Sheena McCormack

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda
    Andrew Abaasa
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    Trials 14:33. 2013
  2. ncbi request reprint EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone
    Sheena McCormack
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Vaccine 26:3162-74. 2008
  3. pmc PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
    Sheena McCormack
    MRC Clinical Trials Unit, London, UK
    Lancet 376:1329-37. 2010
  4. pmc Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, Tanzania
    Andrew Vallely
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Med Ethics 10:17. 2009
  5. pmc Injectable and oral contraceptives and risk of HIV acquisition in women: an analysis of data from the MDP301 trial
    Angela M Crook
    MRC Clinical Trials Unit at UCL, London, UK
    Hum Reprod 29:1810-7. 2014
  6. pmc Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
    Andrew Nunn
    MRC Clinical Trials Unit, UK
    Trials 10:99. 2009
  7. pmc How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania
    Andrew Vallely
    London School of Hygiene and Tropical Medicine, London, UK
    BMC Med Ethics 11:10. 2010
  8. ncbi request reprint A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteers
    Sheena McCormack
    Medical Research Council Clinical Trials Unit, London, UK
    Sex Transm Dis 32:765-70. 2005
  9. pmc HIV prevention research: taking stock and the way forward
    Richard Hayes
    MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
    AIDS 24:S81-92. 2010
  10. doi request reprint Audit of HIV testing frequency and behavioural interventions for men who have sex with men: policy and practice in sexual health clinics in England
    Monica Desai
    HIV and STI Department, Health Protection Agency, London, UK
    Sex Transm Infect 89:404-8. 2013

Collaborators

Detail Information

Publications12

  1. pmc Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda
    Andrew Abaasa
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    Trials 14:33. 2013
    ..We assessed the long-term correlates of consistent gel use in the MDP 301 clinical trial among HIV-negative women in sero-discordant couples in south-west Uganda...
  2. ncbi request reprint EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone
    Sheena McCormack
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Vaccine 26:3162-74. 2008
    ..Of the 9 individuals with responses to envelope and other peptides, 8 were in the DNA-C group. These promising results suggest that DNA-C was an effective priming agent, that merits further investigation...
  3. pmc PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
    Sheena McCormack
    MRC Clinical Trials Unit, London, UK
    Lancet 376:1329-37. 2010
    ..PRO2000 vaginal gel was efficacious against HIV-1 transmission in studies in macaques; we aimed to assess efficacy and safety of 2% and 0·5% PRO2000 gels against vaginal HIV-1 transmission in women in sub-Saharan Africa...
  4. pmc Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, Tanzania
    Andrew Vallely
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Med Ethics 10:17. 2009
    ..This paper describes a community-focused approach to develop a locally-appropriate SoC in the context of a phase III vaginal microbicide trial in Mwanza City, northwest Tanzania...
  5. pmc Injectable and oral contraceptives and risk of HIV acquisition in women: an analysis of data from the MDP301 trial
    Angela M Crook
    MRC Clinical Trials Unit at UCL, London, UK
    Hum Reprod 29:1810-7. 2014
    ..Do injectable and oral contraceptives increase the risk of human immunodeficiency virus (HIV) acquisition in women?..
  6. pmc Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
    Andrew Nunn
    MRC Clinical Trials Unit, UK
    Trials 10:99. 2009
    ..The main objective of the trial is to determine the efficacy and safety of 0.5% and 2% concentrations of PRO 2000/5 gel compared to placebo in preventing vaginally acquired HIV infection...
  7. pmc How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania
    Andrew Vallely
    London School of Hygiene and Tropical Medicine, London, UK
    BMC Med Ethics 11:10. 2010
    ..The purpose of this study was to investigate the effectiveness of a continuous informed consent process adopted during the MDP301 phase III vaginal microbicide trial in Mwanza, Tanzania...
  8. ncbi request reprint A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteers
    Sheena McCormack
    Medical Research Council Clinical Trials Unit, London, UK
    Sex Transm Dis 32:765-70. 2005
    ..Part A was a randomized, placebo-controlled, double-blind, 3-arm trial (DS4%, DS1%, placebo) in HIV-negative women. In part B, HIV-positive women received DS4% and HIV-negative women were randomized to DS4% or no gel...
  9. pmc HIV prevention research: taking stock and the way forward
    Richard Hayes
    MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
    AIDS 24:S81-92. 2010
    ..In future HIV prevention research, it is important that resources are used as efficiently as possible to provide rigorous evidence of the effectiveness of a wider array of complementary prevention tools...
  10. doi request reprint Audit of HIV testing frequency and behavioural interventions for men who have sex with men: policy and practice in sexual health clinics in England
    Monica Desai
    HIV and STI Department, Health Protection Agency, London, UK
    Sex Transm Infect 89:404-8. 2013
    ..We reviewed current policy and practice for HIV testing and behavioural interventions (BI) in England to determine adherence to guidance...
  11. doi request reprint The potential for central monitoring techniques to replace on-site monitoring: findings from an international multi-centre clinical trial
    Julie M Bakobaki
    Medical Research Council Clinical Trials Unit, London, UK
    Clin Trials 9:257-64. 2012
    ....
  12. ncbi request reprint Vaginal microbicides
    Sheena McCormack
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Curr Opin Infect Dis 15:57-62. 2002
    ..The focus of this review will be to highlight articles from 2000 and up to August 2001 that demonstrate the challenges in the evaluation of candidate microbicides, and the ways in which investigators have approached these challenges...