Q L Lu

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi Massive idiosyncratic exon skipping corrects the nonsense mutation in dystrophic mouse muscle and produces functional revertant fibers by clonal expansion
    Q L Lu
    Muscle Cell Biology, Medical Research Council Clinical Science Center, Hammersmith Hospital, London W12 ONN, UK
    J Cell Biol 148:985-96. 2000
  2. ncbi Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse
    Qi Long Lu
    Muscle Cell Biology, MRC Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Med 9:1009-14. 2003
  3. ncbi T-cell-dependent fibrosis in the mdx dystrophic mouse
    J Morrison
    Muscle Cell Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Lab Invest 80:881-91. 2000
  4. ncbi Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage
    Q L Lu
    Muscle Cell Biology, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Gene Ther 10:396-405. 2003
  5. ncbi Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles
    Qi Long Lu
    Muscle Cell Biology, Medical Research Council Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Proc Natl Acad Sci U S A 102:198-203. 2005
  6. ncbi Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology
    Julia Alter
    Muscle Cell Biology, MRC Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Med 12:175-7. 2006
  7. ncbi Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
    Bo Wu
    McColl Lockwood Laboratory for Muscular Dystrophy, Neuromuscular ALS Center, Carolinas Medical Center, Charlotte, NC 28231, USA
    Proc Natl Acad Sci U S A 105:14814-9. 2008
  8. ncbi Optimisation of ultrasound-mediated gene transfer (sonoporation) in skeletal muscle cells
    Hai Dong Liang
    Ultrasound Group, Imaging Sciences Department, Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0HS, UK
    Ultrasound Med Biol 30:1523-9. 2004

Collaborators

Detail Information

Publications8

  1. ncbi Massive idiosyncratic exon skipping corrects the nonsense mutation in dystrophic mouse muscle and produces functional revertant fibers by clonal expansion
    Q L Lu
    Muscle Cell Biology, Medical Research Council Clinical Science Center, Hammersmith Hospital, London W12 ONN, UK
    J Cell Biol 148:985-96. 2000
    ..The dystrophin gene in the mdx mouse provides a favored system for study of exon skipping associated with nonsense mutations...
  2. ncbi Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse
    Qi Long Lu
    Muscle Cell Biology, MRC Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Med 9:1009-14. 2003
    ..Our data establishes the realistic practicality of an approach that is applicable, in principle, to a majority of cases of severe dystrophinopathy...
  3. ncbi T-cell-dependent fibrosis in the mdx dystrophic mouse
    J Morrison
    Muscle Cell Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Lab Invest 80:881-91. 2000
    ..This suggests that T-cells play a role in the onset of the fibrotic events that undermines the ability of dystrophic muscle to regenerate...
  4. ncbi Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage
    Q L Lu
    Muscle Cell Biology, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Gene Ther 10:396-405. 2003
    ..The safe clinical use of microbubbles and therapeutic ultrasound and, particularly, the protective effect of the microbubbles against tissue damage provide a highly promising approach for gene delivery in muscle in vivo...
  5. ncbi Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles
    Qi Long Lu
    Muscle Cell Biology, Medical Research Council Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Proc Natl Acad Sci U S A 102:198-203. 2005
    ..We conclude that a significant therapeutic effect may be achieved by further optimization in dose and regime of administration of antisense oligonucleotide...
  6. ncbi Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology
    Julia Alter
    Muscle Cell Biology, MRC Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Med 12:175-7. 2006
    ..Although the level of dystrophin expression achieved varies considerably between muscles, antisense therapy may provide a realistic hope for the treatment of a majority of individuals with DMD...
  7. ncbi Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
    Bo Wu
    McColl Lockwood Laboratory for Muscular Dystrophy, Neuromuscular ALS Center, Carolinas Medical Center, Charlotte, NC 28231, USA
    Proc Natl Acad Sci U S A 105:14814-9. 2008
    ..The high degree of potency of the oligomer in targeting all muscles and the lack of detectable toxicity and immune response support the feasibility of testing the novel oligomer in treating Duchenne muscular dystrophy patients...
  8. ncbi Optimisation of ultrasound-mediated gene transfer (sonoporation) in skeletal muscle cells
    Hai Dong Liang
    Ultrasound Group, Imaging Sciences Department, Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0HS, UK
    Ultrasound Med Biol 30:1523-9. 2004
    ..We conclude that low-intensity US irradiation provides a safe and effective alternative for gene delivery...