Dallas M Swallow

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Congenital maltase-glucoamylase deficiency associated with lactase and sucrase deficiencies
    Buford L Nichols
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Pediatr Gastroenterol Nutr 35:573-9. 2002
  2. ncbi request reprint Genetics of lactase persistence and lactose intolerance
    Dallas M Swallow
    Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, England
    Annu Rev Genet 37:197-219. 2003
  3. ncbi request reprint Intolerance to lactose and other dietary sugars
    D M Swallow
    Medical Research Council Human Biochemical Genetics Unit, Galton Laboratory, Department of Biology, London, United Kingdom
    Drug Metab Dispos 29:513-6. 2001
  4. doi request reprint Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group
    Catherine J E Ingram
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    J Mol Evol 69:579-88. 2009
  5. ncbi request reprint A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
    Catherine J E Ingram
    Department of Biology, Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London, UK
    Hum Genet 120:779-88. 2007
  6. doi request reprint Lactose digestion and the evolutionary genetics of lactase persistence
    Catherine J E Ingram
    Department of Genetics Evolution and Environment, University College London, London, UK
    Hum Genet 124:579-91. 2009
  7. pmc Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep
    Bryony L Jones
    Research Department of Genetics Evolution and Environment, University College London, Darwin Building, London, UK
    Am J Hum Genet 93:538-44. 2013
  8. doi request reprint Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations
    Laura J Horsfall
    Department of Genetics, Evolution and Environment, University College London, Wolfson House, UK
    Ann Hum Genet 75:236-46. 2011
  9. pmc Evolution of lactase persistence: an example of human niche construction
    Pascale Gerbault
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Philos Trans R Soc Lond B Biol Sci 366:863-77. 2011
  10. ncbi request reprint Alpha1-antitrypsin as a risk for infant and adult respiratory outcomes in a national birth cohort
    Michael E J Wadsworth
    Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free Hospital and University College London Medical School, London, United Kingdom
    Am J Respir Cell Mol Biol 31:559-64. 2004

Collaborators

  • Mark G Thomas
  • Michael E Weale
  • Laura J Horsfall
  • Yuval Itan
  • Jesper T Troelsen
  • Mathias Currat
  • E J Hollox
  • Greta Rait
  • Pascale Gerbault
  • Joachim Burger
  • Sarah L Browning
  • Geoff Daniels
  • Ralf Weiskirchen
  • Catherine J E Ingram
  • Neil Bradman
  • Charlotte A Mulcare
  • Endashaw Bekele
  • Ayele Tarekegn
  • Bryony L Jones
  • Lynne E Vinall
  • Carmen G Tag
  • Mohamed F Elamin
  • Tamiru Oljira Raga
  • Abigail L Jones
  • Michael E J Wadsworth
  • Kitti Németh
  • Buford L Nichols
  • E Thomas Danielsen
  • Tamiru O Raga
  • Anders Krüger Olsen
  • Pawel Zmarz
  • Anke Liebert
  • Maximilian Ledochowski
  • Axel M Gressner
  • Christian Oberkanins
  • Gernot Kriegshäuser
  • Farouk M Elamin
  • Jennifer U Lovegrove
  • Warren S Hilder
  • Bruce Connell
  • David B Whitehouse
  • David Zeitlyn
  • Suzanne L Butterworth
  • Rebecca J Hardy
  • Paul A Kroon
  • Nathalie Juge
  • Jean Guy Berrin
  • Hassan Y Naim
  • Geoff W Plumb
  • Ralf Jacob
  • Gary Williamson
  • Dagmar Hahn
  • Marie King
  • Ursula Luginbuehl
  • Wikrom Karnsakul
  • Martin Sarner
  • Partha Sen
  • Marco Novelli
  • John Hilkens
  • Stephen E Avery
  • Farook Jahoor
  • Erwin E Sterchi
  • Carole A Green

Detail Information

Publications16

  1. ncbi request reprint Congenital maltase-glucoamylase deficiency associated with lactase and sucrase deficiencies
    Buford L Nichols
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Pediatr Gastroenterol Nutr 35:573-9. 2002
    ..Multiple enzyme deficiencies have been reported in some cases of congenital glucoamylase, sucrase, or lactase deficiency. Here we describe such a case and the investigations that we have made to determine the cause of this deficiency...
  2. ncbi request reprint Genetics of lactase persistence and lactose intolerance
    Dallas M Swallow
    Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, England
    Annu Rev Genet 37:197-219. 2003
    ..This single nucleotide polymorphism is located 14 kb upstream from the start of transcription of lactase in an intron of the adjacent gene MCM6. This change does not, however, explain all the variation in lactase expression...
  3. ncbi request reprint Intolerance to lactose and other dietary sugars
    D M Swallow
    Medical Research Council Human Biochemical Genetics Unit, Galton Laboratory, Department of Biology, London, United Kingdom
    Drug Metab Dispos 29:513-6. 2001
    ..This article reviews this topic and discusses in more detail the current state of our own research on lactase...
  4. doi request reprint Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group
    Catherine J E Ingram
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    J Mol Evol 69:579-88. 2009
    ..This contrasts with the well-documented observation that positive selection decreases diversity by driving up the frequency of a single advantageous allele, and has implications for association studies...
  5. ncbi request reprint A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
    Catherine J E Ingram
    Department of Biology, Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London, UK
    Hum Genet 120:779-88. 2007
    ..This study reveals the complexity of this phenotypic polymorphism and highlights the limitations of C-13910T as a diagnostic test for lactase persistence status, at least for people with non-European ancestry...
  6. doi request reprint Lactose digestion and the evolutionary genetics of lactase persistence
    Catherine J E Ingram
    Department of Genetics Evolution and Environment, University College London, London, UK
    Hum Genet 124:579-91. 2009
    ....
  7. pmc Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep
    Bryony L Jones
    Research Department of Genetics Evolution and Environment, University College London, Darwin Building, London, UK
    Am J Hum Genet 93:538-44. 2013
    ..By examining flanking markers to control for the effects of mutation and demography, we further describe, from empirical evidence, the signature of a soft selective sweep. ..
  8. doi request reprint Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations
    Laura J Horsfall
    Department of Genetics, Evolution and Environment, University College London, Wolfson House, UK
    Ann Hum Genet 75:236-46. 2011
    ....
  9. pmc Evolution of lactase persistence: an example of human niche construction
    Pascale Gerbault
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Philos Trans R Soc Lond B Biol Sci 366:863-77. 2011
    ..These studies illustrate how genetic and archaeological information can be integrated to bring new insights to the origins and spread of lactase persistence. Finally, we discuss possible improvements to these models...
  10. ncbi request reprint Alpha1-antitrypsin as a risk for infant and adult respiratory outcomes in a national birth cohort
    Michael E J Wadsworth
    Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free Hospital and University College London Medical School, London, United Kingdom
    Am J Respir Cell Mol Biol 31:559-64. 2004
    ..Lower alpha1-antitrypsin, as indicated by carrier status for the Z and S alleles, was a risk for infant lower respiratory infection, but not for adult respiratory outcomes...
  11. doi request reprint Serum bilirubin and risk of respiratory disease and death
    Laura J Horsfall
    Research Department of Primary Care and Population Health, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, England
    JAMA 305:691-7. 2011
    ..Serum total bilirubin levels in healthy patients reflect genetic and environmental factors that could influence the risk of developing respiratory disease...
  12. pmc The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans
    Charlotte A Mulcare
    The Centre for Genetic Anthropology TCGA, University College London, London NW1 2HE, United Kingdom
    Am J Hum Genet 74:1102-10. 2004
    ..We also present Y-chromosome data that are consistent with previously reported evidence for a back-migration event into Cameroon, and we comment on the implications for the introgression of the -13.9kb*T allele...
  13. ncbi request reprint Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis
    Lynne E Vinall
    Galton Laboratory, Department of Biology, University College London, London, England
    Gastroenterology 123:41-9. 2002
    ..Our aim was to investigate the involvement of MUC1 in chronic gastritis and, by implication, gastric cancer...
  14. doi request reprint Evaluation of a novel reverse-hybridization StripAssay for typing DNA variants useful in diagnosis of adult-type hypolactasia
    Carmen G Tag
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    Clin Chim Acta 392:58-62. 2008
    ..We have recently shown that several novel allelic variants located in close proximity to the C-13910T SNP interfere with the diagnostic accuracy of real-time PCR-based genotyping methods...
  15. ncbi request reprint Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    Kitti Németh
    Institute of Food Research, Colney Lane, Norwich NR4 7 UA, UK
    Eur J Nutr 42:29-42. 2003
    ..Hence, first-pass metabolism (small intestine-liver) appears to involve a critical deglycosylation step for which the mechanisms are not known...
  16. ncbi request reprint Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia
    Ralf Weiskirchen
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    Clin Chim Acta 384:93-8. 2007
    ..Recently, several novel allelic variants have been identified in non-European populations. Three of these variants occur in close proximity to C-13910T, but their effect on the genetic test is unknown...