Alexander Gerhard

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy
    Alexander Gerhard
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, and National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Mov Disord 21:89-93. 2006
  2. ncbi request reprint [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
    A Gerhard
    MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurology 61:686-9. 2003
  3. ncbi request reprint In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration
    Alexander Gerhard
    MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, United Kingdom
    Mov Disord 19:1221-6. 2004
  4. ncbi request reprint Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study
    Alexander Gerhard
    MRC Clinical Sciences Centre and Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK
    Neuroimage 24:591-5. 2005
  5. ncbi request reprint In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
    Alexander Gerhard
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurobiol Dis 21:404-12. 2006
  6. ncbi request reprint Microglial activation in presymptomatic Huntington's disease gene carriers
    Yen F Tai
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Brain 130:1759-66. 2007
  7. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
  8. ncbi request reprint In vivo imaging of neuroinflammation
    Annachiara Cagnin
    Clinical Sciences Centre, PET Neurology, Cyclotron Building, Hammersmith Hospital, DuCane Road, W12 ONN, London, UK
    Eur Neuropsychopharmacol 12:581-6. 2002
  9. ncbi request reprint Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
  10. ncbi request reprint Cardiovascular effects of methamphetamine in Parkinson's disease patients
    Nicola Pavese
    MRC Clinical Science Center and Division of Neurosciences, Faculty of Medicine, Imperial College Hammersmith Hospital Campus, London, United Kingdom
    Mov Disord 19:298-303. 2004

Detail Information

Publications14

  1. ncbi request reprint In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy
    Alexander Gerhard
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, and National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Mov Disord 21:89-93. 2006
    ..11C](R)-PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP...
  2. ncbi request reprint [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
    A Gerhard
    MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurology 61:686-9. 2003
    ..Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA...
  3. ncbi request reprint In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration
    Alexander Gerhard
    MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, United Kingdom
    Mov Disord 19:1221-6. 2004
    ....
  4. ncbi request reprint Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study
    Alexander Gerhard
    MRC Clinical Sciences Centre and Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK
    Neuroimage 24:591-5. 2005
    ..Our data suggest that [11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration...
  5. ncbi request reprint In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
    Alexander Gerhard
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurobiol Dis 21:404-12. 2006
    ..The absence of significant longitudinal changes suggests that microglia are activated early in the disease process, and levels then remain relatively static, possibly driving the disease via cytokine release...
  6. ncbi request reprint Microglial activation in presymptomatic Huntington's disease gene carriers
    Yen F Tai
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Brain 130:1759-66. 2007
    ..PK PET may be a useful marker of active subclinical disease and a means of investigating the efficacy of neuroprotection strategies in PGCs...
  7. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    ..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
  8. ncbi request reprint In vivo imaging of neuroinflammation
    Annachiara Cagnin
    Clinical Sciences Centre, PET Neurology, Cyclotron Building, Hammersmith Hospital, DuCane Road, W12 ONN, London, UK
    Eur Neuropsychopharmacol 12:581-6. 2002
    ....
  9. ncbi request reprint Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
    ....
  10. ncbi request reprint Cardiovascular effects of methamphetamine in Parkinson's disease patients
    Nicola Pavese
    MRC Clinical Science Center and Division of Neurosciences, Faculty of Medicine, Imperial College Hammersmith Hospital Campus, London, United Kingdom
    Mov Disord 19:298-303. 2004
    ..These findings suggest that in PD there is impairment of catecholamine release from peripheral sympathetic presynaptic terminals, which correlates with motor impairment...
  11. ncbi request reprint Imaging microglial activation in Huntington's disease
    Yen F Tai
    Division of Neuroscience and Psychological Medicine, Hammersmith Hospital, Imperial College London, UK
    Brain Res Bull 72:148-51. 2007
    ..Further longitudinal studies are needed to fully elucidate this link...
  12. ncbi request reprint A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    Alexander N Anderson
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
    Neuroimage 36:28-37. 2007
    ..The reference-to-target ratio and the Logan graphical approach were significantly less reliable and less sensitive...
  13. doi request reprint Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease
    Giampaolo Tomasi
    Department of Information Engineering, University of Padova, Padova, Italy
    J Nucl Med 49:1249-56. 2008
    ....
  14. doi request reprint Functional relevant loss of long association fibre tracts integrity in early Alzheimer's disease
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    Neuropsychologia 46:1698-706. 2008
    ....