Susan M Farrington

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci
    James G D Prendergast
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Epigenetics Chromatin 5:6. 2012
  2. pmc Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage
    Fatim Lakha
    Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK
    BMC Cancer 12:487. 2012
  3. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
  4. pmc Germline susceptibility to colorectal cancer due to base-excision repair gene defects
    Susan M Farrington
    Colon Cancer Genetics Group, School of Clinical and Molecular Medicine, University of Edinburgh, United Kingdom
    Am J Hum Genet 77:112-9. 2005
  5. doi request reprint Dietary vitamin B6 intake and the risk of colorectal cancer
    Evropi Theodoratou
    Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:171-82. 2008
  6. pmc Model selection approach suggests causal association between 25-hydroxyvitamin D and colorectal cancer
    Lina Zgaga
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e63475. 2013
  7. ncbi request reprint Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer
    Rebecca A Barnetson
    Colon Cancer Genetics Group, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom
    N Engl J Med 354:2751-63. 2006
  8. doi request reprint Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom
    Int J Cancer 123:2170-9. 2008
  9. ncbi request reprint Dietary fatty acids and colorectal cancer: a case-control study
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Epidemiol 166:181-95. 2007
  10. pmc The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study
    Lina Zgaga
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e38123. 2012

Collaborators

Detail Information

Publications19

  1. pmc A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci
    James G D Prendergast
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Epigenetics Chromatin 5:6. 2012
    ..abstract:..
  2. pmc Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage
    Fatim Lakha
    Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK
    BMC Cancer 12:487. 2012
    ..Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival...
  3. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
    ....
  4. pmc Germline susceptibility to colorectal cancer due to base-excision repair gene defects
    Susan M Farrington
    Colon Cancer Genetics Group, School of Clinical and Molecular Medicine, University of Edinburgh, United Kingdom
    Am J Hum Genet 77:112-9. 2005
    ..These findings have clinical relevance for BER gene testing for patients with colorectal cancer and for genetic counseling of their relatives...
  5. doi request reprint Dietary vitamin B6 intake and the risk of colorectal cancer
    Evropi Theodoratou
    Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:171-82. 2008
    ..Evidence from larger cohort and experimental studies is now required to confirm and define the anticarcinogenic actions of vitamin B6 and to explore the mechanisms by which this effect is mediated...
  6. pmc Model selection approach suggests causal association between 25-hydroxyvitamin D and colorectal cancer
    Lina Zgaga
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e63475. 2013
    ..We investigate the direction of causation between vitamin D and CRC by extending the conventional approaches to allow pleiotropic relationships and by explicitly modelling unmeasured confounders...
  7. ncbi request reprint Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer
    Rebecca A Barnetson
    Colon Cancer Genetics Group, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom
    N Engl J Med 354:2751-63. 2006
    ..The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease...
  8. doi request reprint Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom
    Int J Cancer 123:2170-9. 2008
    ..70, 95% CI 0.56, 0.87). The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR...
  9. ncbi request reprint Dietary fatty acids and colorectal cancer: a case-control study
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Epidemiol 166:181-95. 2007
    ..The observed different effects of different types of fatty acids underline the importance of type of fat in the etiology and prevention of colorectal cancer...
  10. pmc The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study
    Lina Zgaga
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e38123. 2012
    ..Objective of this study was to investigate the association between plasma urate concentration and: a) food items: dairy, sugar-sweetened beverages (SSB) and purine-rich vegetables; b) related nutrients: lactose, calcium and fructose...
  11. pmc Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis
    Evropi Theodoratou
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37662. 2012
    ..To elucidate the effect of vitamin D on CRC cancer risk, additional large studies of vitamin D and CRC risk are required and/or the application of alternative methods that are less sensitive to weak instrument restrictions...
  12. ncbi request reprint Dietary flavonoids and the risk of colorectal cancer
    Evropi Theodoratou
    Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:684-93. 2007
    ..22), and phytoestrogens (P(trend) = 0.26). This was the first of several a priori hypotheses to be tested in this large study and showed strong and linear inverse associations of flavonoids with colorectal cancer risk...
  13. doi request reprint MUTYH-associated polyposis and colorectal cancer
    Malcolm G Dunlop
    Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Surg Oncol Clin N Am 18:599-610. 2009
    ..Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed...
  14. ncbi request reprint Evidence for an age-related influence of microsatellite instability on colorectal cancer survival
    Susan M Farrington
    Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom
    Int J Cancer 98:844-50. 2002
    ..These findings underscore the rationale for surveillance and early identification of tumours in MMR gene carriers as well as refining understanding of the influence of MSI on cancer progression...
  15. doi request reprint Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Carcinogenesis 29:1774-80. 2008
    ..However, further large-scale studies are necessary in order to replicate these findings and confirm the role of these APC gene variants and their interaction with dietary and lifestyle exposures in colorectal carcinogenesis...
  16. pmc Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    Albert Tenesa
    Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Nat Genet 40:631-7. 2008
    ..008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology...
  17. ncbi request reprint Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
    Brent W Zanke
    Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 1L7, Canada
    Nat Genet 39:989-94. 2007
    ..i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer...
  18. ncbi request reprint Re: Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk
    Albert Tenesa
    J Natl Cancer Inst 97:320-1; author reply 321-2. 2005
  19. doi request reprint A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
    Ian P M Tomlinson
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
    Nat Genet 40:623-30. 2008
    ..3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition...