- Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptorsP Gharagozloo
Medical Research Council Collaborative Centre, 1 3 Burtonhole Lane, Mill Hill, London, NW7 1AD, U K
J Med Chem 42:438-45. 1999..The ability to generate subtype-selective allosteric enhancers of acetylcholine binding and function may be of use in the development of drugs for the treatment of Alzheimer's disease...
- Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptorsS Lazareno
MRC Collaborative Centre, Mill Hill, London, UK
Life Sci 64:519-26. 1999..These results provide the first well characterised instance of a positive enhancer of ACh at M2 receptors, and illustrate the difficulty of predicting such an effect...