Research Topics
Genomes and GenesSpecies | Anne E KingSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Detail Information
Publications
Regulation of natural antibiotic expression by inflammatory mediators and mimics of infection in human endometrial epithelial cellsAnne E King
MRC Human Reproductive Sciences Unit and Department of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
Mol Hum Reprod 8:341-9. 2002..g. HBD2) are inducible allowing maximal antimicrobial activity during infection. Natural antimicrobials will have an important role in endometrium in protecting against infection...- Innate immune defences in the human endometriumAnne E King
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Chancellor s Building, 49 Little France Crescent, Edinburgh, UK
Reprod Biol Endocrinol 1:116. 2003.... - Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometriumAnne E King
MRC Human Reproductive Sciences Unit, University of Edinburgh, Academic Centre, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
J Reprod Immunol 59:1-16. 2003..In addition, expression of HBD3 will be upregulated during infection allowing an increased innate immune response at this time... - Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruationAnne E King
Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, United Kingdom EH16 4SB
J Clin Endocrinol Metab 88:4426-31. 2003..This is attributable to the presence of infiltrating leukocytes and increased inflammatory signaling. Elafin will regulate proteolytic enzymes during menstruation and will contribute to the innate defense against uterine infection... - Hormonal contraception can suppress natural antimicrobial gene transcription in human endometriumDiana C Fleming
Human Reproductive Sciences Unit, Medical Research Council, Academic Centre, Edinburgh, United Kingdom
Fertil Steril 79:856-63. 2003.... - Differential regulation of secretory leukocyte protease inhibitor and elafin by progesteroneAnne E King
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Biochem Biophys Res Commun 310:594-9. 2003.... - Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruationAnne E King
Reproductive and Developmental Sciences, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, UK
Mol Hum Reprod 15:311-9. 2009..NODs may have a role in innate immune protection in the uterus and NOD2 may regulate inflammation associated with menstruation... - Inflammatory mediators and endometrial function--focus on the perivascular cellRodney W Kelly
Human Reproductive Sciences Unit, Medical Research Council, Centre for Reproductive Biology, University of Edinburgh, UK
J Reprod Immunol 57:81-93. 2002..The perivascular cell in endometrium is pivotal in both menstruation and early pregnancy and we need to understand this cell better to devise more effective medical treatment for menstrual dysfunction... - Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infectionAnne E King
Reproductive and Developmental Sciences, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Hum Reprod 24:679-86. 2009..They have been demonstrated at multiple mucosal surfaces including those of the female reproductive tract... - Innate immunity and disorders of the female reproductive tractAndrew W Horne
The Queen s Medical Research Institute, Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Reproduction 135:739-49. 2008.... - Oestrogen and progesterone regulation of inflammatory processes in the human endometriumAnne E King
University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Institute, United Kingdom
J Steroid Biochem Mol Biol 120:116-26. 2010.... - PGE/cAMP and GM-CSF synergise to induce a pro-tolerance cytokine profile in monocytic cell linesVivien Grant
Medical Research Council, Human Reproductive Sciences Unit, University of Edinburgh Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Biochem Biophys Res Commun 331:187-93. 2005..Monocytes modified in such a way could provide a pro-tolerant environment (high IL-10, low IL-12) for antigen presentation by dendritic cells and thus may contribute to a normally permissive milieu, e.g., for food absorption... - Prokineticin-1: a novel mediator of the inflammatory response in third-trimester human placentaFiona C Denison
Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, United Kingdom
Endocrinology 149:3470-7. 2008..Using double-immunofluorescent immunohistochemistry, PKR1 colocalized with IL-8 and COX-2 in placenta. These data suggest that PK1 may have a novel role as a mediator of the inflammatory response in placenta... - Neurotrophin-induced preprotachykinin-A gene promoter modulation in organotypic rat spinal cord cultureKathryn J Hilton
Institute of Membrane and Systems Biology, University of Leeds, Leeds, UK
J Neurochem 98:690-9. 2006..The functional consequences of such transcriptional changes within central peptidergic circuitry and their relevance to chronic pain are considered...