Research Topics
| Philip D MinorSummaryAffiliation: National Institute for Biological Standards and Control Country: UK Publications
| Collaborators
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Detail Information
Publications
Emerging/disappearing viruses future issues concerning polio eradicationP Minor
NIBSC, Division of Virology, Potters Bar, Hertfordshire, UK
Virus Res 82:33-7. 2002- Virological issues in the use of cell therapiesP D Minor
NIBSC, Potters Bar, Herts, UK
Dev Biol (Basel) 118:151-3. 2004.... - Production cell substrates and vCJDR D Minor
National Institute for Biological Standards and Control, Potters Bar, Herts, UK
Dev Biol (Basel) 123:325-33; discussion 349-54. 2006 - Gaps in scientific knowledge for the post eradication worldPhilip Minor
National Institute for Biological Standards and Control NIBSC, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
Biologicals 34:167-70. 2006.... 
Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genesRonald Dijkman
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
Virol J 3:106. 2006....- Are recombinant products really infection risk free?P D Minor
National Institute for Biological Standards and Control, Potters Bar Hertfordshire, UK
Haemophilia 7:114-6. 2001..Validated production processes make a major contribution to product safety however... - Transgenic animals for the production of biological medicinesP D Minor
NIBSC, Potters Bar, Herts, UK
Dev Biol (Basel) 118:165-9. 2004 - Effect of different immunisation schedules on the excretion and reversion of oral poliovaccine strainsP D Minor
National Institute for Biological Standards and Control, Blanche Lane South Mimms, Potters Bar, Herts, EN6 3QG, UK
J Med Virol 75:153-60. 2005..The data are consistent with the view that poliovirus is able to escape the immune pressure in the gut to some extent by improving its general fitness rather than direct evasion of immunity... - Standards for the assay of Creutzfeldt-Jakob disease specimensP Minor
NIBSC, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK
J Gen Virol 85:1777-84. 2004..The materials have been given the status of reference reagents by the World Health Organization and are available for further study and assessment of other in vitro or in vivo assay procedures... - Polio eradication, cessation of vaccination and re-emergence of diseasePhilip D Minor
National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3PG, UK
Nat Rev Microbiol 2:473-82. 2004 - Technical aspects of the development and validation of tests for variant Creutzfeldt-Jakob disease in blood transfusionP D Minor
NIBSC, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK
Vox Sang 86:164-70. 2004..A rapid infectivity assay is key to confirming positives in human samples, and dilutions of infected human brain will probably provide adequate routine control samples to ensure the correct performance of the test... - The challenge for the public health systemPhilip D Minor
National Institute for Biological Standards and Control, South Mimms, Potters Bar, UK
Contrib Microbiol 11:208-15. 2004 
Current challenges in implementing cell-derived influenza vaccines: implications for production and regulation, July 2007, NIBSC, Potters Bar, UKPhilip D Minor
National Institute for Biological Standards and Control, South Mimms, Potters Bar, Herts, UK
Vaccine 27:2907-13. 2009..Future studies to progress the field were reviewed...- Antibodies to SV40 in sera from humans and macaquesP Minor
National Institute for Biological Standards and Control, Potters Bar, UK
Dev Biol (Basel) 123:99-107; discussion 119-32. 2006 - Polio vaccines and the cessation of vaccinationPhilip D Minor
Division of Virology, NIBSC, Potters Bar, Herts, UK
Expert Rev Vaccines 2:99-104. 2003..Some of the difficulties that this implies for the eventual complete cessation of vaccination are proving to be real not theoretical... 
Changes in population dynamics during long-term evolution of sabin type 1 poliovirus in an immunodeficient patientJohn K Odoom
Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, Potters Bar, Hertfordshire EN63QG, United Kingdom
J Virol 82:9179-90. 2008..The relevance of vaccine-derived poliovirus strains for disease surveillance and future polio immunization policies is discussed in the context of the Global Polio Eradication Initiative...- Long-term excretion of vaccine-derived poliovirus by a healthy childJavier Martin
Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
J Virol 78:13839-47. 2004..This anomaly could explain the high VP1 sequence drift found and the ability of these virus strains to replicate in the gut for a longer period than expected... - Characterization of formaldehyde-inactivated poliovirus preparations made from live-attenuated strainsJavier Martin
Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire EN6 3QG, UK
J Gen Virol 84:1781-8. 2003..A novel transgenic mouse model to study in vivo the immune protection induced by IPV preparations is described... - Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitisJavier Martin
Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom
J Virol 76:10921-8. 2002.... - Development of working reference materials for clinical virologyJacqueline F Fryer
National Institute for Biological Standards and Control, Hertfordshire EN6 3QG, UK
J Clin Virol 43:367-71. 2008..Preliminary results presented here indicate a high level of variability in intra- and inter-assay detection of these targets, highlighting the need for standardisation of assays within molecular diagnostics... - Interruption of poliovirus transmission in Ghana: molecular epidemiology of wild-type 1 poliovirus isolated from 1995 to 2008John Kofi Odoom
Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom
J Infect Dis 206:1111-20. 2012.... - Characterization of CHAT and Cox type 1 live-attenuated poliovirus vaccine strainsJavier Martin
Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom
J Virol 76:5339-49. 2002..The molecular mechanisms of attenuation and evolution of poliovirus in humans are discussed in the context of the global polio eradication initiative... - Rational design of genetically stable, live-attenuated poliovirus vaccines of all three serotypes: relevance to poliomyelitis eradicationAndrew J Macadam
NIBSC, South Mimms, Herts, UK
J Virol 80:8653-63. 2006.... - Novel parvovirus and related variant in human plasmaJacqueline F Fryer
National Institute for Biological Standards and Control, Hertfordshire, United Kingdom
Emerg Infect Dis 12:151-4. 2006..Viral DNA was detected by using highly selective polymerase chain reaction assays; 5% of pools tested positive, and amounts of DNA ranged from <500 copies/mL to >106 copies/mL plasma... - Evaluation of different assays for the detection of parvovirus B19 DNA in human plasmaSally A Baylis
Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
J Virol Methods 121:7-16. 2004..To improve the detection of these variant viruses a novel assay has been developed and data are presented to show its use for screening pooled plasma for the presence of parvovirus B19 DNA and the variants identified recently... - Mitochondrial DNA and retroviral RNA analyses of archival oral polio vaccine (OPV CHAT) materials: evidence of macaque nuclear sequences confirms substrate identityNeil Berry
Division of Retrovirology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
Vaccine 23:1639-48. 2005..These data reinforce earlier findings on this topic providing no evidence to support the contention that poliovirus vaccination was responsible for the introduction of HIV into humans and sparking the AIDS pandemic... - Application of deglycosylation to SDS PAGE analysis improves calibration of influenza antigen standardsRuth Harvey
Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
Biologicals 40:96-9. 2012..We found that while the final agreed HA value of the samples tested was not significantly different with or without deglycosylation, the deglycosylation step greatly improved between-laboratory agreement... - Neurovirulence tests of three 17D yellow fever vaccine strainsPhilip D Minor
National Institute of Biological Standards and Control, Health Protection Agency, South Mimms, Potters Bar, Hertfordshire, United Kingdom
Biologicals 39:167-70. 2011..In the test described here 168-73 was of lower virulence than either of the other two preparations... - The polio-eradication programme and issues of the end gamePhilip D Minor
National Institute of Biological Standards and Control, Health Protection Agency, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
J Gen Virol 93:457-74. 2012..Understanding the pathogenesis and virology of the infection is of major significance as the programme reaches its conclusion... - Simian cytomegalovirus and contamination of oral poliovirus vaccinesSally A Baylis
Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire EN6 3QG, Potters Bar, UK
Biologicals 31:63-73. 2003..One poliovirus vaccine and one seed, propagated on rhesus macaque kidney cultures were found to be positive for the rhesus monkey CMV by PCR... - Vaccine-derived poliovirus (VDPV): Impact on poliomyelitis eradicationPhilip Minor
Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshirre EN6 3QG, UK
Vaccine 27:2649-52. 2009..VDPV cannot arise from the inactivated poliovirus vaccine (IPV), but financial and logistical barriers to replace OPV with IPV remain... - Lack of serologic evidence for prevalent simian virus 40 infection in humansJoseph J Carter
Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
J Natl Cancer Inst 95:1522-30. 2003..CONCLUSION: These data indicate that some individuals have BKV and/or JCV antibodies that cross-react with SV40, but they do not provide support for SV40 being a prevalent human pathogen... - When can we stop using oral poliovirus vaccine?Harry F Hull
J Infect Dis 192:2033-5. 2005 - Failure to detect measles virus ribonucleic acid in bone cells from patients with Paget's diseaseBrya G Matthews
Department of Medicine, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
J Clin Endocrinol Metab 93:1398-401. 2008..We have tested for measles virus sequences in osteoblasts and bone marrow cells collected from pagetic lesions and healthy bone...