E E M Jaeger

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome
    E E M Jaeger
    Molecular and Population Genetics Laboratory, Cancer Research UK, London, United Kingdom
    Am J Hum Genet 72:1261-7. 2003
  2. ncbi Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation
    O M Sieber
    Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK
    Gut 55:1440-8. 2006
  3. ncbi Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability
    N A Alam
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Cancer Genet Cytogenet 147:121-7. 2003

Collaborators

Detail Information

Publications3

  1. ncbi An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome
    E E M Jaeger
    Molecular and Population Genetics Laboratory, Cancer Research UK, London, United Kingdom
    Am J Hum Genet 72:1261-7. 2003
    ..Although there are probably multiple causes of the multiple colorectal adenoma and cancer phenotype in Ashkenazim, an important one is the HMPS/CRAC1 locus on 15q13-q14...
  2. ncbi Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation
    O M Sieber
    Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK
    Gut 55:1440-8. 2006
    ..Attenuated familial adenomatous polyposis (AFAP) is associated with germline mutations in the 5', 3', and exon 9 of the adenomatous polyposis coli (APC) gene. These mutations probably encode a limited amount of functional APC protein...
  3. ncbi Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability
    N A Alam
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Cancer Genet Cytogenet 147:121-7. 2003
    ..Also of interest is the absence of phenotypic abnormality apart from multiple leiomyomatosis in any deletion carrier even though the adjacent genes RGS7, KMO, CHML, and OPN3 were also deleted...