Affiliation: National Institute for Medical Research
Jacob J, Storm R, Castro D, Milton C, Pla P, Guillemot F, et al. Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009;136:2477-85 pubmed publisher
..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations. ..
Jacob J, Kong J, Moore S, Milton C, Sasai N, Gonzalez Quevedo R, et al. Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol. 2013;23:412-8 pubmed publisher
..Therefore, quantitative differences in the expression of a single component of a transcriptional code can select distinct cell fates. ..