Rajesh P Menon

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition
    Giuseppe Nicastro
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 102:10493-8. 2005
  2. pmc The importance of serine 776 in Ataxin-1 partner selection: a FRET analysis
    Rajesh P Menon
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA UK
    Sci Rep 2:919. 2012
  3. ncbi Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1
    Rajesh P Menon
    Centre for Rheumatology, Royal Free and University College Medical School, Division of Medicine, University College London Hampstead Campus, Rowland Hill Street, London NW3 2PF2, UK
    Exp Cell Res 312:1463-74. 2006
  4. ncbi The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre
    Rajesh P Menon
    National Institute for Medical Research, London NW7 1AA, UK
    J Mol Biol 343:43-53. 2004
  5. ncbi Polyglutamine is not all: the functional role of the AXH domain in the ataxin-1 protein
    Cesira de Chiara
    National Institute for Medical Research, The Ridgeway, London NW71AA, UK
    J Mol Biol 354:883-93. 2005
  6. doi Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites
    Giuseppe Nicastro
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Biopolymers 91:1203-14. 2009
  7. ncbi The AXH domain adopts alternative folds the solution structure of HBP1 AXH
    Cesira de Chiara
    National Institute for Medical Research, The Ridgeway, London, United Kingdom
    Structure 13:743-53. 2005
  8. ncbi Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3
    Laura Masino
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Mol Biol 344:1021-35. 2004
  9. doi Structural bases for recognition of Anp32/LANP proteins
    Cesira de Chiara
    National Institute for Medical Research, The Ridgeway, London, UK
    FEBS J 275:2548-60. 2008
  10. pmc Chemical shift assignment of the ataxin-1 AXH domain in complex with a CIC ligand peptide
    Cesira de Chiara
    MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Biomol NMR Assign 8:325-7. 2014

Collaborators

  • Annalisa Pastore
  • Laura Masino
  • Dimitris Kioussis
  • David J Abraham
  • Toby J Gibson
  • F Fraternali
  • K Matthew Scaglione
  • Cesira de Chiara
  • Giuseppe Nicastro
  • John McCormick
  • Geoff Kelly
  • Serena Faggiano
  • Robert Goold
  • Lesley Calder
  • Sulemana Bawumia
  • Geoff P Kelly
  • Henry L Paulson
  • Sokol V Todi
  • Veronica Esposito
  • Alfonso De Simone
  • Tamas Revesz
  • Antoni Matilla-DueƱas
  • Massimo Pandolfo
  • Michael Hubank
  • Janice Holton
  • Abigail Hunt
  • Salvatore Adinolfi
  • Fabrizio Dal Piaz
  • Neil Q McDonald
  • Philip P Knowles
  • Eleni Ktistaki
  • Jasper de Boer
  • Thomas A Frenkiel
  • R Colin Hughes
  • Eminia A M Barboni

Detail Information

Publications16

  1. pmc The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition
    Giuseppe Nicastro
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 102:10493-8. 2005
    ..The structural similarity with other deubiquitinating enzymes suggests a model for the proteolytic enzymatic activity of ataxin-3...
  2. pmc The importance of serine 776 in Ataxin-1 partner selection: a FRET analysis
    Rajesh P Menon
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA UK
    Sci Rep 2:919. 2012
    ..These results indicate that Ser776 acts as the molecular switch that discriminates between normal and aberrant function and that phosphomimetics is not a generally valid approach whose applicability should be carefully validated...
  3. ncbi Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1
    Rajesh P Menon
    Centre for Rheumatology, Royal Free and University College Medical School, Division of Medicine, University College London Hampstead Campus, Rowland Hill Street, London NW3 2PF2, UK
    Exp Cell Res 312:1463-74. 2006
    ..Our results underline the therapeutic potential of hammerhead ribozymes in dominant negative defects and suggest that changes in microfibril architecture brought about by fibrillin-1 mutation lead to a complex disease phenotype...
  4. ncbi The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre
    Rajesh P Menon
    National Institute for Medical Research, London NW7 1AA, UK
    J Mol Biol 343:43-53. 2004
    ..The interaction with FMRP was mapped in a newly identified CRA motif present in the RanBPM C terminus. Our results suggest that the functional role of RanBPM binding is modulation of the RNA-binding properties of FMRP...
  5. ncbi Polyglutamine is not all: the functional role of the AXH domain in the ataxin-1 protein
    Cesira de Chiara
    National Institute for Medical Research, The Ridgeway, London NW71AA, UK
    J Mol Biol 354:883-93. 2005
    ..These results provide the first direct evidence of an involvement of a region other than the polyglutamine tract in polyglutamine pathologies...
  6. doi Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites
    Giuseppe Nicastro
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Biopolymers 91:1203-14. 2009
    ..The presence of two ubiquitin-binding sites explains how ataxin-3 binds poly-ubiquitin chains and provides new insights into the molecular mechanism of ubiquitin recognition...
  7. ncbi The AXH domain adopts alternative folds the solution structure of HBP1 AXH
    Cesira de Chiara
    National Institute for Medical Research, The Ridgeway, London, United Kingdom
    Structure 13:743-53. 2005
    ..Our results describe an entirely novel, to our knowledge, example of a chameleon fold and suggest a link between these properties and the SCA1 pathogenesis...
  8. ncbi Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3
    Laura Masino
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Mol Biol 344:1021-35. 2004
    ..Our data support a mechanism in which the thermodynamic stability of ataxin-3 is governed by the properties of the Josephin domain, but the presence of an expanded polyQ tract increases dramatically the protein's tendency to aggregate...
  9. doi Structural bases for recognition of Anp32/LANP proteins
    Cesira de Chiara
    National Institute for Medical Research, The Ridgeway, London, UK
    FEBS J 275:2548-60. 2008
    ..e. the microtubule plus-end tracking protein Clip 170/Restin, known to regulate the dynamic properties of microtubules and to be associated with severe human pathologies...
  10. pmc Chemical shift assignment of the ataxin-1 AXH domain in complex with a CIC ligand peptide
    Cesira de Chiara
    MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Biomol NMR Assign 8:325-7. 2014
    ..Here we report the (1)H, (13)C and (15)N backbone and side-chain chemical shift assignments of the human ataxin-1 AXH domain in complex with a CIC ligand-peptide. ..
  11. ncbi Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail
    Laura Masino
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    FEBS Lett 549:21-5. 2003
    ..Moreover, [(15)N]glutamine selectively labelled samples allowed us to have a direct insight by NMR into the structure of the polyQ region...
  12. pmc Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3
    Serena Faggiano
    National Institute for Medical Research, MRC, The Ridgeway, London, United Kingdom
    FEBS Open Bio 3:453-8. 2013
    ..The protocol allows facile selective labelling of the components. Our results provide an important proof-of-concept that may pave the way to new approaches to the in vitro study of ubiquitinated proteins...
  13. ncbi Specificity of interactions of galectin-3 with Chrp, a cysteine- and histidine-rich cytoplasmic protein
    Sulemana Bawumia
    National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Biochimie 85:189-94. 2003
    ..The formation of higher-order complexes containing these proteins and additional binding partners may be relevant to cytoplasmic functions involving galectin-3...
  14. ncbi Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1
    Robert Goold
    UCL Institute of Child Health, University College London, UK
    Hum Mol Genet 16:2122-34. 2007
    ..Therefore, this study identifies novel molecular targets that are regulated by Atxn1 which might contribute to the motor deficits in SCA1, and provides new insights into the mechanisms by which Atxn1 co-regulates transcription...
  15. ncbi Assignment of the 1H, 13C, and 15N resonances of the Josephin domain of human ataxin-3
    Giuseppe Nicastro
    J Biomol NMR 30:457-8. 2004