin Struct Biol 23:473-9. 2013
  7. pmc A mechanical model of cell segregation driven by differential adhesion
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 7:e43226. 2012
  8. pmc Direct correlation analysis improves fold recognition
    Michael I Sadowski
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Biol Chem 35:323-32. 2011
  9. pmc Structural constraints on the covariance matrix derived from multiple aligned protein sequences
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 6:e28265. 2011
  10. pmc Functional site prediction selects correct protein models
    Vijayalakshmi Chelliah
    Division of Mathematical Biology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    BMC Bioinformatics 9:S13. 2008

Collaborators

Detail Information

Publications68

  1. ncbi A structural pattern-based method for protein fold recognition
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Proteins 56:222-34. 2004
    ..Of the other poor rankings, one was the smallest protein and the others were the four largest (all over 250 residues)...
  2. ncbi Decoy models for protein structure comparison score normalisation
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Mol Biol 357:676-99. 2006
    ..A normalised probability measure was derived that allows joint family/family comparison. The method was applied to some of the CASP6 models for targets with new folds...
  3. ncbi Using scores derived from statistical coupling analysis to distinguish correct and incorrect folds in de-novo protein structure prediction
    Gail J Bartlett
    Division of Mathematical Biology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 4BB, United Kingdom
    Proteins 71:950-9. 2008
    ..SCA-distance scoring is a useful addition to the tools available for distinguishing native from non-native folds in protein structure prediction...
  4. pmc Coarse-grained simulation of myosin-V movement
    Zoe Katsimitsoulia
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Math Methods Med 2012:781456. 2012
    ..We compared the simulation results with biophysical data, and despite the lack of atomic detail in our model, we find good agreement and can even suggest some refinements to the current model of myosin-V motion...
  5. pmc De novo backbone scaffolds for protein design
    James T MacDonald
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
    Proteins 78:1311-25. 2010
    ..The de novo scaffolds were sequence designed with RosettaDesign, and the energy distributions and amino acid compositions were comparable with the results for redesigned experimentally solved backbones...
  6. doi Prediction of contacts from correlated sequence substitutions
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Curr Opin Struct Biol 23:473-9. 2013
    ..While concentrating on methods, we also discuss applications to protein and RNA structure prediction as well as potential future developments...
  7. pmc A mechanical model of cell segregation driven by differential adhesion
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 7:e43226. 2012
    ..The latter result suggests that mechanisms additional or alternative to differential adhesion contribute to Eph-ephrin mediated cell segregation...
  8. pmc Direct correlation analysis improves fold recognition
    Michael I Sadowski
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Biol Chem 35:323-32. 2011
    ..We find that DI is able to greatly improve the ranking of the true (native) fold but others still remain high scoring that would be difficult to discard due to small shifts in the core beta sheets...
  9. pmc Structural constraints on the covariance matrix derived from multiple aligned protein sequences
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 6:e28265. 2011
    ....
  10. pmc Functional site prediction selects correct protein models
    Vijayalakshmi Chelliah
    Division of Mathematical Biology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    BMC Bioinformatics 9:S13. 2008
    ....
  11. ncbi A molecular model for the origin of protein translation in an RNA world
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Theor Biol 243:393-406. 2006
    ..A hybrid dimer, half polymerase and half proto-ribosome, could account for mRNA translocation before the advent of protein elongation factors. Some implications for the genetic code are discussed...
  12. ncbi Dynamic domain threading
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proteins 64:601-14. 2006
    ..The method is also compared to an earlier retroviral capsid modeling problem for which the X-ray structure is now known. Some potential extensions of the approach to more distant modeling problems are discussed...
  13. ncbi Modelling molecular stability in the RNA world
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Biol Chem 29:259-72. 2005
    ..It was found that the latter system can operate much more effective in the higher temperatures thought to prevail during the RNA world...
  14. ncbi Topological accessibility shows a distinct asymmetry in the folds of betaalpha proteins
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    FEBS Lett 580:5263-7. 2006
    ..This suggests that the folds of these proteins may have become fixed under the influence of amino-terminal folding before the advent of chaperone assisted folding...
  15. ncbi A molecular model for transcription in the RNA world based on the ribosome large subunit
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Biol Chem 28:313-9. 2004
    ..When combined into a dimeric polymerase, this strategy minimises the exposure of single-stranded RNA and prevents self-hybridisation: both previously difficult problems for the RNA world hypothesis...
  16. pmc Transcription and translation in an RNA world
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Philos Trans R Soc Lond B Biol Sci 361:1751-60. 2006
    ..A hybrid dimer, half polymerase and half proto-ribosome, could account for mRNA translocation before the advent of protein elongation factors...
  17. ncbi Protein knots and fold complexity: some new twists
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Biol Chem 31:151-62. 2007
    ..These measures are related to the complexity of the protein fold and may provide useful filters for selecting predicted model structures...
  18. ncbi Evolutionary transitions in protein fold space
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Curr Opin Struct Biol 17:354-61. 2007
    ..The problem is finally set in the wider context of the genetic environment, introducing complications relating to introns, gene fixation and population size...
  19. doi Prediction of protein structure from ideal forms
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proteins 70:1610-9. 2008
    ..Our method is unique in using a database of ideal models based on general packing rules that, in spirit, is closer to an ab initio approach...
  20. doi Probing the "dark matter" of protein fold space
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, London, UK
    Structure 17:1244-52. 2009
    ..The large excess of novel folds exhibited no unusual properties and has been likened to cosmological dark matter...
  21. doi A soft collision detection algorithm for simple Brownian dynamics
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Biol Chem 34:1-10. 2010
    ..The algorithm is linear in time and memory with the number of bodies and would be suitable for the simulation of 'soft' objects, such as cells...
  22. doi Re-evaluating the "rules" of protein topology
    Ben Grainger
    Division of Mathematical Biology, National Institute for Medical Research, London, United Kingdom
    J Comput Biol 17:1371-84. 2010
    ..Application of the model to a large set of topologies generated during structure prediction showed that many had a similar probability of occurrence to known PDB folds...
  23. doi A coarse-grained molecular model for actin-myosin simulation
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Mol Graph Model 29:266-79. 2010
    ..The effects of the myosin twofold symmetry and the restriction of an attached cargo were also tested. These results provide the basis for the development of a dynamic model of processive motion...
  24. ncbi Simulation of cell movement and interaction
    William Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    J Bioinform Comput Biol 9:91-110. 2011
    ..This analysis showed that cells were best modelled with a degree of stickiness just under the critical threshold level. This allowed fluidlike motion while maintaining cohesiveness across the population...
  25. pmc Protein topology from predicted residue contacts
    William R Taylor
    Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Protein Sci 21:299-305. 2012
    ....
  26. pmc Consensus structural models for the amino terminal domain of the retrovirus restriction gene Fv1 and the murine leukaemia virus capsid proteins
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    BMC Struct Biol 4:1. 2004
    ..As no structures are available for these proteins we have constructed molecular models based on distant sequence similarity to other retroviral capsid proteins...
  27. ncbi A 'periodic table' for protein structures
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, London, UK
    Nature 416:657-60. 2002
    ..Here I formalize both secondary and tertiary links to allow the rigorous and automatic definition of protein topology...
  28. ncbi Protein structure comparison using bipartite graph matching and its application to protein structure classification
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Mol Cell Proteomics 1:334-9. 2002
    ..The method takes 1/10 of a second for a typical comparison making it suitable as a fast pre-filter for slower, more exhaustive approaches. An application to protein structure classification is described...
  29. ncbi A Fourier analysis of symmetry in protein structure
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Protein Eng 15:79-89. 2002
    ....
  30. ncbi Defining linear segments in protein structure
    W R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London, UK
    J Mol Biol 310:1135-50. 2001
    ..When compared over a large number of pairs of homologous proteins, the current method was found to be slightly more consistent than a widely used method based on hydrogen bonds...
  31. ncbi A knot or not a knot? SETting the record 'straight' on proteins
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Comput Biol Chem 27:11-5. 2003
    ..The term pseudo-knot was introduced (from the RNA field) to distinguish hydrogen-bonded 'knots'...
  32. ncbi A deeply knotted protein structure and how it might fold
    W R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London, UK
    Nature 406:916-9. 2000
    ..I propose a protein folding pathway that may explain how such a knot is formed...
  33. ncbi Multiple sequence threading: conditional gap placement
    W R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, London, UK
    Fold Des 2:S33-9. 1997
    ..A similar trend occurred with observed and predicted exposure in inserts. Our eventual aim is to devise a weight incorporating these measures of gap placement to further refine our algorithm for the threading of sequence on structure...
  34. pmc Protein structure comparison using iterated double dynamic programming
    W R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Protein Sci 8:654-65. 1999
    ..The best (lowest RMSD) values found in these populations provided a base-line against which other methods were compared...
  35. ncbi The merozoite surface protein 6 gene codes for a 36 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex
    C Trucco
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London, UK
    Mol Biochem Parasitol 112:91-101. 2001
    ....
  36. ncbi Multiple protein sequence alignment using double-dynamic programming
    W R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, London, UK
    Comput Chem 24:3-12. 2000
    ..The results, however, showed that this overall iteration was not needed and one-pass gave results at least as good as the 'standard' progressive method of multiple sequence alignment. Further applications of the method are discussed...
  37. doi On the evolutionary origins of "Fold Space Continuity": a study of topological convergence and divergence in mixed alpha-beta domains
    M I Sadowski
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    J Struct Biol 172:244-52. 2010
    ..As a resolution we propose that a purely structural classification should be created using an approach similar to that adopted by the Gene Ontology in which proteins are assigned labels describing structure...
  38. ncbi Iterated sequence databank search methods
    W R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London, UK
    Comput Chem 23:365-85. 1999
    ..With the larger databank, SAM produced a good result but, again, this was only achieved using the full range of sequence variation with the default regulariser and use of Dirichlet mixtures completely failed in this situation...
  39. ncbi Three-dimensional domain duplication, swapping and stealing
    J Heringa
    Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London, UK
    Curr Opin Struct Biol 7:416-21. 1997
    ..The recent advances in understanding domain reorganization and mobility highlight the versatility and efficiency of protein structural evolution...
  40. ncbi Homology modelling by distance geometry
    A Aszodi
    Division of Mathematical Biology, National Institute for Medical Research, London, UK
    Fold Des 1:325-34. 1996
    ....
  41. ncbi A novel family of single VWC-domain proteins in invertebrates
    T J Sheldon
    Division of Mathematical Biology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    FEBS Lett 581:5268-74. 2007
    ..SVCs appear to be restricted to arthropods. A role for SVCs in response to environmental challenges is proposed...
  42. ncbi Coevolving protein residues: maximum likelihood identification and relationship to structure
    D D Pollock
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    J Mol Biol 287:187-98. 1999
    ..Sites on the surface of the protein appear to coevolve both when they are close in the structure, and when they are distant, implying a role for folding and/or avoidance of quaternary structure in the coevolution process...
  43. ncbi Amino acid substitution matrices from an artificial neural network model
    K Lin
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill NW7 1AA, United Kingdom
    J Comput Biol 8:471-81. 2001
    ..Our model is more accurate on the prediction of amino acid substitution probabilities...
  44. ncbi Predicted structure of a major Schistosoma mansoni eggshell protein
    V Rodrigues
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London, U K
    Mol Biochem Parasitol 32:7-13. 1989
    ..1970) Parasitology 60, 79-88] could be formed by packing of the polypeptides such that the N-terminal domain contributes counter ions or cross-links to the C-terminal domain of adjacent molecules...
  45. ncbi Modelling zinc-binding proteins with GADGET: genetic algorithm and distance geometry for exploring topology
    Kjell Petersen
    Department of Informatics, University of Bergen, PB7800, N 5020 Bergen, Norway
    J Mol Biol 325:1039-59. 2003
    ..Despite this, the fold-space of 48 theoretically possible folds was greatly reduced with just six topologies found in significant numbers...
  46. ncbi Ab initio modelling of the N-terminal domain of the secretin receptors
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK
    Comput Biol Chem 27:103-14. 2003
    ..One of these was refined into a full atomic model that contained a possible peptide binding site comprising the most conserved residues...
  47. ncbi Protein knots: A tangled problem
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 421:25. 2003
  48. ncbi Toward the detection and validation of repeats in protein structure
    Kevin B Murray
    European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteins 57:365-80. 2004
    ..These reduce the strength of the repeat signal in the SAP matrix, making repeat detection more difficult...
  49. ncbi Threading using neural nEtwork (TUNE): the measure of protein sequence-structure compatibility
    Kuang Lin
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill NW7 1AA, UK
    Bioinformatics 18:1350-7. 2002
    ..Log-odds scores of predicted probabilities from this model can then be used to construct protein sequence-structure alignments...
  50. ncbi Protein fold comparison by the alignment of topological strings
    Linus O Johannissen
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Protein Eng 16:949-55. 2003
    ..Some concluding speculations on the relationship of such trees to the evolutionary history and folding of the proteins are advanced...
  51. ncbi Structure motif discovery and mining the PDB
    Inge Jonassen
    Department of Informatics, University of Bergen, HIB, N5020 Bergen, Norway
    Bioinformatics 18:362-7. 2002
    ..Confidence in such motifs is greatly boosted when they are found in more than a pair of proteins...
  52. ncbi p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2
    Mark W Jackson
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Cell Sci 118:1821-32. 2005
    ....
  53. ncbi Testing homology with Contact Accepted mutatiOn (CAO): a contact-based Markov model of protein evolution
    Kuang Lin
    Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, UK
    Comput Biol Chem 27:93-102. 2003
    ..CAO yields scores that reflect coherently the structural quality of sequence alignments, which has implications particularly for homology modelling and threading techniques...
  54. ncbi Protein model refinement using structural fragment tessellation
    Inge Jonassen
    Computational Biology Unit and Department of Informatics, University of Bergen, Norway
    Comput Biol Chem 30:360-6. 2006
    ..The method was shown to improve the recognition of the native fold in a series of decoys largely as a result of improved secondary structure representation...
  55. ncbi A model for the cytoplasmic domain of the influenza A virus M2 channel by analogy to the HIV-1 Vpu protein
    Jose W Saldanha
    Divisions of Mathematical Biology, NIMR, Mill Hill, London, NW7 1AA, UK
    Protein Pept Lett 9:495-502. 2002
    ..Structural analogies with other proteins contribute support for features of the model and suggest ways in which the M2 cytoplasmic domain can interact with other viral and cellular factors...
  56. ncbi Analyzing the G2/M checkpoint
    George R Stark
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, USA
    Methods Mol Biol 280:51-82. 2004
    ..Elimination of these essential cell cycle proteins helps to keep the cells arrested in G2...
  57. ncbi A survey of formal methods for determining functional joint axes
    Rainald M Ehrig
    Zuse Institute Berlin ZIB, Berlin, Germany
    J Biomech 40:2150-7. 2007
    ..Whilst these initial results using the SARA are promising and are fast enough to be determined "on-line", the technique must now be proven in a clinical environment...
  58. ncbi Gene expression microarrays
    Christopher P Kolbert
    Mayo Clinic Cancer Center, Rochester, MN, USA
    Methods Mol Med 85:239-55. 2003
  59. ncbi Stirring the primordial soup
    William R Taylor
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 434:705. 2005
  60. ncbi FACS-based detection of phosphorylated histone H3 for the quantitation of mitotic cells
    William R Taylor
    Department of Biological Sciences, University of Toledo, OH, USA
    Methods Mol Biol 281:293-9. 2004
    ..Cell staining and FACS analysis can be done in a single day, making this a rapid and reliable method to quantitate mitotic cells for various applications...
  61. ncbi Tibio-femoral joint contact forces in sheep
    William R Taylor
    Musculoskeletal Research Center Berlin, Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Biomech 39:791-8. 2006
    ..This has important implications for the interpretation of knee studies in quadrupeds and their relevance to the clinical situation...
  62. ncbi Mechanical conditions in the initial phase of bone healing
    Devakara R Epari
    Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Free and Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Clin Biomech (Bristol, Avon) 21:646-55. 2006
    ..The purpose of this study was to determine how the initial mechanical conditions produced by interfragmentary shear and torsion differ from those produced by axial compressive movements...
  63. pmc An unusual choanoflagellate protein released by Hedgehog autocatalytic processing
    Elizabeth A Snell
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Proc Biol Sci 273:401-7. 2006
    ..Since Hh-C and Hoglet-C are homologous, but Hh-N and Hoglet-N are not, we argue that metazoan hedgehog genes evolved by fusion of two distinct genes...
  64. ncbi Association of nucleotide patterns with gene function classes: application to human 3' untranslated sequences
    Darrell Conklin
    ZymoGenetics Inc, 1201 Eastlake Avenue East, Seattle, WA 98102, USA
    Bioinformatics 18:182-9. 2002
    ..Many of the identified cis acting elements for translational regulation occur within the 3'untranslated region (3' UTR), and some have been observed to occur with surprising regularity within certain protein function classes...
  65. ncbi Amino acid encoding schemes from protein structure alignments: multi-dimensional vectors to describe residue types
    Kuang Lin
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW, 7 1AA, UK
    J Theor Biol 216:361-65. 2002
    ..We expect it to be useful for visual inspection and manual editing of protein multiple sequence alignments...
  66. pmc Borealin is repressed in response to p53/Rb signaling
    Dipali A Date
    Department of Biological Sciences, University of Toledo, 2801 W Bancroft Street, MS 601, Toledo, OH 43606, USA
    Cell Biol Int 31:1470-81. 2007
    ..It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues...
  67. pmc Analysis of mitotic phosphorylation of borealin
    Harpreet Kaur
    Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA
    BMC Cell Biol 8:5. 2007
    ..Borealin has a consensus CDK1 phosphorylation site, threonine 106 and can be phosphorylated by Aurora B Kinase at serine 165 in vitro...
  68. ncbi Physiologically based boundary conditions in finite element modelling
    Andrew D Speirs
    Center for Musculoskeletal Surgery Charité, Universitatsmedizin Berlin, Free and Humboldt, University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Biomech 40:2318-23. 2007
    ....