G Raisman

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi Olfactory ensheathing cells and repair of brain and spinal cord injuries
    Geoffrey Raisman
    Division of Neurobiology, National Institute for Medical Research MRC, London, UK
    Cloning Stem Cells 6:364-8. 2004
  2. ncbi Myelin inhibitors: does NO mean GO?
    Geoffrey Raisman
    Division of Neurobiology, The Norman and Sadie Lee Research Centre, National Institute for Medical Research, Medical Research Council, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Neurosci 5:157-61. 2004
  3. ncbi Olfactory ensheathing cells - another miracle cure for spinal cord injury?
    G Raisman
    Division of Neurobiology, Norman and Sadie Lee Research Centre, National Institute for Medical Research, Medical Research Council, London NW7 1AA, UK
    Nat Rev Neurosci 2:369-75. 2001
  4. ncbi After facial nerve damage, regenerating axons become aberrant throughout the length of the nerve and not only at the site of the lesion: an experimental study
    D Choi
    Division of Neurobiology, National Institute for Medical Research, London UK
    Br J Neurosurg 18:45-8. 2004
  5. ncbi Ensheathment of the olfactory nerves in the adult rat
    Pm Field
    Division of Neurobiology, Norman and Sadie Lee Research Centre, National Institute for Medical Research, MRC, London, UK
    J Neurocytol 32:317-24. 2003
  6. ncbi Olfactory ensheathing cells in the nasal mucosa of the rat and human
    D Choi
    Institute of Neurology, UCL, London, UK
    Br J Neurosurg 22:301-2. 2008
  7. ncbi Use of Schwann cells to induce repair of adult CNS tracts
    G Raisman
    Norman and Sadie Lee Research Centre, Division of Neurobiology, UK
    Rev Neurol (Paris) 153:521-5. 1997
  8. ncbi Improved post-embedding immunocytochemistry of myelinated nervous tissue for electron microscopy
    E M Hirst
    Division of Neurobiology, National Institute for Medical Research, London, UK
    J Neurosci Methods 95:151-8. 2000
  9. ncbi Loss of directed fore-limb reaching after destruction of spinal grey matter
    M Yamamoto
    Spinal Repair Unit, UCL Institute of Neurology, London, UK
    Brain Res 1265:47-52. 2009
  10. ncbi Repair of spinal cord injury: ripples of an incoming tide, or how I spent my first 40 years in research
    G Raisman
    Spinal Repair Unit, Institute of Neurology, University College London, London, UK
    Spinal Cord 44:406-13. 2006

Collaborators

  • David Choi
  • E M Hirst
  • Thomas Carlstedt
  • Kazunori Sango
  • Ying Li
  • Daqing Li
  • Naghmeh Keyvan-Fouladi
  • Hong Peng Li
  • Hitoshi Kawano
  • Y Li
  • Stuart Law
  • M Yamamoto
  • Koki Kawamura
  • Ahmed Ibrahim
  • Hong-Peng Li
  • Pm Field
  • N Keyvan-Fouladi
  • S Taraviras
  • Akiko Homma
  • Mie Yamamoto
  • Wagih S El Masry
  • Pauline M Field
  • Claes-Henric Berthold
  • Raymond D Lund
  • Patrick Decherchi
  • H Jani
  • M Sukumaran
  • V Pachnis
  • P Durbec
  • M Grigoriou
  • C V Marcos-Gutierrez
  • L C Wang
  • M Hynes

Detail Information

Publications31

  1. ncbi Olfactory ensheathing cells and repair of brain and spinal cord injuries
    Geoffrey Raisman
    Division of Neurobiology, National Institute for Medical Research MRC, London, UK
    Cloning Stem Cells 6:364-8. 2004
    ..The precise lineage relationships are not fully understood. The limitation of numbers of cells obtainable from human samples currently restricts their use to repair of small lesions...
  2. ncbi Myelin inhibitors: does NO mean GO?
    Geoffrey Raisman
    Division of Neurobiology, The Norman and Sadie Lee Research Centre, National Institute for Medical Research, Medical Research Council, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Neurosci 5:157-61. 2004
  3. ncbi Olfactory ensheathing cells - another miracle cure for spinal cord injury?
    G Raisman
    Division of Neurobiology, Norman and Sadie Lee Research Centre, National Institute for Medical Research, Medical Research Council, London NW7 1AA, UK
    Nat Rev Neurosci 2:369-75. 2001
    ..the spinal cord? What are olfactory ensheathing cells, and how might they produce these beneficial effects? And more generally, what do we mean by spinal cord injury? To what extent can we compare repair in an animal to repair in a human?..
  4. ncbi After facial nerve damage, regenerating axons become aberrant throughout the length of the nerve and not only at the site of the lesion: an experimental study
    D Choi
    Division of Neurobiology, National Institute for Medical Research, London UK
    Br J Neurosurg 18:45-8. 2004
    ..Future strategies aimed at improving the organization of regeneration need to provide guidance cues not only at the site of the lesion as previously thought, but also throughout the length of the nerve...
  5. ncbi Ensheathment of the olfactory nerves in the adult rat
    Pm Field
    Division of Neurobiology, Norman and Sadie Lee Research Centre, National Institute for Medical Research, MRC, London, UK
    J Neurocytol 32:317-24. 2003
    ..This paper illustrates the unique ultrastructural features of this ensheathment...
  6. ncbi Olfactory ensheathing cells in the nasal mucosa of the rat and human
    D Choi
    Institute of Neurology, UCL, London, UK
    Br J Neurosurg 22:301-2. 2008
    ..The olfactory mucosa is likely to be a convenient source for these cells in future clinical studies of CNS repair...
  7. ncbi Use of Schwann cells to induce repair of adult CNS tracts
    G Raisman
    Norman and Sadie Lee Research Centre, Division of Neurobiology, UK
    Rev Neurol (Paris) 153:521-5. 1997
    ..e. by making appropriate choices from a wide range of destinations. Therefore the effectiveness of a Schwann cell "bridging" repair must depend upon the self-organising capacity of the adult CNS (e.g. Florence et al., 1996)...
  8. ncbi Improved post-embedding immunocytochemistry of myelinated nervous tissue for electron microscopy
    E M Hirst
    Division of Neurobiology, National Institute for Medical Research, London, UK
    J Neurosci Methods 95:151-8. 2000
    ..Using Lowicryl HM20, we have been able to obtain satisfactory immunostaining for myelin basic protein with good retention of structural integrity in the myelin of both normal and lesioned adult cortico spinal tract...
  9. ncbi Loss of directed fore-limb reaching after destruction of spinal grey matter
    M Yamamoto
    Spinal Repair Unit, UCL Institute of Neurology, London, UK
    Brain Res 1265:47-52. 2009
    ..In the 25 rats with no return of function the lesions also included extensive destruction through the medio-lateral extent of the grey matter...
  10. ncbi Repair of spinal cord injury: ripples of an incoming tide, or how I spent my first 40 years in research
    G Raisman
    Spinal Repair Unit, Institute of Neurology, University College London, London, UK
    Spinal Cord 44:406-13. 2006
    ..The transplants re-opened scarred glial pathways, allowed the regeneration of severed nerve fibres, and the restoration of various functions, including paw reaching, climbing, and supraspinal respiratory impulses to the phrenic nerve...
  11. ncbi Fluorescent retrograde neuronal tracers that label the rat facial nucleus: a comparison of Fast Blue, Fluoro-ruby, Fluoro-emerald, Fluoro-Gold and DiI
    D Choi
    Division of Neurobiology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, UK
    J Neurosci Methods 117:167-72. 2002
    ..All the tracers produced adequate cell labelling after 1 week from nerve application. This labelling persisted for up to 8 weeks for most tracers except FG, which did not produce satisfactory labelling at 8 weeks...
  12. ncbi Somatotopic organization of the facial nucleus is disrupted after lesioning and regeneration of the facial nerve: the histological representation of synkinesis
    David Choi
    Division of Neurobiology, National Institute for Medical Research, London, England
    Neurosurgery 50:355-62; discussion 362-3. 2002
    ..We describe an animal model of facial nerve lesion, repair, and regeneration that demonstrates abnormal organization of the facial nucleus; this model may be used to study synkinesis...
  13. ncbi Interaction of olfactory ensheathing cells with astrocytes may be the key to repair of tract injuries in the spinal cord: the 'pathway hypothesis'
    Ying Li
    Spinal Repair Unit, Institute of Neurology, UCL, Queen Square, London, WC1N 3BG, UK
    J Neurocytol 34:343-51. 2005
    ....
  14. ncbi How do transplanted olfactory ensheathing cells restore function?
    N Keyvan-Fouladi
    Norman and Sadie Lee Research Centre, Division of Neurobiology, National Institute for Medical Research, MRC, The Ridgeway Mill Hill, London NW7 1AA, UK
    Brain Res Brain Res Rev 40:325-7. 2002
    ..The present interpretation on the mechanisms of functional recovery is partly hypothetical, and we emphasize where further experimental evidence is needed...
  15. ncbi Transplantation of olfactory ensheathing cells into spinal cord lesions restores breathing and climbing
    Ying Li
    Norman and Sadie Lee Research Centre, Division of Neurobiology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, United Kingdom
    J Neurosci 23:727-31. 2003
    ..This demonstrates that transplantation can produce simultaneous repair of two independent spinal functions...
  16. ncbi Disorganization of the facial nucleus after nerve lesioning and regeneration in the rat: effects of transplanting candidate reparative cells to the site of injury
    David Choi
    Division of Neurobiology, National Institute for Medical Research, London, England
    Neurosurgery 56:1093-100; discussion 1093-100. 2005
    ....
  17. ncbi Immune rejection of a facial nerve xenograft does not prevent regeneration and the return of function: an experimental study
    D Choi
    The Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Neuroscience 121:501-7. 2003
    ....
  18. ncbi Olfactory ensheathing cells: ripples of an incoming tide?
    Ahmed Ibrahim
    Spinal Repair Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 5:453-7. 2006
    ..Important aspects still need to be worked out at the laboratory level. Overall, the outlook is optimistic, but there is still some way to go...
  19. ncbi Interaction of transplanted olfactory-ensheathing cells and host astrocytic processes provides a bridge for axons to regenerate across the dorsal root entry zone
    Ying Li
    Division of Neurobiology, Norman and Sadie Lee Research Centre, National Institute for Medical Research, MRC, London, UK
    Exp Neurol 188:300-8. 2004
    ....
  20. ncbi Functional repair of the corticospinal tract by delayed transplantation of olfactory ensheathing cells in adult rats
    Naghmeh Keyvan-Fouladi
    Division of Neurobiology, Norman and Sadie Lee Research Centre, Medical Research Council, National Institute for Medical Research, London, NW7 1AA, United Kingdom
    J Neurosci 23:9428-34. 2003
    ..Functional recovery can occur when only approximately 1% of the corticospinal tract axons are present...
  21. ncbi Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system
    S Taraviras
    Divisions of Developmental Neurobiology and Neurobiology, MRC, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Development 126:2785-97. 1999
    ..We suggest that normal function of the RET RTK is required in vivo during early stages of ENS histogenesis for the survival of undifferentiated enteric NC and their derivatives...
  22. ncbi Organotypic slice co-cultures reveal that early postnatal hippocampal axons lose the ability to grow along the fimbria, while retaining the ability to invade and arborise in septal neuropil
    Stuart Law
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    Eur J Neurosci 31:1352-8. 2010
    ..This exactly mirrors the inability of cut central axons to regenerate along their previous fibre pathways while they retain their ability to reinnervate neuropil...
  23. ncbi Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons
    Ying Li
    Division of Neurobiology, Norman and Sadie Lee Research Centre, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 23:7783-8. 2003
    ....
  24. ncbi A promising therapeutic approach to spinal cord repair
    Geoffrey Raisman
    J R Soc Med 96:259-61. 2003
  25. ncbi An experimental model of ventral root repair showing the beneficial effect of transplanting olfactory ensheathing cells
    Ying Li
    Institute of Neurology, University College London, and National Hospital for Neurology and Neurosurgery, London, England
    Neurosurgery 60:734-40; discussion 740-1. 2007
    ....
  26. ncbi Transplanted Schwann cells, not olfactory ensheathing cells, myelinate optic nerve fibres
    Ying Li
    Institute of Neurology, UCL, London, United Kingdom
    Glia 55:312-6. 2007
    ....
  27. ncbi Delayed repair of corticospinal tract lesions as an assay for the effectiveness of transplantation of Schwann cells
    Naghmeh Keyvan-Fouladi
    Spinal Repair Unit, Institute of Neurology, University College London, London, United Kingdom
    Glia 51:306-11. 2005
    ..Without transplantation of exogenous Schwann cells, the ingrowth of endogenous Schwann cells which occurs spontaneously into these lesions does not restore function...
  28. ncbi Regeneration of nigrostriatal dopaminergic axons by degradation of chondroitin sulfate is accompanied by elimination of the fibrotic scar and glia limitans in the lesion site
    Hong Peng Li
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Neurosci Res 85:536-47. 2007
    ....
  29. ncbi Repair of spinal cord injury by transplantation of olfactory ensheathing cells
    Geoffrey Raisman
    Spinal Repair Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    C R Biol 330:557-60. 2007
    ..Ensheathing glial cells cultured from the adult olfactory system can be transplanted into lesions and mediate both regeneration of axons and recovery of function...
  30. ncbi Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibres
    Ying Li
    Spinal Repair Unit, Institute of Neurology, University College London, London, United Kingdom
    Glia 52:245-51. 2005
    ..These properties, which the olfactory ensheathing cells exert in collaboration with olfactory nerve fibroblasts, may also be involved in the reparative effects of these cells when transplanted into lesions of the spinal cord...
  31. ncbi Inhibition of collagen synthesis overrides the age-related failure of regeneration of nigrostriatal dopaminergic axons
    Hitoshi Kawano
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Neurosci Res 80:191-202. 2005
    ....