Henry N Jabbour

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc The expression and regulation of adrenomedullin in the human endometrium: a candidate for endometrial repair
    Jacqueline A Maybin
    Centre for Reproductive Biology, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 152:2845-56. 2011
  2. pmc A role for lipoxin A₄ as an anti-inflammatory mediator in the human endometrium
    Linsay J Macdonald
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Reproduction 142:345-52. 2011
  3. pmc Chorionic gonadotrophin regulates CXCR4 expression in human endometrium via E-series prostanoid receptor 2 signalling to PI3K-ERK1/2: implications for fetal-maternal crosstalk for embryo implantation
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 17:22-32. 2011
  4. pmc Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Old Dalkeith Road, Edinburgh, United Kingdom
    Mol Cell Endocrinol 285:51-61. 2008
  5. pmc Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Biochim Biophys Acta 1793:1917-28. 2009
  6. pmc Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway
    David Maldonado-Pérez
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh EH16 4TJ, UK
    Biochim Biophys Acta 1793:1315-24. 2009
  7. pmc CTGF expression is up-regulated by PROK1 in early pregnancy and influences HTR-8/Svneo cell adhesion and network formation
    Jennifer M Waddell
    Medical Research Council, Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod 26:67-75. 2011
  8. pmc Hypoxia and prostaglandin E receptor 4 signalling pathways synergise to promote endometrial adenocarcinoma cell proliferation and tumour growth
    Rob D Catalano
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e19209. 2011
  9. pmc Potential roles of the prokineticins in reproduction
    David Maldonado-Pérez
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Trends Endocrinol Metab 18:66-72. 2007
  10. pmc Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle
    Rob D Catalano
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 17:182-92. 2011

Collaborators

Detail Information

Publications78

  1. pmc The expression and regulation of adrenomedullin in the human endometrium: a candidate for endometrial repair
    Jacqueline A Maybin
    Centre for Reproductive Biology, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 152:2845-56. 2011
    ..These physiological mechanisms may provide novel therapeutic targets for disorders such as heavy menstrual bleeding...
  2. pmc A role for lipoxin A₄ as an anti-inflammatory mediator in the human endometrium
    Linsay J Macdonald
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Reproduction 142:345-52. 2011
    ..These results demonstrate for the first time that lipoxin A(4) and its receptor FPR2/ALX can regulate inflammatory events in the human endometrium and decidua of early pregnancy...
  3. pmc Chorionic gonadotrophin regulates CXCR4 expression in human endometrium via E-series prostanoid receptor 2 signalling to PI3K-ERK1/2: implications for fetal-maternal crosstalk for embryo implantation
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 17:22-32. 2011
    ..Taken together, our data suggest that early embryonic signals may regulate fetal-maternal crosstalk in the human endometrium by inducing CXCR4 expression via the PGE₂-PTGER2-mediated induction of the EGFR, PI3K and ERK1/2 pathways...
  4. pmc Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Old Dalkeith Road, Edinburgh, United Kingdom
    Mol Cell Endocrinol 285:51-61. 2008
    ..These data indicate that PGE(2) and PGF(2alpha) biosynthesized locally within endometrial adenocarcinomas can regulate tumor cell function in an autocrine/paracrine manner via the FP receptor...
  5. pmc Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Biochim Biophys Acta 1793:1917-28. 2009
    ....
  6. pmc Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway
    David Maldonado-Pérez
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh EH16 4TJ, UK
    Biochim Biophys Acta 1793:1315-24. 2009
    ..Our findings show that in endometrial cells PROK1 can activate the calcineurin/NFAT pathway to induce IL-8 expression and that this is negatively modulated by the induction of expression of RCAN1-4...
  7. pmc CTGF expression is up-regulated by PROK1 in early pregnancy and influences HTR-8/Svneo cell adhesion and network formation
    Jennifer M Waddell
    Medical Research Council, Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod 26:67-75. 2011
    ..Secondly, the effect of CTGF on trophoblast-derived HTR-8/SVneo cell adhesion and network formation was investigated...
  8. pmc Hypoxia and prostaglandin E receptor 4 signalling pathways synergise to promote endometrial adenocarcinoma cell proliferation and tumour growth
    Rob D Catalano
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e19209. 2011
    ..Finally we have shown that PGE(2) and hypoxia synergise to promote cellular proliferation of endometrial adenocarcinoma cells...
  9. pmc Potential roles of the prokineticins in reproduction
    David Maldonado-Pérez
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Trends Endocrinol Metab 18:66-72. 2007
    ..Their expression has also been reported in various pathologies of the reproductive tract, and future studies will highlight whether inhibition of prokineticin function in these pathologies would be a useful therapeutic target...
  10. pmc Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle
    Rob D Catalano
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 17:182-92. 2011
    ..The expression profiles described have the potential to identify specific prostanoid components that may be dysregulated in inflammatory-associated disorders of the endometrium...
  11. pmc Prokineticin 1 induces inflammatory response in human myometrium: a potential role in initiating term and preterm parturition
    Marta R Gorowiec
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Am J Pathol 179:2709-19. 2011
    ..We propose that PROK1 is a novel inflammatory mediator that can contribute to the onset of human parturition at term and partially mediate premature onset of inflammatory pathways during bacterial infection...
  12. pmc Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway
    Ian H Cook
    Medical Research Council, Human Reproductive Sciences Unit, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 16:158-69. 2010
    ..Overall we have identified and characterized the signalling components of a novel PROK1-PROKR1 signalling pathway regulating IL-11...
  13. pmc EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway
    A B Abera
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Cell Signal 22:71-9. 2010
    ..In conclusion, this study demonstrates that co-activation of the FP and EP2 receptors results in enhanced release of cAMP via FP receptor-G alpha(q)-Ca(2+)-calmodulin pathway by activating calcium sensitive AC3 isoform...
  14. ncbi request reprint Prostaglandin receptor signalling and function in human endometrial pathology
    H N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
    Trends Endocrinol Metab 15:398-404. 2004
    ..The potential role of prostaglandin receptors in pathological changes of the endometrium has significance for the future development of therapeutic interventions...
  15. ncbi request reprint A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway
    Henry N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 146:4657-64. 2005
    ..Finally, we have shown that PGF2alpha could potentiate tumorigenesis in endometrial adenocarcinoma explants by inducing the expression of COX-2 mRNA...
  16. ncbi request reprint Endocrine regulation of menstruation
    Henry N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocr Rev 27:17-46. 2006
    ....
  17. ncbi request reprint Prostaglandin E2 induces proliferation of glandular epithelial cells of the human endometrium via extracellular regulated kinase 1/2-mediated pathway
    H N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, The University of Edinburgh Academic Centre, Edinburgh, Scotland EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:4481-7. 2003
    ....
  18. ncbi request reprint Prostaglandin receptors are mediators of vascular function in endometrial pathologies
    Henry N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Mol Cell Endocrinol 252:191-200. 2006
    ..Here we provide an overview of some of the findings from these studies with specific emphasis on the role of cyclooxygenase enzymes, prostaglandins and their receptors in benign and neoplastic pathologies of the human endometrium...
  19. doi request reprint Inflammatory pathways in female reproductive health and disease
    Henry N Jabbour
    MRC Human Reproductive Sciences Unit Reproductive and Developmental Sciences, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Reproduction 138:903-19. 2009
    ..This review will address the role of inflammatory events in normal reproductive function and its pathologies...
  20. ncbi request reprint Potential roles of decidual prolactin in early pregnancy
    H N Jabbour
    MRC Human Reproductive Sciences Unit and Obstetrics and Gynaecology, Department of Reproductive and Development Sciences, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 121:197-205. 2001
    ..Localization of the sites of expression of the prolactin receptor indicates that the cytokine may regulate an array of functions in the pregnant uterus that are crucial in im-plantation and early pregnancy...
  21. ncbi request reprint Autocrine/paracrine regulation of apoptosis in epithelial cells by prostaglandin E2
    H N Jabbour
    Human Reproductive Sciences, Centre for Reproductive Biology, The University of Edinburg Academic Centre, 49 Little France Crescent, UK
    Prostaglandins Leukot Essent Fatty Acids 67:357-63. 2002
    ..These data demonstrate that PGE(2) inhibits apoptosis of epithelial cells possibly via cAMP-dependent pathway...
  22. pmc Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    Am J Pathol 176:435-45. 2010
    ..This study has highlighted a new mechanism regulating IL-11 expression in endometrial adenocarcinoma cells by the FP receptor via the calcium-calcineurin-nuclear factor of activated T cells pathway...
  23. ncbi request reprint F-prostanoid receptor regulation of fibroblast growth factor 2 signaling in endometrial adenocarcinoma cells
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland EH16 4TJ, United Kingdom
    Endocrinology 148:3635-44. 2007
    ....
  24. ncbi request reprint Seminal plasma promotes the expression of tumorigenic and angiogenic genes in cervical adenocarcinoma cells via the E-series prostanoid 4 receptor
    Melissa Muller
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Institute for Medical Research, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 147:3356-65. 2006
    ..Therefore, we have demonstrated that seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways...
  25. ncbi request reprint Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3',5'-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular sign
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, Edinburgh, Scotland EH16 4SB, United Kingdom
    Mol Endocrinol 18:1533-45. 2004
    ....
  26. pmc Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma
    Alison E Wallace
    Medical Research Council Human Reproductive Sciences Unit, Department of Reproductive and Developmental Sciences, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Cancer Res 69:5726-33. 2009
    ..In conclusion, our results show a novel PGF(2alpha)-FP pathway that may regulate the inflammatory microenvironment in endometrial adenocarcinoma via neutrophil chemotaxis...
  27. pmc Prokineticin 1 signaling and gene regulation in early human pregnancy
    Jemma Evans
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:2877-87. 2008
    ..These data demonstrate that PROK1 and PROKR1 expression is elevated in human decidua during early pregnancy and that PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes...
  28. ncbi request reprint Prostaglandin (PG) F(2alpha) receptor expression and signaling in human endometrium: role of PGF(2alpha) in epithelial cell proliferation
    Stuart A Milne
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:1825-32. 2003
    ....
  29. ncbi request reprint Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh Academic Center, Edinburgh, United Kingdom EH16 4SB
    J Clin Endocrinol Metab 89:986-93. 2004
    ..These data suggest that PGF(2 alpha)-FP receptor promote endometrial tumorigenesis via a phospholipase C-mediated phosphorylation of the EGFR and MAPK signaling pathways...
  30. pmc Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium
    Linsay J Macdonald
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Mol Hum Reprod 17:626-36. 2011
    ..These data demonstrate important roles for PROK1 and DKK1 during endometrial receptivity and early pregnancy, which include regulation of endometrial cell proliferation and decidualization...
  31. ncbi request reprint Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway
    Oliver P Milling Smith
    Medical Research Council Human Reproductive Science Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, Scotland, UK
    Endocrinology 147:1697-705. 2006
    ..These data suggest that PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR...
  32. pmc Prokineticin-1: a novel mediator of the inflammatory response in third-trimester human placenta
    Fiona C Denison
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, United Kingdom
    Endocrinology 149:3470-7. 2008
    ..Using double-immunofluorescent immunohistochemistry, PKR1 colocalized with IL-8 and COX-2 in placenta. These data suggest that PK1 may have a novel role as a mediator of the inflammatory response in placenta...
  33. pmc Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor
    Jemma Evans
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    FASEB J 23:2165-75. 2009
    ..These data describe a novel signaling pathway mediating maternal-embryonic crosstalk, in which embryonic hCG via endometrial PROK1 may play a pivotal role in enhancing receptivity and maintaining early pregnancy...
  34. ncbi request reprint Prostaglandin E2 mediates phosphorylation and down-regulation of the tuberous sclerosis-2 tumor suppressor (tuberin) in human endometrial adenocarcinoma cells via the Akt signaling pathway
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:6112-8. 2004
    ..These data suggest that PGE2 signaling may promote endometrial tumorigenesis by inactivation of tuberin after its phosphorylation via the Akt signaling pathway...
  35. pmc Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion
    Zvi Naor
    Medical Research Council MRC, Huamn Reproduction Sciences, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Mol Endocrinol 21:524-37. 2007
    ....
  36. pmc The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair
    Jacqueline A Maybin
    Centre for Reproductive Biology, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Clin Endocrinol Metab 96:2475-83. 2011
    ..We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor...
  37. pmc PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer
    Margaret C Keightley
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK
    BMC Cancer 10:488. 2010
    ..This study investigates the expression, regulation and role of a disintegrin and metalloproteinase with thrombospondin repeat 1 (ADAMTS1) in endometrial adenocarcinoma cells by PGF2α via the FP receptor...
  38. pmc Novel roles for hypoxia and prostaglandin E2 in the regulation of IL-8 during endometrial repair
    Jacqueline A Maybin
    University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, Scotland
    Am J Pathol 178:1245-56. 2011
    ..Progesterone withdrawal, hypoxia, and PGE(2) regulate endometrial IL-8 by acting via HIF-1 and NF-κB. Hence, progesterone withdrawal may activate two distinct pathways to initiate endometrial repair...
  39. pmc F-Prostaglandin receptor regulates endothelial cell function via fibroblast growth factor-2
    Margaret C Keightley
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH164TJ, UK
    BMC Cell Biol 11:8. 2010
    ....
  40. doi request reprint Inflammatory events in endometrial adenocarcinoma
    Alison E Wallace
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 206:141-57. 2010
    ..This review discusses the contribution of inflammation to the initiation and progression of endometrial adenocarcinoma. Manipulation of inflammatory pathways may therefore represent a therapeutic target in endometrial adenocarcinoma...
  41. pmc A novel angiogenic role for prostaglandin F2alpha-FP receptor interaction in human endometrial adenocarcinomas
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Res 65:7707-16. 2005
    ..Finally, we confirmed that PGF2alpha could potentiate angiogenesis in endometrial adenocarcinoma explants by transactivation of the EGFR and induction of VEGF mRNA expression...
  42. doi request reprint Inflammatory pathways in endometrial disorders
    Jacqueline A Maybin
    University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Cell Endocrinol 335:42-51. 2011
    ....
  43. doi request reprint Prokineticins: novel mediators of inflammatory and contractile pathways at parturition?
    Rob D Catalano
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 16:311-9. 2010
    ..Antagonism of prokineticin action may provide a suitable therapy for preterm labour that targets both inflammation and contractile pathways...
  44. doi request reprint A novel antiinflammatory role for the short-chain fatty acids in human labor
    Chiara Voltolini
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 153:395-403. 2012
    ..Suppression of inflammatory pathways by SCFA may be therapeutically beneficial for pregnant women at risk of pathogen-induced preterm delivery...
  45. ncbi request reprint Cyclooxygenase-2 overexpression inhibits cathepsin D-mediated cleavage of plasminogen to the potent antiangiogenic factor angiostatin
    Gabrielle B Perchick
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, Chancellor s Building, Edinburgh, Scotland EH16 4SB, United Kingdom
    Endocrinology 144:5322-8. 2003
    ..These data demonstrate that COX-2 exerts a negative feedback on the expression of cathepsin D. This in turn reduces the generation of the antiangiogenic factor angiostatin, hence promoting a proangiogenic environment...
  46. pmc Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, Academic Centre, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Mol Hum Reprod 8:1065-70. 2002
    ..05). These data suggest that, in sexually active women, seminal plasma may play a role in modulating neoplastic cell function and cervical tumorigenesis...
  47. ncbi request reprint Expression and localization of endothelial monocyte-activating polypeptide II in the human endometrium across the menstrual cycle: regulation of expression by prostaglandin E(2)
    Sharon Battersby
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, Edinburgh EH3 9ET, United Kingdom
    J Clin Endocrinol Metab 87:3928-35. 2002
    ..Moreover, EMAP II expression is negatively regulated by PGE(2)...
  48. pmc Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh Academic Center, 49 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SB, UK
    Reproduction 126:559-67. 2003
    ....
  49. doi request reprint A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition
    David Maldonado-Pérez
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    FASEB J 25:569-75. 2011
    ..05), compared to vehicle-treated controls. We demonstrate for the first time a potential role for lipoxin A(4) and its receptor in the resolution of the inflammatory events of both physiological and pathological labor...
  50. pmc Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha
    Frances Collins
    MRC Human Reproductive Sciences Unit, The University of Edinburgh Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    BMC Cancer 9:330. 2009
    ..PGs act in an autocrine or paracrine manner by binding to specific G-protein coupled receptors...
  51. doi request reprint Chemokine (C-C) motif ligand 20 is regulated by PGF(2α)-F-prostanoid receptor signalling in endometrial adenocarcinoma and promotes cell proliferation
    Alison E Wallace
    MRC Human Reproductive Sciences Unit The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Mol Cell Endocrinol 331:129-35. 2011
    ..Therefore these data demonstrate a role for the FP receptor in regulation of the chemokine CCL20, which can mediate proliferation of endometrial adenocarcinoma epithelial cells...
  52. pmc Evidence of prokineticin dysregulation in fallopian tube from women with ectopic pregnancy
    Julie L V Shaw
    Centre for Reproductive Biology, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Fertil Steril 94:1601-8.e1. 2010
    ..To demonstrate expression and regulation of prokineticins (PROKs) and their receptors (PROKRs) in fallopian tube (FT) from women who are not pregnant and women with ectopic pregnancy (EP)...
  53. ncbi request reprint Expression, localization, and signaling of PGE(2) and EP2/EP4 receptors in human nonpregnant endometrium across the menstrual cycle
    S A Milne
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, United Kingdom EH3 9ET
    J Clin Endocrinol Metab 86:4453-9. 2001
    ....
  54. pmc Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy
    Julie L V Shaw
    Centre for Reproductive Biology, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, UK
    Am J Pathol 177:2509-15. 2010
    ..05), which was negated by cotreatment with nAChRα-7 antagonist. Smoking targets human FTs via nAChRα-7 to increase tubal PROKR1, leading to alterations in the tubal microenvironment that could predispose to EP...
  55. pmc Placental growth factor: a promising diagnostic biomarker for tubal ectopic pregnancy
    Andrew W Horne
    Centre for Reproductive Biology, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 96:E104-8. 2011
    ..There is currently no serum test to differentiate tubal from intrauterine implantation, and an effective biomarker of ectopic pregnancy would be a major clinical advance...
  56. ncbi request reprint Hypoxia-inducible factor-1alpha expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2)
    Hilary O D Critchley
    University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Building, Scotland, UK
    Endocrinology 147:744-53. 2006
    ....
  57. ncbi request reprint Prolactin induces ERK phosphorylation in epithelial and CD56(+) natural killer cells of the human endometrium
    O Gubbay
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, Edinburgh EH3 9ET, United Kingdom
    J Clin Endocrinol Metab 87:2329-35. 2002
    ..Our data demonstrate that PRL stimulates the ERK pathway in multiple cellular compartments of the human endometrium and identify uterine CD56(+) NK cells as novel PRL target cells...
  58. doi request reprint Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary
    Sharon L Eddie
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 18:88-95. 2012
    ..These data establish that IL6-type cytokines and their receptors are expressed in the human fetal ovary and may directly influence GC development at multiple stages of maturation...
  59. pmc Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy
    Julie L V Shaw
    Centre for Reproductive Biology, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Am J Pathol 178:253-60. 2011
    ..trachomatis-induced PROKR2 expression. We propose that ligation of tubal TLR2 and activation of NFκB by C. trachomatis leads to increased tubal PROKR2, thereby predisposing the tubal microenvironment to ectopic implantation...
  60. doi request reprint Prostaglandin E2 as a regulator of germ cells during ovarian development
    Rosemary A L Bayne
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 94:4053-60. 2009
    ..The prostaglandins have pleiotrophic roles in reproduction, notably in ovulation and implantation, but there are no data regarding roles for prostaglandins in human fetal ovarian development...
  61. ncbi request reprint Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors
    H N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, EH3 9ET, United Kingdom
    Br J Cancer 85:1023-31. 2001
    ..42 +/- 0.46 vs 1.15 +/- 0.05 respectively; P< 0.001). In conclusion, these data suggest that PGE(2)may regulate neoplastic cell function in an autocrine/paracrine manner via the EP2/EP4 receptors...
  62. pmc Prostaglandin E2 affects T cell responses through modulation of CD46 expression
    Karoline Kickler
    Centre for Inflammation Research, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Immunol 188:5303-10. 2012
    ..These data demonstrate a novel role of the PGE(2)-EP4 axis in CD46 functions, which might at least partly explain the diverse roles of PGE(2) in T cell functions...
  63. doi request reprint Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system
    James L Hutchinson
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    Reproduction 142:15-28. 2011
    ....
  64. ncbi request reprint Prolactin receptor expression in the testis of the ram: localisation, functional activation and the influence of gonadotrophins
    H N Jabbour
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    Mol Cell Endocrinol 148:151-61. 1999
    ..The site and pattern of expression of the receptor gene suggest a role for prolactin in the regulation of steroidogenesis and spermatogenesis...
  65. ncbi request reprint Localization of interferon regulatory factor-1 (IRF-1) in nonpregnant human endometrium: expression of IRF-1 is up-regulated by prolactin during the secretory phase of the menstrual cycle
    H N Jabbour
    Medical Research Council Reproductive Biology Unit, University of Edinburgh Center for Reproductive Biology, United Kingdom
    J Clin Endocrinol Metab 84:4260-5. 1999
    ....
  66. ncbi request reprint Prolactin actions in the sheep testis: a test of the priming hypothesis
    G A Lincoln
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, United Kingdom
    Biol Reprod 65:936-43. 2001
    ..Testis diameter and inhibin A were marginally increased in group B + PRL. Overall, this thorough experiment provides minimal support for the priming hypothesis...
  67. ncbi request reprint Pattern and localisation of expression of vascular endothelial growth factor and its receptor flt-1 in the ovine pituitary gland: expression is independent of hypothalamic control
    H N Jabbour
    MRC Reproductive Biology Unit, Edinburgh, UK
    Mol Cell Endocrinol 134:91-100. 1997
    ....
  68. ncbi request reprint Expression of functional prolactin receptors in nonpregnant human endometrium: janus kinase-2, signal transducer and activator of transcription-1 (STAT1), and STAT5 proteins are phosphorylated after stimulation with prolactin
    H N Jabbour
    Medical Research Council Reproductive Biology Unit, Center for Reproductive Biology, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 83:2545-53. 1998
    ..The target genes activated by PRL in the glandular epithelium of the nonpregnant human endometrium remain to be elucidated...
  69. ncbi request reprint Cloning, sequencing and functional analysis of a truncated cDNA encoding red deer prolactin receptor: an alternative tyrosine residue mediates beta-casein promoter activation
    H N Jabbour
    Institute of Zoology, London, UK
    Mol Cell Endocrinol 123:17-26. 1996
    ..Northern blot analysis of red deer testis suggests that this species expresses a second form of the receptor, encoded by a transcript of 1.7 kb, which may correspond to a smaller receptor form or a binding protein...
  70. pmc Temporal expression and signalling of prostacyclin receptor in the human endometrium across the menstrual cycle
    S Battersby
    MRC Human Reproductive Sciences Unit and Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh Chancellor s Building, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Reproduction 127:79-86. 2004
    ..This may underscore a pivotal role for PGI(2) receptor signalling in normal and dysfunctional menstruation...
  71. ncbi request reprint Prolactin receptor expression in human testis and accessory tissues: localization and function
    W M Hair
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW, UK
    Mol Hum Reprod 8:606-11. 2002
    ..The demonstration of function and localization of PRL-R presented here suggests multiple roles for PRL in the human male reproductive tract...
  72. pmc Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulate
    S Battersby
    Medical Research Council Human Reproductive Science Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod 22:36-44. 2007
    ..Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma...
  73. ncbi request reprint Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle
    S Battersby
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:2463-9. 2004
    ..91 +/- 0.75-fold elevation in PK1 expression, compared with controls (P < 0.05). These data identify a paracrine role for the PKs and their receptors in endometrial vascular function...
  74. pmc Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation
    O P Milling Smith
    Department of Reproductive and Developmental Sciences, The University of Edinburgh, Edinburgh, UK
    Hum Reprod 22:1450-6. 2007
    ..This study was initiated to elucidate a pattern of expression of the various components of the cyclooxygenase (COX)-prostaglandin signalling pathways present in the endometrium of women with normal and heavy MBLs...
  75. ncbi request reprint Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathology
    K J Sales
    MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Prostaglandins Other Lipid Mediat 71:97-117. 2003
    ....
  76. pmc F-prostanoid receptor alters adhesion, morphology and migration of endometrial adenocarcinoma cells
    K J Sales
    MRC Human Reproductive Sciences Unit, Medical Research Council, The Queen s Medical Research Institute, Edinburgh, UK
    Oncogene 27:2466-77. 2008
    ..These results reveal a mechanism by which prostanoids regulate cell movement, which may be relevant to pathologies of the endometrium...
  77. pmc Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells
    David Qualtrough
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Int J Cancer 121:734-40. 2007
    ..These data show that PGF(2alpha) may play an important role in the malignant progression of colorectal tumors...
  78. pmc Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1
    Kurt J Sales
    Department of Medical Biochemistry, University of Cape Town Medical School, Cape Town 7925, South Africa
    Cancer Res 62:424-32. 2002
    ..It is likely that similar mechanisms may act in vivo to modulate tumorigenesis of cervical carcinomas...