Jean Langhorne

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections
    Bernd Lepenies
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 9:687-94. 2007
  2. doi request reprint Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria
    Nikolai N Belyaev
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 11:477-85. 2010
  3. pmc Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells
    Anne Marit Sponaas
    Division of Parasitology and 2Division of Immunoregulation, National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Exp Med 203:1427-33. 2006
  4. pmc Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria
    Robin Stephens
    MRC National Institute for Medical Research, London, UK
    PLoS Pathog 6:e1001208. 2010
  5. pmc Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure
    Sophie Roetynck
    Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 8:e55195. 2013
  6. pmc Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?
    Deirdre Cunningham
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    PLoS ONE 4:e4285. 2009
  7. pmc Functional memory B cells and long-lived plasma cells are generated after a single Plasmodium chabaudi infection in mice
    Francis Maina Ndungu
    Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Pathog 5:e1000690. 2009
  8. pmc Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malaria
    Robin Stephens
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    PLoS ONE 6:e26686. 2011
  9. pmc Vector transmission regulates immune control of Plasmodium virulence
    Philip J Spence
    Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nature 498:228-31. 2013
  10. pmc Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells
    R Stephens
    National Institute for Medical Research, Division of Parasitology, London, UK
    Parasite Immunol 31:20-31. 2009

Detail Information

Publications63

  1. ncbi request reprint CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections
    Bernd Lepenies
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 9:687-94. 2007
    ..In contrast, blockade of CTLA-4 during infection with a P. yoelii strain exhibiting a higher parasitemia induced markedly increased serum-levels of TNF-alpha, which was associated with severe inflammation and reduced survival...
  2. doi request reprint Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria
    Nikolai N Belyaev
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 11:477-85. 2010
    ..Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection...
  3. pmc Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells
    Anne Marit Sponaas
    Division of Parasitology and 2Division of Immunoregulation, National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Exp Med 203:1427-33. 2006
    ..Our data suggest that the switch in CD4 T cell responses observed in P. chabaudi-infected mice may be the result of the presentation by different DC populations modified by the malaria infection...
  4. pmc Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria
    Robin Stephens
    MRC National Institute for Medical Research, London, UK
    PLoS Pathog 6:e1001208. 2010
    ..These findings may explain the observation that in humans with chronic malaria, activated effector memory cells are best maintained in conditions of repeated exposure...
  5. pmc Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure
    Sophie Roetynck
    Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 8:e55195. 2013
    ..The aim of this study was to establish and validate reliable and feasible flow cytometry assays, which will allow us to characterize CD4 T cell population in humans in field studies more fully...
  6. pmc Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?
    Deirdre Cunningham
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    PLoS ONE 4:e4285. 2009
    ..Thus, regulation of pir gene transcription may be different from that of the well-characterised multigene family, var, of Plasmodium falciparum...
  7. pmc Functional memory B cells and long-lived plasma cells are generated after a single Plasmodium chabaudi infection in mice
    Francis Maina Ndungu
    Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Pathog 5:e1000690. 2009
    ....
  8. pmc Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malaria
    Robin Stephens
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    PLoS ONE 6:e26686. 2011
    ....
  9. pmc Vector transmission regulates immune control of Plasmodium virulence
    Philip J Spence
    Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nature 498:228-31. 2013
    ..These results place the mosquito at the centre of our efforts to dissect mechanisms of protective immunity to malaria for the development of an effective vaccine...
  10. pmc Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells
    R Stephens
    National Institute for Medical Research, Division of Parasitology, London, UK
    Parasite Immunol 31:20-31. 2009
    ....
  11. pmc IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection
    Beatris Mastelic
    Divisions of Parasitology, MRC National Institute for Medical Research London, UK
    Front Immunol 3:85. 2012
    ..chabaudi infection...
  12. pmc Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice
    Eunice W Nduati
    KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographical Medicine Research Coast, Kilifi, Kenya
    PLoS ONE 5:e15007. 2010
    ..Studies should therefore include multiple sampling points, and at times of infection/immunisation when the B-cell phenotypes of interest are likely to be found in peripheral blood...
  13. pmc Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates
    Jane E Blythe
    Nanyang Technological University, School of Biological Sciences, Singapore, Singapore
    Malar J 8:140. 2009
    ..falciparum lines. However, these studies did not address whether or not there are ancestral stevor that can be found in different parasites...
  14. pmc Cellular responses to modified Plasmodium falciparum MSP119 antigens in individuals previously exposed to natural malaria infection
    Christian M F Okafor
    Cellular Parasitology Programme, Department of Zoology University of Ibadan, Ibadan, Nigeria
    Malar J 8:263. 2009
    ..However, it was unclear whether the modification of MSP1(19) would affect critical T-cell responses to epitopes in this antigen...
  15. pmc Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria
    Amy Saunders
    The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Malar J 8:53. 2009
    ..GIMAP1 was the first reported member of this gene family, identified as a gene up-regulated at the RNA level in the spleens of mice infected with the malarial parasite, Plasmodium chabaudi...
  16. pmc Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity
    Karen J Fairlie-Clarke
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    BMC Immunol 11:6. 2010
    ..The potential for cross-reactive antibodies to influence disease outcome is also discussed...
  17. ncbi request reprint Immunity to malaria: more questions than answers
    Jean Langhorne
    Division of Parasitology, National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 9:725-32. 2008
    ..This review will highlight key aspects of immunity to malaria, about which surprisingly little is known and which will prove critical in the search for effective malaria vaccines...
  18. pmc The relevance of non-human primate and rodent malaria models for humans
    Jean Langhorne
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Malar J 10:23. 2011
    ..The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material...
  19. ncbi request reprint Dendritic cells, pro-inflammatory responses, and antigen presentation in a rodent malaria infection
    Jean Langhorne
    Division of Parasitology, National Institute for Medical Research, London, UK
    Immunol Rev 201:35-47. 2004
    ....
  20. ncbi request reprint Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology
    Jean Langhorne
    Division of Parasitology, National Institute for Medical Research, London, UK
    Chem Immunol 80:204-28. 2002
  21. doi request reprint Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
    ..We propose that these monocytes, which are rapidly produced in the bone marrow as part of the early defense mechanism against invading pathogens, are important for controlling blood-stage malaria parasites...
  22. pmc Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1
    Calogero Tulone
    Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS ONE 6:e24886. 2011
    ..The role of different proteinases in generating the CD4 T cell repertoire, therefore, depends on the context in which an antigen is introduced to the immune system...
  23. ncbi request reprint Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance
    Robin Stephens
    National Institute of Medical Research, The Ridgeway, Mill Hill London, NW7 1AA, United Kingdom
    Blood 106:1676-84. 2005
    ....
  24. ncbi request reprint Host immunity modulates transcriptional changes in a multigene family (yir) of rodent malaria
    Deirdre A Cunningham
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mol Microbiol 58:636-47. 2005
    ..This provides a unique opportunity to study the regulation and expression of the pir superfamily, and its role in both protective immunity and antigenic variation, in an easily accessible animal model system...
  25. ncbi request reprint CD4 T cells from malaria-nonexposed individuals respond to the CD36-Binding Domain of Plasmodium falciparum erythrocyte membrane protein-1 via an MHC class II-TCR-independent pathway
    Francis M Ndungu
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    J Immunol 176:5504-12. 2006
    ..falciparum-infected erythrocytes reported previously...
  26. ncbi request reprint Transcription and alternative splicing in the yir multigene family of the malaria parasite Plasmodium y. yoelii: identification of motifs suggesting epigenetic and post-transcriptional control of RNA expression
    Jannik Fonager
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Mol Biochem Parasitol 156:1-11. 2007
    ..However, its presence in front of all yirs makes it unlikely to play a role in regulating differential expression...
  27. ncbi request reprint Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect the in vivo antibody response
    Meike Hensmann
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, GB
    Eur J Immunol 34:639-48. 2004
    ..Although the reduced form of MSP1(19) does not induce protective antibodies, our data suggest that inclusion of unfolded protein may improve the efficacy of MSP1(19) as a vaccine...
  28. pmc Cytokine responses of CD4+ T cells during a Plasmodium chabaudi chabaudi (ER) blood-stage infection in mice initiated by the natural route of infection
    Luis Fonseca
    Division of Parasitology, National Institute for Medical Research, London, UK
    Malar J 6:77. 2007
    ....
  29. pmc Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS)
    Jennifer Lawton
    Division of Parasitology, MRC National Institute for Medical Research, London, UK
    BMC Genomics 13:125. 2012
    ..In order to fully understand the role(s) of CIR proteins during P. chabaudi infection, a detailed characterization of the cir gene family was required...
  30. ncbi request reprint Limiting dilution analysis of antigen-specific CD4+ T-cell responses in mice
    Elsa Seixas
    Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
    Methods Mol Med 72:385-99. 2002
  31. doi request reprint Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria
    Cecile Voisine
    Division of Parasitology, MRC National Institute for Medical Research, London, UK
    Int J Parasitol 40:711-9. 2010
    ..We conclude that classical DC are the major antigen-presenting cells for CD4 T cells in this infection, but that pDC and IFN alpha beta may play minor roles in controlling the magnitude of acute stage pathology...
  32. pmc Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi
    Latifu A Sanni
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 72:3054-8. 2004
    ..Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice...
  33. ncbi request reprint B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area
    Jeffrey R Dorfman
    Kenya Medical Research Institute, Wellcome Trust Research Laboratories, Kilifi, Kenya
    J Infect Dis 191:1623-30. 2005
    ....
  34. doi request reprint The pir multigene family of Plasmodium: antigenic variation and beyond
    Deirdre Cunningham
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Mol Biochem Parasitol 170:65-73. 2010
    ..The presence of pir in rodent models will allow the investigation of this gene family in vivo and thus their potential as vaccines or in other interventions in human P. vivax infections...
  35. pmc IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
    Ana Paula Freitas do Rosario
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, NW7 1AA, United Kingdom
    J Immunol 188:1178-90. 2012
    ..Finally, in this model of malaria, we demonstrate that the generation of protective IL10(+)IFN-γ(+) Th1 cells is dependent on IL-27 signaling and independent of IL-21...
  36. pmc Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity
    Emma T Cadman
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 76:3924-31. 2008
    ....
  37. pmc Cellular responses to Plasmodium falciparum erythrocyte membrane protein-1: use of relatively conserved synthetic peptide pools to determine CD4 T cell responses in malaria-exposed individuals in Benin, West Africa
    Latifu A Sanni
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Malar J 1:7. 2002
    ..However, within the relatively conserved region, there is variation. It is not possible to test T cell responses from small field samples with all possible peptides...
  38. ncbi request reprint The influence of gammadelta T cells on the CD4+ T cell and antibody response during a primary Plasmodium chabaudi chabaudi infection in mice
    Elsa Seixas
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London, UK
    Parasite Immunol 24:131-40. 2002
    ..c. chabaudi. The majority of the single IL-2 knockout mice, in contrast, were able to control and clear a primary infection, suggesting that for the CD4+ T cell and antibody response, IL-2 could be replaced by other cytokines...
  39. pmc Transient deficiency of dendritic cells results in lack of a merozoite surface protein 1-specific CD4 T cell response during peak Plasmodium chabaudi blood-stage infection
    Anne Marit Sponaas
    Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
    Infect Immun 80:4248-56. 2012
    ....
  40. pmc Pathology of Plasmodium chabaudi chabaudi infection and mortality in interleukin-10-deficient mice are ameliorated by anti-tumor necrosis factor alpha and exacerbated by anti-transforming growth factor beta antibodies
    Ching Li
    Division of Parasitology, National Institute for Medical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 71:4850-6. 2003
    ..Our data suggest that a tight regulation of the balance between regulatory cytokines such as IL-10 and TGF-beta and inflammatory cytokines such as IFN-gamma and TNF-alpha is critical for survival in a mouse malaria infection...
  41. pmc Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi
    Philip J Spence
    Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Malar J 11:407. 2012
    ..It is, therefore, imperative that all aspects of experimental malaria research are studied in the context of the complete Plasmodium life cycle...
  42. pmc The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites
    Tracey J Lamb
    Division of Parasitology, National Institute for Medical Research, The Ridgeway Mill Hill, NW7 1AA, UK
    Malar J 7:68. 2008
    ..An understanding of the causes of severe malarial anaemia is necessary to develop and implement new therapeutic strategies to tackle this syndrome of malaria infection...
  43. pmc The plasma concentration of the B cell activating factor is increased in children with acute malaria
    Eunice Nduati
    KEMRI Wellcome Trust Collaborative Research Program, Centre for Geographical Medicine Research, Kilifi, Kenya
    J Infect Dis 204:962-70. 2011
    ..In summary, this study suggests a potential role for BAFF during malaria disease, both as a marker for disease severity and in shaping the differentiation pattern of antigen-specific B cells...
  44. doi request reprint Transformation of the rodent malaria parasite Plasmodium chabaudi
    Philip J Spence
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, UK
    Nat Protoc 6:553-61. 2011
    ..c. chabaudi parasites expressing fluorescent, bioluminescent and model antigens that can be used in vivo to dissect many of the fundamental principles of malaria infection...
  45. pmc Extramedullary myelopoiesis in malaria depends on mobilization of myeloid-restricted progenitors by IFN-γ induced chemokines
    Nikolai N Belyaev
    Division of Molecular Immunology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Pathog 9:e1003406. 2013
    ..Our findings reveal how the activated immune system mobilizes early myeloid progenitors out of the BM thereby transiently establishing myelopoiesis in the spleen in order to contain and resolve the infection locally...
  46. doi request reprint Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors
    Eun Ang Raiber
    Department of Chemistry, UCL, London, UK
    ACS Chem Biol 5:461-76. 2010
    ..The strategy adopted for MPC6 synthesis may therefore represent a more general way to deliver chemical inhibitors to cells of the innate immune system, especially at sites of inflammation...
  47. ncbi request reprint Sequestration and histopathology in Plasmodium chabaudi malaria are influenced by the immune response in an organ-specific manner
    Thibaut Brugat
    Division of Parasitology, MRC National Institute for Medical Research, London, NW7 1AA, UK
    Cell Microbiol 16:687-700. 2014
    ..P.  chabaudi AS provides a good model to investigate the influence of the host response on the sequestration and specific organ pathology, which is applicable to human malaria...
  48. ncbi request reprint Mouse models for erythrocytic-stage malaria
    Latifu A Sanni
    Division of Parasitology, National Institute for Medical Research, London, UK
    Methods Mol Med 72:57-76. 2002
  49. ncbi request reprint Plasmodium chabaudi chabaudi infection in mice induces strong B cell responses and striking but temporary changes in splenic cell distribution
    Ariel H Achtman
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    J Immunol 171:317-24. 2003
    ..These results show that the changes in splenic cell distribution are linked to the presence of parasites and do not seem to interfere with the development of the humoral response...
  50. doi request reprint The role of the spleen in malaria
    Hernando A del Portillo
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Cell Microbiol 14:343-55. 2012
    ..Here, the role of the spleen in malaria is reviewed with special emphasis in lessons learned from human infections and mouse models...
  51. ncbi request reprint CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas
    Catherine E M Allsopp
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    J Infect Dis 185:812-9. 2002
    ....
  52. doi request reprint T cell-derived IL-10 and its impact on the regulation of host responses during malaria
    Ana Paula Freitas do Rosario
    Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
    Int J Parasitol 42:549-55. 2012
    ....
  53. ncbi request reprint Insights into the immunopathogenesis of malaria using mouse models
    Tracey J Lamb
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
    Expert Rev Mol Med 8:1-22. 2006
    ..Finally, we discuss some of the implications of immunopathology, and of host and parasite genetic variation, for the design and implementation of anti-malarial vaccines...
  54. ncbi request reprint PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes
    Isabelle Delrieu
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, London, UK
    Mol Biochem Parasitol 121:11-20. 2002
    ..falciparum. We suggest that PSLAP functions in the mosquito, for example, in modulation of the invertebrate host immune response or in protection against complement factors in the blood meal...
  55. doi request reprint T cell control of malaria pathogenesis
    Philip J Spence
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Curr Opin Immunol 24:444-8. 2012
    ..Only then can we predict their capacity to dictate the outcome of human disease...
  56. pmc Recovery of an Antiviral Antibody Response following Attrition Caused by Unrelated Infection
    Dorothy H L Ng
    Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Pathog 10:e1003843. 2014
    ..These data have implications for understanding the longevity of protective efficacy of vaccinations in countries where continuous infections are endemic. ..
  57. pmc Epitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins
    Jon Eric Tongren
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 73:8119-29. 2005
    ....
  58. ncbi request reprint Molecular approaches to malaria
    Klaus Lingelbach
    FB Biology, Philipps University, Marburg, Germany
    Mol Microbiol 54:575-87. 2004
    ..In this report we summarize the results and new research avenues presented at a recent meeting held with the aim of developing interdisciplinary approaches to combat this disease...
  59. ncbi request reprint Assessing antigen-specific proliferation and cytokine responses using flow cytometry
    Catherine E M Allsopp
    Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Methods Mol Med 72:409-21. 2002
  60. pmc Plasmodium falciparum STEVOR proteins are highly expressed in patient isolates and located in the surface membranes of infected red blood cells and the apical tips of merozoites
    Jane E Blythe
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore
    Infect Immun 76:3329-36. 2008
    ....
  61. pmc Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria
    Menna R Clatworthy
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 104:7169-74. 2007
    ....
  62. ncbi request reprint Malarial anemia: of mice and men
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Blood 110:18-28. 2007
    ....
  63. ncbi request reprint Functional characterization of an LCCL-lectin domain containing protein family in Plasmodium berghei
    Holly E Trueman
    Immunology and Infection Section, Department of Biological Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK
    J Parasitol 90:1062-71. 2004
    ..The mutant is not rescued by coparasitization of mosquitoes with a mixture Pblap1+ and Pblap1- homokaryotic oocysts...