Andrew J Nunn

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi Treatment of pulmonary tuberculosis
    Andrew Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Curr Opin Pulm Med 19:273-9. 2013
  2. ncbi Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
    Andrew Nunn
    MRC Clinical Trials Unit, UK
    Trials 10:99. 2009
  3. ncbi Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London NW1 2DA
    BMJ 337:a257. 2008
  4. ncbi Design issues in pivotal drug trials for drug sensitive tuberculosis (TB)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    Tuberculosis (Edinb) 88:S85-92. 2008
  5. ncbi Randomised, placebo-controlled trial to evaluate co-trimoxazole to reduce mortality and morbidity in HIV-infected post-natal women in Zambia (TOPAZ)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Trop Med Int Health 16:518-26. 2011
  6. ncbi A randomized controlled safety and acceptability trial of dextrin sulphate vaginal microbicide gel in sexually active women in Uganda
    Julie M Bakobaki
    Medical Research Council Programme on AIDS in Uganda Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 19:2149-56. 2005
  7. ncbi When inferiority meets non-inferiority: implications for interim analyses
    Daniel J Bratton
    MRC Clinical Trials Unit, London, UK
    Clin Trials 9:605-9. 2012
  8. ncbi Statistical and methodological issues in microbicide trial design
    Angela M Crook
    MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London WC2B 6NH, UK
    Best Pract Res Clin Obstet Gynaecol 26:463-71. 2012
  9. ncbi Challenges of Phase III study design for trials of new drug regimens for the treatment of TB
    Patrick P J Phillips
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    Future Med Chem 2:1273-82. 2010
  10. ncbi An Evaluation of Culture Results during Treatment for Tuberculosis as Surrogate Endpoints for Treatment Failure and Relapse
    Patrick P J Phillips
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    PLoS ONE 8:e63840. 2013

Collaborators

Detail Information

Publications13

  1. ncbi Treatment of pulmonary tuberculosis
    Andrew Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Curr Opin Pulm Med 19:273-9. 2013
    ..There is an urgent need to develop better regimens, to shorten treatment and to effectively manage both drug-sensitive and drug-resistant disease...
  2. ncbi Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
    Andrew Nunn
    MRC Clinical Trials Unit, UK
    Trials 10:99. 2009
    ..The main objective of the trial is to determine the efficacy and safety of 0.5% and 2% concentrations of PRO 2000/5 gel compared to placebo in preventing vaginally acquired HIV infection...
  3. ncbi Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London NW1 2DA
    BMJ 337:a257. 2008
    ..To assess the impact of prophylactic oral co-trimoxazole in reducing mortality in HIV positive Zambian adults being treated for pulmonary tuberculosis...
  4. ncbi Design issues in pivotal drug trials for drug sensitive tuberculosis (TB)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    Tuberculosis (Edinb) 88:S85-92. 2008
    ..Non-inferiority pivotal trials require that, as far as practicable, the same techniques are used as were employed when the trials assessing the standard regimen were conducted...
  5. ncbi Randomised, placebo-controlled trial to evaluate co-trimoxazole to reduce mortality and morbidity in HIV-infected post-natal women in Zambia (TOPAZ)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Trop Med Int Health 16:518-26. 2011
    ..To evaluate the role of prophylactic trimethoprim-sulfamethoxazole (co-trimoxazole) antibacterial prophylaxis in reducing morbidity and mortality in HIV-infected post-natal women in southern Africa...
  6. ncbi A randomized controlled safety and acceptability trial of dextrin sulphate vaginal microbicide gel in sexually active women in Uganda
    Julie M Bakobaki
    Medical Research Council Programme on AIDS in Uganda Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 19:2149-56. 2005
    ..To assess the safety of dextrin sulphate (DS) gel compared to placebo gel in terms of local and systemic adverse events, and to determine the acceptability of dextrin sulphate gel...
  7. ncbi When inferiority meets non-inferiority: implications for interim analyses
    Daniel J Bratton
    MRC Clinical Trials Unit, London, UK
    Clin Trials 9:605-9. 2012
    ..In non-inferiority trials, however, even if a new treatment is found to be inferior to the control at an interim analysis, there may still be a reasonable chance of demonstrating non-inferiority in the final analysis...
  8. ncbi Statistical and methodological issues in microbicide trial design
    Angela M Crook
    MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London WC2B 6NH, UK
    Best Pract Res Clin Obstet Gynaecol 26:463-71. 2012
    ..In this chapter we outline the main features of microbicide trial design, key issues during conduct and analysis, and discuss the challenges specific to these types of clinical trials...
  9. ncbi Challenges of Phase III study design for trials of new drug regimens for the treatment of TB
    Patrick P J Phillips
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    Future Med Chem 2:1273-82. 2010
    ..Most of these trials are likely to be large and expensive and public-private partnerships will be required to conduct them...
  10. ncbi An Evaluation of Culture Results during Treatment for Tuberculosis as Surrogate Endpoints for Treatment Failure and Relapse
    Patrick P J Phillips
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    PLoS ONE 8:e63840. 2013
    ..More data are needed before any endpoint can be used as a surrogate in a confirmatory phase III trial...
  11. ncbi Effectiveness of cotrimoxazole prophylaxis on mortality in adults with tuberculosis in rural South Africa
    Kate Grimwade
    Hlabisa Hospital, KwaZulu Natal, South Africa
    AIDS 19:163-8. 2005
    ..Adults with dual tuberculosis (TB) and HIV infection have a poor outcome. Studies in West Africa suggest that cotrimoxazole prophylaxis may reduce this mortality...
  12. ncbi Dextrin sulfate as a vaginal microbicide: randomized, double-blind, placebo-controlled trial including healthy female volunteers and their male partners
    Naomi Low-Beer
    Faculty of Medicine, Imperial College, London, United Kingdom
    J Acquir Immune Defic Syndr 31:391-8. 2002
    ..Ten male partners (4 with DS exposure and 6 with placebo exposure) were enrolled in the study and all completed follow-up. There was no evidence of systemic toxicity or genital epithelial disruption attributable to DS gel...
  13. ncbi U.K. Controlled trial of intrapleural streptokinase for pleural infection
    Nicholas A Maskell
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford, United Kingdom
    N Engl J Med 352:865-74. 2005
    ..98 to 6.36]; P=0.08). CONCLUSIONS: The intrapleural administration of streptokinase does not improve mortality, the rate of surgery, or the length of the hospital stay among patients with pleural infection...