Diana M Gibb

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial
    Diana M Gibb
    MRC Clinical Trials Unit, London, UK
    PLoS Med 9:e1001217. 2012
  2. pmc National policy development for cotrimoxazole prophylaxis in Malawi, Uganda and Zambia: the relationship between Context, Evidence and Links
    Eleanor Hutchinson
    Department of Global Health and Development, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London, UK
    Health Res Policy Syst 9:S6. 2011
  3. pmc Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study
    Heather B Jaspan
    Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health and Centre for Infectious Diseases, Stellenbosch University, Tygerberg, South Africa
    BMC Pediatr 11:104. 2011
  4. doi request reprint Lopinavir/ritonavir monotherapy after 24 weeks of second-line antiretroviral therapy in Africa: a randomized controlled trial (SARA)
    Charles F Gilks
    Imperial College, London, UK
    Antivir Ther 17:1363-73. 2012
  5. ncbi request reprint Is nevirapine dose-escalation appropriate in young, African, HIV-infected children?
    Quirine Fillekes
    aRadboud University Nijmegen Medical Centre, Nijmegen, The Netherlands bUniversity Teaching Hospital, Lusaka, Zambia cMRC Clinical Trials Unit, London, UK
    AIDS 27:2111-5. 2013
  6. ncbi request reprint Transient viral load increases in HIV-infected children in the U.K. and Ireland: what do they mean?
    Katherine J Lee
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 12:949-56. 2007
  7. ncbi request reprint The impact of daily cotrimoxazole prophylaxis and antiretroviral therapy on mortality and hospital admissions in HIV-infected Zambian children
    A Sarah Walker
    MRC Clinical Trials Unit, London, United Kingdom
    Clin Infect Dis 44:1361-7. 2007
  8. ncbi request reprint A randomized controlled trial of genotypic HIV drug resistance testing in HIV-1-infected children: the PERA (PENTA 8) trial
    Hannah Green
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 11:857-67. 2006
  9. doi request reprint Glomerular dysfunction and associated risk factors over 4-5 years following antiretroviral therapy initiation in Africa
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 16:1011-20. 2011
  10. ncbi request reprint Determinants of survival without antiretroviral therapy after infancy in HIV-1-infected Zambian children in the CHAP Trial
    A Sarah Walker
    MRC Clinical Trials Unit, London, UK
    J Acquir Immune Defic Syndr 42:637-45. 2006

Detail Information

Publications29

  1. pmc Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial
    Diana M Gibb
    MRC Clinical Trials Unit, London, UK
    PLoS Med 9:e1001217. 2012
    ....
  2. pmc National policy development for cotrimoxazole prophylaxis in Malawi, Uganda and Zambia: the relationship between Context, Evidence and Links
    Eleanor Hutchinson
    Department of Global Health and Development, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London, UK
    Health Res Policy Syst 9:S6. 2011
    ....
  3. pmc Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study
    Heather B Jaspan
    Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health and Centre for Infectious Diseases, Stellenbosch University, Tygerberg, South Africa
    BMC Pediatr 11:104. 2011
    ..Receiver Operating Characteristic (ROC) curves were compiled using combinations of clinical findings...
  4. doi request reprint Lopinavir/ritonavir monotherapy after 24 weeks of second-line antiretroviral therapy in Africa: a randomized controlled trial (SARA)
    Charles F Gilks
    Imperial College, London, UK
    Antivir Ther 17:1363-73. 2012
    ..Boosted protease inhibitor (bPI) monotherapy (bPImono) potentially has substantial cost, safety and operational benefits. It has never been evaluated as second-line antiretroviral therapy (ART) in Africa...
  5. ncbi request reprint Is nevirapine dose-escalation appropriate in young, African, HIV-infected children?
    Quirine Fillekes
    aRadboud University Nijmegen Medical Centre, Nijmegen, The Netherlands bUniversity Teaching Hospital, Lusaka, Zambia cMRC Clinical Trials Unit, London, UK
    AIDS 27:2111-5. 2013
    ..Young children metabolize nevirapine faster than older children/adults. We evaluated nevirapine pharmacokinetics with or without dose-escalation in Zambian, HIV-infected infants/children and its relationship with safety/efficacy...
  6. ncbi request reprint Transient viral load increases in HIV-infected children in the U.K. and Ireland: what do they mean?
    Katherine J Lee
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 12:949-56. 2007
    ..To investigate transient increases in viral load during sustained suppression in children in the UK and Ireland Collaborative HIV Paediatric Study (CHIPS)...
  7. ncbi request reprint The impact of daily cotrimoxazole prophylaxis and antiretroviral therapy on mortality and hospital admissions in HIV-infected Zambian children
    A Sarah Walker
    MRC Clinical Trials Unit, London, United Kingdom
    Clin Infect Dis 44:1361-7. 2007
    ..Data on the population effectiveness of cotrimoxazole prophylaxis and antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected African children are few...
  8. ncbi request reprint A randomized controlled trial of genotypic HIV drug resistance testing in HIV-1-infected children: the PERA (PENTA 8) trial
    Hannah Green
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 11:857-67. 2006
    ..To evaluate the longer-term utility of genotypic resistance testing in HIV-1-infected children with virological failure...
  9. doi request reprint Glomerular dysfunction and associated risk factors over 4-5 years following antiretroviral therapy initiation in Africa
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 16:1011-20. 2011
    ..The aim of this study was to investigate long-term renal function in HIV-infected adults initiating antiretroviral therapy (ART) with a CD4(+) T-cell count < 200 cells/mm³ in Africa...
  10. ncbi request reprint Determinants of survival without antiretroviral therapy after infancy in HIV-1-infected Zambian children in the CHAP Trial
    A Sarah Walker
    MRC Clinical Trials Unit, London, UK
    J Acquir Immune Defic Syndr 42:637-45. 2006
    ..There are few data on predictors of HIV progression in untreated children in resource-limited settings...
  11. pmc Adherence to antiretroviral therapy and acceptability of planned treatment interruptions in HIV-infected children
    Linda Harrison
    Medical Research Council Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK
    AIDS Behav 17:193-202. 2013
    ..004). The majority of families indicated they were happy to have further PTIs (carer: 23/36, 64 %; children: 8/13, 62 %), however many reported more clinic visits during PTI were a problem (carer: 15/36, 42 %; children: 6/12, 50 %)...
  12. doi request reprint The prevalence of darunavir-associated mutations in HIV-1-infected children in the UK
    Katherine L Donegan
    Medical Research Council Clinical Trials Unit, London, UK
    Antivir Ther 17:599-603. 2012
    ....
  13. doi request reprint Improved growth and anemia in HIV-infected African children taking cotrimoxazole prophylaxis
    Andrew Prendergast
    MRC Clinical Trials Unit, London, United Kingdom
    Clin Infect Dis 52:953-6. 2011
    ..04) and height-for-age (P=.01), and greater increase in hemoglobin level (P=.01). These findings argue for expanded early CTX use...
  14. ncbi request reprint HIV drug resistance testing: is the evidence really there?
    David T Dunn
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 9:641-8. 2004
    ..To assess the strength of evidence supporting the routine use of HIV drug resistance testing...
  15. doi request reprint Adherence to both cotrimoxazole and placebo is associated with improved survival among HIV-infected Zambian children
    A Sarah Walker
    Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
    AIDS Behav 13:33-41. 2009
    ....
  16. pmc Immediate antiretroviral therapy in young HIV-infected children: benefits and risks
    Intira J Collins
    MRC Clinical Trials Unit at University College London, London, UK
    Curr Opin HIV AIDS 9:87-94. 2014
    ..Concerns include long-term toxicities and treatment failure, particularly in resource-constrained settings with limited paediatric treatment options...
  17. ncbi request reprint Immunologic changes during unplanned treatment interruptions of highly active antiretroviral therapy in children with human immunodeficiency virus type 1 infection
    Diana M Gibb
    Medical Research Council Trials Unit, London, UK
    Pediatr Infect Dis J 23:446-50. 2004
    ..There are few data on the decline of CD4 cells or percentage during unplanned treatment interruptions in HIV-infected children...
  18. pmc Mortality in the year following antiretroviral therapy initiation in HIV-infected adults and children in Uganda and Zimbabwe
    A Sarah Walker
    MRC Clinical Trials Unit, London, UK
    Clin Infect Dis 55:1707-18. 2012
    ..However, the specific patterns of changing risk and causes of death have rarely been investigated in adults, nor compared with children in low-income countries...
  19. pmc First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial
    Abdel Babiker
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Lancet Infect Dis 11:273-83. 2011
    ..We assess the long-term outcome of protease inhibitor and non-nucleoside reverse transcriptase inhibitor (NNRTI) first-line ART and viral load switch criteria in children...
  20. doi request reprint Monitoring of highly active antiretroviral therapy in HIV infection
    A Sarah Walker
    MRC Clinical Trials Unit, London, UK
    Curr Opin Infect Dis 24:27-33. 2011
    ..We review studies describing the outcomes and costs of different monitoring approaches, predominantly in low-income countries...
  21. doi request reprint Hospitalization for severe malnutrition among HIV-infected children starting antiretroviral therapy
    Andrew Prendergast
    MRC Clinical Trials Unit, 222 Euston Road, London, UK
    AIDS 25:951-6. 2011
    ..To describe early hospitalization for severe malnutrition in HIV-infected children initiating antiretroviral therapy (ART)...
  22. pmc The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains
    Jean L Mbisa
    Virus Reference Department, Microbiology Services, Colindale, Health Protection Agency, London, UK
    Retrovirology 8:31. 2011
    ..In this study we examined the genotypic, phenotypic and fitness correlates associated with the development of Q151M MDR in the absence of viral load monitoring...
  23. ncbi request reprint Early infant diagnosis of HIV infection in low-income and middle-income countries: does one size fit all?
    Martina Penazzato
    MRC Clinical Trials Unit, London, UK Electronic address
    Lancet Infect Dis 14:650-5. 2014
    ....
  24. ncbi request reprint Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy
    Marietta Charakida
    Vascular Physiology Unit, Institute of Child Health, London, UK
    Circulation 112:103-9. 2005
    ..The purpose of this study was to determine the impact of HIV infection and antiretroviral therapy (ART) on markers of early vascular disease in children...
  25. doi request reprint The needs for HIV treatment and care of children, adolescents, pregnant women and older people in low-income and middle-income countries
    Julia Kenny
    Clinical Trials Unit, Medical Research Council, and Department of Infectious Diseases and Microbiology, Institute of Child Health, University College London, 30 Guilford St, London, UK
    AIDS 26:S105-16. 2012
    ..We review the special needs and barriers to scaling up care and antiretroviral therapy (ART) coverage in these populations...
  26. pmc A primary care level algorithm for identifying HIV-infected adolescents in populations at high risk through mother-to-child transmission
    Rashida A Ferrand
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 16:349-55. 2011
    ..To present an algorithm for primary-care health workers for identifying HIV-infected adolescents in populations at high risk through mother-to-child transmission...
  27. ncbi request reprint A national sample of individuals who acquired hepatitis C virus infections in childhood or adolescence: risk factors for advanced disease
    Helen E Harris
    Immunisation Department, Health Protection Agency, Centre for Infections, London, UK
    J Pediatr Gastroenterol Nutr 45:335-41. 2007
    ..To describe hepatitis C virus (HCV)-related liver disease in a national cohort of patients who acquired their infections in childhood or adolescence and to assess risk factors for progressive disease and response to antiviral therapy...
  28. ncbi request reprint Treatment interruption in children with HIV infection
    Hannah Green
    Medical Research Council Clinical Trials Unit, London, UK
    Curr Opin HIV AIDS 2:62-8. 2007
    ..It is vital that this research continues as antiretroviral therapy is rolled out to increasing numbers of young children in resource-limited settings...
  29. ncbi request reprint Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial)
    Diana M Gibb
    Medical Research Council Clinical Trials Unit, London, UK
    Antivir Ther 7:293-303. 2002
    ....