Affiliation: National Institute for Medical Research
- Use of Schwann cells to induce repair of adult CNS tractsG Raisman
Norman and Sadie Lee Research Centre, Division of Neurobiology, UK
Rev Neurol (Paris) 153:521-5. 1997..e. by making appropriate choices from a wide range of destinations. Therefore the effectiveness of a Schwann cell "bridging" repair must depend upon the self-organising capacity of the adult CNS (e.g. Florence et al., 1996)...
- Improved post-embedding immunocytochemistry of myelinated nervous tissue for electron microscopyE M Hirst
Division of Neurobiology, National Institute for Medical Research, London, UK
J Neurosci Methods 95:151-8. 2000..Using Lowicryl HM20, we have been able to obtain satisfactory immunostaining for myelin basic protein with good retention of structural integrity in the myelin of both normal and lesioned adult cortico spinal tract...
- Olfactory ensheathing cells - another miracle cure for spinal cord injury?G Raisman
Division of Neurobiology, Norman and Sadie Lee Research Centre, National Institute for Medical Research, Medical Research Council, London NW7 1AA, UK
Nat Rev Neurosci 2:369-75. 2001..the spinal cord? What are olfactory ensheathing cells, and how might they produce these beneficial effects? And more generally, what do we mean by spinal cord injury? To what extent can we compare repair in an animal to repair in a human?..
- Ensheathment of the olfactory nerves in the adult ratPm Field
Division of Neurobiology, Norman and Sadie Lee Research Centre, National Institute for Medical Research, MRC, London, UK
J Neurocytol 32:317-24. 2003..This paper illustrates the unique ultrastructural features of this ensheathment...
- After facial nerve damage, regenerating axons become aberrant throughout the length of the nerve and not only at the site of the lesion: an experimental studyD Choi
Division of Neurobiology, National Institute for Medical Research, London UK
Br J Neurosurg 18:45-8. 2004..Future strategies aimed at improving the organization of regeneration need to provide guidance cues not only at the site of the lesion as previously thought, but also throughout the length of the nerve...
- Immune rejection of a facial nerve xenograft does not prevent regeneration and the return of function: an experimental studyD Choi
The Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Neuroscience 121:501-7. 2003....
- Fluorescent retrograde neuronal tracers that label the rat facial nucleus: a comparison of Fast Blue, Fluoro-ruby, Fluoro-emerald, Fluoro-Gold and DiID Choi
Division of Neurobiology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, UK
J Neurosci Methods 117:167-72. 2002..All the tracers produced adequate cell labelling after 1 week from nerve application. This labelling persisted for up to 8 weeks for most tracers except FG, which did not produce satisfactory labelling at 8 weeks...
- How do transplanted olfactory ensheathing cells restore function?N Keyvan-Fouladi
Norman and Sadie Lee Research Centre, Division of Neurobiology, National Institute for Medical Research, MRC, The Ridgeway Mill Hill, London NW7 1AA, UK
Brain Res Brain Res Rev 40:325-7. 2002..The present interpretation on the mechanisms of functional recovery is partly hypothetical, and we emphasize where further experimental evidence is needed...
- Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous systemS Taraviras
Divisions of Developmental Neurobiology and Neurobiology, MRC, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
Development 126:2785-97. 1999..We suggest that normal function of the RET RTK is required in vivo during early stages of ENS histogenesis for the survival of undifferentiated enteric NC and their derivatives...
- Repair of spinal cord injury: ripples of an incoming tide, or how I spent my first 40 years in researchG Raisman
Spinal Repair Unit, Institute of Neurology, University College London, London, UK
Spinal Cord 44:406-13. 2006..The transplants re-opened scarred glial pathways, allowed the regeneration of severed nerve fibres, and the restoration of various functions, including paw reaching, climbing, and supraspinal respiratory impulses to the phrenic nerve...
- Olfactory ensheathing cells in the nasal mucosa of the rat and humanD Choi
Institute of Neurology, UCL, London, UK
Br J Neurosurg 22:301-2. 2008..The olfactory mucosa is likely to be a convenient source for these cells in future clinical studies of CNS repair...
- Transplanted olfactory ensheathing cells incorporated into the optic nerve head ensheathe retinal ganglion cell axons: possible relevance to glaucomaY Li
Spinal Repair Unit, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Neurosci Lett 440:251-4. 2008..The incorporation of olfactory ensheathing cells in the optic nerve head may suggest future possibilities for protection of the axons in this vulnerable region from mechanical damage, as in the raised intraocular pressure of glaucoma...