Dimitris Kioussis

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. doi Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development
    Nicola Harker
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, United Kingdom
    J Immunol 186:6368-77. 2011
  2. pmc Position effect variegation and imprinting of transgenes in lymphocytes
    Adam Williams
    Division of Molecular Immunology, The National Institute for Medical Research, London, NW71AA, UK
    Nucleic Acids Res 36:2320-9. 2008
  3. ncbi Epigenetic flexibility underlying lineage choices in the adaptive immune system
    Dimitris Kioussis
    Molecular Immunology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Science 317:620-2. 2007
  4. pmc Life without geminin
    Dimitris Karamitros
    Department of Physiology, Medical School, University of Patras, Patras, Greece
    Cell Cycle 9:3181-5. 2010
  5. ncbi Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation
    Dimitris Kioussis
    Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Nat Rev Immunol 2:909-19. 2002
  6. ncbi Aiolos: an ungrateful member of the Ikaros family
    Dimitris Kioussis
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 26:275-7. 2007
  7. doi Differential geminin requirement for proliferation of thymocytes and mature T cells
    Dimitris Karamitros
    Department of Pharmacology, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 184:2432-41. 2010
  8. ncbi The CD8alpha gene locus is regulated by the Ikaros family of proteins
    Nicola Harker
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, NW7 1AA, London, United Kingdom
    Mol Cell 10:1403-15. 2002
  9. ncbi Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation
    Belaid Sekkali
    National Institute for Medical Research, Division of Molecular Immunology, London, United Kingdom
    J Immunol 175:5203-12. 2005
  10. ncbi T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin
    Dimitris Karamitros
    Department of Physiology, Medical School, University of Patras, Rio, Patras, Greece
    Crit Rev Immunol 31:209-31. 2011

Collaborators

Detail Information

Publications48

  1. doi Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development
    Nicola Harker
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, United Kingdom
    J Immunol 186:6368-77. 2011
    ..Differential binding of Ikaros, NuRD, and heterochromatin protein 1α on the locus during these processes may participate in the complex regulation of CD8...
  2. pmc Position effect variegation and imprinting of transgenes in lymphocytes
    Adam Williams
    Division of Molecular Immunology, The National Institute for Medical Research, London, NW71AA, UK
    Nucleic Acids Res 36:2320-9. 2008
    ....
  3. ncbi Epigenetic flexibility underlying lineage choices in the adaptive immune system
    Dimitris Kioussis
    Molecular Immunology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Science 317:620-2. 2007
    ....
  4. pmc Life without geminin
    Dimitris Karamitros
    Department of Physiology, Medical School, University of Patras, Patras, Greece
    Cell Cycle 9:3181-5. 2010
    ..In contrast, rapid cell divisions, taking place in vitro upon TCR receptor activation or in vivo during homeostatic proliferation, are defective...
  5. ncbi Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation
    Dimitris Kioussis
    Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Nat Rev Immunol 2:909-19. 2002
    ....
  6. ncbi Aiolos: an ungrateful member of the Ikaros family
    Dimitris Kioussis
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 26:275-7. 2007
    ..Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance...
  7. doi Differential geminin requirement for proliferation of thymocytes and mature T cells
    Dimitris Karamitros
    Department of Pharmacology, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 184:2432-41. 2010
    ....
  8. ncbi The CD8alpha gene locus is regulated by the Ikaros family of proteins
    Nicola Harker
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, NW7 1AA, London, United Kingdom
    Mol Cell 10:1403-15. 2002
    ....
  9. ncbi Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation
    Belaid Sekkali
    National Institute for Medical Research, Division of Molecular Immunology, London, United Kingdom
    J Immunol 175:5203-12. 2005
    ..Alternatively, the extra HBP1 molecules may sequester repressive elements away from the LCR, thus allowing transcription permissive states to form on the transgene locus...
  10. ncbi T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin
    Dimitris Karamitros
    Department of Physiology, Medical School, University of Patras, Rio, Patras, Greece
    Crit Rev Immunol 31:209-31. 2011
    ..However, Geminin is required for TCR response in vitro and T cell proliferation upon lymphopenia-induced proliferation, suggesting that Geminin might be an essential factor for T cell expansion during the immune response...
  11. doi The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
    Duncan M Gascoyne
    Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health and Great Ormond Street Hospital for Children, London, UK
    Nat Immunol 10:1118-24. 2009
    ..E4bp4(-/-) mice may provide a model for definitive analysis of the contribution of NK cells to immune responses and pathologies...
  12. ncbi Transgenic mice with hematopoietic and lymphoid specific expression of Cre
    Jasper de Boer
    Department of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London, GB
    Eur J Immunol 33:314-25. 2003
    ..Both of these Cre-transgenic lines will be useful in generating tissue-specific gene deletions within all the cells of hematopoietic or lymphoid tissues...
  13. doi CD8 locus nuclear dynamics during thymocyte development
    Eleni Ktistaki
    Division of Molecular Immunology, Medical Research Council, National Institute for Medical Research, London, United Kingdom
    J Immunol 184:5686-95. 2010
    ..In contrast, in nonexpressing cells, the gene remains close to the main body of its chromosomal domain and the regulatory elements appear not to interact with each other...
  14. pmc Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages
    Ursula Menzel
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, UK
    Proc Natl Acad Sci U S A 107:16928-33. 2010
    ....
  15. doi Modulation of the murine CD8 gene complex following the targeted integration of human CD2-locus control region sequences
    Ursula Menzel
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, United Kingdom
    J Immunol 187:3712-20. 2011
    ..This analysis revealed a dynamic interaction between the hCD2-LCR and the endogenous regulatory elements of the CD8 genes...
  16. ncbi Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis
    Henrique Veiga-Fernandes
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 446:547-51. 2007
    ..Our work strongly suggests that the RET signalling pathway, by regulating the development of both the nervous and lymphoid system in the gut, has a key role in the molecular mechanisms that orchestrate intestine organogenesis...
  17. ncbi An essential role for the stalk region of CD8 beta in the coreceptor function of CD8
    Lorna Rettig
    Molecular Immunology, Medical Research Council National Institute for Medical Research, London, United Kingdom
    J Immunol 182:121-9. 2009
    ..Thus, the stalk region of the CD8beta polypeptide has an essential role in ensuring functionality of the CD8alphabeta heterodimer and its replacement compromises the interaction of CD8 with peptide-MHC complexes...
  18. ncbi Contribution of neural crest-derived cells in the embryonic and adult thymus
    Katie Foster
    Molecular Immunology, National Institute for Medical Research, Edinburgh, UK
    J Immunol 180:3183-9. 2008
    ..In the adult organ at 3 mo of age, these NC-derived perivascular cells continue to be associated with the vasculature, providing structural support to the blood vessels and possibly regulating endothelial cell function...
  19. pmc Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes
    Mark C Coles
    Division of Molecular Immunology and Immune Cell Biology and Confocal Microscopy and Image Analysis Laboratory, National Institute for Medical Research, Mill Hill, London, United Kingdom
    Proc Natl Acad Sci U S A 103:13457-62. 2006
    ..Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role...
  20. pmc EphB-ephrin-B2 interactions are required for thymus migration during organogenesis
    Katie E Foster
    Molecular Immunology, National Institute of Medical Research, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 107:13414-9. 2010
    ..This implies a NC-derived cell-specific role of EphB-ephrin-B2 interactions in the collective migration of the thymic rudiment during organogenesis...
  21. pmc Rac GTPases play critical roles in early T-cell development
    Celine Dumont
    Division of Immune Cell Biology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 113:3990-8. 2009
    ..These results show that a pathway containing Vav and Rac proteins may negatively regulate Notch signaling during early thymic development...
  22. doi Geminin regulates cortical progenitor proliferation and differentiation
    Magda Spella
    Department of Physiology, Medical School, University of Patras, Patras, Greece
    Stem Cells 29:1269-82. 2011
    ..Our study suggests that Geminin has an important role during cortical development in regulating progenitor number and ultimately neuron generation...
  23. ncbi ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
    Stamatia Papoutsopoulou
    Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 7:606-15. 2006
    ..Thus, ABIN-2 acts to positively regulate the Erk signaling potential by stabilizing TPL-2...
  24. pmc Generalized immune activation as a direct result of activated CD4+ T cell killing
    Rute Marques
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Biol 8:93. 2009
    ..In addition to progressive CD4(+) T cell immune deficiency, HIV infection is characterized by generalized immune activation, thought to arise from increased microbial exposure resulting from diminishing immunity...
  25. doi Visualisation of lymphoid organ development
    Henrique Veiga-Fernandes
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Methods Mol Biol 616:161-79. 2010
    ....
  26. ncbi Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences
    Anna Garefalaki
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    Immunity 16:635-47. 2002
    ..Furthermore, these sequences contribute to the levels of expression of the CD8 alpha gene...
  27. doi Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal
    Kathryn A McMahon
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London, WC1N 1EH, UK
    Cell Stem Cell 1:338-45. 2007
    ..However, transplanted Mll-deficient bone marrow cells are highly compromised in their ability to competitively reconstitute irradiated recipients. These results suggest a critical role for Mll in regulating stem cell self-renewal...
  28. ncbi Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells
    Panagiota Stamou
    Division of Molecular Immunology, The National Institute for Medical Research, London, United Kingdom
    J Immunol 171:1278-84. 2003
    ..This suggests that up-regulation of negative T cell regulators in peripheral T cells exposed to chronic stimulation by Ag may prevent full functionality and thus avoid overt autoreactivity...
  29. ncbi Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide
    Lesley A Smyth
    Division of Molecular Immunology, The National Institute for Medical Research, London, GB
    Eur J Immunol 32:3386-94. 2002
    ....
  30. ncbi The AXH domain adopts alternative folds the solution structure of HBP1 AXH
    Cesira de Chiara
    National Institute for Medical Research, The Ridgeway, London, United Kingdom
    Structure 13:743-53. 2005
    ..Our results describe an entirely novel, to our knowledge, example of a chameleon fold and suggest a link between these properties and the SCA1 pathogenesis...
  31. ncbi Identification of a macrophage-specific chromatin signature in the IL-10 locus
    Margarida Saraiva
    Divisions of Immunoregulation, Immune Cell Biology and Molecular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 175:1041-6. 2005
    ..In support of a function for this site, NF-kappaB p65/RelA was recruited to HSS-4.5 in vivo and its activation was required for optimal IL-10 gene expression in LPS-stimulated macrophages...
  32. doi Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems
    Amisha Patel
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Sci Signal 5:ra55. 2012
    ..Our study shows that a trans RET response in LTin cells determines the initial phase of enteric lymphoid organ morphogenesis, and suggests that differential co-expression of Ret and Gfra can control the specificity of RET signaling...
  33. pmc L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes
    Elena Galkina
    Division of Cellular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Exp Med 198:1323-35. 2003
    ..These results suggest that the ability to shed L-selectin is not required for T cell recirculation and homing to PLNs. However, L-selectin shedding from antigen-activated T cells prevents reentry into PLNs...
  34. pmc Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways
    Lucinda F Reynolds
    National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Exp Med 195:1103-14. 2002
    ..We show that this latter function is independent of PI3K...
  35. doi Immune and nervous systems: more than just a superficial similarity?
    Dimitris Kioussis
    Division of Molecular Immunology, MRC National Institute for Medical Research, London NW7 1AA, UK
    Immunity 31:705-10. 2009
    ....
  36. pmc Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease
    Bo Zhu
    Institute of Cell and Molecular Science, Barts and London School of Medicine and Dentistry, University of London, London E1 2AT, England, UK
    J Exp Med 205:2295-307. 2008
    ..These results demonstrate that Egr-2 is an intrinsic regulator of effector T cells and controls the expansion of self-reactive T cells and development of autoimmune disease...
  37. ncbi Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation
    Shin Young Na
    Institutes of Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    J Immunol 171:1285-96. 2003
    ..Thus, our observations clearly indicate a cross-talk between PKB and important signaling molecules downstream of TCR that modulate the thresholds of thymocyte selection and T cell activation...
  38. ncbi Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8610, Japan
    Biochem Biophys Res Commun 365:589-94. 2008
    ..Moreover, the C-terminal part of ASH1 interacts with HDAC1 repression complexes, suggesting that the PHD finger of ASH1 may be involved in down-regulation of genes for normal development of alphabeta T cells...
  39. ncbi TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity
    Michelle Morrow
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London, United Kingdom
    Blood 103:3890-6. 2004
    ..Our study provides a unique insight into the role of TEL-AML1 in leukemia predisposition and a potential model to study the mechanism of leukemogenesis associated with this fusion...
  40. ncbi Killer cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression
    Danny Belkin
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 171:3056-63. 2003
    ....
  41. ncbi Gene regulation: kissing chromosomes
    Dimitris Kioussis
    Nature 435:579-80. 2005
  42. ncbi Thymocyte differentiation: it's time to bend a little
    Dimitris Kioussis
    Nat Immunol 3:214-5. 2002
  43. ncbi Shh! Shh! It's, oh, so quiet
    Dimitris Kioussis
    Nat Immunol 5:353-4. 2004
  44. ncbi Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance
    Robin Stephens
    National Institute of Medical Research, The Ridgeway, Mill Hill London, NW7 1AA, United Kingdom
    Blood 106:1676-84. 2005
    ....
  45. ncbi Trithorax-group protein ASH1 methylates histone H3 lysine 36
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo, Japan
    Gene 397:161-8. 2007
    ..Taken together, our data suggest that ASH1 subfamily of SET domain proteins have K36-specific methyltransferase activities evolutionarily conserved from flies to mammals...
  46. ncbi Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells
    Sarah J Horton
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London
    Cancer Res 65:9245-52. 2005
    ..Thus, MLL-ENL is required to initiate and maintain immortalization of myeloid progenitors and may contribute to leukemogenesis by aberrantly sustaining the expression of a "Hox code" consisting of Hoxa4 to Hoxa11...
  47. ncbi The relative efficiency of acquisition of MHC:peptide complexes and cross-presentation depends on dendritic cell type
    Lesley Ann Smyth
    Department of Nephrology and Transplantation, King s College London, School of Medicine, Guy s Hospital, London, United Kingdom
    J Immunol 181:3212-20. 2008
    ..We conclude from these observations that the relative efficiency of MHC transfer vs cross-presentation differs markedly between different DC subsets...
  48. ncbi Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells
    Richard Festenstein
    CSC Gene Control Mechanisms and Disease Group, Division of Medicine, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Science 299:719-21. 2003
    ....