Anne O'Garra

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    Margarida Saraiva
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 31:209-19. 2009
  2. pmc TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells
    Frank Kaiser
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Exp Med 206:1863-71. 2009
  3. pmc Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung
    Paul S Redford
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Eur J Immunol 40:2200-10. 2010
  4. pmc Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway
    Paul S Redford
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London
    J Infect Dis 209:270-4. 2014
  5. pmc In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    Franck J Barrat
    DNAX Research Institute, Department of Immunology, Palo Alto, CA 94304, USA
    J Exp Med 195:603-16. 2002
  6. doi The immune response in tuberculosis
    Anne O'Garra
    Division of Immunoregulation, MRC National Institute for Medical Research, London NW7 1AA, UK
    Annu Rev Immunol 31:475-527. 2013
  7. ncbi Regulatory T cells and mechanisms of immune system control
    Anne O'Garra
    Division of Immunoregulation, The National Institute for Medical Research, London NW7 1AA, UK
    Nat Med 10:801-5. 2004
  8. doi Strategies for use of IL-10 or its antagonists in human disease
    Anne O'Garra
    Division of Immunoregulation, MRC National Institute for Medical Research, Mill Hill, London, UK
    Immunol Rev 223:114-31. 2008
  9. doi Quantitative events determine the differentiation and function of helper T cells
    Anne O'Garra
    Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 12:288-94. 2011
  10. ncbi T(H)1 cells control themselves by producing interleukin-10
    Anne O'Garra
    Division of Immunoregulation, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nat Rev Immunol 7:425-8. 2007

Research Grants

Detail Information

Publications48

  1. pmc Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    Margarida Saraiva
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 31:209-19. 2009
    ..IL-10 expression also correlated with c-maf expression. Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production...
  2. pmc TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells
    Frank Kaiser
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Exp Med 206:1863-71. 2009
    ....
  3. pmc Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung
    Paul S Redford
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Eur J Immunol 40:2200-10. 2010
    ..This suggests that IL-17 may contribute to dissemination of Mtb...
  4. pmc Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway
    Paul S Redford
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London
    J Infect Dis 209:270-4. 2014
    ..Our findings highlight the detrimental influence influenza virus infection can have before or during M. tuberculosis infection. ..
  5. pmc In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    Franck J Barrat
    DNAX Research Institute, Department of Immunology, Palo Alto, CA 94304, USA
    J Exp Med 195:603-16. 2002
    ..Generating homogeneous populations of IL-10-producing T cells in vitro will thus facilitate the use of regulatory T cells in immunotherapy...
  6. doi The immune response in tuberculosis
    Anne O'Garra
    Division of Immunoregulation, MRC National Institute for Medical Research, London NW7 1AA, UK
    Annu Rev Immunol 31:475-527. 2013
    ....
  7. ncbi Regulatory T cells and mechanisms of immune system control
    Anne O'Garra
    Division of Immunoregulation, The National Institute for Medical Research, London NW7 1AA, UK
    Nat Med 10:801-5. 2004
    ..We discuss here the varied mechanisms used by T(reg) cells to suppress the immune system...
  8. doi Strategies for use of IL-10 or its antagonists in human disease
    Anne O'Garra
    Division of Immunoregulation, MRC National Institute for Medical Research, Mill Hill, London, UK
    Immunol Rev 223:114-31. 2008
    ..This article reviews basic published studies on IL-10, which may lead to potential uses of IL-10 or its antagonists in human disease...
  9. doi Quantitative events determine the differentiation and function of helper T cells
    Anne O'Garra
    Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 12:288-94. 2011
    ....
  10. ncbi T(H)1 cells control themselves by producing interleukin-10
    Anne O'Garra
    Division of Immunoregulation, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nat Rev Immunol 7:425-8. 2007
    ..Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection...
  11. doi From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development
    Anne O'Garra
    Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 10:929-32. 2009
    ..Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells...
  12. pmc IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage
    Anne O'Garra
    Division of Immunoregulation, The National Institute for Medical Research, London, United Kingdom
    J Clin Invest 114:1372-8. 2004
    ..However, additional mechanisms have evolved to ensure that pathogen eradication is achieved with minimum damage to the host. Here we discuss those mechanisms that operate to regulate effector immune responses...
  13. pmc TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production
    Finlay W McNab
    Division of Immunoregulation, Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Immunol 191:1732-43. 2013
    ..These findings describe an important regulatory mechanism for controlling tuberculosis and reveal mechanisms by which type I IFN may promote susceptibility to this important disease...
  14. ncbi IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    Pedro L Vieira
    Division of Immunoregulation, The National Institute for Medical Research, London, United Kingdom
    J Immunol 172:5986-93. 2004
    ..These data show that Foxp3 expression is not a prerequisite for IL-10-T(Reg) activity in vitro or in vivo, and suggest that IL-10-T(Reg) and naturally occurring CD4(+)CD25(+) T(Reg) may have distinct origins...
  15. ncbi Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    Andre Boonstra
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 177:7551-8. 2006
    ....
  16. ncbi Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells
    Ricardo Rajsbaum
    Division of Immunoregulation, National Institute for Medical Research, London, UK
    Eur J Immunol 38:619-30. 2008
    ....
  17. ncbi Identification of a macrophage-specific chromatin signature in the IL-10 locus
    Margarida Saraiva
    Divisions of Immunoregulation, Immune Cell Biology and Molecular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 175:1041-6. 2005
    ..In support of a function for this site, NF-kappaB p65/RelA was recruited to HSS-4.5 in vivo and its activation was required for optimal IL-10 gene expression in LPS-stimulated macrophages...
  18. pmc Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 206:43-9. 2009
    ....
  19. ncbi ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
    Stamatia Papoutsopoulou
    Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 7:606-15. 2006
    ..Thus, ABIN-2 acts to positively regulate the Erk signaling potential by stabilizing TPL-2...
  20. pmc Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers
    Chloe I Bloom
    Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 8:e70630. 2013
    ..Comparing the blood transcriptional response of tuberculosis to other similar pulmonary diseases will advance knowledge of disease pathways and help distinguish diseases with similar clinical presentations...
  21. pmc Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy
    Chloe I Bloom
    Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 7:e46191. 2012
    ..Inadequate treatment leads to worsening disease, disease transmission and drug resistance...
  22. pmc Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase
    Srividya Sriskantharajah
    Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Immunol 192:3518-29. 2014
    ..Our data therefore raise the possibility that small molecule inhibitors of TPL-2 may be beneficial in multiple sclerosis therapy. ..
  23. pmc Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis
    Finlay W McNab
    Division of Immunoregulation, MRC National Institute for Medical Research, London, UK
    Eur J Immunol 41:1941-7. 2011
    ....
  24. pmc NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation
    Huei Ting Yang
    Division of Immune Cell Biology, National Institute for Medical Research, London, United Kingdom
    J Immunol 186:1989-96. 2011
    ..These data indicate that p50/p105 negatively regulates LPS-induced IFN signaling in macrophages by stabilizing TPL-2, thereby facilitating activation of ERK...
  25. ncbi GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells
    John Shoemaker
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 176:3470-9. 2006
    ..We therefore suggest a key role of GATA-3 in instructing Il-10 gene expression in primary CD4+ T cells, possibly by switching and stabilizing the Il-10 locus into a transcriptionally competent status...
  26. ncbi In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines
    Anne O'Garra
    Division of Immunoregulation, The National Institute for Medical Research NIMR, The Ridgeway, Mill Hill, NW7 1AA, London, UK
    Immunol Lett 85:135-9. 2003
  27. ncbi CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production
    Thomas Barthlott
    Division of Molecular Immunology, National Institute for Medical Research, London, UK
    Int Immunol 17:279-88. 2005
    ..Although IL-10 is not required for in vitro suppression, it is vital for the in vivo function of regulatory T cells. Our data provide a link explaining the apparent difference in regulatory mechanisms in vitro and in vivo...
  28. pmc Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells
    Anne Marit Sponaas
    Division of Parasitology and 2Division of Immunoregulation, National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Exp Med 203:1427-33. 2006
    ..Our data suggest that the switch in CD4 T cell responses observed in P. chabaudi-infected mice may be the result of the presentation by different DC populations modified by the malaria infection...
  29. doi Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells
    Leona Gabryšová
    Division of Immunoregulation, MRC National Institute for Medical Research, London, UK
    Eur J Immunol 41:1242-8. 2011
    ..Thus, induction/maintenance of Foxp3 expression by TGF-β is modulated by the integrated strength of TCR/costimulatory signals...
  30. pmc Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro
    Simon Blankley
    Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 9:e97702. 2014
    ..Our study demonstrates that a transcriptomic analysis of mRNA isolated from human whole blood can delineate both the temporal response and the key transcriptional differences following TLR2 and TLR4 ligation. ..
  31. pmc The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells
    Zoe Urry
    MRC and Asthma UK Centre for Allergic Mechanisms in Asthma, King s College London, London, UK
    Eur J Immunol 42:2697-708. 2012
    ..In a translational setting, these data suggest that 1α25VitD3, over a broad concentration range, will be effective in enhancing the frequency of Treg cells...
  32. doi Systems approaches to studying the immune response in tuberculosis
    Matthew Paul Reddoch Berry
    Division of Immunoregulation, MRC National Institute for Medical Research, London NW7 1AA, UK Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, St Mary s Hospital, London W2 1NY, UK
    Curr Opin Immunol 25:579-87. 2013
    ..In addition, these studies have provided candidate biomarkers which may advance diagnosis and treatment monitoring. These studies thus exemplify the promise of a systems biology approach to study complex infectious disease such as TB. ..
  33. pmc IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
    Ana Paula Freitas do Rosario
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, NW7 1AA, United Kingdom
    J Immunol 188:1178-90. 2012
    ..Finally, in this model of malaria, we demonstrate that the generation of protective IL10(+)IFN-γ(+) Th1 cells is dependent on IL-27 signaling and independent of IL-21...
  34. pmc Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy
    Sonja Tattermusch
    Department of Immunology, Imperial College London, London, United Kingdom
    PLoS Pathog 8:e1002480. 2012
    ..We conclude that over-expression of a subset of IFN-stimulated genes in chronic HTLV-1 infection does not constitute an efficient host response but instead contributes to the development of HAM/TSP...
  35. pmc An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Matthew P R Berry
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 466:973-7. 2010
    ..Our study also provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic...
  36. pmc Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation
    Andre Boonstra
    Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
    J Exp Med 197:101-9. 2003
    ..Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops...
  37. pmc Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection
    Jonathan M Pitt
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Immunol 189:4079-87. 2012
    ..2(+)CD3(-) lymphoid population. We show that IL-10 inhibits optimal BCG-elicited protection, therefore suggesting that antagonists of IL-10 may be of great benefit as adjuvants in preventive vaccination against tuberculosis...
  38. pmc The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis
    Simon Blankley
    Division of Immunoregulation, MRC National Institute for Medical Research, London NW7 1AA, UK
    Philos Trans R Soc Lond B Biol Sci 369:20130427. 2014
    ....
  39. doi Tripartite-motif proteins and innate immune regulation
    Finlay W McNab
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Curr Opin Immunol 23:46-56. 2011
    ..In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs...
  40. ncbi Contribution of cytokines to pathology and protection in virus infection
    Andreas Wack
    Division of Immunoregulation, The MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Curr Opin Virol 1:184-95. 2011
    ..Here, we review recent progress in understanding the protective and damaging roles in viral infections of cytokines and chemokines associated with innate, regulatory, and Th1, Th2 and Th17 responses...
  41. ncbi The regulation of IL-10 expression
    Leona Gabryšová
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Curr Top Microbiol Immunol 380:157-90. 2014
    ..Here, we outline the complexity of IL-10 production by discussing what is known about its regulation in macrophages, monocytes, DCs and CD4(+) T helper cells. ..
  42. ncbi Vaccination against tuberculosis: how can we better BCG?
    Jonathan M Pitt
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Microb Pathog 58:2-16. 2013
    ....
  43. ncbi Further checkpoints in Th1 development
    Douglas S Robinson
    Allergy and Clinical Immunology and Leukocyte Biology, Faculty of Medicine, Imperial College, SW7 2AK, London, United Kingdom
    Immunity 16:755-8. 2002
    ..In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function...
  44. pmc IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice
    Jens Loebbermann
    MRC and Asthma UK Centre, Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    PLoS ONE 7:e32371. 2012
    ..Similar findings were made in mice treated with anti-IL-10R antibody and infected with RSV. Therefore, IL-10 inhibits disease and inflammation in mice infected with RSV, especially during recovery from infection...
  45. doi Establishing the follicular helper identity
    George Kassiotis
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 31:450-2. 2009
    ..In this issue of Immunity, Yu et al. (2009) demonstrate that Bcl-6 directs Tfh cell differentiation...
  46. doi Immunology. Immunity benefits from a little suppression
    George Kassiotis
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Science 320:1168-9. 2008
  47. pmc Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients
    Emmanuel Xystrakis
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma at King s College London, Strand, London, United Kingdom
    J Clin Invest 116:146-55. 2006
    ..This strongly suggests that vitamin D3 could potentially increase the therapeutic response to glucocorticoids in SR patients...

Research Grants2

  1. Conference on Dedritic Cells..Innate & Adaptive Immunity
    ANNE O GARRA; Fiscal Year: 2004
    ....
  2. Conference--Host Resistance/Susceptability/Immunopatholo
    ANNE O GARRA; Fiscal Year: 2005
    ..abstract_text> ..