Elke A Ober

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Organ-specific requirements for Hdac1 in liver and pancreas formation
    Emily S Noël
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Dev Biol 322:237-50. 2008
  2. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
  3. ncbi Mesodermal Wnt2b signalling positively regulates liver specification
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Liver Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94143, USA
    Nature 442:688-91. 2006
  4. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
  5. pmc Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis
    Katarzyna Koltowska
    Developmental Biology, MRC National Institute for Medical Research, London, UK
    Development 140:1912-8. 2013
  6. pmc Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development
    Morgane Poulain
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 138:3557-68. 2011
  7. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
  8. pmc The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model
    Silvia Curado
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94158 2324, USA
    Dis Model Mech 3:486-95. 2010
  9. ncbi Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development
    Dimitris Beis
    Department of Biochemistry and Biophysics and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 132:4193-204. 2005
  10. pmc A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos
    Suk Won Jin
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
    Dev Biol 307:29-42. 2007

Collaborators

Detail Information

Publications19

  1. pmc Organ-specific requirements for Hdac1 in liver and pancreas formation
    Emily S Noël
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Dev Biol 322:237-50. 2008
    ..These findings establish zebrafish as a tractable system to investigate chromatin remodelling factor functions in controlling gene expression programmes in vertebrate endodermal organogenesis...
  2. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
    ..Here we report on a large-scale effort to map the mutations generated in mutagenesis screening at the Max Planck Institute for Developmental Biology by genome scanning with microsatellite markers...
  3. ncbi Mesodermal Wnt2b signalling positively regulates liver specification
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Liver Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94143, USA
    Nature 442:688-91. 2006
    ..Taken together, these data reveal an unexpected positive role for Wnt signalling in liver specification, and indicate a possible common theme for the localized formation of endodermal organs along the gut tube...
  4. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
    ....
  5. pmc Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis
    Katarzyna Koltowska
    Developmental Biology, MRC National Institute for Medical Research, London, UK
    Development 140:1912-8. 2013
    ....
  6. pmc Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development
    Morgane Poulain
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 138:3557-68. 2011
    ..Thus, tightly regulated spatiotemporal expression of wnt2bb, wnt2 and fzd5 is central to coordinating early liver, pancreas and swim bladder development from a multipotent foregut endoderm...
  7. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  8. pmc The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model
    Silvia Curado
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94158 2324, USA
    Dis Model Mech 3:486-95. 2010
    ..We used this regeneration model to analyze the signaling commonalities between hepatocyte development and regeneration...
  9. ncbi Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development
    Dimitris Beis
    Department of Biochemistry and Biophysics and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 132:4193-204. 2005
    ..This collection of mutants provides a unique set of tools to further our understanding of the genetic basis of cell behavior and differentiation during AV valve development...
  10. pmc A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos
    Suk Won Jin
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
    Dev Biol 307:29-42. 2007
    ..The analysis of the newly defined loci should lead to a greater understanding of vascular development and possibly provide new drug targets to treat the numerous pathologies associated with dysregulated blood vessel growth...
  11. pmc The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish
    Nick Osborne
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
    Curr Biol 18:1882-8. 2008
    ..Through gain- and loss-of-function analyses, we show that toh is required for signaling by S1P(2). Further evidence indicates that Toh is involved in the trafficking or cellular release of S1P...
  12. doi Analysis of the Albumin/alpha-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation
    Emily S Noël
    MRC National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Gene Expr Patterns 10:237-43. 2010
    ..Furthermore, the identification of gc adds a valuable temporal marker for investigating progressive hepatic differentiation in zebrafish...
  13. pmc Vegfc is required for vascular development and endoderm morphogenesis in zebrafish
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, California 94143 0448, USA
    EMBO Rep 5:78-84. 2004
    ....
  14. doi Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos
    William P Dunworth
    From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT W P D, J C C, E C B, J D K, Y W, y Q, S W J MRC National Institute for Medical Research, Division of Developmental Biology, Mill Hill, London, United Kingdom J C F, E A O and Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX S M, O C
    Circ Res 114:56-66. 2014
    ..Although several factors that promote the differentiation of LECs in embryonic development have been identified, those that negatively regulate this process are largely unknown...
  15. pmc Regulation of neurocoel morphogenesis by Pard6 gamma b
    Chantilly Munson
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, University of California, San Francisco, CA 94158, USA
    Dev Biol 324:41-54. 2008
    ..Altogether, these data indicate a previously unappreciated functional diversity and complexity within the vertebrate pard6 gene family...
  16. ncbi From endoderm formation to liver and pancreas development in zebrafish
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, CA 94143 0448, USA
    Mech Dev 120:5-18. 2003
    ..The generation of transgenic lines expressing GFP in these organs promises to be particularly helpful in such studies...
  17. ncbi Formation of the digestive system in zebrafish. I. Liver morphogenesis
    Holly A Field
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:279-90. 2003
    ....
  18. doi Chromatin modification in zebrafish development
    Jordi Cayuso Mas
    MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Methods Cell Biol 104:401-28. 2011
    ....
  19. pmc Loss of eyes in zebrafish caused by mutation of chokh/rx3
    Felix Loosli
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, PO Box 10 2209, 69012 Heidelberg, Germany
    EMBO Rep 4:894-9. 2003
    ..Thus, these mutations in orthologous genes allow us to study the evolution of vertebrate eye development at the molecular level...