Elke A Ober

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Organ-specific requirements for Hdac1 in liver and pancreas formation
    Emily S Noël
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Dev Biol 322:237-50. 2008
  2. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
  3. ncbi Mesodermal Wnt2b signalling positively regulates liver specification
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Liver Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94143, USA
    Nature 442:688-91. 2006
  4. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
  5. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
  6. ncbi Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development
    Dimitris Beis
    Department of Biochemistry and Biophysics and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 132:4193-204. 2005
  7. pmc The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish
    Nick Osborne
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
    Curr Biol 18:1882-8. 2008
  8. pmc A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos
    Suk Won Jin
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
    Dev Biol 307:29-42. 2007
  9. pmc The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model
    Silvia Curado
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94158 2324, USA
    Dis Model Mech 3:486-95. 2010
  10. pmc Vegfc is required for vascular development and endoderm morphogenesis in zebrafish
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, California 94143 0448, USA
    EMBO Rep 5:78-84. 2004

Collaborators

Detail Information

Publications14

  1. pmc Organ-specific requirements for Hdac1 in liver and pancreas formation
    Emily S Noël
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Dev Biol 322:237-50. 2008
    ..These findings establish zebrafish as a tractable system to investigate chromatin remodelling factor functions in controlling gene expression programmes in vertebrate endodermal organogenesis...
  2. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
    ..Here we report on a large-scale effort to map the mutations generated in mutagenesis screening at the Max Planck Institute for Developmental Biology by genome scanning with microsatellite markers...
  3. ncbi Mesodermal Wnt2b signalling positively regulates liver specification
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Liver Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94143, USA
    Nature 442:688-91. 2006
    ..Taken together, these data reveal an unexpected positive role for Wnt signalling in liver specification, and indicate a possible common theme for the localized formation of endodermal organs along the gut tube...
  4. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
    ....
  5. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  6. ncbi Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development
    Dimitris Beis
    Department of Biochemistry and Biophysics and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 132:4193-204. 2005
    ..This collection of mutants provides a unique set of tools to further our understanding of the genetic basis of cell behavior and differentiation during AV valve development...
  7. pmc The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish
    Nick Osborne
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
    Curr Biol 18:1882-8. 2008
    ..Through gain- and loss-of-function analyses, we show that toh is required for signaling by S1P(2). Further evidence indicates that Toh is involved in the trafficking or cellular release of S1P...
  8. pmc A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos
    Suk Won Jin
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
    Dev Biol 307:29-42. 2007
    ..The analysis of the newly defined loci should lead to a greater understanding of vascular development and possibly provide new drug targets to treat the numerous pathologies associated with dysregulated blood vessel growth...
  9. pmc The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model
    Silvia Curado
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94158 2324, USA
    Dis Model Mech 3:486-95. 2010
    ..We used this regeneration model to analyze the signaling commonalities between hepatocyte development and regeneration...
  10. pmc Vegfc is required for vascular development and endoderm morphogenesis in zebrafish
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, California 94143 0448, USA
    EMBO Rep 5:78-84. 2004
    ....
  11. pmc Regulation of neurocoel morphogenesis by Pard6 gamma b
    Chantilly Munson
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, University of California, San Francisco, CA 94158, USA
    Dev Biol 324:41-54. 2008
    ..Altogether, these data indicate a previously unappreciated functional diversity and complexity within the vertebrate pard6 gene family...
  12. ncbi Formation of the digestive system in zebrafish. I. Liver morphogenesis
    Holly A Field
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:279-90. 2003
    ....
  13. ncbi From endoderm formation to liver and pancreas development in zebrafish
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, CA 94143 0448, USA
    Mech Dev 120:5-18. 2003
    ..The generation of transgenic lines expressing GFP in these organs promises to be particularly helpful in such studies...
  14. pmc Loss of eyes in zebrafish caused by mutation of chokh/rx3
    Felix Loosli
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, PO Box 10 2209, 69012 Heidelberg, Germany
    EMBO Rep 4:894-9. 2003
    ..Thus, these mutations in orthologous genes allow us to study the evolution of vertebrate eye development at the molecular level...