Nicola Reynolds

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Role of the DAZ genes in male fertility
    Nicola Reynolds
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Reprod Biomed Online 10:72-80. 2005
  2. ncbi request reprint Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells
    Nicola Reynolds
    MRC Human Genetics Unit, Western General Hospital, University of Edinburgh, UK
    Hum Mol Genet 14:3899-909. 2005
  3. pmc Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl
    Nicola Reynolds
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK
    RNA 13:974-81. 2007
  4. pmc Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice
    Rupert Ollinger
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    PLoS Genet 4:e1000199. 2008

Collaborators

  • H J Cooke
  • Rupert Ollinger
  • Ian R Adams
  • Pia R Lundegaard
  • Andrew J Childs
  • Robert M Speed
  • Hannah M Burgess
  • Nicola K Gray

Detail Information

Publications4

  1. ncbi request reprint Role of the DAZ genes in male fertility
    Nicola Reynolds
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Reprod Biomed Online 10:72-80. 2005
    ..Advances in knowledge of how this gene family acts to regulate key meiotic events in model organisms will lead to a fuller understanding of their function in human fertility...
  2. ncbi request reprint Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells
    Nicola Reynolds
    MRC Human Genetics Unit, Western General Hospital, University of Edinburgh, UK
    Hum Mol Genet 14:3899-909. 2005
    ..Finally, we show that germ cells of Dazl null mice contain reduced levels of Mvh protein, indicating that Dazl-mediated regulation of Mvh translation is crucial for mammalian spermatogenesis...
  3. pmc Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl
    Nicola Reynolds
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK
    RNA 13:974-81. 2007
    ..This suggests that azoospermia associated with a decrease in DAZ gene function in humans may in part be a consequence of failure at synapsis caused by reduced levels of SYCP3 protein...
  4. pmc Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice
    Rupert Ollinger
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    PLoS Genet 4:e1000199. 2008
    ..Our results suggest that Tex19.1 is part of a specialised mechanism that operates in the germline to repress transposable genetic elements and maintain genomic stability through successive generations...