Mahesh Kb Parmar
Affiliation: National Institute for Medical Research
- Speeding up the evaluation of new agents in cancerMahesh K B Parmar
Clinical Trials Unit, London, UK
J Natl Cancer Inst 100:1204-14. 2008..By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented...
- Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefitPatrick Royston
MRC Clinical Trials, London NW1 2DA UK
Trials 12:81. 2011..Such trials can terminate at any of the intermediate stages or the final stage...
- How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design--a reanalysis of 4 trialsF M S Barthel
Department of Biostatistics, Institute of Psychiatry, King s College London, London, UK
Trials 10:21. 2009..To speed up the evaluation of new therapies, the multi-arm, multi-stage trial design was suggested previously by the authors...
- Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trialMatthew R Sydes
MRC Clinical Trials Unit, London, UK
Trials 10:39. 2009..The MAMS design will potentially facilitate evaluation and testing of new therapies in this and other diseases...