Research Topics
Genomes and GenesSpecies | Susan M FarringtonSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Detail Information
Publications
Sequencing and analysis of an Irish human genomePin Tong
Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Genome Biol 11:R91. 2010....- Germline susceptibility to colorectal cancer due to base-excision repair gene defectsSusan M Farrington
Colon Cancer Genetics Group, School of Clinical and Molecular Medicine, University of Edinburgh, United Kingdom
Am J Hum Genet 77:112-9. 2005..These findings have clinical relevance for BER gene testing for patients with colorectal cancer and for genetic counseling of their relatives... 
Dietary vitamin B6 intake and the risk of colorectal cancerEvropi Theodoratou
Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cancer Epidemiol Biomarkers Prev 17:171-82. 2008..Evidence from larger cohort and experimental studies is now required to confirm and define the anticarcinogenic actions of vitamin B6 and to explore the mechanisms by which this effect is mediated...- Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR bindingEvropi Theodoratou
Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom
Int J Cancer 123:2170-9. 2008..70, 95% CI 0.56, 0.87). The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR... 
Dietary fatty acids and colorectal cancer: a case-control studyEvropi Theodoratou
Public Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
Am J Epidemiol 166:181-95. 2007..The observed different effects of different types of fatty acids underline the importance of type of fat in the etiology and prevention of colorectal cancer...- Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancerRebecca A Barnetson
Colon Cancer Genetics Group, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom
N Engl J Med 354:2751-63. 2006..The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease... - The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional studyLina Zgaga
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 7:e38123. 2012..Objective of this study was to investigate the association between plasma urate concentration and: a) food items: dairy, sugar-sweetened beverages (SSB) and purine-rich vegetables; b) related nutrients: lactose, calcium and fructose... - Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysisEvropi Theodoratou
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 7:e37662. 2012..To elucidate the effect of vitamin D on CRC cancer risk, additional large studies of vitamin D and CRC risk are required and/or the application of alternative methods that are less sensitive to weak instrument restrictions... - Dietary flavonoids and the risk of colorectal cancerEvropi Theodoratou
Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:684-93. 2007..22), and phytoestrogens (P(trend) = 0.26). This was the first of several a priori hypotheses to be tested in this large study and showed strong and linear inverse associations of flavonoids with colorectal cancer risk... - MUTYH-associated polyposis and colorectal cancerMalcolm G Dunlop
Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
Surg Oncol Clin N Am 18:599-610. 2009..Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed... - Evidence for an age-related influence of microsatellite instability on colorectal cancer survivalSusan M Farrington
Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom
Int J Cancer 98:844-50. 2002..These findings underscore the rationale for surveillance and early identification of tumours in MMR gene carriers as well as refining understanding of the influence of MSI on cancer progression... - Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variantsEvropi Theodoratou
Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
Carcinogenesis 29:1774-80. 2008..However, further large-scale studies are necessary in order to replicate these findings and confirm the role of these APC gene variants and their interaction with dietary and lifestyle exposures in colorectal carcinogenesis... - A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3Ian P M Tomlinson
Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
Nat Genet 40:623-30. 2008..3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition... - Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24Brent W Zanke
Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 1L7, Canada
Nat Genet 39:989-94. 2007..i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer... - Re: Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer riskAlbert Tenesa
J Natl Cancer Inst 97:320-1; author reply 321-2. 2005 - Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21Albert Tenesa
Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
Nat Genet 40:631-7. 2008..008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology...