Andrew J Nunn

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda
    Andrew Abaasa
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    Trials 14:33. 2013
  2. pmc The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study
    Daniel J Bratton
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Trials 13:50. 2012
  3. doi request reprint Treatment of pulmonary tuberculosis
    Andrew Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Curr Opin Pulm Med 19:273-9. 2013
  4. pmc Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
    Andrew Nunn
    MRC Clinical Trials Unit, UK
    Trials 10:99. 2009
  5. pmc Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London NW1 2DA
    BMJ 337:a257. 2008
  6. doi request reprint Design issues in pivotal drug trials for drug sensitive tuberculosis (TB)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    Tuberculosis (Edinb) 88:S85-92. 2008
  7. doi request reprint Randomised, placebo-controlled trial to evaluate co-trimoxazole to reduce mortality and morbidity in HIV-infected post-natal women in Zambia (TOPAZ)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Trop Med Int Health 16:518-26. 2011
  8. ncbi request reprint New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects
    Alimuddin I Zumla
    Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, London, UK University College London Hospitals NHS Foundation Trust, London, UK Electronic address
    Lancet Infect Dis 14:327-40. 2014
  9. ncbi request reprint A randomized controlled safety and acceptability trial of dextrin sulphate vaginal microbicide gel in sexually active women in Uganda
    Julie M Bakobaki
    Medical Research Council Programme on AIDS in Uganda Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 19:2149-56. 2005
  10. pmc An evaluation of culture results during treatment for tuberculosis as surrogate endpoints for treatment failure and relapse
    Patrick P J Phillips
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    PLoS ONE 8:e63840. 2013

Collaborators

Detail Information

Publications16

  1. pmc Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda
    Andrew Abaasa
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    Trials 14:33. 2013
    ..We assessed the long-term correlates of consistent gel use in the MDP 301 clinical trial among HIV-negative women in sero-discordant couples in south-west Uganda...
  2. pmc The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study
    Daniel J Bratton
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Trials 13:50. 2012
    ..Our team applied this tool to an ongoing trial (BLISTER) to determine whether the initial suggestion among some team members that the trial could be described as largely pragmatic was the consensus...
  3. doi request reprint Treatment of pulmonary tuberculosis
    Andrew Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Curr Opin Pulm Med 19:273-9. 2013
    ..There is an urgent need to develop better regimens, to shorten treatment and to effectively manage both drug-sensitive and drug-resistant disease...
  4. pmc Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
    Andrew Nunn
    MRC Clinical Trials Unit, UK
    Trials 10:99. 2009
    ..The main objective of the trial is to determine the efficacy and safety of 0.5% and 2% concentrations of PRO 2000/5 gel compared to placebo in preventing vaginally acquired HIV infection...
  5. pmc Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London NW1 2DA
    BMJ 337:a257. 2008
    ..To assess the impact of prophylactic oral co-trimoxazole in reducing mortality in HIV positive Zambian adults being treated for pulmonary tuberculosis...
  6. doi request reprint Design issues in pivotal drug trials for drug sensitive tuberculosis (TB)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    Tuberculosis (Edinb) 88:S85-92. 2008
    ..Non-inferiority pivotal trials require that, as far as practicable, the same techniques are used as were employed when the trials assessing the standard regimen were conducted...
  7. doi request reprint Randomised, placebo-controlled trial to evaluate co-trimoxazole to reduce mortality and morbidity in HIV-infected post-natal women in Zambia (TOPAZ)
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London, UK
    Trop Med Int Health 16:518-26. 2011
    ..To evaluate the role of prophylactic trimethoprim-sulfamethoxazole (co-trimoxazole) antibacterial prophylaxis in reducing morbidity and mortality in HIV-infected post-natal women in southern Africa...
  8. ncbi request reprint New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects
    Alimuddin I Zumla
    Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, London, UK University College London Hospitals NHS Foundation Trust, London, UK Electronic address
    Lancet Infect Dis 14:327-40. 2014
    ..We also emphasise the need to engage the community in design, implementation, and uptake of research, to increase international cooperation between drug developers and health-care providers adopting new regimens. ..
  9. ncbi request reprint A randomized controlled safety and acceptability trial of dextrin sulphate vaginal microbicide gel in sexually active women in Uganda
    Julie M Bakobaki
    Medical Research Council Programme on AIDS in Uganda Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 19:2149-56. 2005
    ..To assess the safety of dextrin sulphate (DS) gel compared to placebo gel in terms of local and systemic adverse events, and to determine the acceptability of dextrin sulphate gel...
  10. pmc An evaluation of culture results during treatment for tuberculosis as surrogate endpoints for treatment failure and relapse
    Patrick P J Phillips
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    PLoS ONE 8:e63840. 2013
    ..More data are needed before any endpoint can be used as a surrogate in a confirmatory phase III trial...
  11. doi request reprint When inferiority meets non-inferiority: implications for interim analyses
    Daniel J Bratton
    MRC Clinical Trials Unit, London, UK
    Clin Trials 9:605-9. 2012
    ..In non-inferiority trials, however, even if a new treatment is found to be inferior to the control at an interim analysis, there may still be a reasonable chance of demonstrating non-inferiority in the final analysis...
  12. doi request reprint Statistical and methodological issues in microbicide trial design
    Angela M Crook
    MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London WC2B 6NH, UK
    Best Pract Res Clin Obstet Gynaecol 26:463-71. 2012
    ..In this chapter we outline the main features of microbicide trial design, key issues during conduct and analysis, and discuss the challenges specific to these types of clinical trials...
  13. doi request reprint Challenges of Phase III study design for trials of new drug regimens for the treatment of TB
    Patrick P J Phillips
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    Future Med Chem 2:1273-82. 2010
    ..Most of these trials are likely to be large and expensive and public-private partnerships will be required to conduct them...
  14. ncbi request reprint Effectiveness of cotrimoxazole prophylaxis on mortality in adults with tuberculosis in rural South Africa
    Kate Grimwade
    Hlabisa Hospital, KwaZulu Natal, South Africa
    AIDS 19:163-8. 2005
    ..Adults with dual tuberculosis (TB) and HIV infection have a poor outcome. Studies in West Africa suggest that cotrimoxazole prophylaxis may reduce this mortality...
  15. ncbi request reprint Dextrin sulfate as a vaginal microbicide: randomized, double-blind, placebo-controlled trial including healthy female volunteers and their male partners
    Naomi Low-Beer
    Faculty of Medicine, Imperial College, London, United Kingdom
    J Acquir Immune Defic Syndr 31:391-8. 2002
    ..Ten male partners (4 with DS exposure and 6 with placebo exposure) were enrolled in the study and all completed follow-up. There was no evidence of systemic toxicity or genital epithelial disruption attributable to DS gel...
  16. ncbi request reprint U.K. Controlled trial of intrapleural streptokinase for pleural infection
    Nicholas A Maskell
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford, United Kingdom
    N Engl J Med 352:865-74. 2005
    ..This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase...