Mary F Lyon

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint X-chromosome inactivation: a repeat hypothesis
    M F Lyon
    Medical Research Council, Mammalian Genetics Unit, Didcot, Oxon, UK
    Cytogenet Cell Genet 80:133-7. 1998
  2. ncbi request reprint Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop)
    M F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, UK
    Mol Vis 6:199-203. 2000
  3. ncbi request reprint X-chromosome inactivation and human genetic disease
    M F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, UK
    Acta Paediatr Suppl 91:107-12. 2002
  4. pmc Narrowing the critical regions for mouse t complex transmission ratio distortion factors by use of deletions
    M F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxon, United Kingdom
    Genetics 155:793-801. 2000
  5. ncbi request reprint A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding
    Mary F Lyon
    Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD, UK
    Hum Mol Genet 12:585-94. 2003
  6. ncbi request reprint A personal history of the mouse genome
    Mary F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 0RD, United Kingdom
    Annu Rev Genomics Hum Genet 3:1-16. 2002
  7. ncbi request reprint James Neel and the doubling dose concept
    Mary F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot OX11 0RD, UK
    Mutat Res 543:115-20. 2003
  8. ncbi request reprint Transmission ratio distortion in mice
    Mary F Lyon
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxon OX11 0RD, United Kingdom
    Annu Rev Genet 37:393-408. 2003
  9. ncbi request reprint The Lyon and the LINE hypothesis
    Mary F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 ORD, UK
    Semin Cell Dev Biol 14:313-8. 2003
  10. pmc Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification
    Tertius A Hough
    Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council, Harwell, Oxfordshire OX11 0RD, United Kingdom
    Proc Natl Acad Sci U S A 101:13566-71. 2004

Detail Information

Publications24

  1. ncbi request reprint X-chromosome inactivation: a repeat hypothesis
    M F Lyon
    Medical Research Council, Mammalian Genetics Unit, Didcot, Oxon, UK
    Cytogenet Cell Genet 80:133-7. 1998
    ..This leads to the silencing of these elements and the intervening unique sequences by their conversion to heterochromatin...
  2. ncbi request reprint Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop)
    M F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, UK
    Mol Vis 6:199-203. 2000
    ..Here we report further studies of the mutant cataract and curly whiskers (Ccw), previously mapped to Chromosome 4, and also investigations of the corneal opacity (Coop) mutant, which is shown to involve a mutation in the Pax6 gene...
  3. ncbi request reprint X-chromosome inactivation and human genetic disease
    M F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, UK
    Acta Paediatr Suppl 91:107-12. 2002
    ..In rare cases, changes in the Xist gene can cause skewing of X-inactivation. A few genes escape from X-inactivation either wholly or partially...
  4. pmc Narrowing the critical regions for mouse t complex transmission ratio distortion factors by use of deletions
    M F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxon, United Kingdom
    Genetics 155:793-801. 2000
    ..It is suggested that the original distorter Tcd1 in fact consists of two loci: Tcd1a, lying between D17Mit164 and D17Leh48, and Tcd1b, lying between T and D17Leh66E...
  5. ncbi request reprint A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding
    Mary F Lyon
    Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD, UK
    Hum Mol Genet 12:585-94. 2003
    ..The Ofl mutant therefore provides a valuable model system for the study of Maf, and its interacting factors, in normal and abnormal lens and anterior segment development...
  6. ncbi request reprint A personal history of the mouse genome
    Mary F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 0RD, United Kingdom
    Annu Rev Genomics Hum Genet 3:1-16. 2002
    ..The completion of the mouse DNA sequence is now imminent, opening fascinating prospects for the analysis of gene function...
  7. ncbi request reprint James Neel and the doubling dose concept
    Mary F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot OX11 0RD, UK
    Mutat Res 543:115-20. 2003
    ..James Neel, as a result of his studies on the offspring of atomic bomb survivors, showed that this was not so, but that different doubling doses could be inferred from different endpoints...
  8. ncbi request reprint Transmission ratio distortion in mice
    Mary F Lyon
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxon OX11 0RD, United Kingdom
    Annu Rev Genet 37:393-408. 2003
    ..Three candidate distorter genes have also been identified as genes coding for dynein chains, and thus possibly involved in sperm flagellar function...
  9. ncbi request reprint The Lyon and the LINE hypothesis
    Mary F Lyon
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 ORD, UK
    Semin Cell Dev Biol 14:313-8. 2003
    ..Interspersed repeat elements, and in particular long interspersed elements (LINEs), have been suggested as the relevant enriching features. Recent evidence concerning this hypothesis is discussed...
  10. pmc Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification
    Tertius A Hough
    Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council, Harwell, Oxfordshire OX11 0RD, United Kingdom
    Proc Natl Acad Sci U S A 101:13566-71. 2004
    ....
  11. ncbi request reprint An additional type of male sterility and inherited urinary obstruction in mice with the t-haplotype th7
    M F Lyon
    Mammalian Genetics Unit, Medical Research Council, Didcot, Oxon, UK
    Genet Res 67:249-56. 1996
    ..The symbol Msu for male sterility and urinary obstruction is suggested for the locus concerned. Previously a recessive form of abnormal behaviour had also been attributed to this duplication...
  12. ncbi request reprint Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse
    S Kerscher
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 ORD, United Kingdom
    Genomics 36:17-21. 1996
    ..While there are no obvious candidate genes in the vicinity of the Ccw, Npp, and Opj mutations, To3 lies remarkably close to the recently mapped Lim2 locus, which encodes lens intrinsic membrane protein 2, also called MP19...
  13. pmc The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome
    M F Lyon
    Medical Research Council Radiobiology Unit, Didcot, Oxon, United Kingdom
    Proc Natl Acad Sci U S A 87:2433-7. 1990
    ..Scurfy differs from Wiskott-Aldrich syndrome in that scurfy males are consistently hypogonadal...
  14. ncbi request reprint Deletion of mouse t-complex distorter-1 produces an effect like that of the t-form of the distorter
    M F Lyon
    MRC Radiobiology Unit, Didcot, Oxon, UK
    Genet Res 59:27-33. 1992
    ..It is speculated that other t-complex distorters, Tcd-2t and Tcd-3t, may also be amorphs or hypomorphs.(ABSTRACT TRUNCATED AT 250 WORDS)..
  15. ncbi request reprint Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19)
    S Kerscher
    MRC Radiobiology Unit, Didcot, Oxfordshire, United Kingdom
    Genomics 29:445-50. 1995
    ..5 +/- 2.5 cM proximal to Ngfg. All four map positions, when compared with the corresponding positions in human, lie within known regions of conserved synteny between mouse and human chromosomes...
  16. pmc Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse
    M F Lyon
    Medical Research Council Radiobiology Unit, Didcot, Oxon, England
    Proc Natl Acad Sci U S A 89:6968-72. 1992
    ..The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome...
  17. ncbi request reprint Doublefoot: a new mouse mutant affecting development of limbs and head
    M F Lyon
    Mammalian Genetics Unit, Medical Research Council, Didcot, Oxfordshire, UK
    Genet Res 68:221-31. 1996
    ..The gene maps close to the locus of Pax3, but crossovers between Dbf and Pax3 have been found, ruling out the possibility that a gain-of-function mutation in Pax3 might be involved...
  18. pmc A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4
    M F Lyon
    Medical Research Council Radiobiology Unit, Didcot, Oxon, United Kingdom
    Proc Natl Acad Sci U S A 90:9717-20. 1993
    ..71 +/- 0.50 cM-(Eno-1, D4Mit33)-1.4 +/- 0.70 cM-D4Mit42-2.5 +/- 0.93 cM-D4Smh6b. The information on the position of the Wld locus should be valuable in further characterization of this gene involved in nerve degeneration and regeneration...
  19. ncbi request reprint Mapping of six dominant cataract genes in the mouse
    C A Everett
    MRC Radiobiology Unit, Chilton, Didcot, Oxon, United Kingdom
    Genomics 20:429-34. 1994
    ..A third mutant, provisionally designated Npp, mapped to Chromosome 5, 1.3 +/- 0.9 cM from the locus of W, and thus probably has a homologue on human Chromosome 4...
  20. ncbi request reprint Mouse globin gene nomenclature
    M F Lyon
    MRC Radiobiology Unit, Didcot, Oxon, England
    J Hered 79:93-5. 1988
    ..A new system of nomenclature for haplotypes, genes, alleles, and mutant alleles in the mouse alpha- and beta-globin gene complexes was formulated at a meeting of workers in the field and is presented here...
  21. ncbi request reprint A high-resolution genetic, physical, and comparative gene map of the doublefoot (Dbf) region of mouse chromosome 1 and the region of conserved synteny on human chromosome 2q35
    C Hayes
    Medical Research Council, Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Didcot, Oxon, OX11 0RD, UK
    Genomics 78:197-205. 2001
    ..These genes include those encoding known developmental signaling molecules such as WNT proteins and IHH, and we provide evidence that these genes are candidates for the Dbf mutation...
  22. ncbi request reprint Extent of the mouse t complex and its inversions shown by in situ hybridization
    M F Lyon
    M R C Radiobiology Unit, Chilton, Didcot, Oxon, UK
    Immunogenetics 27:375-82. 1988
    ..It may soon be possible to correlate the length of the t complex in terms of chromosomal distance with its physical length in megabases...
  23. ncbi request reprint Elucidating mouse transmission ratio distortion
    Mary F Lyon
    Nat Genet 37:924-5. 2005
  24. ncbi request reprint No longer 'all-or-none'
    Mary F Lyon
    Eur J Hum Genet 13:796-7. 2005