Mary F Lyon

..This leads to the silencing of these elements and the intervening unique sequences by their conversion to heterochromatin...

..Here we report further studies of the mutant cataract and curly whiskers (Ccw), previously mapped to Chromosome 4, and also investigations of the corneal opacity (Coop) mutant, which is shown to involve a mutation in the Pax6 gene...

..The occurrence of this normal process affects the phenotype seen in females carrying X-linked mutant genes or chromosome anomalies...

..It is suggested that the original distorter Tcd1 in fact consists of two loci: Tcd1a, lying between D17Mit164 and D17Leh48, and Tcd1b, lying between T and D17Leh66E...

..The Ofl mutant therefore provides a valuable model system for the study of Maf, and its interacting factors, in normal and abnormal lens and anterior segment development...

..The completion of the mouse DNA sequence is now imminent, opening fascinating prospects for the analysis of gene function...

..James Neel, as a result of his studies on the offspring of atomic bomb survivors, showed that this was not so, but that different doubling doses could be inferred from different endpoints...

..Three candidate distorter genes have also been identified as genes coding for dynein chains, and thus possibly involved in sperm flagellar function...

..Interspersed repeat elements, and in particular long interspersed elements (LINEs), have been suggested as the relevant enriching features. Recent evidence concerning this hypothesis is discussed...

....

..The symbol Msu for male sterility and urinary obstruction is suggested for the locus concerned. Previously a recessive form of abnormal behaviour had also been attributed to this duplication...

..While there are no obvious candidate genes in the vicinity of the Ccw, Npp, and Opj mutations, To3 lies remarkably close to the recently mapped Lim2 locus, which encodes lens intrinsic membrane protein 2, also called MP19...

..Scurfy differs from Wiskott-Aldrich syndrome in that scurfy males are consistently hypogonadal...

..It is speculated that other t-complex distorters, Tcd-2t and Tcd-3t, may also be amorphs or hypomorphs.(ABSTRACT TRUNCATED AT 250 WORDS)..

..5 +/- 2.5 cM proximal to Ngfg. All four map positions, when compared with the corresponding positions in human, lie within known regions of conserved synteny between mouse and human chromosomes...

..The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome...

..The gene maps close to the locus of Pax3, but crossovers between Dbf and Pax3 have been found, ruling out the possibility that a gain-of-function mutation in Pax3 might be involved...

..71 +/- 0.50 cM-(Eno-1, D4Mit33)-1.4 +/- 0.70 cM-D4Mit42-2.5 +/- 0.93 cM-D4Smh6b. The information on the position of the Wld locus should be valuable in further characterization of this gene involved in nerve degeneration and regeneration...

..A third mutant, provisionally designated Npp, mapped to Chromosome 5, 1.3 +/- 0.9 cM from the locus of W, and thus probably has a homologue on human Chromosome 4...

..A new system of nomenclature for haplotypes, genes, alleles, and mutant alleles in the mouse alpha- and beta-globin gene complexes was formulated at a meeting of workers in the field and is presented here...

..These genes include those encoding known developmental signaling molecules such as WNT proteins and IHH, and we provide evidence that these genes are candidates for the Dbf mutation...

..It may soon be possible to correlate the length of the t complex in terms of chromosomal distance with its physical length in megabases...