Basant K Puri

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparations
    Basant K Puri
    Department of Imaging Sciences, MRI Unit, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    Med Hypotheses 62:116-8. 2004
  2. pmc Prevalence of cataract in adult Down's syndrome patients aged 28 to 83 years
    Basant K Puri
    Mental Health Unit, Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex UB8 3NN, UK
    Clin Pract Epidemiol Ment Health 3:26. 2007
  3. pmc Fatty acids and oxidative stress in psychiatric disorders
    Sofia Tsaluchidu
    Universita di Bologna, Bologna, Italy
    BMC Psychiatry 8:S5. 2008
  4. pmc The use of artificial neural networks to study fatty acids in neuropsychiatric disorders
    Massimo Cocchi
    Universita di Bologna, Bologna, Italy
    BMC Psychiatry 8:S3. 2008
  5. pmc Cerebral spectroscopic and oxidative stress studies in patients with schizophrenia who have dangerously violently offended
    Ian H Treasaden
    Three Bridges Medium Secure Unit, West London Mental Health NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK
    BMC Psychiatry 8:S7. 2008
  6. pmc Fatty acids and neuropsychiatric disorders
    Basant K Puri
    BMC Psychiatry 8:S1. 2008
  7. ncbi request reprint Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia
    Basant K Puri
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Int Rev Psychiatry 18:145-7. 2006
  8. ncbi request reprint Schizophrenia syndromes associated with changes in ventricle-to-brain ratios: a serial high-resolution three-dimensional magnetic resonance imaging study in first-episode schizophrenia patients using subvoxel registration and semiautomated quantification
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Int J Clin Pract 59:399-402. 2005
  9. ncbi request reprint Monomodal rigid-body registration and applications to the investigation of the effects of eicosapentaenoic acid intervention in neuropsychiatric disorders
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
    Prostaglandins Leukot Essent Fatty Acids 71:177-9. 2004
  10. ncbi request reprint The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
    Prostaglandins Leukot Essent Fatty Acids 70:399-401. 2004

Collaborators

Detail Information

Publications61

  1. ncbi request reprint The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparations
    Basant K Puri
    Department of Imaging Sciences, MRI Unit, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    Med Hypotheses 62:116-8. 2004
    ....
  2. pmc Prevalence of cataract in adult Down's syndrome patients aged 28 to 83 years
    Basant K Puri
    Mental Health Unit, Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex UB8 3NN, UK
    Clin Pract Epidemiol Ment Health 3:26. 2007
    ..The objective of the present study was to study the prevalence of cataract in a well-defined population of adults with Down's syndrome...
  3. pmc Fatty acids and oxidative stress in psychiatric disorders
    Sofia Tsaluchidu
    Universita di Bologna, Bologna, Italy
    BMC Psychiatry 8:S5. 2008
    ..The aim of this study was to determine whether there is published evidence for increased oxidative stress in neuropsychiatric disorders...
  4. pmc The use of artificial neural networks to study fatty acids in neuropsychiatric disorders
    Massimo Cocchi
    Universita di Bologna, Bologna, Italy
    BMC Psychiatry 8:S3. 2008
    ..In this paper we investigate, for the first time, whether the study of the platelet fatty acids from such patients may be facilitated by means of artificial neural networks...
  5. pmc Cerebral spectroscopic and oxidative stress studies in patients with schizophrenia who have dangerously violently offended
    Ian H Treasaden
    Three Bridges Medium Secure Unit, West London Mental Health NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK
    BMC Psychiatry 8:S7. 2008
    ....
  6. pmc Fatty acids and neuropsychiatric disorders
    Basant K Puri
    BMC Psychiatry 8:S1. 2008
  7. ncbi request reprint Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia
    Basant K Puri
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Int Rev Psychiatry 18:145-7. 2006
    ..The application of these techniques to the investigation of membrane phospholipid metabolism in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis or M.E.) and dyslexia is described...
  8. ncbi request reprint Schizophrenia syndromes associated with changes in ventricle-to-brain ratios: a serial high-resolution three-dimensional magnetic resonance imaging study in first-episode schizophrenia patients using subvoxel registration and semiautomated quantification
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Int J Clin Pract 59:399-402. 2005
    ....
  9. ncbi request reprint Monomodal rigid-body registration and applications to the investigation of the effects of eicosapentaenoic acid intervention in neuropsychiatric disorders
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
    Prostaglandins Leukot Essent Fatty Acids 71:177-9. 2004
    ..The evidence thus far indicates that researchers investigating the benefits of treatment with essential fatty acids in neuropsychiatric disorders should consider utilizing this technique...
  10. ncbi request reprint The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
    Prostaglandins Leukot Essent Fatty Acids 70:399-401. 2004
    ....
  11. ncbi request reprint High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in
    Basant K Puri
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Int Rev Psychiatry 18:149-54. 2006
    ....
  12. pmc Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome)
    B K Puri
    MRI Unit, Hammersmith Hospital, London, UK
    J Clin Pathol 60:122-4. 2007
    ..Furthermore, both arachidonic acid and eicosapentaenoic acid are, at relatively low concentrations, directly virucidal...
  13. ncbi request reprint A 31-phosphorus neurospectroscopy study of omega-3 long-chain polyunsaturated fatty acid intervention with eicosapentaenoic acid and docosahexaenoic acid in patients with chronic refractory epilepsy
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Prostaglandins Leukot Essent Fatty Acids 77:105-7. 2007
    ..The unfavourable biochemical changes observed in the placebo group may be a feature of chronic intractable epilepsy...
  14. ncbi request reprint The safety of evening primrose oil in epilepsy
    B K Puri
    Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Campus, Imperial College London, London, UK
    Prostaglandins Leukot Essent Fatty Acids 77:101-3. 2007
    ....
  15. doi request reprint Brain cell membrane motion-restricted phospholipids: a cerebral 31-phosphorus magnetic resonance spectroscopy study of patients with schizophrenia
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Prostaglandins Leukot Essent Fatty Acids 79:233-5. 2008
    ..26 (0.01) in the patients and 0.25 (0.01) in the controls. These results appear to be at variance with the changes expected under the membrane phospholipid hypothesis of schizophrenia...
  16. doi request reprint Brain cell membrane motion-restricted phospholipids in patients with schizophrenia who have seriously and dangerously violently offended
    Basant K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England, W12 0HS, UK
    Prog Neuropsychopharmacol Biol Psychiatry 32:751-4. 2008
    ..These results suggest that patients with schizophrenia who have predominantly positive symptoms may not show neuroimaging-based signs compatible with the membrane phospholipid hypothesis of schizophrenia...
  17. doi request reprint Increased levels of ethane, a non-invasive, quantitative, direct marker of n-3 lipid peroxidation, in the breath of patients with schizophrenia
    Basant K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, England, W12 0HS, UK
    Prog Neuropsychopharmacol Biol Psychiatry 32:858-62. 2008
    ..These results suggest that the measurement of exhaled ethane levels may offer a non-invasive direct biomarker of increased n-3 lipid peroxidation in schizophrenia...
  18. pmc Evidence from in vivo 31-phosphorus magnetic resonance spectroscopy phosphodiesters that exhaled ethane is a biomarker of cerebral n-3 polyunsaturated fatty acid peroxidation in humans
    Basant K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    BMC Psychiatry 8:S2. 2008
    ..Schizophrenia patients were chosen because of evidence of increased free radical-mediated damage and cerebral lipid peroxidation in this disorder...
  19. pmc A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidation
    Basant K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    BMC Psychiatry 8:S4. 2008
    ..The aim was to carry out the first study of the relationship of smoking in humans to the level of n-3 lipid peroxidation indexed by the level of ethane in exhaled breath...
  20. pmc Regional grey matter volumetric changes in forensic schizophrenia patients: an MRI study comparing the brain structure of patients who have seriously and violently offended with that of patients who have not
    Basant K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    BMC Psychiatry 8:S6. 2008
    ..The aim was to carry out the first voxel-based morphometry study of grey matter changes in the whole brain in schizophrenia associated with a history of seriously and violently offending...
  21. ncbi request reprint Normal phospholipid-related signal transduction in autism
    Basant K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Prog Neuropsychopharmacol Biol Psychiatry 26:1405-7. 2002
    ..Furthermore, since the VNR is reduced in a related disorder, schizophrenia, these results suggest fatty acid abnormalities in autism are likely to differ from those in schizophrenia...
  22. ncbi request reprint Relative increase in choline in the occipital cortex in chronic fatigue syndrome
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Acta Psychiatr Scand 106:224-6. 2002
    ..To test the hypothesis that chronic fatigue syndrome (CFS) is associated with altered cerebral metabolites in the frontal and occipital cortices...
  23. ncbi request reprint Impaired phospholipid-related signal transduction in advanced Huntington's disease
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, UK
    Exp Physiol 86:683-5. 2001
    ..004). These results are consistent with the conclusion that Huntington's disease may be associated with an abnormality of neuronal membrane fatty acid metabolism, possibly as a consequence of an as yet unidentified action of huntingtin...
  24. ncbi request reprint Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    J Int Med Res 36:896-905. 2008
    ..These findings show that treatment with ethyl-EPA is associated with significant reduction in brain atrophy, particularly in the caudate and thalamus. No other drug tested in Huntington's disease has shown this effect...
  25. ncbi request reprint SPECT neuroimaging in schizophrenia with religious delusions
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK
    Int J Psychophysiol 40:143-8. 2001
    ..99mTc HMPAO high-resolution SPECT neuroimaging showed an association of religious delusions with left temporal overactivation and reduced occipital uptake, particularly on the left...
  26. ncbi request reprint MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment
    Basant K Puri
    Magnetic Resonance Unit, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London UK
    Neuroreport 13:123-6. 2002
    ..We conclude that treatment with ethyl-EPA is associated with beneficial motor and MRI changes...
  27. ncbi request reprint A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia
    Basant K Puri
    MRI Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College School of Medicine, London, England, UK
    Prog Neuropsychopharmacol Biol Psychiatry 26:49-52. 2002
    ....
  28. ncbi request reprint Changes in brain size with treatment in patients with hyper- or hypothyroidism
    Angela Oatridge
    Robert Steiner Magnetic Resonance Unit, Imaging Sciences Department, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London W12 0HS, England, UK
    AJNR Am J Neuroradiol 23:1539-44. 2002
    ..We performed brain MR imaging in patients with hyperthyroidism or hypothyroidism before and after treatment and correlated the results with hormonal markers...
  29. ncbi request reprint Hypothermia and amiloride preserve energetics in a neonatal brain slice model
    Nicola J Robertson
    Department of Paediatrics, Division of Paediatrics, Obstetrics and Gynaecology, Division of Clinical Sciences, Hammersmith Hospital, Imperial College London, London W12 ONN, UK
    Pediatr Res 58:288-96. 2005
    ..81 +/- 0.05; these parameters were not significantly different at 5 h. Our interpretation of these findings is that the brain slice model underwent secondary energy failure, which was delayed with hypothermia or amiloride...
  30. ncbi request reprint In vitro 1H-magnetic resonance spectroscopy of Barrett's esophageal mucosa using magic angle spinning techniques
    Umakant Dave
    Division of Medicine A, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Eur J Gastroenterol Hepatol 16:1199-205. 2004
    ..We report the first prospective MAS MRS study of Barrett's esophagus using endoscopic biopsies with direct histological correlation...
  31. ncbi request reprint The human mirror system: a motor resonance theory of mind-reading
    Zarinah K Agnew
    MRC Clinical Sciences Center, Imperial College London, UK
    Brain Res Rev 54:286-93. 2007
    ..Preliminary evidence indicates that mirror neurons may be involved in theory of mind; however, these data by their very nature are reliant on the presence, and precise characterization, of the human mirror system...
  32. ncbi request reprint Red cell and plasma fatty acid changes accompanying symptom remission in a patient with schizophrenia treated with eicosapentaenoic acid
    A J Richardson
    Division of Neurosciences and Psychological Medicine, Imperial College School of Medicine, Charing Cross Campus, St Dunstan s Road, London, UK
    Eur Neuropsychopharmacol 10:189-93. 2000
    ..Correction by EPA of abnormalities in both enzyme systems is not ruled out...
  33. ncbi request reprint Change in brain size during and after pregnancy: study in healthy women and women with preeclampsia
    Angela Oatridge
    Robert Steiner Magnetic Resonance Unit, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England
    AJNR Am J Neuroradiol 23:19-26. 2002
    ..The aim of this study was to quantitatively evaluate changes to the maternal brain during and after healthy pregnancy and to compare these changes with those observed in cases of preeclampsia...
  34. ncbi request reprint Laterality changes accompanying symptom remission in schizophrenia following treatment with eicosapentaenoic acid
    A J Richardson
    Division of Neurosciences and Psychological Medicine, Imperial College School of Medicine, Charing Cross Campus, London, UK
    Int J Psychophysiol 34:333-9. 1999
    ..Longitudinal studies have previously shown changes in functional lateralisation with symptom remission in schizophrenia, hence this was examined at intervals over the 6-month period...
  35. doi request reprint A human in vivo study of the extent to which 31-phosphorus neurospectroscopy phosphomonoesters index cerebral cell membrane phospholipid anabolism
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
    Prostaglandins Leukot Essent Fatty Acids 81:307-8. 2009
    ..404, P<0.005). These results are consistent with the hypothesis that the phosphomonoester narrow resonance does indeed index cell membrane phospholipid anabolism in brain studies...
  36. ncbi request reprint Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial
    B K Puri
    Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Neurology 65:286-92. 2005
    ..Preliminary evidence suggests beneficial effects of pure ethyl-eicosapentaenoate (ethyl-EPA) in Huntington disease (HD)...
  37. ncbi request reprint Negative correlation between cerebral inorganic phosphate and the volumetric niacin response in male patients with schizophrenia who have seriously and dangerously violently offended: a (31)P magnetic resonance spectroscopy study
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Prostaglandins Leukot Essent Fatty Acids 77:97-9. 2007
    ..005). Our results suggest that patients with schizophrenia who have violently offended and have poor phospholipid-related signal transduction may have higher levels of cerebral energy metabolism...
  38. ncbi request reprint Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover
    B K Puri
    MRI Unit, Imperial College School of Medicine, Hammersmith Hospital, London, W12 0HS, UK
    Int J Clin Pract 55:560-3. 2001
    ..Registered difference images showed that the EPA treatment was accompanied by structural brain changes including, in particular, a reduction in the lateral ventricular volume...
  39. doi request reprint Progressive structural brain changes in schizophrenia
    Basant K Puri
    Imperial College London, MRI Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK
    Expert Rev Neurother 10:33-42. 2010
    ..The rate of decline in the sizes of the putamen and corpus callosum is greater in patients with a poor outcome compared to those with a good-outcome. In addition to describing these phenomena, their potential causes are discussed...
  40. doi request reprint Brain tissue changes and antipsychotic medication
    Basant K Puri
    Department of Imaging, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK and Imperial College London, London, UK
    Expert Rev Neurother 11:943-6. 2011
    ..The study and its implications are discussed in the context of the current state of knowledge regarding the pathophysiology of schizophrenia...
  41. ncbi request reprint Magnetic resonance imaging of the liver with ultrashort TE (UTE) pulse sequences
    Karyn E Chappell
    Imaging Sciences Department, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, England
    J Magn Reson Imaging 18:709-13. 2003
    ..To assess the feasibility of imaging the liver in volunteers and patients with ultrashort echo time (UTE) pulse sequences...
  42. ncbi request reprint A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties
    Alexandra J Richardson
    University Department of Physiology, Oxford, England, UK
    Prog Neuropsychopharmacol Biol Psychiatry 26:233-9. 2002
    ..Given the safety and tolerability of this simple treatment, results from this pilot study strongly support the case for further investigations...
  43. ncbi request reprint Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Prostaglandins Leukot Essent Fatty Acids 70:409-11. 2004
    ..betaNTP was lower (P < 0.04) and gammaNTP was higher (P < 0.04) in the patient group compared with the normal control group. Our results are suggestive of increased cerebral energy metabolism taking place in the forensic patients...
  44. ncbi request reprint The niacin skin flush test in schizophrenia: a replication study
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London
    Int J Clin Pract 55:368-70. 2001
    ..Our results are therefore consistent with the previous published report and suggest that this test may be useful clinically in the diagnosis of schizophrenia...
  45. ncbi request reprint In vivo MR spectroscopy in diagnosis and research of neuropsychiatric disorders
    I J Cox
    Faculty of Medicine, Imaging Sciences Department, Imperial College London, Division of Clinical Sciences, Robert Steiner Magnetic Resonance Unit, Hammersmith Campus, Du Cane Road, London W12 0HS, UK
    Prostaglandins Leukot Essent Fatty Acids 70:357-60. 2004
    ..Cerebral proton and phosphorus magnetic resonance spectroscopy findings are summarized in relation to schizophrenia, dyslexia and chronic fatigue syndrome...
  46. ncbi request reprint What insights can we gain from studying early-onset schizophrenia? The neurodevelopmental pathway and beyond
    Nora S Vyas
    Department of Imaging, Imperial College Healthcare Trust, London, W12 OHS, UK
    Expert Rev Neurother 10:1243-7. 2010
  47. ncbi request reprint Cerebellum segmentation employing texture properties and knowledge based image processing: applied to normal adult controls and patients
    N Saeed
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0HS, UK
    Magn Reson Imaging 20:425-9. 2002
    ..18). The whole cerebellum was segmented in approximately 30 min using the semi-automated procedure. The method described is robust, easy-to-use, fairly fast and gives objective measurements...
  48. doi request reprint An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome)
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
    Prostaglandins Leukot Essent Fatty Acids 81:303-5. 2009
    ..At the present time, based on the results of this study, there is no evidence to support the suggestion that, by taking glutathione supplements, an improvement in the brain-related symptomatology of myalgic encephalomyelitis may occur...
  49. ncbi request reprint Two methods for semi-automated quantification of changes in ventricular volume and their use in schizophrenia
    N Saeed
    Picker Research Group, MRI Unit, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Magn Reson Imaging 16:1237-47. 1998
    ..All measurements agreed with a radiologist's visual grading of the changes. Robust, objective, fast, easy-to-use, and fairly accurate procedures have been developed and validated to quantify volumetric changes...
  50. ncbi request reprint MRI changes in multiple sclerosis following treatment with lofepramine and L-phenylalanine
    B K Puri
    Magnetic Resonance Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Neuroreport 12:1821-4. 2001
    ..71, p = 0.07) and Gulick MS-related activities of daily living scale scores (rs = -0.83, p = 0.02). It is concluded that treatment with lofepramine and l-phenylalanine is associated with significant MRI changes...
  51. ncbi request reprint Cerebral ventricular asymmetry in schizophrenia: a high resolution 3D magnetic resonance imaging study
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Int J Psychophysiol 34:207-11. 1999
    ..It is suggested that a syndromal approach might help to resolve some of the inconsistencies in the existing literature on lateralised neuroanatomical differences in schizophrenia...
  52. ncbi request reprint Age of seizure onset in adults with Down's syndrome
    B K Puri
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Int J Clin Pract 55:442-4. 2001
    ..It is suggested that late-onset epilepsy in Down's syndrome is associated with Alzheimer's disease, while early-onset epilepsy is associated with an absence of dementia...
  53. ncbi request reprint Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes
    B K Puri
    MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Int J Clin Pract 58:297-9. 2004
    ....
  54. ncbi request reprint A serial longitudinal quantitative MRI study of cerebral changes in first-episode schizophrenia using image segmentation and subvoxel registration
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, W12-0HS, London, UK
    Psychiatry Res 106:141-50. 2001
    ..It is suggested that this may reflect improvement in nutrition and hydration following treatment...
  55. ncbi request reprint Reduction in left supplementary motor area grey matter in adult female fibromyalgia sufferers with marked fatigue and without affective disorder: a pilot controlled 3-T magnetic resonance imaging voxel-based morphometry study
    B K Puri
    Imaging Department, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
    J Int Med Res 38:1468-72. 2010
    ..This brain region plays an important role in cognitive or executive control and in the translation of painful cognition; these functions are impaired in fibromyalgia associated with marked fatigue...
  56. ncbi request reprint Corticospinal inhibition appears normal in patients with chronic fatigue syndrome
    R Zaman
    Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF, UK
    Exp Physiol 86:547-50. 2001
    ....
  57. ncbi request reprint Spatial transformation of motion and deformation fields using nonrigid registration
    A Rao
    Visual Information Processing Group, Department of Computing, Imperial College London, London SW7 2AZ, UK
    IEEE Trans Med Imaging 23:1065-76. 2004
    ..The accuracy of our numerical inversion technique is demonstrated using a synthetic example, after which we present applications of our method to sequences of cardiac and brain images...
  58. ncbi request reprint Excitability of the motor cortex in schizophrenia following typical and atypical antipsychotics: two serial case reports
    B K Puri
    MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Int J Clin Pract 57:831-3. 2003
    ..We conclude that these opposite neurophysiological effects are related to the relative dopaminergic and serotonergic actions of the two classes of drug...
  59. ncbi request reprint Voluntary motor function in patients with chronic fatigue syndrome
    N J Davey
    Department of Sensimotor Systems, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fullham Palace Road, W6 8RF, London, UK
    J Psychosom Res 50:17-20. 2001
    ..The pathogenesis of chronic fatigue syndrome (CFS) remains unknown. In particular, little is known of the involvement of the motor cortex and corticospinal system...
  60. ncbi request reprint Reduction in IQ in patients with schizophrenia who have seriously and dangerously violently offended
    Basant K Puri
    Schizophr Res 53:267-8. 2002
  61. ncbi request reprint Eicosapentaenoic acid in treatment-resistant depression
    Basant K Puri
    Arch Gen Psychiatry 59:91-2. 2002