B Stockinger

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
  2. pmc Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 206:43-9. 2009
  3. pmc T cell regulation as a side effect of homeostasis and competition
    Thomas Barthlott
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    J Exp Med 197:451-60. 2003
  4. pmc Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells
    George Kassiotis
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Exp Med 197:1007-16. 2003
  5. pmc Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo
    João H Duarte
    Division of Molecular Immunology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 8:e79819. 2013
  6. doi request reprint The aryl hydrocarbon receptor: multitasking in the immune system
    Brigitta Stockinger
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom email
    Annu Rev Immunol 32:403-32. 2014
  7. ncbi request reprint CD4+ memory T cells: functional differentiation and homeostasis
    Brigitta Stockinger
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, UK
    Immunol Rev 211:39-48. 2006
  8. ncbi request reprint Good for Goose, but not for Gander: IL-2 interferes with Th17 differentiation
    Brigitta Stockinger
    Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Immunity 26:278-9. 2007
  9. ncbi request reprint Differentiation and function of Th17 T cells
    Brigitta Stockinger
    Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Curr Opin Immunol 19:281-6. 2007
  10. ncbi request reprint Homeostasis and T cell regulation
    Brigitta Stockinger
    National Institute for Medical Research, Division of Molecular Immunology, Mill Hill, London, UK
    Curr Opin Immunol 16:775-9. 2004

Collaborators

Detail Information

Publications58

  1. ncbi request reprint TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
    ..Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells...
  2. pmc Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 206:43-9. 2009
    ....
  3. pmc T cell regulation as a side effect of homeostasis and competition
    Thomas Barthlott
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    J Exp Med 197:451-60. 2003
    ....
  4. pmc Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells
    George Kassiotis
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Exp Med 197:1007-16. 2003
    ..In contrast to naive T cells, however, memory T cells can reach a homeostatic equilibrium, in which survival/self-renewal of each clone is dissociated from their avidity for MHC-derived signals...
  5. pmc Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo
    João H Duarte
    Division of Molecular Immunology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 8:e79819. 2013
    ....
  6. doi request reprint The aryl hydrocarbon receptor: multitasking in the immune system
    Brigitta Stockinger
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom email
    Annu Rev Immunol 32:403-32. 2014
    ....
  7. ncbi request reprint CD4+ memory T cells: functional differentiation and homeostasis
    Brigitta Stockinger
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, UK
    Immunol Rev 211:39-48. 2006
    ..Finally, we discuss a number of factors that affect long-term maintenance of memory CD4+ T cells...
  8. ncbi request reprint Good for Goose, but not for Gander: IL-2 interferes with Th17 differentiation
    Brigitta Stockinger
    Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Immunity 26:278-9. 2007
    ..2007) examined the effects of interleukin-2 on differentiation of the T helper 17 (Th17) cells and found that this essential growth factor for all other T cell subsets blocks the development of Th17 T cells...
  9. ncbi request reprint Differentiation and function of Th17 T cells
    Brigitta Stockinger
    Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Curr Opin Immunol 19:281-6. 2007
    ..Furthermore, the role of pathogens and pathogen-derived molecules in influencing effector T-cell polarization needs to be re-evaluated in the light of the differentiation conditions that favor Th17 T-cell responses...
  10. ncbi request reprint Homeostasis and T cell regulation
    Brigitta Stockinger
    National Institute for Medical Research, Division of Molecular Immunology, Mill Hill, London, UK
    Curr Opin Immunol 16:775-9. 2004
    ..On the positive side, lymphopenia-provoked T cell expansion might enhance weak immune responses and thereby aid the rejection of tumours or the elimination of parasites...
  11. ncbi request reprint CD4 T-cell memory
    Brigitta Stockinger
    Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Semin Immunol 16:295-303. 2004
    ..The emerging picture is one of great versatility and functional heterogeneity as befits their central position within the immune system...
  12. ncbi request reprint Th17 T cells: linking innate and adaptive immunity
    Brigitta Stockinger
    Division of Molecular Immunology, The MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Semin Immunol 19:353-61. 2007
    ..In order to avoid too many repetitions we focus this review mainly on publications in 2006 and 2007 and refer to a number of reviews, which cover earlier aspects of Th17/IL-17 biology...
  13. pmc The concept of space and competition in immune regulation
    Brigitta Stockinger
    Division of Molecular Immunology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1 AA, UK
    Immunology 111:241-7. 2004
  14. ncbi request reprint Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation
    Sarah Flynn
    Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London United Kingdom
    Blood 101:4472-8. 2003
    ..This was not because of a defect in T-cell homing to the tumor site or loss of MHC class II or costimulatory molecules by the tumor, but reflected mutual paralysis of T-cell responsiveness and antigen processing by tumor cells...
  15. doi request reprint External influences on the immune system via activation of the aryl hydrocarbon receptor
    Brigitta Stockinger
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, London, United Kingdom
    Semin Immunol 23:99-105. 2011
    ..A number of recent reviews have highlighted potential new avenues of research. This review addresses recent new insight into physiological roles of AhR in the immune system...
  16. doi request reprint Modulation of Th17 development and function by activation of the aryl hydrocarbon receptor--the role of endogenous ligands
    Brigitta Stockinger
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Eur J Immunol 39:652-4. 2009
    ..Here we discuss recent discoveries linking the development and functional potential of Th17 cells to a transcription factor that mediates the response to exogenous and endogenous environmental signals...
  17. pmc Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system
    Brigitta Stockinger
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Biol 8:61. 2009
    ....
  18. ncbi request reprint Differential survival of naive CD4 and CD8 T cells
    C Ferreira
    Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    J Immunol 165:3689-94. 2000
    ..However, expression levels of Bcl-2 in either transgenic or polyclonal naive CD4 and CD8 T cells are similar, excluding a role for this molecule as a key factor in differential survival of CD4 vs CD8 T cells...
  19. ncbi request reprint Following the development of a CD4 T cell response in vivo: from activation to memory formation
    S Garcia
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, United Kingdom
    Immunity 11:163-71. 1999
    ..They differ qualitatively from naive T cells, suggesting that accelerated CD4 memory responses can occur without the need for increased frequencies of specific T cells...
  20. pmc Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage
    A Volkmann
    Division of Molecular Immunology, The National Institute for Medical Research, London, United Kingdom
    J Exp Med 188:1083-9. 1998
    ..These results are in line with recent observations that antagonistic signals direct differentiation into the CD8 lineage, regardless of MHC specificity...
  21. pmc Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function
    T Zal
    Division of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, United Kingdom
    Proc Natl Acad Sci U S A 93:9102-7. 1996
    ....
  22. ncbi request reprint Functional specialization of memory Th cells revealed by expression of integrin CD49b
    George Kassiotis
    Division of Molecular Immunology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    J Immunol 177:968-75. 2006
    ..Modulation of the CD49b-defined memory Th subsets may provide infection type-specific interventions, where either enhancement of the inflammatory response or reduction of immunopathology is essential...
  23. ncbi request reprint Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties
    T Barthlott
    National Institute for Medical Research, Division of Molecular Immunology, London, UK
    Eur J Immunol 31:3595-601. 2001
    ..Despite the presence of these unidentified MHC class II ligands in the H-2(q) background and their potential influence on developing A18 thymocytes, however, MHC class I molecules were essential for thymic selection of A18 CD8 T cells...
  24. pmc Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen
    T Zal
    Department of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Exp Med 180:2089-99. 1994
    ..This indicates that endogenous T cell receptor rearrangements possibly leading to the expression of two receptors might be a prerequisite for their survival and export into the periphery...
  25. ncbi request reprint Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen
    A Volkmann
    Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    J Immunol 158:693-706. 1997
    ..Their failure to present exogenous self Ag for negative selection suggests that macrophages concentrate on their primary function in the thymus, the disposal of dying thymocytes...
  26. pmc Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes
    G Fossati
    Division of Molecular Immunology, The National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Exp Med 190:577-83. 1999
    ..We propose that antigenic stimulation of cells with low levels of TCR produces signals inadequate for full activation, resulting instead in anergy...
  27. pmc The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice
    R J Wright
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, UK
    Immunology 95:309-13. 1998
    ..The data show that Ii41 fully substitutes for wild-type invariant chain in both positive and negative selection events during functional maturation of T cells with specificity for a natural, blood-borne self antigen...
  28. ncbi request reprint Normal thymic selection of TCR transgenic CD4 T cells, but impaired survival in the periphery despite the presence of selecting MHC molecules
    T Barthlott
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Immunol 161:3992-9. 1998
    ..This explains the failure to accumulate high numbers of peripheral T cells and suggests that the MHC-bound ligand(s) responsible for initiating survival signals is limiting for the selection and maintenance of A18 transgenic CD4 T cells...
  29. ncbi request reprint A major role for memory CD4 T cells in the control of lymphopenia-induced proliferation of naive CD4 T cells
    Christine Bourgeois
    Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    J Immunol 174:5316-23. 2005
    ..Thus, memory T cells have a major role in the control of lymphopenia-induced proliferation of naive cells because they inhibit both the generation of memory-like T cells and their persistence within the memory compartment...
  30. doi request reprint The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 453:106-9. 2008
    ..AHR ligands may therefore represent co-factors in the development of autoimmune diseases...
  31. ncbi request reprint Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules
    M I Brazil
    Division of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, GB
    Eur J Immunol 27:1506-14. 1997
    ....
  32. pmc The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease
    Halima Moncrieffe
    Division of Molecular Immunology, The MRC National Institute for Medical Research, Mill Hill, London, UK
    Immunology 125:459-68. 2008
    ..Naïve T cells deficient in OX40 expression caused markedly reduced GVH in onset and severity despite some level of expansion in the adoptive host, suggesting an important role of this molecule in the immune pathology of GVHD...
  33. ncbi request reprint CD25+CD4+ regulatory T cells and memory T cells prevent lymphopenia-induced proliferation of naive T cells in transient states of lymphopenia
    Christine Bourgeois
    Division of Molecular Immunology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, U K
    J Immunol 177:4558-66. 2006
    ..It therefore seems unlikely that lymphopenia-induced proliferation of peripheral T cells causes deleterious side effects that result in immune pathology in states of partial and transient lymphopenia...
  34. ncbi request reprint Anatomical heterogeneity of memory CD4+ T cells due to reversible adaptation to the microenvironment
    George Kassiotis
    Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    J Immunol 173:7292-8. 2004
    ..Furthermore, such intermittent activation during or after migration into extralymphoid sites could provide an important signal, promoting the survival and functional competence of memory T cells in the absence of Ag...
  35. ncbi request reprint Impairment of immunological memory in the absence of MHC despite survival of memory T cells
    George Kassiotis
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nat Immunol 3:244-50. 2002
    ..Thus, in contrast to their survival, maintenance of the typical quality of memory T cells crucially depends on MHC-derived signals...
  36. pmc B cells solicit their own help from T cells
    B Stockinger
    National Institute for Medical Research, Division of Molecular Immunology, London, United Kingdom
    J Exp Med 183:891-9. 1996
    ..We show in this paper that B cell presentation in vitro induces a switch to the Th2 subset indicated by production of IL-4, and targetting C5 to B cells in vivo results in the generation of C5-specific antibodies...
  37. pmc Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen
    Christine Bourgeois
    Division of Molecular Immunology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 105:8691-6. 2008
    ..As our data show, continued replenishment with cells from the thymus seems to be required to maintain efficient gut mucosal defense...
  38. doi request reprint Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals
    Bruno Martin
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Immunity 31:321-30. 2009
    ....
  39. doi request reprint Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 9:1341-6. 2008
    ..Thus, transforming growth factor-beta constitutes a regulatory 'switch' that in combination with other cytokines can 'reprogram' effector T cell differentiation along different pathways...
  40. ncbi request reprint Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function
    Alessandra de Riva
    Division of Molecular Immunology, Medical Research Council Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    J Immunol 178:5488-95. 2007
    ..Signals via AKT coordinate survival and metabolic pathways and may be one of the crucial events linking interaction with MHC class II molecules to the successful generation of a long-lived functional memory CD4 T cell population...
  41. ncbi request reprint Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells
    Panagiota Stamou
    Division of Molecular Immunology, The National Institute for Medical Research, London, United Kingdom
    J Immunol 171:1278-84. 2003
    ..This suggests that up-regulation of negative T cell regulators in peripheral T cells exposed to chronic stimulation by Ag may prevent full functionality and thus avoid overt autoreactivity...
  42. ncbi request reprint CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production
    Thomas Barthlott
    Division of Molecular Immunology, National Institute for Medical Research, London, UK
    Int Immunol 17:279-88. 2005
    ..Although IL-10 is not required for in vitro suppression, it is vital for the in vivo function of regulatory T cells. Our data provide a link explaining the apparent difference in regulatory mechanisms in vitro and in vivo...
  43. ncbi request reprint Transduction of naive CD4 T cells with kinase-deficient Lck-HIV-Tat fusion protein dampens T cell activation and provokes a switch to regulatory function
    Marc Veldhoen
    Division of Molecular Immunology, The National Institute for Medical Research, London, UK
    Eur J Immunol 35:207-16. 2005
    ..Our data indicate that signals encountered by a naive T cell during its initial activation can profoundly influence its subsequent functional behavior and elicit T cells, which can have regulatory activity...
  44. ncbi request reprint TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, London NW7 1AA, UK
    Trends Immunol 27:358-61. 2006
    ..An excess production of Th17 cells in response to infection or trauma could result in leakage into peripheral tissues and cause autoimmune pathology...
  45. ncbi request reprint IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    Pedro L Vieira
    Division of Immunoregulation, The National Institute for Medical Research, London, United Kingdom
    J Immunol 172:5986-93. 2004
    ..These data show that Foxp3 expression is not a prerequisite for IL-10-T(Reg) activity in vitro or in vivo, and suggest that IL-10-T(Reg) and naturally occurring CD4(+)CD25(+) T(Reg) may have distinct origins...
  46. ncbi request reprint Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 7:1151-6. 2006
    ..These data show that TGF-beta is essential for the initiation of EAE and suggest that disease progression may require ongoing chronic inflammation and production of interleukin 23...
  47. pmc Factors affecting the susceptibility of the mouse pituitary gland to CD8 T-cell-mediated autoimmunity
    James de Jersey
    Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Immunology 111:254-61. 2004
    ....
  48. ncbi request reprint Activation of CD8 T cells by antigen expressed in the pituitary gland
    James de Jersey
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Immunol 169:6753-9. 2002
    ..Thus, CD8 T cells have access to the neuroendocrine system and get fully activated in the absence of CD4 help, but Ag recognition in this location causes autoimmune pathology only in the presence of excessive CD8 T cell numbers...
  49. ncbi request reprint Modulation of dendritic cell function by naive and regulatory CD4+ T cells
    Marc Veldhoen
    Division of Molecular Immunology, The Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    J Immunol 176:6202-10. 2006
    ..Thus, mutual interactions between DC and CD4+ T cell subpopulations following contact with pathogens are likely to influence the strength and quality of incipient immune responses in the local microenvironment...
  50. ncbi request reprint T cell homeostasis in steady state and lymphopenic conditions
    Christine Bourgeois
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Immunol Lett 107:89-92. 2006
    ..We review here the different scenarios of homeostatic control mechanisms in steady state as well as severely or partially lymphopenic environments...
  51. ncbi request reprint CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells
    Pål Johansen
    Division of Mycobacterial Research, National Institute for Medical Research, London, GB
    Eur J Immunol 34:91-7. 2004
    ..Therefore, the requirement for CD4 help in CD8 T cell memory extends to homeostatic parameters that ensure the maintenance and competitive fitness of memory clones...
  52. ncbi request reprint Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance
    Robin Stephens
    National Institute of Medical Research, The Ridgeway, Mill Hill London, NW7 1AA, United Kingdom
    Blood 106:1676-84. 2005
    ....
  53. pmc CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40
    Megan Macleod
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    J Exp Med 203:897-906. 2006
    ..However, differentiation of the memory cells into cytokine-producing effector cells did not occur in the absence of CD40. The data indicate that memory cells can be generated without passing through the effector cell stage...
  54. ncbi request reprint Th17 cells: An orphan with influence
    Brigitta Stockinger
    Immunol Cell Biol 85:83-4. 2007
  55. ncbi request reprint Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice
    Lucia Kuffova
    Department of Ophthalmology, Institute of Molecular Sciences, Medical School Foresterhill, University of Aberdeen, Aberdeen, Scotland
    J Immunol 180:1353-61. 2008
    ..Ag is cross-presented to host CD4(+) T cells on MHC class II and leads to the activation of Ag-specific effector T cells and clonal expansion in the draining lymph node...
  56. doi request reprint Differentiation of human T(H)-17 cells does require TGF-beta!
    Anne O'Garra
    Nat Immunol 9:588-90. 2008