Research Topics
Genomes and Genes
| Farida LatifSummaryAffiliation: National Institute for Medical Research Country: UK Publications
| Collaborators
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Detail Information
Publications
A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylationHelena Caren
Department of Clinical Genetics, Institute for the Health of Women and Children, Goteborg University, Sahlgrenska Univ, Hospital East, SE 41685 Gothenburg, Sweden
Mol Cancer 4:10. 2005..22 region in order to find an explanation for a possible down-regulation of this region...
Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancersAshraf Dallol
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
Oncogene 21:3020-8. 2002..Our findings suggest that DUTT1 warrants further analysis as a candidate for the tumour suppressor gene (TSG) at 3p12, a region defined by hemi and homozygous deletions and functional analysis...- Involvement of the RASSF1A tumor suppressor gene in controlling cell migrationAshraf Dallol
Section of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Cancer Res 65:7653-9. 2005..These findings represent a novel function for RASSF1A, which may help explain its tumor suppression ability independently of its effects on cell cycle and apoptosis... - The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemiasLuke B Hesson
Department of Medical and Molecular Genetics, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, B15 2TT, UK
Mol Cancer 8:42. 2009..We also determined the methylation status of CpG islands associated with RASSF1-10 in a series of childhood acute lymphocytic leukaemias (ALL) and normal blood and bone marrow samples... - SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cellsAshraf Dallol
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, United Kingdom
Cancer Res 63:1054-8. 2003..In addition, conditioned medium from SLIT2-transfected COS-7 cells reduced cell growth and induced apoptosis in SW48 colorectal tumor cell line. In conclusion, SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer... - Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastomaAngelo Agathanggelou
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, United Kingdom
Cancer Res 63:5344-51. 2003..The identified targets are involved in diverse cellular processes; this should help toward understanding mechanisms that contribute to RASSF1A biological activity... - Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinomaMark R Morris
Cancer Research UK Renal Molecular Oncology Group, University of Birmingham, Edgbaston, United Kingdom
Cancer Res 65:4598-606. 2005..This information provides opportunities to develop novel targeted approaches to the treatment of RCC... - A genome-wide screen identifies frequently methylated genes in haematological and epithelial cancersThomas Dunwell
Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B152TT, UK
Mol Cancer 9:44. 2010..High throughput screens are required to identify epigenetic markers that can be useful for diagnostic and prognostic purposes across malignancies... - Frequent epigenetic inactivation of the SLIT2 gene in gliomasAshraf Dallol
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, UK
Oncogene 22:4611-6. 2003..2. Furthermore, our data suggest that a detailed analysis of both the cancer genome and epigenome will be required to identify key TSGs involved in glioma development... 
Germline SDHB mutations and familial renal cell carcinomaChristopher Ricketts
Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK
J Natl Cancer Inst 100:1260-2. 2008....- Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancersAngelo Agathanggelou
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
Oncogene 22:1580-8. 2003..Together, these data suggest a significant role for epigenetic inactivation of BLU in the pathogenesis of common human cancers and that methylation inactivation of BLU occurs independent of RASSF1A in SCLC and neuroblastoma tumours... - SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancersAshraf Dallol
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, United Kingdom
Cancer Res 62:5874-80. 2002..2... - Identification of 5 novel genes methylated in breast and other epithelial cancersVictoria K Hill
Department of Medical and Molecular Genetics, University of Birmingham, UK
Mol Cancer 9:51. 2010..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer... - CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutationsLuke B Hesson
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Oncogene 24:3987-94. 2005.... - Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemiaVictoria K Hill
Medical and Molecular Genetics, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK
Epigenetics 6:326-32. 2011..Hence KIBRA methylation occurs frequently in B-cell acute lymphocytic leukemia but not in epithelial cancers and is linked to specific genetic event in B-ALL... - Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibilityDewi Astuti
Centre for Rare Diseases and Personalised Medicine, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK
Nat Genet 44:277-84. 2012..We also detected evidence of DIS3L2 mutations in sporadic Wilms tumor. These observations suggest that DIS3L2 has a critical role in RNA metabolism and is essential for the regulation of cell growth and division... - Frequent epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic leukemiaThomas L Dunwell
Section of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK
Epigenetics 4:265-9. 2009..Our results demonstrate that methylation of the SLIT2 5' CpG island is conserved between mice and humans, and therefore is likely to be of functional importance... - Transcriptional regulation of cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin A2 promoterJalal Ahmed-Choudhury
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
Cancer Res 65:2690-7. 2005..Together, these data identify the cyclin A2 gene as a cellular target for RASSF1A through p120(E4F) and for the first time suggest a transcriptional mechanism for RASSF1A-dependent cell cycle regulation... - Investigation of the Birt-Hogg-Dube tumour suppressor gene (FLCN) in familial and sporadic colorectal cancerMichael S Nahorski
Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, University of Birmingham College of Medical and Dental Sciences, Edgbaston, Birmingham B15 2TT, UK
J Med Genet 47:385-90. 2010..CONCLUSIONS These findings suggest that the previously reported clinical heterogeneity for colorectal neoplasia may reflect allelic heterogeneity and the risk of colorectal neoplasia in BHD syndrome requires further investigation... - Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumoursSofia Honorio
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, UK
Oncogene 22:461-6. 2003..0016). These findings are consistent with a multistep model for TGCT pathogenesis in which RASSF1A methylation occurs early in tumorigenesis and additional epigenetic events characterize progression from seminoma to NSTGCTs... - Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor geneSarah L Fenton
Section of Medical and Molecular Genetics, Department of Reproductive and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham, United Kingdom
Cancer Res 64:102-7. 2004..As p120(E4F) has been reported previously to interact with p14ARF, retinoblastoma, and p53, these findings provide an important link between the function of RASSF1A and other major human tumor suppressor genes... - Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomasLuke Hesson
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, UK
Oncogene 23:2408-19. 2004..In addition, RASSF1A and BLU methylation appear to be independent and specific events and not due to region-wide changes in DNA methylation... - Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patientsSofia Honorio
Department of Paediatrics and Child Health, University of Birmingham, UK
Oncogene 22:147-50. 2003..Furthermore, since RASSF1A promoter hypermethylation was detected in ductal carcinoma in situ, inactivation of RASSF1A may be an early event in breast tumorigenesis... - RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamicsAshraf Dallol
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham, United Kingdom
Cancer Res 64:4112-6. 2004..Our data identify a role for RASSF1A in the regulation of microtubules and cell cycle dynamics that could be part of the mechanism(s) by which RASSF1A exerts its growth inhibition on cancer cells... - KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemiaThoraia Shinawi
University of Birmingham, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, Medical and Molecular Genetics, Edgbaston, Birmingham, UK
Epigenetics 7:211-5. 2012..007) and high CD38 expression (p < 0.05)... - Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinomaChristopher J Ricketts
Centre for Rare Diseases and Personalized Medicine, University of Birmingham, Birmingham, UK
Epigenetics 7:278-90. 2012.... - Frequent epigenetic inactivation of the RASSF1A tumor suppressor gene in Hodgkin's lymphomaPaul G Murray
Department of Pathology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Oncogene 23:1326-31. 2004..Inactivation of RASSF1A could be one mechanism by which HRS cells escape the apoptosis that should occur following nonproductive immunoglobulin gene rearrangements... - Multigene methylation analysis of Wilms' tumour and adult renal cell carcinomaMark R Morris
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, UK
Oncogene 22:6794-801. 2003.... - NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancersLuke Hesson
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, UK
Oncogene 22:947-54. 2003..Our results demonstrate that NORE1A is inactivated in a subset of human cancers by CpG island promoter hypermethylation, and in lung cancer this hypermethylation may be histological type specific... - Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalitiesAshraf Dallol
Section of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Cancer Res 67:492-500. 2007.... - RAN GTPase is a RASSF1A effector involved in controlling microtubule organizationAshraf Dallol
Section of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Curr Biol 19:1227-32. 2009..These findings reveal a mechanism for how RASSF1A controls microtubule stability and for how its loss compromises the integrity of the mitotic spindle, leading to aneuploidy and tumorigenesis... - CpG methylation profiling in VHL related and VHL unrelated renal cell carcinomaFiona E McRonald
Cancer Research UK Renal Molecular Oncology Group, University of Birmingham, Birmingham, UK
Mol Cancer 8:31. 2009.... - Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinomaMark R Morris
Department of Medical and Molecular Genetics, University of Birmingham, Institute of Biomedical Research, Edgbaston, Birmingham, B15 2TT, UK
Anticancer Res 29:4337-43. 2009..Loss of HIF-1alpha expression has been described in RCC cell lines and primary tumours. Whether mutations in the alpha-subunits of HIF-1alpha and HIF-2alpha contribute to renal tumourigenesis was investigated here... - Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibilityDewi Astuti
Centre for Rare Diseases and Personalised Medicine, University of Birmingham, Birmingham B15 2TT, UK
Endocr Relat Cancer 18:73-83. 2011..No confirmed pathogenic mutations were detected suggesting that mutations in these genes are not a frequent cause of inherited phaeochromocytoma or RCC... - Copy number profiling in von Hippel-Lindau disease renal cell carcinomaSalwati Shuib
Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK
Genes Chromosomes Cancer 50:479-88. 2011.... - Epigenetic analysis of childhood acute lymphoblastic leukemiaThomas L Dunwell
Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
Epigenetics 4:185-93. 2009..The identification of frequently methylated genes showing cancer specific methylation will be useful in developing early cancer detection screens and for targeted epigenetic therapies... - Role of the Ras-association domain family 1 tumor suppressor gene in human cancersAngelo Agathanggelou
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, The Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Cancer Res 65:3497-508. 2005..This review summarizes our current knowledge on genetic, epigenetic, and functional analysis of RASSF1A tumor suppressor gene and its homologues... - Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancerKate J Wagner
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, UK
Oncogene 21:7277-82. 2002..We have demonstrated that RASSF1A inactivation is the most frequent genetic or epigenetic event yet reported in Wilms' tumourigenesis and that allelotyping studies may fail to identify regions containing important TSGs... - Epigenetic markers in human gliomas: prospects for therapeutic interventionLuke B Hesson
Department of Reproductive and Child Health, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, B15 2TT, UK
Expert Rev Neurother 8:1475-96. 2008..The eventual application of epigenetic profiling of tumors may help to indicate the most effective tailored therapy for individual patients... - The role of RASSF1A methylation in cancerLuke B Hesson
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
Dis Markers 23:73-87. 2007..This review will discuss the feasibility of using RASSF1A methylation as a diagnostic and prognostic marker in cancer management... - Microarray based analysis of 3p25-p26 deletions (3p- syndrome)Salwati Shuib
Department of Medical and Molecular Genetics, University of Birmingham, Birmingham, UK
Am J Med Genet A 149:2099-105. 2009..We suggest that current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions... - N-terminal RASSF family: RASSF7-RASSF10Nicholas Underhill-Day
Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK
Epigenetics 6:284-92. 2011..Molecular and biological analysis of these newer members has just begun. This review highlights what we currently know in respects to structural, functional and molecular properties of the N-Terminal RASSFs... - Characterization of a 3;6 translocation associated with renal cell carcinomaRebecca E Foster
Department of Medical and Molecular Genetics, University of Birmingham, The Medical School, Birmingham B15 2TT, UK
Genes Chromosomes Cancer 46:311-7. 2007..No known genes were disrupted by the translocation breakpoints but several candidate TSGs (e.g., EPHB1, EPHA7, PPP2R3A RNF184, and STAG1) map within close proximity to the breakpoints... - Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibilityDewi Astuti
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Edgbaston, Birmingham, UK
Clin Endocrinol (Oxf) 59:728-33. 2003..CONCLUSION: The significantly lower frequency (P = 0.028) of germline SDH subunit mutations in familial PC only cases compared to those with familial PC and HNPGL suggests that further PC susceptibility gene(s) remain to be identified... - Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau diseaseMalgorzata Zatyka
Section of Medical and Molecular Genetics, Department of Pediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, United Kingdom
Cancer Res 62:3803-11. 2002..05). These findings suggest that a variety of HIF-independent mechanisms may contribute to pVHL tumor suppressor activity and that polymorphic variation at one pVHL target influences the phenotypic expression of VHL disease... - Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cellsAnil Prasad
Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 283:26624-33. 2008..Our study for the first time reveals that Slit-2-overexpressing breast cancer cells exhibit tumor suppressor capabilities through the novel mechanism of beta-catenin modulation... - Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma developmentMeryl E Lusher
Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle-upon-Tyne, NE2 4HH, United Kingdom
Cancer Res 62:5906-11. 2002..Importantly, these data demonstrate that comprehensive analysis of the genome and epigenome will be required for identification of the key tumor suppressor genes involved in medulloblastoma development... - RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potentialCandice Elam
Department of Cell and Cancer Biology, National Cancer Institute, 9610 Medical Center Drive, Rockville, MD 20820, USA
Cancer Res 65:3117-25. 2005..Thus, we identify a new member of the Ras superfamily that can serve as a potential tumor suppressor... - The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell deathShairaz Baksh
Cancer Biology Program, Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 1038 NRB, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Mol Cell 18:637-50. 2005..Our findings identify RASSF1A and MAP-1 as important components between death receptors and the apoptotic machinery and reveal a potential link between tumor suppression and death receptor signaling... - The RASSF1A tumor suppressor activates Bax via MOAP-1Michele D Vos
Department of Cell and Cancer Biology, NCI, National Institutes of Health, Rockville, Maryland 20850 3300, USA
J Biol Chem 281:4557-63. 2006..Moreover, inhibition of RASSF1A by shRNA impaired the ability of K-Ras to activate Bax. Thus, we identify a novel pro-apoptotic pathway linking K-Ras, RASSF1A and Bax that is specifically impaired in some human tumors... - Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutationsPatrick J Pollard
Molecular and Populations Genetics laboratory, London Research Institute, Cancer Research UK, London, UK
J Clin Endocrinol Metab 91:4593-8. 2006.... - Familial non-VHL clear cell (conventional) renal cell carcinoma: clinical features, segregation analysis, and mutation analysis of FLCNEmma R Woodward
Cancer Research UK Renal Molecular Oncology Group and Department of Medical and Molecular Genetics, University of Birmingham and West Midlands Regional Genetics Service, Birmingham Women s Hospital, United Kingdom
Clin Cancer Res 14:5925-30. 2008.... - RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF familyKristin Eckfeld
Department of Cell and Cancer Biology, National Cancer Institute, Rockville, Maryland 20850, USA
Cancer Res 64:8688-93. 2004..Although broadly expressed in normal tissue, RASSF4 is frequently down-regulated by promoter methylation in human tumor cells. Thus, RASSF4 appears to be a new member of the RASSF family of potential Ras effector/tumor suppressors...