Ann Marie Mallon

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint CRAVE: a database, middleware and visualization system for phenotype ontologies
    Georgios V Gkoutos
    Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Bioinformatics 21:1257-62. 2005
  2. pmc Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project
    Chris F Taylor
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    Nat Biotechnol 26:889-96. 2008
  3. pmc EuroPhenome: a repository for high-throughput mouse phenotyping data
    Hugh Morgan
    MRC Harwell, Mammalian Genetics Unit, MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK
    Nucleic Acids Res 38:D577-85. 2010
  4. pmc MouseBook: an integrated portal of mouse resources
    Andrew Blake
    MRC Harwell, Mammalian Genetics Unit and the Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK
    Nucleic Acids Res 38:D593-9. 2010
  5. doi request reprint Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans
    Ann Marie Mallon
    Mammalian Genetics Unit, Medical Research Council Harwell, Harwell, Oxfordshire OX11 0RD, UK
    Mamm Genome 23:641-52. 2012
  6. pmc Anatomy ontologies and potential users: bridging the gap
    Ravensara S Travillian
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    J Biomed Semantics 2:S3. 2011
  7. pmc EuroPhenome and EMPReSS: online mouse phenotyping resource
    Ann Marie Mallon
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK
    Nucleic Acids Res 36:D715-8. 2008
  8. pmc Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data
    Tim Beck
    MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK
    BMC Bioinformatics 10:S2. 2009
  9. pmc Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease
    John M Hancock
    Bioinformatics Group, MRC Harwell, Harwell, Oxfordshire, OX11 0RD, UK
    Mamm Genome 20:457-61. 2009
  10. pmc Using ontologies to describe mouse phenotypes
    Georgios V Gkoutos
    Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK
    Genome Biol 6:R8. 2005

Detail Information

Publications17

  1. ncbi request reprint CRAVE: a database, middleware and visualization system for phenotype ontologies
    Georgios V Gkoutos
    Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Bioinformatics 21:1257-62. 2005
    ..However tools are not currently available to visualize combinations of ontologies. Here we describe CRAVE (Concept Relation Assay Value Explorer), a package allowing storage, active updating and visualization of multiple ontologies...
  2. pmc Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project
    Chris F Taylor
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    Nat Biotechnol 26:889-96. 2008
  3. pmc EuroPhenome: a repository for high-throughput mouse phenotyping data
    Hugh Morgan
    MRC Harwell, Mammalian Genetics Unit, MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK
    Nucleic Acids Res 38:D577-85. 2010
    ..To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies...
  4. pmc MouseBook: an integrated portal of mouse resources
    Andrew Blake
    MRC Harwell, Mammalian Genetics Unit and the Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK
    Nucleic Acids Res 38:D593-9. 2010
    ..The infrastructure underlying MouseBook has been designed to be extensible, allowing additional data sources to be added and enabling other sites to make their data directly available through MouseBook...
  5. doi request reprint Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans
    Ann Marie Mallon
    Mammalian Genetics Unit, Medical Research Council Harwell, Harwell, Oxfordshire OX11 0RD, UK
    Mamm Genome 23:641-52. 2012
    ..Here we review the existing EuroPhenome and WTSI phenotype informatics systems and the IKMC portal, and present plans for extending these systems and lessons learned to the development of a robust IMPC informatics infrastructure...
  6. pmc Anatomy ontologies and potential users: bridging the gap
    Ravensara S Travillian
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    J Biomed Semantics 2:S3. 2011
    ..To evaluate how well current anatomical ontologies fit the way real-world users apply anatomy terms in their data annotations...
  7. pmc EuroPhenome and EMPReSS: online mouse phenotyping resource
    Ann Marie Mallon
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK
    Nucleic Acids Res 36:D715-8. 2008
    ..EuroPhenome will be the repository for a recently initiated effort to carry out large-scale phenotyping on a large number of knockout mouse lines (EUMODIC)...
  8. pmc Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data
    Tim Beck
    MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK
    BMC Bioinformatics 10:S2. 2009
    ....
  9. pmc Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease
    John M Hancock
    Bioinformatics Group, MRC Harwell, Harwell, Oxfordshire, OX11 0RD, UK
    Mamm Genome 20:457-61. 2009
    ....
  10. pmc Using ontologies to describe mouse phenotypes
    Georgios V Gkoutos
    Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK
    Genome Biol 6:R8. 2005
    ..This produces a framework with greater flexibility, power and economy than previous approaches. We discuss some of the issues this approach raises...
  11. doi request reprint The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
    Gautier Koscielny
    European Molecular Biology Laboratory, European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Medical Research Council Harwell Mammalian Genetics Unit and Mary Lyon Centre, Harwell, Oxfordshire OX11 0RD, UK and Mouse Informatics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 42:D802-9. 2014
    ..As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases. ..
  12. doi request reprint Accessing and mining data from large-scale mouse phenotyping projects
    Hugh Morgan
    MRC Mammalian Genetics Unit, MRC Harwell, Oxfordshire, OX11 0RD, UK
    Int Rev Neurobiol 104:47-70. 2012
    ..nih.gov/KOMP2/)-funded informatics consortium to scale these implementations to manage the surge in data from the IMPC...
  13. doi request reprint High-throughput mouse phenotyping
    Hilary Gates
    MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0RD, UK
    Methods 53:394-404. 2011
    ..EMPReSSslim data is displayed within the EuroPhenome database, where a variety of tools are available to allow the user to search for interesting biological or clinical phenotypes...
  14. doi request reprint Phenobabelomics--mouse phenotype data resources
    John M Hancock
    Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Brief Funct Genomic Proteomic 6:292-301. 2007
    ....
  15. pmc Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse
    Ann Marie Mallon
    Medical Research Council Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom
    Genome Res 14:1888-901. 2004
    ..This analysis will facilitate functional genomic analysis of Del36H and provides insights into mouse genome evolution...
  16. ncbi request reprint Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31
    Philomena Mburu
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
    Nat Genet 34:421-8. 2003
    ..Our findings suggest that this novel PDZ domain-containing molecule acts as an organizer of submembranous molecular complexes that control the coordinated actin polymerization and membrane growth of stereocilia...
  17. ncbi request reprint Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources
    John M Hancock
    Mamm Genome 18:157-63. 2007
    ..This process is ongoing and needs to be supported by the wider mouse genetics and phenotyping communities to succeed. We invite interested parties to contact us as we develop this process further...