A Greenfield

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, UK
    Hum Mol Genet 9:1553-60. 2000
  2. pmc The molecular and cellular basis of gonadal sex reversal in mice and humans
    Nick Warr
    Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK
    Wiley Interdiscip Rev Dev Biol 1:559-77. 2012
  3. pmc Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1
    Nick Warr
    Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire, UK
    PLoS ONE 6:e19572. 2011
  4. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
    Debora Bogani
    Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
    PLoS Biol 7:e1000196. 2009
  5. pmc Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression
    Nick Warr
    Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Dev Cell 23:1020-31. 2012
  6. pmc Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation
    Stephen Frankenberg
    The Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, Tennis Court Rd, Cambridge, UK
    BMC Dev Biol 7:8. 2007
  7. ncbi request reprint An H-YDb epitope is encoded by a novel mouse Y chromosome gene
    A Greenfield
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Nat Genet 14:474-8. 1996
  8. ncbi request reprint The UTX gene escapes X inactivation in mice and humans
    A Greenfield
    Centre for Molecular and Cellular Biology and Department of Anatomical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Hum Mol Genet 7:737-42. 1998
  9. ncbi request reprint Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, Didcot, UK
    Mech Dev 102:209-11. 2001
  10. ncbi request reprint Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1)
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, United Kingdom
    Genomics 70:74-81. 2000

Collaborators

  • M B Soares
  • Dagmar Wilhelm
  • Hongbo Chi
  • Ying Xia
  • A P Monaco
  • G Blanco
  • P Koopman
  • D Scott
  • P P Tam
  • T Evans
  • E Simpson
  • Steve Dm Brown
  • Yuefei Liu
  • M J Mitchell
  • Nick Warr
  • Debora Bogani
  • S Grimmond
  • Sara Wells
  • Pam Siggers
  • Rachel Brixey
  • Michael Cheeseman
  • Harry Ostrer
  • Stephen Frankenberg
  • R Larder
  • P Siggers
  • N Van Hateren
  • R Arkell
  • Jessica Vitos Faleato
  • Melissa Childers
  • Angel R Nebreda
  • Ivan del Barco Barrantes
  • Marianna Tedesco
  • Madeleine Pope
  • Cheryl L Scudamore
  • Gwenn Aël Carré
  • Paul A Trainor
  • Hilda Tateossian
  • Asha Dopplapudi
  • Sarah Beddow
  • Jessica Edwards
  • Debbie Williams
  • Richard A Flavell
  • D Grbavec
  • Magdalena Zernicka-Goetz
  • Lee Smith
  • S Mazeyrat
  • T Hacker
  • S Morse
  • T J Hulsebos
  • Y W Jeske
  • C Wells
  • Z Tymowska-Lalanne
  • E Wright
  • L Smith
  • M de Fatima Bonaldo
  • S Stifani
  • R Lo
  • G Longepied
  • N A Affara
  • P S Ellis
  • I E Ehrmann
  • N Saut
  • C A Sargent
  • J Christiansen
  • J Bowles
  • M R Hargrave
  • L Cooper
  • U Gangadharan
  • J Kun

Detail Information

Publications16

  1. ncbi request reprint Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, UK
    Hum Mol Genet 9:1553-60. 2000
    ....
  2. pmc The molecular and cellular basis of gonadal sex reversal in mice and humans
    Nick Warr
    Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK
    Wiley Interdiscip Rev Dev Biol 1:559-77. 2012
    ..Finally, we discuss sex-determining loci and disorders of sex development in humans and the future of research in this important area...
  3. pmc Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1
    Nick Warr
    Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire, UK
    PLoS ONE 6:e19572. 2011
    ..Based on these observations, we conclude that MAP3K1 is not required for mouse testis determination. We discuss the significance of these data for the functional interpretation of sex-reversing MAP3K1 mutations in humans...
  4. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
    Debora Bogani
    Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
    PLoS Biol 7:e1000196. 2009
    ....
  5. pmc Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression
    Nick Warr
    Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Dev Cell 23:1020-31. 2012
    ..Taken together, our data suggest a requirement for GADD45γ in promoting MAP3K4-mediated activation of p38 MAPK signaling in embryonic gonadal somatic cells for testis determination in the mouse...
  6. pmc Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation
    Stephen Frankenberg
    The Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, Tennis Court Rd, Cambridge, UK
    BMC Dev Biol 7:8. 2007
    ..5. At E5.5, prospective anterior markers are expressed at the distal tip of the embryo, whereas prospective posterior markers are expressed more proximally, close to the boundary with the extraembryonic region...
  7. ncbi request reprint An H-YDb epitope is encoded by a novel mouse Y chromosome gene
    A Greenfield
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Nat Genet 14:474-8. 1996
    ..We identify the peptide WMHHNMDLI derived from the UTY protein as an H-Y epitope, H-YDb. Our data formally demonstrate that H-Y antigen is the product of more than one gene on the Y chromosome...
  8. ncbi request reprint The UTX gene escapes X inactivation in mice and humans
    A Greenfield
    Centre for Molecular and Cellular Biology and Department of Anatomical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Hum Mol Genet 7:737-42. 1998
    ..The human UTX gene was also found to be expressed from Xi. We discuss the significance of these data for our understanding of dosage compensation of X-Y homologous genes in humans and mice...
  9. ncbi request reprint Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, Didcot, UK
    Mech Dev 102:209-11. 2001
    ..Scube2 transcription is restricted to the embryonic neurectoderm but is also detectable in the adult heart, lung and testis...
  10. ncbi request reprint Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1)
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, United Kingdom
    Genomics 70:74-81. 2000
    ..We discuss the possible functions of this novel gene and its role in heritable disease in light of these data...
  11. ncbi request reprint The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
    E Wright
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Nat Genet 9:15-20. 1995
    ..The expression pattern and chromosomal location of Sox9 suggest that it may be the gene defective in the mouse skeletal mutant Tail-short, a potential animal model for campomelic dysplasia...
  12. ncbi request reprint Expression of a linear Sry transcript in the mouse genital ridge
    Y W Jeske
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Nat Genet 10:480-2. 1995
    ..The spatial and temporal profile of Sry expression suggests that its role in the mouse fetus is limited to initiating Sertoli cell development during testis determination...
  13. ncbi request reprint The Sry-related gene Sox18 maps to distal mouse chromosome 2
    A Greenfield
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Genomics 36:558-9. 1996
  14. ncbi request reprint Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle
    G Blanco
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
    Neuromuscul Disord 14:217-28. 2004
    ..Altogether, the data presented suggest that the ky muscular dystrophy develops by a distinctive pathogenic mechanism...
  15. pmc Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms
    D Grbavec
    Center for Neuronal Survival, Montreal Neurological Institute, 3801 rue University, Montreal, Quebec, H3A 2B4 Canada
    Biochem J 337:13-7. 1999
    ..These findings suggest that mammalian TLE and UTY/X proteins may mediate repression mechanisms similar to those performed by TUP1-SSN6 in yeast...
  16. ncbi request reprint The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region
    S Mazeyrat
    INSERM U491, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Hum Mol Genet 7:1713-24. 1998
    ..Our results therefore show that AZFa and Spy may be encoded by homologous genes...