Affiliation: National Institute for Medical Research
- An exact method for analysis following a two-stage phase II cancer clinical trialGordana Jovic
Institute of Medical Statistics and Biometry, University of Milan, Italy
Stat Med 29:3118-25. 2010..In this paper, an approximate approach based on a log-odds ratio parameterisation will be compared with an exact method through the calculation of the precise coverage probabilities of each approach...
- Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trialMatthew R Sydes
MRC Clinical Trials Unit, London, UK
Trials 13:168. 2012..We describe methodological and practical issues arising with (1) stopping recruitment to research arms following a pre-planned intermediate analysis and (2) adding a new research arm during the trial...