Affiliation: National Institute for Medical Research
- Role of the DAZ genes in male fertilityNicola Reynolds
MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
Reprod Biomed Online 10:72-80. 2005..Advances in knowledge of how this gene family acts to regulate key meiotic events in model organisms will lead to a fuller understanding of their function in human fertility...
- Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cellsNicola Reynolds
MRC Human Genetics Unit, Western General Hospital, University of Edinburgh, UK
Hum Mol Genet 14:3899-909. 2005..Finally, we show that germ cells of Dazl null mice contain reduced levels of Mvh protein, indicating that Dazl-mediated regulation of Mvh translation is crucial for mammalian spermatogenesis...
- Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator DazlNicola Reynolds
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK
RNA 13:974-81. 2007..This suggests that azoospermia associated with a decrease in DAZ gene function in humans may in part be a consequence of failure at synapsis caused by reduced levels of SYCP3 protein...
- Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in miceRupert Ollinger
MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
PLoS Genet 4:e1000199. 2008..Our results suggest that Tex19.1 is part of a specialised mechanism that operates in the germline to repress transposable genetic elements and maintain genomic stability through successive generations...