A S McNeilly

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi Lactation and fertility
    A S McNeilly
    MRC Reproductive Biology Unit, Edinburgh, Scotland, United Kingdom
    J Mammary Gland Biol Neoplasia 2:291-8. 1997
  2. ncbi Lactational endocrinology: the biology of LAM
    Alan S McNeilly
    MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, Scotland, UK
    Adv Exp Med Biol 503:199-205. 2002
  3. ncbi Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland
    Caroline Pope
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Dev Biol 297:172-81. 2006
  4. ncbi The differential secretion of FSH and LH: regulation through genes, feedback and packaging
    A S McNeilly
    MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Chancellor s Building, New Royal Infirmary, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Reprod Suppl 61:463-76. 2003
  5. ncbi Differential secretion of gonadotrophins: investigation of the role of secretogranin II and chromogranin A in the release of LH and FSH in LbetaT2 cells
    L Nicol
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    J Mol Endocrinol 32:467-80. 2004
  6. ncbi Expression of tissue inhibitor of metalloproteinases-1 in the human corpus luteum after luteal rescue
    W C Duncan
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    J Endocrinol 148:59-67. 1996
  7. ncbi Manipulating the in vivo mRNA expression profile of FSH beta to resemble that of LH beta does not promote a concomitant increase in intracellular storage of follicle-stimulating hormone
    P Brown
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK
    J Neuroendocrinol 13:50-62. 2001
  8. ncbi Influence of steroids and GnRH on biosynthesis and secretion of secretogranin II and chromogranin A in relation to LH release in LbetaT2 gonadotroph cells
    L Nicol
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    J Endocrinol 174:473-83. 2002
  9. ncbi No evidence for pituitary priming to gonadotropin-releasing hormone in relation to luteinizing hormone (LH) secretion prior to the preovulatory LH surge in ewes
    J L Crawford
    Human Reproductive Sciences Unit, Medical Research Council, University of Edinburgh Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    Biol Reprod 71:224-35. 2004
  10. ncbi Co-localisation of gonadotrophins and granins in gonadotrophs at different stages of the oestrous cycle in sheep
    J L Crawford
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    J Endocrinol 174:179-94. 2002

Collaborators

Detail Information

Publications36

  1. ncbi Lactation and fertility
    A S McNeilly
    MRC Reproductive Biology Unit, Edinburgh, Scotland, United Kingdom
    J Mammary Gland Biol Neoplasia 2:291-8. 1997
    ..The birth spacing effects of breastfeeding in women have a profound effect on infant well-being, and breastfeeding still prevents more pregnancies than all forms of artificial contraception...
  2. ncbi Lactational endocrinology: the biology of LAM
    Alan S McNeilly
    MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, Scotland, UK
    Adv Exp Med Biol 503:199-205. 2002
  3. ncbi Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland
    Caroline Pope
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Dev Biol 297:172-81. 2006
    ..The mechanism(s) responsible for the different molecular regulation of alpha-GSU gene expression in gonadotropes and thyrotropes in the developing human fetal pituitary now requires investigation...
  4. ncbi The differential secretion of FSH and LH: regulation through genes, feedback and packaging
    A S McNeilly
    MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Chancellor s Building, New Royal Infirmary, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Reprod Suppl 61:463-76. 2003
    ..Packaging of LH and FSH into different secretory granules within the same cell is thus pivotal for the differential secretion of these gonadotrophins...
  5. ncbi Differential secretion of gonadotrophins: investigation of the role of secretogranin II and chromogranin A in the release of LH and FSH in LbetaT2 cells
    L Nicol
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    J Mol Endocrinol 32:467-80. 2004
    ....
  6. ncbi Expression of tissue inhibitor of metalloproteinases-1 in the human corpus luteum after luteal rescue
    W C Duncan
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    J Endocrinol 148:59-67. 1996
    ....
  7. ncbi Manipulating the in vivo mRNA expression profile of FSH beta to resemble that of LH beta does not promote a concomitant increase in intracellular storage of follicle-stimulating hormone
    P Brown
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK
    J Neuroendocrinol 13:50-62. 2001
    ..This suggests that, regardless of the levels of synthesis, post-translational sorting preferentially promotes FSH secretion from the pituitary...
  8. ncbi Influence of steroids and GnRH on biosynthesis and secretion of secretogranin II and chromogranin A in relation to LH release in LbetaT2 gonadotroph cells
    L Nicol
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    J Endocrinol 174:473-83. 2002
    ....
  9. ncbi No evidence for pituitary priming to gonadotropin-releasing hormone in relation to luteinizing hormone (LH) secretion prior to the preovulatory LH surge in ewes
    J L Crawford
    Human Reproductive Sciences Unit, Medical Research Council, University of Edinburgh Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    Biol Reprod 71:224-35. 2004
    ..Constitutive release of LH(+ve)/SgII(-ve) granules may maintain basal LH levels while smaller sized, presumably mature granules may be preferentially released after GnRH stimulation...
  10. ncbi Co-localisation of gonadotrophins and granins in gonadotrophs at different stages of the oestrous cycle in sheep
    J L Crawford
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    J Endocrinol 174:179-94. 2002
    ..Conversely, CgB mRNA levels decreased around the time of PS. These novel results illustrate major differences in granin-gonadotrophin interactions between sheep and rodents...
  11. pmc Inhibin removes the inhibitory effects of activin on steroid enzyme expression and androgen production by normal ovarian thecal cells
    J M Young
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Mol Endocrinol 48:49-60. 2012
    ..Inhibin and other blockers of activin action reversed this effect, supporting the concept that endogenous thecal activin modulates androgen production in theca cells...
  12. pmc Activin B is produced early in antral follicular development and suppresses thecal androgen production
    J M Young
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Reproduction 143:637-50. 2012
    ..This would inhibit the negative effects of thecal activins B and A ensuring maximum androgen production for enhanced estradiol production by the preovulatory follicle(s)...
  13. ncbi Replenishment of LH stores of gonadotrophs in relation to gene expression, synthesis and secretion of LH after the preovulatory phase of the sheep oestrous cycle
    J L Crawford
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    J Endocrinol 167:453-63. 2000
    ..These results suggest that restoration of pulsatile LH secretion after a preovulatory LH surge is related to replenishment of LH beta secretory granule stores and an increase in GnRH binding levels...
  14. pmc Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in LbetaT2 gonadotrophs
    L Nicol
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ UK
    J Endocrinol 196:497-507. 2008
    ..BMPs as important modulators of activin and/or GnRH-stimulated gonadotrophin synthesis and release and 2. important species differences in these effects, which could relate to differences in BMP receptor expression in gonadotrophs...
  15. ncbi Lactational control of reproduction
    A S McNeilly
    MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, Scotland, UK
    Reprod Fertil Dev 13:583-90. 2001
    ....
  16. ncbi Inhibin-B: a likely candidate for the physiologically important form of inhibin in men
    P J Illingworth
    Medical Research Council Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    J Clin Endocrinol Metab 81:1321-5. 1996
    ..These results strongly suggest that the physiologically important form of inhibin in men is inhibin B, which has a critical effect on FSH release. Inhibin B may offer a clinically useful serum marker of testicular function...
  17. ncbi Neuroendocrine changes and fertility in breast-feeding women
    A S McNeilly
    MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Prog Brain Res 133:207-14. 2001
    ....
  18. ncbi Follicle-stimulating hormone-inhibin B interactions during the follicular phase of the primate menstrual cycle revealed by gonadotropin-releasing hormone antagonist and antiestrogen treatment
    H M Fraser
    Medical Research Council Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 84:1365-9. 1999
    ..These results show that follicular phase FSH is the major stimulus for inhibin B secretion...
  19. ncbi Detection of prolactin receptor gene expression in the sheep pituitary gland and visualization of the specific translation of the signal in gonadotrophs
    D J Tortonese
    Medical Research Council Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, Scotland, United Kingdom
    Endocrinology 139:5215-23. 1998
    ....
  20. ncbi The effect of luteal "rescue" on the expression and localization of matrix metalloproteinases and their tissue inhibitors in the human corpus luteum
    W C Duncan
    Medical Research Council Reproductive Biology Unit, Center for Reproductive Biology, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 83:2470-8. 1998
    ..MMPs can function in an environment containing large amounts of TIMP-1, as they have a different cellular localization...
  21. ncbi Promotion of intragranular co-aggregation with LH by enhancement of secretogranin II storage resulted in increased intracellular granule storage in gonadotrophs of GnRH-deprived male mice
    J L Crawford
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Chancellor s Building, 49 Little France Crescent, Old Dalkeith Road, UK
    Reproduction 124:267-77. 2002
    ..In contrast, secretion of LH(+ve)/SgII(-ve) granules did not appear to be influenced by the actions of Buserelin and, therefore, may have been destined for constitutive release, possibly to maintain basal plasma LH concentrations...
  22. ncbi Production of inhibin A not B in rams: changes in plasma inhibin A during testis growth, and expression of inhibin/activin subunit mRNA and protein in adult testis
    A S McNeilly
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 123:827-35. 2002
    ....
  23. doi Theca: the forgotten cell of the ovarian follicle
    J M Young
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, UK
    Reproduction 140:489-504. 2010
    ....
  24. ncbi The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene
    C J Souza
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers St, Edinburgh, EH3 9ET, UK
    J Endocrinol 169:R1-6. 2001
    ....
  25. doi Imaging of the ovine corpus luteum microcirculation with contrast ultrasound
    Vassilis Sboros
    Medical Physics and Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Ultrasound Med Biol 37:59-68. 2011
    ..Our initial results demonstrate a highly reproducible model for the study of the microvascular hemodynamics in a range of tissues and organs...
  26. ncbi Development and validation of a new monoclonal antibody to mammalian aromatase
    K J Turner
    MRC Human Reproductive Sciences Unit, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    J Endocrinol 172:21-30. 2002
    ..Its ability to work on fixed tissue sections will facilitate identification of individual cells expressing P450 arom within complex tissues...
  27. ncbi Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation
    S J Martins da Silva
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, UK
    Dev Biol 266:334-45. 2004
    ..These data indicate that activin may be involved in the autocrine and paracrine regulation of germ cell proliferation in the human ovary during the crucial period of development leading up to primordial follicle formation...
  28. ncbi Cloning and sequencing of the sheep pituitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycle
    J Brooks
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    Mol Cell Endocrinol 94:R23-7. 1993
    ..05) decreased after the preovulatory LH surge. These results suggest that there is a close relationship between the abundance of GnRH-R mRNA and translation of the GnRH-R in sheep...
  29. pmc In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep
    Paul A Fowler
    Department of Obstetrics and Gynaecology, Institute of Medical Sciences, CLSM, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Hum Reprod 14:269-80. 2008
    ..Fetal exposure to environmental chemicals, via the mother, significantly perturbs fetal ovarian development. If such effects are replicated in humans, premature menopause could be an outcome...
  30. ncbi Infant feeding with soy formula milk: effects on the testis and on blood testosterone levels in marmoset monkeys during the period of neonatal testicular activity
    Richard M Sharpe
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Hum Reprod 17:1692-703. 2002
    ..This study has addressed concerns about possible effects of feeding human infants soy formula milk (SFM)...
  31. ncbi Features of follicle-stimulating hormone-stimulated follicles in a sheep model: keys to elucidate embryo failure in assisted reproductive technique cycles
    Almudena Veiga-Lopez
    Departamento de Reproduccion Animal, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Madrid, Spain
    Fertil Steril 89:1328-37. 2008
    ..To evaluate the individual functionality of gonadotropin-stimulated preovulatory follicles, for understanding embryo failure in assisted reproductive technique cycles, in a sheep model...
  32. doi Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression
    Shiona M Coutts
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, UK
    Dev Biol 314:189-99. 2008
    ..The effects of activin on germ cells are indirect and include mediation by the kit ligand/c-Kit pathway, rather than being an autocrine germ cell effect...
  33. ncbi Elevated prolactin levels immediately precede decisions to babysit by male meerkat helpers
    Anne A Carlson
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Horm Behav 50:94-100. 2006
    ..Together, these results lend significant weight to the idea that decisions to help in cooperative vertebrates have a hormonal basis, although different hormones appear to be associated with different types of care...
  34. ncbi Multiple factors affecting the efficiency of multiple ovulation and embryo transfer in sheep and goats
    Antonio Gonzalez-Bulnes
    Departamento de Reproduccion Animal, INIA, Madrid, Spain
    Reprod Fertil Dev 16:421-35. 2004
    ..The accomplishment of this objective, the improvement of procedures for embryo conservation and for the selection and management of recipient females, will allow further development and application of this technology...
  35. ncbi Effect of progestin-only pill on pituitary-ovarian axis activity during lactation
    Antti Perheentupa
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Chancellor s Building, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Contraception 67:467-71. 2003
    ..Thus, the contraceptive effect of POP is likely mediated through local actions at the endometrium and cervix in a manner similar to that in menstruating women...
  36. ncbi Hormonal correlates of dominance in meerkats (Suricata suricatta)
    Anne A Carlson
    Large Animal Research Group, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Horm Behav 46:141-50. 2004
    ....