P H Francis-West
Affiliation: National Institute for Medical Research
- BMP/GDF-signalling interactions during synovial joint developmentP H Francis-West
Department of Craniofacial Development, King s College London, Guy s Tower, Floor 28, London Bridge, SE1 9RT, UK
Cell Tissue Res 296:111-9. 1999..Finally, we discuss possible mechanisms of how a joint forms and the evidence that the joint is a 'signalling centre' that may coordinate the development of adjacent skeletal structures...
- Mechanisms of GDF-5 action during skeletal developmentP H Francis-West
Department of Craniofacial Development, Guy s, King s and St Thomas School of Dentistry, Guy s Tower, Floor 28, London Bridge, London, SE1 9RT, UK
Development 126:1305-15. 1999....
- Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick developmentR K Ladher
Department of Craniofacial Development, Guy s, King s and St Thomas School of Dentistry, Guy s Tower, Floor 27, Guy s Hospital, London, SE1 9RT, United Kingdom
Dev Biol 218:183-98. 2000..Finally, we have used the early Xenopus embryo as an in vivo assay to show that Sfrp-2, like Frzb, is a Wnt antagonist. These results suggest that Sfrp-2 and Frzb may function in the developing embryo by modulating Wnt signalling...
- Identification of synergistic signals initiating inner ear developmentR K Ladher
Department of Craniofacial Development, King s College, London, SE1 9RT, UK
Science 290:1965-7. 2000..Furthermore, we demonstrate the synergistic interactions of the extracellular polypeptide ligands FGF-19 and Wnt-8c as mediators of mesodermal and neural signals, respectively, initiating inner ear development...
- Misexpression of noggin leads to septal defects in the outflow tract of the chick heartS P Allen
Department of Craniofacial Development, Guy s, King s and St Thomas School of Dentistry, Guy s Tower, Floor 28, London Bridge, London, SE1 9RT, United Kingdom
Dev Biol 235:98-109. 2001..These results suggest that BMP-2/4 function may mediate several key events during cardiac development...
- Craniofacial development: the tissue and molecular interactions that control development of the headP H Francis-West
Department of Craniofacial Development King s College, London, SE1 9RT, UK
Adv Anat Embryol Cell Biol 169:III-VI, 1-138. 2003..Our current knowledge of the genes responsible for these human syndromes together with how the head develops, is rapidly advancing so that we will soon understand the complex set of molecular and tissue interactions that build a head...
- Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterningP H Francis-West
Department of Anatomy and Developmental Biology, University College of London, United Kingdom
Dev Dyn 203:187-97. 1995..In addition, the dissociation between the expression of shh and Bmps suggests distinct roles for the encoded molecules in signalling and response in a-p patterning of limb buds...
- Expression of chick Barx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordiaA J Barlow
Department of Craniofacial Development, Guy s, King s, and St Thomas School of Dentistry, Guy s Hospital, London, United Kingdom
Dev Dyn 214:291-302. 1999..This provides evidence that the differential expression of FGF-8 and BMPs may determine homeobox-containing gene expression and hence patterning of the facial primordia...
- Differential regulation of GDF-5 and FGF-2/4 by immobilisation in ovo exposes distinct roles in joint formationE Kavanagh
Department of Veterinary Basic Sciences, The Royal Veterinary College, London, UK
Dev Dyn 235:826-34. 2006..These findings support a direct mechano-dependent role for FGF-2, but not FGF-4, in the cavitation process and indicate that GDF-5 is likely to influence chondrogenesis positively without contributing directly to joint cavity formation...
- Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland developmentD J Phippard
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
Development 122:2729-37. 1996..The regulation of Msx-2 expression by oestrogen raises the possibility that hormonal regulation of mammary development is mediated through the control of epithelial-mesenchymal interactions...