Research Topics
| Michael F MurphySummaryAffiliation: National Blood Service Country: UK Publications
| Collaborators
|
Detail Information
Publications
Platelet transfusion in neonatal alloimmune thrombocytopeniaDavid Allen
Blood 109:388-9. 2007- Barcode identification for transfusion safetyM F Murphy
National Blood Service, John Radcliffe Hospital, Oxford, UK
Curr Opin Hematol 11:334-8. 2004..Errors related to blood transfusion in hospitals may produce catastrophic consequences. This review addresses potential solutions to prevent patient misidentification including the use of new technology, such as barcoding... - Advances in the management of alloimmune thrombocytopeniaMichael F Murphy
National Blood Service, Department of Haematology, John Radcliffe Hospital, University of Oxford, Oxford, UK
Br J Haematol 136:366-78. 2007..However, the ideal antenatal treatment, which is effective without causing significant side-effects to the mother or fetus, has yet to be determined, and further clinical trials are needed... - Surveillance of transfusion errors: putting data to use in the U.KM F Murphy
National Blood Service, Department of Haematology, John Radcliffe Hospital, Oxford, and the University of Oxford, UK
Dev Biol (Basel) 120:179-87. 2005.... - Patient identification: problems and potential solutionsM F Murphy
National Blood Service, Oxford Radcliffe Hospital, UK
Vox Sang 87:197-202. 2004 - Survey of the implementation of the recommendations in the Health Services Circular 1998/224 'Better Blood Transfusion'M F Murphy
National Blood Service, Oxford Radcliffe Hospitals, and University of Oxford, Oxford, UK
Transfus Med 13:121-5. 2003..New initiatives including the issue of a further HSC on 'Better Blood Transfusion' are aimed at enabling hospitals to improve their transfusion practice in a more systematic way than that was found in the results of this survey... - Prevention of bedside errors in transfusion medicine (PROBE-TM) study: a cluster-randomized, matched-paired clinical areas trial of a simple intervention to reduce errors in the pretransfusion bedside checkMichael F Murphy
National Blood Service, John Radcliffe Hospital, Oxford, UK
Transfusion 47:771-80. 2007..The intervention was a tag on blood bags reminding staff to check the patient's wristband. The tag was positioned in such a way that the transfusionist was required to remove the tag to spike the unit... - Survey of the implementation of the recommendations in the Health Service Circular 2002/009 'Better Blood Transfusion'M F Murphy
National Blood Service, Oxford, UK
Transfus Med 15:453-60. 2005..This information should be used to plan further local, regional and national initiatives to implement the Better Blood Transfusion action plan and improve transfusion practice... - Antenatal screening for fetomaternal alloimmune thrombocytopenia: should we be doing it?M F Murphy
National Blood Service, Department of Haematology, John Radcliffe Hospital, and University of Oxford
Vox Sang 83:409-16. 2002 - Strategies for reducing the exposure to donor bloodMike Murphy
National Blood Service, Department of Haematology, Oxford Radcliffe Hospitals, University of Oxford
Clin Med 5:337-40. 2005 - National audit of the blood transfusion process in the UKM F Murphy
National Blood Service, John Radcliffe Hospital, Oxford OX3 9DU, UK
Transfus Med 11:363-70. 2001..The type of analysis and the method used for the presentation of audit data developed in this study may be useful for setting performance indicators for the clinical transfusion process... - Current performance of patient sample collection in the UKM F Murphy
National Blood Service, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, UK
Transfus Med 14:113-21. 2004..Regular tracking of the rates of sample rejection and WBIT could be used to identify poor performance in individual hospitals requiring investigation and action... - Application of bar code technology at the bedside: the Oxford experienceMichael F Murphy
National Blood Service and John Radcliffe Hospital, Oxford, UK
Transfusion 47:120S-124S; discussion 130S-131S. 2007 
What is the maximum time that a unit of red blood cells can be safely left out of controlled temperature storage?Susan Brunskill
NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK, OX3 9BQ
Transfus Med Rev 26:209-223.e3. 2012....- Electronic remote blood issue: a combination of remote blood issue with a system for end-to-end electronic control of transfusion to provide a "total solution" for a safe and timely hospital blood transfusion serviceJulie Staves
Oxford Radcliffe Hospitals, National Blood Service, Oxford, UK
Transfusion 48:415-24. 2008..A further development is the issue of blood under electronic control at blood refrigerator remote from the blood bank... - Evaluation of the Impact-R for monitoring the platelet storage lesionAbdul Majeed Albanyan
Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK
Platelets 20:1-6. 2009..The Impact-R is a simple device to perform rapid test which may be useful for the assessment of platelet function within platelet concentrates... - Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with annexin VAbdul Majeed Albanyan
Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Transfusion 49:99-107. 2009..The aim of this study was to compare annexin V and lactadherin labeling of PLTs in PLT concentrates (PCs)... - Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantationLise Estcourt
Haematology Transfusion Medicine, NHS Blood and Transplant, Oxford, UK
Cochrane Database Syst Rev 5:CD004269. 2012.... - End-to-end electronic control of the hospital transfusion process to increase the safety of blood transfusion: strengths and weaknessesAmanda Davies
National Blood Service, Oxford Radcliffe Hospitals, Oxford, UK
Transfusion 46:352-64. 2006..These results provide support for further work on the development of such systems for both transfusion and other procedures requiring patient identification... - Prophylactic platelet transfusionsLise J Estcourt
Haematology Transfusion Medicine, NHS Blood and Transplant and the NIHR Biomedical Research Centre, Oxford, UK
Curr Opin Hematol 17:411-7. 2010..This review highlights the recent research on the use of prophylactic platelet transfusions, which is a topic that still provokes controversy. Over the last 12 months, there have been several studies with important new findings... - A systematic review of randomized controlled trials for plasma exchange in the treatment of thrombotic thrombocytopenic purpuraS J Brunskill
National Blood Service, John Radcliffe Hospital, Headley Way, Oxford, UK
Transfus Med 17:17-35. 2007..Continued support of existing TTP patient registries and establishment of new registries would facilitate this... - National comparative audit of the use of platelet transfusions in the UKH Qureshi
National Blood Service, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom
Transfus Clin Biol 14:509-13. 2007.... - Feasibility and usefulness of self-assessment of bleeding in patients with haematological malignancies, and the association between platelet count and bleedingS J Stanworth
Department of Haematology, John Radcliffe Hospital, Headington, Oxford, UK
Vox Sang 91:63-9. 2006..The aim of this study was to evaluate the collection of daily prospective information about bleeding outcomes in patients with thrombocytopenia, including information obtained by patient self-assessment... - Evidence for indications of fresh frozen plasmaS J Stanworth
National Blood Service, John Radcliffe Hospital, Osler Road, Headington, Oxford, United Kingdom
Transfus Clin Biol 14:551-6. 2007..In addition, new haemostatic tests should be validated which better define risk of bleeding... - Leucocyte-depleted blood in prevention of post-operative infections following elective orthopaedic and cardiac proceduresL M Williamson
National Blood Service, and University of Cambridge
Vox Sang 83:457-60. 2002 - Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trialsS J Stanworth
NBS, Level 2, John Radcliffe Hospital, Headington, Oxford, UK
Br J Haematol 126:139-52. 2004..Trials of modified FFP (e.g. pathogen inactivated) are of questionable value when there is little evidence that the standard product is an effective treatment... - Survey of the use of whole blood in current blood transfusion practiceS Maclennan
National Blood Service Transfusion Medicine Clinical Policies Group, National Blood Service, Leeds, UK
Clin Lab Haematol 23:391-6. 2001..It is worth noting that, as currently supplied in the UK, "whole blood" is not strictly "whole" as the leucocyte-depletion process removes platelets... - Survey of the use and clinical effectiveness of HPA-1a/5b-negative platelet concentrates in proven or suspected platelet alloimmunizationD L Allen
National Blood Service, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, UK
Transfus Med 14:409-17. 2004..Increased use and cost-effectiveness could be achieved by the delivery of an educational programme to neonatal unit clinical staff to increase the awareness and appropriate treatment of NAIT... - Platelet transfusion prophylaxis for patients with haematological malignancies: where to now?S J Stanworth
National Blood Service, John Radcliffe Hospital, Headington, Oxford, UK
Br J Haematol 131:588-95. 2005.... - Improving the evidence base for transfusion medicine: the work of the UK systematic review initiativeS J Brunskill
NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
Transfus Med 19:59-65. 2009..Collaboration between international and local research groups is important if these challenges are to be met... - Human platelet antigen 1a epitopes are dependent on the cation-regulated conformation of integrin α(IIb)β(3) (GPIIb/IIIa)David L Allen
NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
J Immunol Methods 375:166-75. 2012.... - The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: a UK national study using three data sourcesMarian Knight
National Perinatal Epidemiology Unit, University of Oxford, Oxford NHS Blood and Transplant Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
Br J Haematol 152:460-8. 2011..There were a number of cases in which the significance of a history of FMAIT in a previous sibling was not recognized and there is a need to raise awareness of the importance of this diagnosis... - European collaborative study of the antenatal management of feto-maternal alloimmune thrombocytopeniaJanet E Birchall
National Blood Service, John Radcliffe Hospital, Oxford, UK
Br J Haematol 122:275-88. 2003..The results of this study suggest that the start of therapy can be stratified on the basis of the sibling history of FMAIT, and support the use of maternal therapy as first-line treatment... - Markers of platelet activation and apoptosis during storage of apheresis- and buffy coat-derived platelet concentrates for 7 daysAbdul Majeed Albanyan
Nuffield Department of Clinical Medicine, University of Oxford, National, Oxford, UK
Transfusion 49:108-17. 2009..The aim of this study was to compare in vitro variables of PCs produced by apheresis (AP-PC) or the buffy coat (BC-PC) method by applying a number of new and established assays... - Reducing blood use: how we did itMichael F Murphy
National Blood Service and John Radcliffe Hospital, Oxford, UK
Transfusion 47:149S-151S; discussion 155S-156S. 2007 - Barcode technology: its role in increasing the safety of blood transfusionC L Turner
National Blood Service, Oxford, UK
Transfusion 43:1200-9. 2003..These results provide support for further work on the development of such systems for transfusion and for other hospital procedures requiring patient identification... 
Neonatal alloimmune thrombocytopeniaR Rayment
National Blood Service, John Radcliffe Hospital, Oxford OX3 9DU
BMJ 327:331-2. 2003- Accuracy of platelet counting haematology analysers in severe thrombocytopenia and potential impact on platelet transfusionH C Segal
National Blood Service, Oxford, UK
Br J Haematol 128:520-5. 2005..It re-emphasizes the need for external quality control to improve analyser calibration for samples with low platelet counts, and suggests that the optimal thresholds for prophylactic platelet transfusions should be re-evaluated... - Review: platelet alloantigens and antibodies and their clinical significanceA Norton
Department of Hematology, National Blood Service, Oxford OX3 9BQ, UK
Immunohematology 20:89-102. 2004 - Appraisal of the evidence for the clinical use of FFP and plasma fractionsS J Stanworth
National Blood Service, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, UK
Best Pract Res Clin Haematol 19:67-82. 2006..Although the SAFE trial showed no increase in mortality with albumin compared with saline, it is difficult to justify its use in critical care given its considerably greater cost... - High incidence of defective high-shear platelet function among platelet donorsPaul Harrison
Oxford Haemophilia Center and Thrombosis Unit, Churchill Hospital, Headington, Oxford, UK
Transfusion 44:764-70. 2004..There has been little previous work on PLT function in blood donors... - Towards better blood transfusion--recruitment and trainingQ A Hill
Department of Haematology, St James s Institute of Oncology, St James s University Hospital, Leeds, UK
Transfus Med 19:2-5. 2009..Improved research opportunities, joint NHSBT/hospital posts and a separate subspecialty training curriculum may stimulate interest in transfusion medicine... - Immunoplatelet counting: potential for reducing the use of platelet transfusions through more accurate platelet countingScott Norris
Haematology Department, Oxford Radcliffe NHS Trust, Oxford, UK
Br J Haematol 121:605-13. 2003..4% in comparison with the same threshold using the Bayer H3 analyser. The immunoplatelet count may aid the clinical decision to transfuse platelets, but would not necessarily lead to a reduced use of platelet transfusions... - Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United StatesD C Whiteman
ICRF General Practice Research Group, University of Oxford, Oxford, UK
Br J Cancer 83:1231-3. 2000..16 expected based on national rates (standardized rate ratio 0.68, 95% confidence interval 0.34-1.22) and conclude that any adverse influence of in utero oestrogen exposure is likely to be small... - Childhood cancer incidence in a cohort of twin babiesM F Murphy
Imperial Cancer Research Fund, General Practice Research Group, Institute of Health Sciences, Old Road, Headington, Oxford, OX3 7LF, UK
Br J Cancer 84:1460-2. 2001..Pooled analysis with data from published cohort studies indicates a similar significant incidence reduction (SIR 81, 95% CI 67-96). Further studies are warranted...