Affiliation: National Institute for Medical Research
- The past and future of tuberculosis researchIñaki Comas
Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
PLoS Pathog 5:e1000600. 2009..We argue here, however, that new multidisciplinary approaches--especially the integration of epidemiology with systems biology in what we call "systems epidemiology"--will be required to eliminate TB...
- Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologiesIñaki Comas
Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK
PLoS ONE 4:e7815. 2009..Our findings have implications for strain typing in other genetically monomorphic bacteria...
- Fitness cost of drug resistance in Mycobacterium tuberculosisS Gagneux
Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London, UK
Clin Microbiol Infect 15:66-8. 2009..Here, recent experimental and molecular epidemiological data that illustrate how heterogeneity among drug-resistant strains of Mycobacterium tuberculosis can influence the relative fitness and transmission of this pathogen are reviewed...
- Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosisS Borrell
Division of Mycobacterial Research, Medical Research Council National Institute for Medical Research, London, UK
Int J Tuberc Lung Dis 13:1456-66. 2009..Such increased knowledge will allow for better epidemiological predictions and assist in the development of new tools and strategies to fight drug-resistant TB...