Sarah E Harris

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. doi request reprint Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936
    Sarah E Harris
    Centre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics Section, University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 33:1486.e3-8. 2012
  2. pmc A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition
    Sarah E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    BMC Genet 8:43. 2007
  3. ncbi request reprint The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
    Sarah E Harris
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, UK
    Neurosci Lett 406:260-4. 2006
  4. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills
    S E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 11:505-13. 2006
  5. doi request reprint Apolipoprotein E is not related to memory abilities at 70 years of age
    Michelle Luciano
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Behav Genet 39:6-14. 2009
  6. doi request reprint Variation in the uric acid transporter gene (SLC2A9) and memory performance
    Lorna M Houlihan
    Department of Psychology, The University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, Edinburgh EH8 9JZ, UK
    Hum Mol Genet 19:2321-30. 2010
  7. pmc Genetic copy number variation and general cognitive ability
    Andrew K MacLeod
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37385. 2012
  8. doi request reprint Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
    Biol Psychiatry 73:938-43. 2013
  9. doi request reprint Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
    Riccardo E Marioni
    Public Health Sciences Section, Division of Community Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, EH8 9AG Edinburgh, Scotland, UK
    Behav Genet 40:3-11. 2010
  10. ncbi request reprint The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk
    Gillian Hamilton
    Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 159:696-709. 2012

Detail Information

Publications40

  1. doi request reprint Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936
    Sarah E Harris
    Centre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics Section, University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 33:1486.e3-8. 2012
    ..In conclusion we find little evidence that telomere length is a significant biomarker of normal aging in important cognitive and physical domains...
  2. pmc A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition
    Sarah E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    BMC Genet 8:43. 2007
    ..Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing...
  3. ncbi request reprint The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
    Sarah E Harris
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, UK
    Neurosci Lett 406:260-4. 2006
    ..17, p=0.022) adjustment for mental ability at age 11. This might be a type 1 error. Otherwise, we find that telomere length in old age does not have a significant association with age-related physical and cognitive decline or mortality...
  4. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills
    S E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 11:505-13. 2006
    ..This study indicates that BDNF genotype contributes to age-related changes in reasoning skills, which are closely related to general intelligence...
  5. doi request reprint Apolipoprotein E is not related to memory abilities at 70 years of age
    Michelle Luciano
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Behav Genet 39:6-14. 2009
    ..04) in the analysis not controlling for IQ. Neither of these tests was significant when a correction for multiple testing was applied. APOE e4 does not influence memory abilities in a normal population of 70-year-olds...
  6. doi request reprint Variation in the uric acid transporter gene (SLC2A9) and memory performance
    Lorna M Houlihan
    Department of Psychology, The University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, Edinburgh EH8 9JZ, UK
    Hum Mol Genet 19:2321-30. 2010
    ..These associations were not replicated in ET2DS (all P > 0.1). If the positive associations withstand, then this study could suggest that higher uric acid levels may be associated with increased performance on memory-related tasks...
  7. pmc Genetic copy number variation and general cognitive ability
    Andrew K MacLeod
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37385. 2012
    ..This is the first study to examine the effects of rare CNVs as called by multiple algorithms on cognition in a large non-clinical sample, and finds no effects of such variants on general cognitive ability...
  8. doi request reprint Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
    Biol Psychiatry 73:938-43. 2013
    ..No study has determined whether cognitive impairments can be attributed to schizophrenia's polygenic architecture using data from GWAS...
  9. doi request reprint Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
    Riccardo E Marioni
    Public Health Sciences Section, Division of Community Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, EH8 9AG Edinburgh, Scotland, UK
    Behav Genet 40:3-11. 2010
    ..038). After correction for multiple testing and adjustment for age and sex, no statistically significant associations were found between the SNPs and cognition. CRP is unlikely to be a causal determinant of late-life cognitive ability...
  10. ncbi request reprint The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk
    Gillian Hamilton
    Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 159:696-709. 2012
    ..We observed significantly less expression from the 338A variant in two human neuroblastoma cell lines and speculate that this promoter may be subject to tissue-specific regulation...
  11. pmc Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts
    Lorna M Lopez
    Department of Psychology, The University of Edinburgh, Edinburgh, UK
    Eur J Hum Genet 20:341-7. 2012
    ..A meta-analysis replicated the SYNJ2 association with cognitive abilities (lowest P=0.00077). SYNJ2 is a novel gene in which variation is potentially associated with cognitive abilities...
  12. doi request reprint Genetic contributions to stability and change in intelligence from childhood to old age
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Nature 482:212-5. 2012
    ..62. These estimates, derived from rarely available data on lifetime cognitive measures, warrant the search for genetic causes of cognitive stability and change...
  13. doi request reprint PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes
    Wendy Johnson
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Neurosci Lett 434:50-5. 2008
    ..The data did suggest that risk of cognitive decline is greater when Pro12Ala carriers contract diabetes...
  14. ncbi request reprint Association of existing and new candidate genes for anxiety, depression and personality traits in older people
    Michelle Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, Scotland, UK
    Behav Genet 40:518-32. 2010
    ..No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality...
  15. ncbi request reprint No association of CETP genotype with cognitive function or age-related cognitive change
    Wendy Johnson
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Neurosci Lett 420:189-92. 2007
    ..There were, however, no significant associations of CETP genotype with either childhood IQ or current cognitive function in old age, or with lifetime change in cognitive function...
  16. doi request reprint Age-associated cognitive decline
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Br Med Bull 92:135-52. 2009
    ..The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences...
  17. doi request reprint Cognitive ability at age 11 and 70 years, information processing speed, and APOE variation: the Lothian Birth Cohort 1936 study
    Michelle Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland
    Psychol Aging 24:129-38. 2009
    ..05): The correlation between childhood ability and speed was lower in e4 allele carriers. APOE has an influence on nonverbal cognition in old age and interacts with childhood IQ to influence processing speed...
  18. doi request reprint Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function
    Jennifer L Bolton
    Public Health Sciences, University of Edinburgh, Medical School, Edinburgh EH9 1NN, UK
    Behav Genet 40:630-8. 2010
    ..003), and DRD2 rs1800497 heterozygotes had lowest mean general cognitive ability 'g' (p = 0.007). There was an indication of a potential interaction between the DRD2 SNPs...
  19. ncbi request reprint Genetic influences on oxidative stress and their association with normal cognitive ageing
    Swati J Kachiwala
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 386:116-20. 2005
    ..An interaction between PRNP and klotho (KL) genotypes was also identified (p=0.015), highlighting the importance of analysing gene interactions when investigating associations with quantitative traits...
  20. ncbi request reprint KLOTHO genotype and cognitive ability in childhood and old age in the same individuals
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 378:22-7. 2005
    ..Variation in the KLOTHO gene is a possible contributor to life-long reasoning differences in humans and/or to the ageing of non-verbal reasoning, especially in women...
  21. ncbi request reprint Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey
    John M Starr
    MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Royal Victoria Hospital, Edinburgh EH4 2DN, UK
    Mech Ageing Dev 129:745-51. 2008
    ..Oxidative stress may explain, at least in part, associations between telomere shortening and physiological aging...
  22. pmc Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time
    Lorna M Houlihan
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Am J Hum Genet 86:626-31. 2010
    ..16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain approximately 18% of phenotypic variance in aPTT in the Lothian Birth Cohorts...
  23. ncbi request reprint The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds
    Sarah E Harris
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 385:1-6. 2005
    ..Therefore, COMT genotype may contribute to differences in normal cognitive aging and to differences in some of the major personality traits in old age...
  24. doi request reprint The genetics of cognitive ability and cognitive ageing in healthy older people
    Sarah E Harris
    Centre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics Section, University of Edinburgh, Edinburgh, EH4 2XU, UK
    Trends Cogn Sci 15:388-94. 2011
    ..Advances in exome and/or whole-genome sequencing, transcriptomics, proteomics and methylomics hold significant promise for uncovering the genetic underpinnings of cognitive ability and decline in old age...
  25. doi request reprint Association of KIBRA and memory
    Timothy C Bates
    Department of Psychology, University of Edinburgh, 7 George Square, EH89JZ, Scotland, UK
    Neurosci Lett 458:140-3. 2009
    ....
  26. ncbi request reprint Association between telomere length and heart disease in a narrow age cohort of older people
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, The Royal Victoria Hospital, Craigleith Road, Edinburgh, Scotland, UK
    Exp Gerontol 42:571-3. 2007
    ..Telomere shortening in peripheral blood leukocytes is a promising index of ischemic heart disease risk in older people and deserves further investigation as a potential mechanism...
  27. ncbi request reprint Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People
    Sarah E Harris
    Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    J Alzheimers Dis 39:565-74. 2014
    ..We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ. ..
  28. pmc Alzheimer's disease genes are associated with measures of cognitive ageing in the lothian birth cohorts of 1921 and 1936
    Gillian Hamilton
    Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK
    Int J Alzheimers Dis 2011:505984. 2011
    ..This haplotype explains a small proportion of the phenotypic variability (1.8%). These findings warrant further investigation as biological modifiers of cognitive ageing...
  29. ncbi request reprint Searching for genetic influences on normal cognitive ageing
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Trends Cogn Sci 8:178-84. 2004
    ..However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area...
  30. doi request reprint Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936
    L M Houlihan
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Genes Brain Behav 8:238-47. 2009
    ..All results are also presented so that they are valuable for future meta-analyses of candidate genes for cognition...
  31. ncbi request reprint Testing replication of a 5-SNP set for general cognitive ability in six population samples
    Michelle Luciano
    Department of Psychology, MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
    Eur J Hum Genet 16:1388-95. 2008
    ..01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied...
  32. pmc Longevity candidate genes and their association with personality traits in the elderly
    Michelle Luciano
    Centre for Cognitive Aging and Cognitive Epidemiology, The University of Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 159:192-200. 2012
    ....
  33. ncbi request reprint Association between genotype at an exonic SNP in DISC1 and normal cognitive aging
    P A Thomson
    Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neurosci Lett 389:41-5. 2005
    ..034 and 0.043, respectively). Women homozygous for the Cys allele had significantly lower cognitive ability scores than men at age 79, p = 0.003. Variation in DISC1 may therefore affect cognitive aging especially in women...
  34. doi request reprint Variation in the dysbindin gene and normal cognitive function in three independent population samples
    M Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Genes Brain Behav 8:218-27. 2009
    ..Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and the cognitive abilities with which they are associated...
  35. ncbi request reprint COMT genotype and cognitive ability: a longitudinal aging study
    John M Starr
    Department of Geriatric Medicine, Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, UK
    Neurosci Lett 421:57-61. 2007
    ..9 (95% C.I. 34.3-35.5), and Met/Met 34.9 (95% C.I. 34.1-35.8). This study adds to the evidence that the Val/Val polymorphism has a detrimental effect on cognition, extending upwards the age range in which such an effect has been detected...
  36. doi request reprint GSTz1 genotype and cognitive ability
    John M Starr
    Psychiatr Genet 18:211-2. 2008
  37. ncbi request reprint The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence
    Nitzan Mekel-Bobrov
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 16:600-8. 2007
    ....
  38. pmc Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Med Genet 44:373-80. 2007
    ..RIMS1 encodes a synapse active-zone protein with important roles in the maintenance of normal synaptic function: mice lacking this protein have greatly reduced learning ability and memory function...
  39. ncbi request reprint Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure
    Wendy J Watkins
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Fertil Steril 86:1518-21. 2006
    ..2%) and FOXO1A (1/90; 1.1%) were identified in POF patients; however, the pathological role of these mutations will be determined only by screening increased numbers of patients and controls, or by functional studies...
  40. ncbi request reprint INHA promoter polymorphisms are associated with premature ovarian failure
    Sarah E Harris
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Mol Hum Reprod 11:779-84. 2005
    ..Interestingly, haplotype B failed to show any promoter activity. We conclude that the inheritance of specific INHA promoter haplotypes predispose to the development of premature ovarian failure...