Research Topics
| Sheena McCormackSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Detail Information
Publications
EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C aloneSheena McCormack
MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
Vaccine 26:3162-74. 2008..Of the 9 individuals with responses to envelope and other peptides, 8 were in the DNA-C group. These promising results suggest that DNA-C was an effective priming agent, that merits further investigation...
PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trialSheena McCormack
MRC Clinical Trials Unit, London, UK
Lancet 376:1329-37. 2010..PRO2000 vaginal gel was efficacious against HIV-1 transmission in studies in macaques; we aimed to assess efficacy and safety of 2% and 0·5% PRO2000 gels against vaginal HIV-1 transmission in women in sub-Saharan Africa...- Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, TanzaniaAndrew Vallely
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
BMC Med Ethics 10:17. 2009..This paper describes a community-focused approach to develop a locally-appropriate SoC in the context of a phase III vaginal microbicide trial in Mwanza City, northwest Tanzania... - Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV preventionAndrew Nunn
MRC Clinical Trials Unit, UK
Trials 10:99. 2009..The main objective of the trial is to determine the efficacy and safety of 0.5% and 2% concentrations of PRO 2000/5 gel compared to placebo in preventing vaginally acquired HIV infection... - How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, TanzaniaAndrew Vallely
London School of Hygiene and Tropical Medicine, London, UK
BMC Med Ethics 11:10. 2010..The purpose of this study was to investigate the effectiveness of a continuous informed consent process adopted during the MDP301 phase III vaginal microbicide trial in Mwanza, Tanzania... 
A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteersSheena McCormack
Medical Research Council Clinical Trials Unit, London, UK
Sex Transm Dis 32:765-70. 2005..Part A was a randomized, placebo-controlled, double-blind, 3-arm trial (DS4%, DS1%, placebo) in HIV-negative women. In part B, HIV-positive women received DS4% and HIV-negative women were randomized to DS4% or no gel...- HIV prevention research: taking stock and the way forwardRichard Hayes
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
AIDS 24:S81-92. 2010..In future HIV prevention research, it is important that resources are used as efficiently as possible to provide rigorous evidence of the effectiveness of a wider array of complementary prevention tools... - The potential for central monitoring techniques to replace on-site monitoring: findings from an international multi-centre clinical trialJulie M Bakobaki
Medical Research Council Clinical Trials Unit, London, UK
Clin Trials 9:257-64. 2012.... - Vaginal microbicidesSheena McCormack
MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
Curr Opin Infect Dis 15:57-62. 2002..The focus of this review will be to highlight articles from 2000 and up to August 2001 that demonstrate the challenges in the evaluation of candidate microbicides, and the ways in which investigators have approached these challenges...