A T McKie

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    A T McKie
    Department of Molecular Medicine, King s College London, Guy s, King s, St Thomas School of Medicine, United Kingdom
    Mol Cell 5:299-309. 2000
  2. ncbi An iron-regulated ferric reductase associated with the absorption of dietary iron
    A T McKie
    Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
    Science 291:1755-9. 2001
  3. ncbi Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine
    A T McKie
    Department of Molecular Medicine, King s College School of Medicine and Dentistry, London, U K
    Clin Sci (Lond) 91:213-8. 1996
  4. pmc A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption
    D M Frazer
    Joint Clinical Sciences Program, The Queensland Institute of Medical Research and The University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Gut 52:340-6. 2003
  5. pmc Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse
    Y M Kuo
    Departments of Medicine and Pediatrics, University of California San Francisco, San Francisco, CA 94143 0794, USA
    Gut 53:201-6. 2004
  6. pmc Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis
    D M Frazer
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Gut 53:1509-15. 2004
  7. ncbi Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice
    A H Laftah
    Department of Life Sciences, King s College, Franklin Wilkins Building, Stamford Street, London, SE1 9NN, UK
    Ann Hematol 84:177-82. 2005
  8. ncbi Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis
    G O Latunde-Dada
    Department of Life Sciences, King s College, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Biochim Biophys Acta 1690:169-76. 2004
  9. pmc Modulation of iron transport proteins in human colorectal carcinogenesis
    M J Brookes
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Birmingham B15 2TH, UK
    Gut 55:1449-60. 2006
  10. ncbi Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status
    A C Y Li
    Gastrointestinal Laboratory, St Thomas Hospital, London, UK
    Eur J Clin Invest 36:890-8. 2006

Collaborators

Detail Information

Publications22

  1. ncbi A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    A T McKie
    Department of Molecular Medicine, King s College London, Guy s, King s, St Thomas School of Medicine, United Kingdom
    Mol Cell 5:299-309. 2000
    ..IREG1 stimulates iron efflux following expression in Xenopus oocytes. We conclude that IREG1 represents the long-sought duodenal iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis...
  2. ncbi An iron-regulated ferric reductase associated with the absorption of dietary iron
    A T McKie
    Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
    Science 291:1755-9. 2001
    ..Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway...
  3. ncbi Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine
    A T McKie
    Department of Molecular Medicine, King s College School of Medicine and Dentistry, London, U K
    Clin Sci (Lond) 91:213-8. 1996
    ..6. The data presented suggest regulation of pancreatitis-associated protein gene expression by both oxygen tension and iron status...
  4. pmc A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption
    D M Frazer
    Joint Clinical Sciences Program, The Queensland Institute of Medical Research and The University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Gut 52:340-6. 2003
    ..A large oral dose of iron will reduce the absorption of a subsequent smaller dose of iron in a phenomenon known as mucosal block. Molecular analysis of this process may provide insights into the regulation of intestinal iron absorption...
  5. pmc Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse
    Y M Kuo
    Departments of Medicine and Pediatrics, University of California San Francisco, San Francisco, CA 94143 0794, USA
    Gut 53:201-6. 2004
    ..Sex linked anaemia (sla) mice have a defect in the release of iron from intestinal enterocytes into the circulation due to an interstitial deletion in the hephaestin gene (heph)...
  6. pmc Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis
    D M Frazer
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Gut 53:1509-15. 2004
    ..Recent data however suggest that signals from the body to alter absorption are mediated by circulating hepcidin and that this peptide exerts its effect on mature villus enterocytes...
  7. ncbi Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice
    A H Laftah
    Department of Life Sciences, King s College, Franklin Wilkins Building, Stamford Street, London, SE1 9NN, UK
    Ann Hematol 84:177-82. 2005
    ..This study further supports the hypothesis that alterations in haem biosynthesis influence duodenal iron absorption. ALA in particular appears to function as a modulator in controlling intestinal iron absorption...
  8. ncbi Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis
    G O Latunde-Dada
    Department of Life Sciences, King s College, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Biochim Biophys Acta 1690:169-76. 2004
    ..The probable association of the erythroid and the store regulators of iron homeostasis and absorption in the mice is discussed...
  9. pmc Modulation of iron transport proteins in human colorectal carcinogenesis
    M J Brookes
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Birmingham B15 2TH, UK
    Gut 55:1449-60. 2006
    ....
  10. ncbi Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status
    A C Y Li
    Gastrointestinal Laboratory, St Thomas Hospital, London, UK
    Eur J Clin Invest 36:890-8. 2006
    ..This study investigated Dcytb expression in patients with normal iron status or mild iron deficiency and its relationships with enterocyte iron status...
  11. ncbi Different behaviour of 63Ni and 59Fe during absorption in iron-deficient and iron-adequate jejunal rat segments ex vivo
    M Müller-Fassbender
    Walther Straub Institut für Pharmakologie und Toxikologie der Ludwig Maximilians Universität, Nussbaumstr 26, 80336, Munich, Germany
    Toxicology 185:141-53. 2003
    ..Binding of 63Ni to food and tissue ligands in the small intestine may, thus, be a likely explanation for the low oral nickel toxicity...
  12. ncbi Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption
    G J Anderson
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Queensland 4029, Australia
    Biochem Soc Trans 30:724-6. 2002
    ..These data are consistent with hepcidin playing a role as a negative regulator of intestinal iron absorption...
  13. ncbi Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption
    A T McKie
    Department of Molecular Medicine, King s College School of Medicine and Dentistry, London
    Biochem Soc Trans 26:S264. 1998
  14. ncbi Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins
    D M Frazer
    Joint Clinical Sciences Program, The Queensland Institute of Medical Research and The University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Am J Physiol Gastrointest Liver Physiol 281:G931-9. 2001
    ..The high sequence conservation between rat and mouse hephaestin is consistent with this protein playing a central role in intestinal iron absorption, although its precise function remains to be determined...
  15. ncbi Identification of 96 single nucleotide polymorphisms in eight genes involved in iron metabolism: efficiency of bioinformatic extraction compared with a systematic sequencing approach
    V Douabin-Gicquel
    Département de Biochimie et Biologie Moléculaire, et UMR6061 CNRS, Faculte de Medecine, 2 Avenue du Pr Léon Bernard CS34317, 35043 Rennes Cedex, France
    Hum Genet 109:393-401. 2001
    ..The average distance between the SNPs and minor allele frequencies were higher than reported by others authors; this discrepancy may reflect the nature of the genes studied and the ethnic homogeneity of our test population...
  16. ncbi Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis
    A Lebeau
    Pathologisches Institut, Ludwig Maximilians Universitat, Munchen, Germany, Universitat Hohenheim, Stuttgart, Germany
    Eur J Clin Invest 32:603-12. 2002
    ..HFE knockout mice (C57BL/6 x 129/Ola strain) mimic the functional aberrations of human hereditary haemochromatosis (HH) in short-term experiments. The present study investigates functional and morphological long-term changes...
  17. ncbi Molecular evidence for the role of a ferric reductase in iron transport
    A T McKie
    Division of Life Sciences, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Biochem Soc Trans 30:722-4. 2002
    ..The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body...
  18. ncbi Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases
    J D Vargas
    Department of Human Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, UK
    Biochim Biophys Acta 1651:116-23. 2003
    ..Moreover, we demonstrate the presence of mouse sdr2 in the choroid plexus and in the ependymal cells lining the four ventricles, through in situ hybridization analysis...
  19. ncbi Effect of transition metal ions (cobalt and nickel chlorides) on intestinal iron absorption
    G O Latunde-Dada
    King s College, London, UK
    Eur J Clin Invest 34:626-30. 2004
    ..CoCl2 and NiCl2 are activators of haem oxygenase, the rate-limiting enzyme in haem catabolism. Co2+ and Ni2+ may also regulate and increase iron absorption through a mechanism that simulates hypoxic conditions in the tissues...
  20. ncbi Impaired iron transport activity of ferroportin 1 in hereditary iron overload
    J A McGregor
    Division of Nutritional Sciences, King s College London, London, UK
    J Membr Biol 206:3-7. 2005
    ..The Q248H and V162Delta mutations were intermediate between these values. Co-injection of mutant and wild-type mRNAs revealed that the A77D and N144H mutations had a dominant negative effect on the function of the WT protein...
  21. ncbi Time-course of iron overload and biochemical, histopathological and ultrastructural evidence of pancreatic damage in hypotransferrinaemic mice
    R J Simpson
    Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London, U K
    Clin Sci (Lond) 93:453-62. 1997
    ..The hypotransferrinaemic mouse pancreas is a useful model system for investigation of parenchymal cell damage by iron...
  22. ncbi Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism
    G O Latunde-Dada
    Division of Life Sciences, King s College, 150 Stamford Street, London SE1 9NN, UK
    Blood Cells Mol Dis 29:356-60. 2002
    ..Dcytb expression was found in other tissues apart from the duodenum and its regulation and functions at these other sites are of interest in iron metabolism...