P Gharagozloo

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors
    P Gharagozloo
    Medical Research Council Collaborative Centre, 1 3 Burtonhole Lane, Mill Hill, London, NW7 1AD, U K
    J Med Chem 42:438-45. 1999
  2. ncbi request reprint Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors
    S Lazareno
    MRC Collaborative Centre, Mill Hill, London, UK
    Life Sci 64:519-26. 1999

Detail Information

Publications2

  1. ncbi request reprint Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors
    P Gharagozloo
    Medical Research Council Collaborative Centre, 1 3 Burtonhole Lane, Mill Hill, London, NW7 1AD, U K
    J Med Chem 42:438-45. 1999
    ..The ability to generate subtype-selective allosteric enhancers of acetylcholine binding and function may be of use in the development of drugs for the treatment of Alzheimer's disease...
  2. ncbi request reprint Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors
    S Lazareno
    MRC Collaborative Centre, Mill Hill, London, UK
    Life Sci 64:519-26. 1999
    ..These results provide the first well characterised instance of a positive enhancer of ACh at M2 receptors, and illustrate the difficulty of predicting such an effect...